VOKANAMET 50/1000mg Tablet 60's
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Introduction About VOKANAMET 50/1000MG TABLET
VOKANAMET 50/1000MG TABLET is a combination of Canagliflozin and Metformin, which belongs to the group of medicines called Antidiabetic agents. It is used as an adjunct to diet and exercise to control blood sugar levels and also helps manage heart disease in adults with type II diabetes mellitus when it cannot be controlled by metformin alone or together with other diabetes medicines.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.
Before and during management with VOKANAMET 50/1000MG TABLET, your doctor will check for kidney function by conducting a blood test. VOKANAMET 50/1000MG TABLET is not recommended for use during pregnancy or in breastfeeding women. Talk to your doctor about whether to stop taking VOKANAMET 50/1000MG TABLET or to stop breast-feeding.
[GBKEYWORD] is not recommended for use if you have severe breathing difficulties, severe kidney disease, liver disease, a heart attack, or have severe blood circulation problems, such as shock. Consult your doctor before taking this VOKANAMET 50/1000MG TABLET.
The most common side effects of taking VOKANAMET 50/1000MG TABLET are low blood glucose levels, severe infection of the urinary tract, vaginal yeast infection, constipation, feeling thirsty, and nausea. Consult your doctor if any of the side effects worsen.
Uses Of VOKANAMET 50/1000MG TABLET
- To manage type II diabetes mellitus
How VOKANAMET 50/1000MG TABLET Works
VOKANAMET 50/1000MG TABLET effectively controls blood glucose levels, where canagliflozin works by inhibiting sodium-glucose co-transporter 2 protein in the kidneys and managing the reabsorption of glucose from the blood into the kidneys. As a result, more glucose is excreted in urine, which helps lower blood glucose levels in the body. Metformin works by decreasing the production of glucose in the liver, decreasing the intestinal absorption of glucose, increasing insulin sensitivity, and allowing better glucose uptake and utilization by the body.
How to use VOKANAMET 50/1000MG TABLET
Take VOKANAMET 50/1000MG TABLET, preferably with meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Do not stop taking VOKANAMET 50/1000MG TABLET unless your doctor advises you to stop.
Side Effects Of VOKANAMET 50/1000MG TABLET
Common
- signs of low blood glucose levels are blurred vision, tingling lips, trembling, sweating, looking pale, a change in mood, or feeling anxious or confused
- signs of a severe infection of the urinary tract, such as fever and/or chills, a burning sensation while urinating, and pain in your back or side
- vaginal yeast infection
- rash or redness of the penis or foreskin (yeast infection)
- changes in urination (including urinating more frequently or in larger amounts, urgent need to urinate, need to urinate at night)
- constipation
- feeling thirsty and nausea
Uncommon
- signs of dehydration are feeling light-headed or dizzy, feeling dizzy or faint when you stand up, having a very dry or sticky mouth, feeling very thirsty, feeling very weak or tired, passing little or no urine, and having a fast heartbeat
- rashes, hives, redness, itching, and raised bumps, oozing fluid, or blisters
- bone fracture
- kidney failure
- lower limb amputations (mainly of the toe)
- phimosis
- skin reactions after exposure to sunlight
Rare
Stop taking VOKANAMET 50/1000MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- symptoms of lactic acidosis include vomiting, stomach aches, muscle cramps, a general feeling of not being well with severe tiredness, difficulty breathing, reduced body temperature, and a slow heartbeat
- signs and symptoms of diabetic ketoacidosis such as rapid weight loss, nausea, vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth, or a different odour to your urine or sweat
- signs and symptoms of necrotizing fasciitis of the perineum or Fournier’s gangrene include pain, tenderness, redness, or swelling of the genitals or the area between the genitals and the anus with fever or feeling generally unwell
- sign of an allergic reaction such as swelling of the face, lips, mouth, tongue, or throat that may cause difficulty breathing or swallowing
How To Manage Side Effects
Constipation
Include fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole-grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if constipation persists.
Diarrhea
Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Dry Mouth
Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if the dry mouth gets worse.
Hypoglycemia
Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If you have not reached your optimum level, take another sugary snack or drink and check your blood sugar levels once again. Contact your doctor if there is no improvement in your condition.
Nausea And Vomiting
Take VOKANAMET 50/1000MG TABLET with a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting do not improve.
Skin rash Or Itching
Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if your rashes worsen.
Stomach Pain
Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-manage on your own, consult your doctor if the symptom does not improve on its own.
Warning & Precautions
Pregnancy
ContraindicatedVOKANAMET 50/1000MG TABLET is not recommended for use during pregnancy. Consult your doctor before taking it.
Breastfeeding
ContraindicatedVOKANAMET 50/1000MG TABLET is not recommended for use by breastfeeding women. Talk to your doctor about whether to stop taking VOKANAMET 50/1000MG TABLET or to stop breast-feeding.
Driving and Using Machines
ContraindicatedDo not drive or operate any machinery if you feel dizziness or lightheadedness after taking VOKANAMET 50/1000MG TABLET.
Alcohol
RiskyAvoid excessive consumption of alcohol while taking VOKANAMET 50/1000MG TABLET, as it may increase the risk of lactic acidosis.
Kidney
Consult your doctorVOKANAMET 50/1000MG TABLET is not recommended for use if you have severe kidney disease. Inform your doctor before taking VOKANAMET 50/1000MG TABLET if you have a serious infection of the kidney or the urinary tract with fever.
Liver
ContraindicatedVOKANAMET 50/1000MG TABLET is not recommended for use if you have liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take VOKANAMET 50/1000MG TABLET if you are allergic to canagliflozin, metformin, or any of the other ingredients of this medicine.
Lungs
Contraindicated[GBKEYWORD] is not recommended for use if you have severe breathing difficulties. Consult your doctor before taking it.
Heart Disease
Consult your doctor[GBKEYWORD] is not recommended for use if you have recently had a heart attack or have severe blood circulation problems, such as shock. Inform your doctor if you have high blood pressure or have ever had serious heart disease before taking it.
Use In Pediatrics
ContraindicatedVOKANAMET 50/1000MG TABLET is not recommended for use in children and adults under 18 years of age. Consult your doctor before taking it.
Use In Geriatrics
Use with CautionVOKANAMET 50/1000MG TABLET should be used with caution with elderly patients. Consult your doctor before taking it.
Others
VOKANAMET 50/1000MG TABLET is not recommended for use if you:
- have uncontrolled diabetes with severe high blood sugar levels, nausea, vomiting, diarrhea, rapid weight loss, lactic acidosis, or ketoacidosis
- have a severe infection
- have dehydration Ex. due to severe diarrhea or vomiting’s.
- have a diabetic pre-coma
Before taking VOKANAMET 50/1000MG TABLET, inform your doctor if you:
- have type 1 diabetes mellitus
- have had a stroke
- have had a lower limb amputation
- have signs of a genital yeast infection such as irritation, itching, unusual discharge, or odour
- are scheduled for surgery
- are going to have an x-ray or scan
Interactions
A. Drug-drug interactions:
Before taking VOKANAMET 50/1000MG TABLET, inform your doctor if you are taking any of the following medicines, such as:
- insulin or a sulphonylurea Ex. glimepiride or glipizide (other medicines used to manage diabetes mellitus)
- medicines that increase urine production (diuretics) Ex. furosemide
- John's wort (an herbal medicine used to manage depression)
- carbamazepine, phenytoin, or phenobarbital (medicines used to manage seizures)
- lithium (a medicine used to manage bipolar disorder)
- efavirenz or ritonavir (medicines used to manage HIV infection)
- rifampicin (an antibiotic used to manage tuberculosis)
- cholestyramine (a medicine used to manage cholesterol levels in the blood)
- digoxin or digitoxin (medicines used for managing certain heart problems)
- dabigatran (a medicine used in the management of blood clots)
- medicines that contain alcohol
- cimetidine (a medicine used to manage stomach problems)
- corticosteroids (used to manage a variety of conditions, such as severe inflammation of the skin or asthma), Ex. beclomethasone dipropionate, budesonide
- beta-2 agonists (medicines used to manage asthma) Ex. salbutamol or terbutaline
- medicines used to manage pain and inflammation (NSAIDs and COX-2-inhibitors, such as ibuprofen and celecoxib)
- medicines for the management of high blood pressure (ACE inhibitors and angiotensin II receptor antagonists) Ex. Enalapril, captopril, losartan, olmesartan, and telmisartan
Overdosage:
If you or anyone else accidentally took more VOKANAMET 50/1000MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage may cause lactic acidosis, and symptoms include vomiting, stomach ache, muscle cramps, feeling unwell with severe tiredness, difficulty breathing, reduced body temperature, and heartbeat.
Synopsis
| Drug | : | Canagliflozin and Metformin |
| Pharmacological Category | : | Sodium-glucose co-transporter 2 inhibitors, biguanides |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep VOKANAMET 50/1000MG TABLET out of the sight and reach of children
- Store VOKANAMET 50/1000MG TABLET below 30°C
FAQs About VOKANAMET 50/1000MG TABLET
Q: When is the best time to take VOKANAMET 50/1000MG TABLET?
A: Take VOKANAMET 50/1000MG TABLET, preferably with meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Q: What are the side effects of VOKANAMET 50/1000MG TABLET?
A: The most common side effects of taking VOKANAMET 50/1000MG TABLET are low blood glucose levels, severe infection of the urinary tract, vaginal yeast infection, constipation, feeling thirsty, and nausea. Consult your doctor if any of the side effects worsen.
Q: How does VOKANAMET 50/1000MG TABLET work?
A: VOKANAMET 50/1000MG TABLET effectively controls blood glucose levels, where canagliflozin works by inhibiting sodium-glucose co-transporter 2 protein in the kidneys and managing the reabsorption of glucose from the blood into the kidneys. As a result, more glucose is excreted in urine, which helps lower blood glucose levels in the body. Metformin works by decreasing the production of glucose in the liver, decreasing the intestinal absorption of glucose, increasing insulin sensitivity, and allowing better glucose uptake and utilization by the body.
Q: Is VOKANAMET 50/1000MG TABLET safe during pregnancy?
A: VOKANAMET 50/1000MG TABLET is not recommended for use during pregnancy. Inform your doctor if you are pregnant or planning to be pregnant before taking it.
Q: Who should not take VOKANAMET 50/1000MG TABLET?
A: [GBKEYWORD] is not recommended for use if you have severe breathing difficulties, severe kidney disease, liver disease, a recent history of a heart attack, or have severe blood circulation problems, such as shock, uncontrolled diabetes with lactic acidosis or ketoacidosis, severe infection, dehydration, or diabetic pre-coma. Consult your doctor before taking VOKANAMET 50/1000MG TABLET.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 301 & 299.
2. Zirui Hao, Yue Sun, Guiping Li, Yuli Shen, Yingzhen Wen and Yan Liu. Effects of canagliflozin and metformin on insulin resistance and visceral adipose tissue in people with newly-diagnosed type 2 diabetes. BMC Endocrine Disorders. February 2022. [Accessed on 20th December 2023]. https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-022-00949-0
3. Janssen-Cilag SpA. Electronic Medicines Compendium (EMC) [Revised in August 2023] [Accessed on 20th December 2023]. https://www.medicines.org.uk/emc/files/pil.3407.pdf
4. Janssen Pharmaceuticals, Inc. Canagliflozin and metformin. [Revised in July 2023] [Accessed on 20th December 2023]. https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVOKAMET+XR-pi.pdf
5. Drug bank. Canagliflozin. [Accessed on 20th December 2023]. https://go.drugbank.com/drugs/DB08907
6. Drug bank. Metformin. [Accessed on 20th December 2023]. https://go.drugbank.com/drugs/DB00331
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (RBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin – Fasting
- Insulin Postprandial (PP)
- Vital Diabetes Care
- Extended Diabetes Care
- Advance Diabetes Care
- Comprehensive Diabetes Care
Author Details
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