Uses of Dapagliflozin+Vildagliptin

The combination of Dapagliflozin and Vildagliptin is used in adults to treat type II diabetes mellitus which is poorly controlled on metformin monotherapy. 

Therapeutic Category

Dapagliflozin: Antidiabetic agents (Sodium-glucose co-transporter 2 (SGLT2) inhibitors)

Vildagliptin: Antidiabetic agents (Dipeptidyl peptidase 4 (DPP-4) inhibitor) 

How Dapagliflozin+Vildagliptin works

Dapagliflozin + Vildagliptin effectively lowers blood sugar levels where Dapagliflozin inhibits the sodium-glucose cotransporter 2 (SGLT2) in kidneys which allows excretion of excessive glucose through urine and Vildagliptin decreases the glucose production in liver and increases the insulin sensitivity to absorb glucose. 

Common side effects of Dapagliflozin+Vildagliptin

• dizziness
• genital infection (thrush) of penis or vagina (itching, irritation, unusual discharge or odour)
• back pain
• frequent or excessive urination than normal
• rash

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience angioedema (signs include swollen face, throat or tongue, trouble swallowing and breathing, sudden onset of hives or rash)
• If you experience liver inflammation (signs include yellowing of skin and eyes, nausea, loss of appetite, dark-coloured urine)
• If you experience inflammation of the pancreas (signs include persistent and severe stomach pain which may radiate to your back, nausea, vomiting)
• If you experience diabetic ketoacidosis (signs include nausea, vomiting, stomach pain, excessive thirst, deep and fast breathing, confusion, unusual tiredness or sleepiness, sweet breath odour, metallic or sweet taste in mouth or a different odour in your sweat, rapid weight loss)
• If you experience fournier’s gangrene or necrotising fasciitis of the perineum (signs include soft tissue infection of genitals or between anus and genital which might be serious)
• If you experience urinary tract infection (signs include fever, chills, burning sensation, seeing blood while urinating, back or side pain)
• If you experience low blood sugar level (signs include sweating, shaking, anxiety, fast heartbeat, feeling hungry, headache, change in vision, mood changes or confusion)
• If you experience new onset of blisters or ulcers

Health Tips for Dapagliflozin+Vildagliptin

• Maintain a balanced diet that includes whole foods such as fruits, vegetables, whole grains, lean meats, and healthy fats. To assist maintain blood sugar levels, keep track of your carbohydrate intake. Try taking foods with a low glycemic index, as they have a slower impact on blood sugar levels
• Stay hydrated by drinking plenty of water throughout the day. Hydration is important for kidney function and general health
• Exercise on a regular basis can assist increase insulin sensitivity and blood sugar control. Aim for a combination of aerobic and strength training, as prescribed by your doctor
• Monitor your blood sugar levels on a regular basis, as directed by your doctor. Keeping track of your levels will help you understand how your body reacts to the medicine and can help you make dietary decisions
• Evaluate your feet on a regular basis for any signs of blisters, sores, or cuts. Diabetes patients must take special care of their feet
• Avoid drinking alcohol as it can affect blood sugar levels and interact with your medications
• Meditation and deep breathing exercises are all effective stress-reduction approaches. Stress management has been shown to improve blood sugar levels
• Take Dapagliflozin + Vildagliptin exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor