Uses of Canagliflozin+Metformin

The combination of Canagliflozin+Metformin is used as an adjunct to diet and exercise to control blood sugar levels and also helps manage heart disease in adults with type II diabetes mellitus when it cannot be controlled by metformin alone or together with other diabetes medicines.

Therapeutic Category

Canagliflozin+Metformin: Antidiabetic agents

How Canagliflozin+Metformin works

Canagliflozin+Metformin effectively controls blood glucose levels, where canagliflozin works by inhibiting sodium-glucose co-transporter 2 protein in the kidneys and preventing the reabsorption of glucose from the blood into the kidneys. As a result, more glucose is excreted in urine, which helps lower blood glucose levels in the body. Metformin works by decreasing the production of glucose in the liver, decreasing the intestinal absorption of glucose, increasing insulin sensitivity, and allowing better glucose uptake and utilization by the body.

Common side effects of Canagliflozin+Metformin

• Signs of low blood glucose levels are blurred vision, tingling lips, trembling, sweating, looking pale, a change in mood, or feeling anxious or confused
• Signs of a severe infection of the urinary tract, such as fever and/or chills, a burning sensation while urinating, and pain in your back or side
• Vaginal yeast infection
• Rash or redness of the penis or foreskin (yeast infection)
• Changes in urination (including urinating more frequently or in larger amounts, urgent need to urinate, need to urinate at night)
• Constipation
• Feeling thirsty and nausea

When to consult your doctor

Consult your doctor, if you experience:

• Symptoms of lactic acidosis include vomiting, stomach aches, muscle cramps, a general feeling of not being well with severe tiredness, difficulty breathing, reduced body temperature, and a slow heartbeat
• Signs and symptoms of diabetic ketoacidosis such as rapid weight loss, nausea, vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth, or a different odour to your urine or sweat
• Signs and symptoms of necrotizing fasciitis of the perineum or Fournier’s gangrene include pain, tenderness, redness, or swelling of the genitals or the area between the genitals and the anus with fever or feeling generally unwell
• Sign of an allergic reaction such as swelling of the face, lips, mouth, tongue, or throat that may cause difficulty breathing or swallowing

Health Tips for Canagliflozin+Metformin

• Always take Canagliflozin+Metformin as prescribed by your healthcare provider. It can be taken with or without food Do not skip doses or stop taking them without consulting your doctor
• Drink plenty of water while taking Canagliflozin+Metformin to help prevent dehydration
• Do not drive or operate any machinery if you feel dizziness or lightheadedness after taking Canagliflozin+Metformin
• Avoid alcohol while taking Canagliflozin+Metformin as it can reduce their effectiveness and may cause adverse reactions
• Eating a balanced diet, getting enough rest, and managing stress can support your body's ability
• Regularly check your blood sugar levels as recommended by your healthcare provider
• Attend follow-up appointments as scheduled to monitor your progress
• Canagliflozin+Metformin is not recommended for use in pregnant or planning for pregnancy or breastfeeding women