INTRODUCTION

SEROCIT 467MG contains Tri-sodium citrate which belongs to the group of medicines called Anticoagulants. It is used for anticoagulation of whole blood as a part of an automated apheresis procedure which is a process of collecting platelets and other components of blood using a cell separator from the donor to which an anticoagulant is added to delay the process of clotting in the collected or donated blood.

SEROCIT 467MG is not recommended to be directly infused to the donor. It is not recommended for use in patients who are allergic to sodium citrate. It should be used with caution in patients with impaired liver or renal function, low body temperature, and low blood calcium levels. SEROCIT 467MG should be used with caution in pregnant and breastfeeding women.

Also, it should be used with caution in children and adolescents (aged below 18 years) and in elderly patients (aged 65 years and above). The most common side effect that can occur with the use of SEROCIT 467MG is mild pseudohyponatremia (transient decrease in blood sodium levels) which is generally associated with signs such as nausea, vomiting, headache, and confusion. Inform your doctor if you experience any unusual effects.

USES OF SEROCIT 467MG

• Used for anticoagulation of whole blood as part of an automated apheresis (blood donation) procedure

HOW SEROCIT 467MG WORKS

SEROCIT 467MG works by binding to the free calcium ion present in the blood which is a necessary co-factor/component required for the clotting process, thus results in preventing the clotting process of collected or donated blood (anti-coagulation process).

DIRECTIONS FOR USE

SEROCIT 467MG will be given to you only by a doctor or a nurse following the apheresis device operator's manual. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.  

SIDE EFFECTS OF SEROCIT 467MG

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

Before receiving SEROCIT 467MG inform your doctor, if you are receiving or taking any medicines including prescription, non-prescription, herbals or vitamin supplements.

Overdosage:

SEROCIT 467MG will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. Symptoms of overdosage are reaction to the infusion of citrate blood products such as burning sensation in hands, tingling sensation around the mouth or in the extremities, chills, stomach cramps, pressure in the chest, low blood pressure, or irregular heartbeat.   

SYNOPSIS

MORE INFORMATION

• Keep the medicine out of reach of children
• Store SEROCIT 467MG at temperature between 15°C to 30°C

FAQs ABOUT SEROCIT 467MG

What is SEROCIT 467MG used for?

SEROCIT 467MG is used for anticoagulation of whole blood as a part of automated apheresis procedure which is a process of collection of platelets and other components of blood from the donor to which an anticoagulant is added to delay the process of clotting in the collected or donated blood.

What are the common side effects of SEROCIT 467MG?

The most common side effect that can occur with the use of SEROCIT 467MG are mild pseudohyponatremia (transient decrease in blood sodium levels) which is generally associated with signs such as nausea, vomiting, headache and confusion.

How does SEROCIT 467MG work?

SEROCIT 467MG works by binding to the free calcium ion present in the blood which is a necessary co-factor/component required for the clotting process, thus results in preventing the clotting process of collected or donated blood (anti-coagulation process).

What is the method of receiving SEROCIT 467MG?

SEROCIT 467MG will be given to you only by a doctor or a nurse following the apheresis device operator's manual. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

When should SEROCIT 467MG be administered with caution?

SEROCIT 467MG should be administered with caution in patients with low body temperature, low calcium levels, impaired liver or renal function. Also, it is administered with caution in pregnant and breastfeeding women, children and adolescents (aged below 18 years) and in elderly patients (aged above 65 years). Consult your doctor before receiving SEROCIT 467MG.

REFERENCES

1. William L. Henrich. Anticoagulation Strategies During Hemodialysis Procedures. Principles and Practice of Dialysis. 2012. Page – 69.

2. Janice Milliere, Daryl Corriveau, Malvinder S. Parmar. Pseudohypernatremia secondary to trisodium citrate (Citra-LockTM). NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. June 2016. [Accessed on 23rd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910264/

3. Manisha Singh. Advances in Chronic Kidney Disease. Breastfeeding and Medication Use in Kidney Disease. ScienceDirect. Elsevier. May 2020. [Accessed on 23rd August 2022] https://www.sciencedirect.com/science/article/pii/S1548559520300719

4. Kang Xun, Hong Qiu, Miao Jia, Lihua Lin, Meiling He, Damei Li, Donghua Jin. Management Effect of Regional Sodium Citrate Anticoagulation in Elderly Patients with High-Risk Bleeding Receiving Continuous Renal Replacement Therapy. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. October 2021. [Accessed on 23rd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559185/

5. Nahum Elhanan, Peter Skippen, Gabrielle Nuthall, Gordon Krahn, Michael Seear.  Citrate anticoagulation in pediatric continuous venovenous hemofiltration. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. February 2004. [Accessed on 23rd August 2022] https://pubmed.ncbi.nlm.nih.gov/14669096/

6. Citra Labs LLC. Tricitrasol. DailyMed. NIH U.S National Library of Medicine. [Revised in November 2019] [Accessed on 23rd August 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=64e7652c-1437-43bd-8ea2-3cafab447b8c

7. Terumo BCT. Ltd. Sodium Citrate w/v Anticoagulant. DailyMed. NIH U.S National Library of Medicine. [Revised in January 2020] [Accessed on 23rd August 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c9d0e9c8-379f-4895-b272-329efab575c4

USEFUL DIAGNOSTIC TESTS

• Blood Coagulation Test