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VINGLYN D 5 TABLET is a combination medication used to manage blood sugar levels in adults with type 2 diabetes mellitus which is poorly controlled on metformin monotherapy. Along with a healthy diet and regular exercise, it helps improve blood sugar control by enhancing the proper use of insulin, thereby reducing blood sugar levels effectively.
VINGLYN D 5 TABLET can be taken with or without food at any time of the day, but it’s important to take it consistently at the same time each day. The dosage is determined by your doctor, and it’s crucial not to stop taking it without consulting them, as this could lead to increased blood sugar levels and serious complications like kidney damage or vision problems. It works best as part of a comprehensive diabetes management plan, including weight control, as recommended by your doctor.
Common side effects include low blood sugar (hypoglycemia), urinary tract infections, vaginal inflammation, dizziness, tremors, and headaches. Drinking plenty of fluids can help prevent dehydration, and maintaining good hygiene may reduce the risk of genital fungal infections.
Before starting VINGLYN D 5 TABLET, inform your doctor if you have kidney or liver issues, urinary tract infections, or if you are taking diuretics (water pills). Pregnant or breastfeeding women should consult their doctor before use. Limit alcohol consumption to avoid an increased risk of side effects and monitor your blood sugar levels regularly while on this treatment.
Uses Of VINGLYN D 5 TABLET
How VINGLYN D 5 TABLET Works
VINGLYN D 5 TABLET contains two active ingredients: Dapagliflozin and Vildagliptin, which work together to manage blood sugar levels in type 2 diabetes. Dapagliflozin is an SGLT2 inhibitor that reduces blood sugar by blocking the reabsorption of glucose in the kidneys, allowing excess sugar to be removed from the body through urine. This helps lower blood sugar levels, especially fasting glucose, and can also assist in weight management and lowering blood pressure.
Vildagliptin is a DPP-4 inhibitor that enhances the body’s natural hormones involved in blood sugar control. It increases insulin secretion in response to meals and reduces the release of glucagon, a hormone that raises blood sugar. This dual action helps stabilize blood sugar levels after eating and throughout the day, providing effective glycemic control when used alongside a healthy diet and exercise. Together, these components complement each other to improve overall diabetes management.
How to use VINGLYN D 5 TABLET
- Take VINGLYN D 5 TABLET exactly as prescribed by your doctor.
- Swallow the tablet whole with a glass of water, preferably at the same time each day to maintain consistent blood sugar levels.
- VINGLYN D 5 TABLET can be taken with or without food.
- Do not crush, chew, or break the tablet.
- Follow your doctor’s instructions regarding the dosage and duration of use.
- Continue taking the medication regularly, even if you feel better, and do not stop without consulting your doctor, as this could lead to uncontrolled blood sugar levels.
- Ensure to follow a healthy diet, exercise regularly, and monitor your blood sugar levels as advised.
Side Effects Of VINGLYN D 5 TABLET
Like all medicines, VINGLYN D 5 TABLET may cause side effects, although not everybody gets them
Common Side Effects of VINGLYN D 5 TABLET are:
- Dizziness
- Genital infection (thrush) of penis or vagina (itching, irritation, unusual discharge, or odour)
- Back pain
- Frequent or excessive urination than normal
- Rash
- Changes in the blood cholesterol or fat level
- Increased amount of red blood cells
- Decrease in creatinine renal clearance in the beginning of management
- Headache
- Constipation, heartburn
- Swelling of hands, feet or ankle and joint pain
- Dehydration or loss of too much body fluid (very dry or sticky mouth, fast heartbeat, little or no urination)
- Thirst
- Waking in between sleep at night to pass urine
- Weight loss
- Increased urea and creatinine levels
Stop taking VINGLYN D 5 TABLET and contact your doctor immediately if you experience any of the following side effects:
- Angioedema (swollen face, throat or tongue, trouble swallowing and breathing, sudden onset of hives or rash)
- Liver inflammation (yellowing of skin and eyes, nausea, loss of appetite, dark-coloured urine)
- Inflammation of the pancreas (persistent and severe stomach pain which may radiate to your back, nausea, vomiting)
- Diabetic ketoacidosis (nausea, vomiting, stomach pain, excessive thirst, deep and fast breathing, confusion, unusual tiredness or sleepiness, sweet breath odour, metallic or sweet taste in mouth or a different odour in your sweat, rapid weight loss)
- Fournier’s gangrene or necrotising fasciitis of the perineum (soft tissue infection of genitals or between anus and genital which might be serious)
- Urinary tract infection (fever, chills, burning sensation, seeing blood while urinating, back or side pain)
- Low blood sugar level (sweating, shaking, anxiety, fast heartbeat, feeling hungry, headache, change in vision, mood changes or confusion)
How To Manage Side Effects
Diarrhea
To manage diarrhea at home, follow these steps:
- Stay Hydrated: Drink plenty of fluids, such as water, clear broths, or oral rehydration solutions (ORS), to prevent dehydration. Avoid sugary drinks, caffeine, and alcohol as they may worsen diarrhea.
- Eat a Bland Diet: Consume easily digestible foods like bananas, rice, applesauce, and toast (the BRAT diet) to soothe your stomach. Avoid spicy, greasy, or high-fiber foods until your symptoms improve.
- Take Probiotics: Yogurt or probiotic supplements can help restore the natural balance of gut bacteria, speeding up recovery.
- Avoid Trigger Foods: Steer clear of dairy products, fatty foods, or anything that seems to aggravate your symptoms.
- Rest: Give your body time to recover by avoiding strenuous activities and getting enough rest.
If diarrhea persists for more than 2–3 days, is accompanied by severe pain, blood in stool, or signs of dehydration (such as extreme thirst, dry mouth, or dizziness), seek medical attention.
Hypoglycemia
To manage hypoglycemia (low blood sugar) at home, follow these steps:
- Recognize Symptoms: Look for signs like shakiness, sweating, dizziness, irritability, confusion, or rapid heartbeat.
- Consume Quick-Acting Sugar: Immediately eat or drink something with fast-absorbing sugar, such as:
- 3–4 glucose tablets.
- 1/2 cup (120 mL) of juice or regular soda (not diet).
- 1 tablespoon of honey or sugar.
- 5–6 hard candies
- Wait and Recheck: After consuming sugar, wait 15 minutes and recheck your blood sugar. If it’s still low (below 70 mg/dL), repeat the sugar intake.
- Eat a Small Snack: Once your blood sugar stabilizes, eat a small, balanced snack containing carbohydrates and protein, like a peanut butter sandwich, to prevent another drop.
- Prevent Recurrence: Monitor blood sugar regularly, eat meals on time, and adjust medications or insulin as directed by your doctor.
If symptoms persist or worsen, or if you lose consciousness, seek emergency medical attention immediately. Always carry a source of sugar if you have diabetes.
Warning & Precautions
Pregnancy
Monitoring requiredThere are no well controlled human studies regarding the use of Dapagliflozin + Vildagliptin in pregnant women. Animal studies have indicated few harmful side effects in their progeny. Therefore, VINGLYN D 5 TABLET should be taken by pregnant women only if your doctor considers it as clearly necessary.
Breastfeeding
Monitoring requiredIt is not known whether the medicines, Dapagliflozin + vildgliptin gets excreted in breast milk. Animal studies have reported the excretion of medicine in milk as well as pharmacologically mediated effects in nursing offspring. A risk to the infant cannot be excluded. Therefore, breastfeeding women should not take VINGLYN D 5 TABLET unless considered necessary by the physician.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy after taking VINGLYN D 5 TABLET.
Alcohol
Consult your doctorVINGLYN D 5 TABLET should be used with caution in patients with a history of alcohol abuse. Consult your doctor for advice.
Kidney
Use with CautionVINGLYN D 5 TABLET should be used with caution in patients having moderate or severe kidney disease and in those undergoing dialysis. Consult your doctor before taking it.
Liver
Use with CautionVINGLYN D 5 TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take VINGLYN D 5 TABLET if you are allergic to Dapagliflozin, Vildagliptin, or any of the other ingredients of this medicine.
Heart Disease
Use with CautionVINGLYN D 5 TABLET should be used with caution in patients suffering from heart failure. Consult your doctor before taking it.
Use In Pediatrics
ContraindicatedVINGLYN D 5 TABLET is not recommended for use in children and adolescents (below 18 years of age). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionVINGLYN D 5 TABLET should be used with caution in elderly patients (above 65 years of age). Consult your doctor for advice.
Others
Before taking VINGLYN D 5 TABLET, inform your doctor if you:
- Have or had any pancreatic disease
Interactions
A. Drug-Drug interactions:
Before taking VINGLYN D 5 TABLET, inform your doctor if you are taking any of the following medicines:
- Other medicines used to lower blood sugar levels (Ex. glimepiride, glipizide)
- Medicines used to remove excess body fluids from the body (Ex. methyclothiazide, trichlormethiazide, furosemide)
- Medicines used to reduce inflammation (Ex. prednisolone, hydrocortisone)
- Medicines used to manage underactive thyroid (Ex. levothyroxine, liothyronine)
- Medicines used to manage fits (Ex. phenytoin, phenobarbital)
Overdosage:
If you or anyone else accidentally take too much of VINGLYN D 5 TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Dapagliflozin, Vildagliptin |
| Pharmacological Category | : | Dipeptidyl Peptidase 4 (DPP-4) inhibitor |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep VINGLYN D 5 TABLET out of reach of children
- Store VINGLYN D 5 TABLET below 30°C
FAQs About VINGLYN D 5 TABLET
Q: What is VINGLYN D 5 TABLETused for?
A: VINGLYN D 5 TABLETis a combination medicine used to manage type 2 diabetes mellitus in adults. It helps control blood sugar levels when used along with a healthy diet and regular exercise. The two active ingredients, Dapagliflozin and Vildagliptin, work together to reduce blood sugar and improve insulin sensitivity.
Q: How does VINGLYN D 5 TABLET work?
A: The Dapagliflozin in Torglip D helps lower blood sugar by blocking glucose reabsorption in the kidneys, causing excess sugar to be excreted in the urine. Vildagliptin, on the other hand, increases insulin secretion and reduces glucagon levels, which helps lower blood sugar after meals. Together, they provide effective blood sugar control.
Q: When should I take Torglip D 5 Tablet SR?
A: You can take VINGLYN D 5 TABLET with or without food, but it is recommended to take it at the same time each day. This helps maintain a consistent blood sugar level and ensures you do not forget to take the medication. Always follow your doctor's instructions regarding the timing and dosage.
4. What are the common side effects of VINGLYN D 5 TABLET?
A: Common side effects include: Hypoglycemia (low blood sugar), especially if taken with other diabetes medications, Urinary tract infections (UTIs) or genital infections due to the effects of dapagliflozin, Headaches, dizziness, or tremors and Vaginal inflammation or fungal infections. It's important to stay hydrated and maintain good hygiene to reduce the risk of infections.
Q: Can I stop taking VINGLYN D 5 TABLET if I feel fine?
A: No, do not stop taking VINGLYN D 5 TABLET without consulting your doctor. Stopping the medication suddenly can cause your blood sugar levels to rise, increasing the risk of serious complications such as kidney damage, vision loss, or heart problems. Always follow your doctor’s advice regarding the duration of treatment.
Q: Can VINGLYN D 5 TABLETbe taken during pregnancy or breastfeeding?
A: It is not recommended to take VINGLYN D 5 TABLET during pregnancy or while breastfeeding unless clearly needed and prescribed by a doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider to discuss the risks and alternatives.
Q: What should I do if I miss a dose of VINGLYN D 5 TABLET?
A: If you miss a dose of VINGLYN D 5 TABLET, take it as soon as you remember, unless it’s nearly time for your next dose. Do not double the dose to make up for a missed one. Stick to your prescribed schedule to maintain effective blood sugar control.
Q: Are there any foods or drinks I should avoid while taking VINGLYN D 5 TABLET?
A: It’s advisable to avoid excessive alcohol while taking VINGLYN D 5 TABLET, as it may increase the risk of side effects, including hypoglycemia. Additionally, high-sugar foods or drinks can interfere with blood sugar control and should be limited. A balanced diet with healthy meals, as advised by your doctor or dietitian, is essential for managing diabetes.
Q: Can I take VINGLYN D 5 TABLET with other medications?
A: VINGLYN D 5 TABLET may interact with certain medications. Be sure to inform your doctor about all the medicines you are taking, including over-the-counter drugs, herbal supplements, and other diabetes medications like insulin or sulfonylureas. This is important to avoid potential drug interactions and adjust dosages as necessary.
Q: Can VINGLYN D 5 TABLET management affect my skin?
A: Not VINGLYN D 5 TABLET, but diabetes has a complication of diabetic skin lesions. You should follow the recommendations for skin and foot care that you are given by your doctor and should pay particular attention to new onset of blisters or ulcers while taking VINGLYN D 5 TABLET. Should these occur, you should immediately consult your doctor.
Q: How long should I take VINGLYN D 5 TABLET?
A: Take VINGLYN D 5 TABLET every day for as long as your doctor advises you. You may have to take this medicine over a long period of time. Your doctor will regularly monitor your condition to ensure that management with VINGLYN D 5 TABLET is having the desired effect.
Q: Does VINGLYN D 5 TABLET cause weight loss?
A: Yes. VINGLYN D 5 TABLET may cause weight loss in some individuals. To avoid weight loss, follow a healthy diet and regular exercise as advised by your physician. However, if the weight loss worries you, consult your doctor.
Q: Can VINGLYN D 5 TABLET cause vaginal infections?
A: Women taking VINGLYN D 5 TABLET may get vaginal yeast infections because of one of its components (Dapagliflozin). If you experience white or yellowish vaginal discharge, vaginal odour or itching while taking VINGLYN D 5 TABLET, consult your doctor immediately.
Q: What should I do if I forgot to take VINGLYN D 5 TABLET?
A: If you forget to take a dose by chance, try to take the next dose of VINGLYN D 5 TABLET as soon as you notice. However, if the time for the next dose is closer, skip the missed dose and do not try to take a double dose.
Q: Can VINGLYN D 5 TABLET make me feel dehydrated?
A: One of the ingredients of VINGLYN D 5 TABLET (Dapagliflozin) can make some people feel dehydrated (loss of body water and salt). If you feel dizzy, faint, lightheaded, or weak, especially when you stand up, see your doctor immediately.
References
1. KD. Tripathi. Insulin, Oral Anti Diabetic Drugs and Glucagon. Essentials of Medical Pharmacology. Eighth edition. 2013. Page-298, 301.
2. PubChem Compound Summary for CID 9887712, Dapagliflozin. National Center for Biotechnology Information. PubChem. November 2022. [Accessed on 18th November 2022] click here
3. PubChem Compound Summary for CID 6918537, Vildagliptin. National Center for Biotechnology Information. PubChem. November 2022. [Accessed on 18th November 2022] click here
4. Exemed Pharmaceuticals. TORGLIP D 5/ TORGLIP D 10 (Dapagliflozin + Vildagliptin). Torrent Pharmaceuticals Ltd. [Revised in April 2022] [Accessed on 18th November 2022] click here
5. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 18th November 2022] click here
6. Pharmadox Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 18th November 2022] click here
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