Introduction About SAAZ TABLET

Saaz Tablet contains Sulfasalazine (500mg), a specially formulated medication that supports joint comfort and promotes digestive health. This medicine is widely used to help manage symptoms related to inflammatory conditions affecting both the joints and the digestive tract.

Commonly prescribed for autoimmune and inflammatory disorders, Saaz Tablet plays a vital role in managing conditions such as rheumatoid arthritis and psoriatic arthritis, which affect the joints, as well as ulcerative colitis and Crohn’s disease, which impact the bowel. By reducing inflammation and controlling symptoms, Saaz Tablet helps improve mobility, ease digestive discomfort, and enhance overall daily wellbeing.

Saaz Tablet can be taken with or without food. For optimal results, take it consistently at the same time each day. Follow your doctor's prescription and complete the full course even if symptoms improve. Staying well-hydrated by drinking plenty of water while using Saaz Tablet helps reduce the risk of kidney-related issues, including kidney stones. Maintaining this routine supports safer and more effective use of the medication.

Common side effects of Saaz Tablet include nausea, headache, vomiting, gastrointestinal discomfort, dizziness, and oligospermia (low sperm count). If these symptoms persist or worsen over time, it is important to consult your healthcare provider. Your doctor can offer guidance on managing or alleviating these side effects to ensure your management remains comfortable and effective. Timely medical advice helps optimize Saaz Tablet’s safe usage and supports your overall wellbeing.

To ensure the safe use of Saaz Tablet, inform your doctor if you have any history of heart, kidney, or liver problems. It is important to disclose all medications you are currently taking to avoid potential interactions. Your doctor may recommend regular blood tests to monitor kidney and liver function as well as blood counts during your management. Pregnant or breastfeeding women should always seek medical advice before using Saaz Tablet to ensure safety for both mother and baby.

Uses Of SAAZ TABLET

• Managing inflammatory and autoimmune conditions including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, and Crohn’s disease.

Benefits of SAAZ TABLET

1. Supports Joint Comfort and Mobility: Saaz Tablet helps reduce inflammation, swelling, and stiffness in joints affected by rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, improving daily movement and comfort.
2. Promotes Digestive Health: By targeting inflammation in the digestive tract, Saaz Tablet aids in managing symptoms of ulcerative colitis and Crohn’s disease, helping maintain bowel health and symptom relief.
3. Regulates Immune Response: Saaz Tablet modulates immune system activity to reduce unwanted immune reactions, supporting management of autoimmune inflammatory conditions.
4. Enhances Quality of Life: Regular use of Saaz Tablet contributes to improved functionality and wellbeing by controlling symptoms across joint and bowel-related inflammatory diseases.

How SAAZ TABLET Works

How Saaz Tablet Works in the Body

Saaz Tablet (Sulfasalazine) acts as a disease-modifying agent that reduces inflammation by modulating the immune response, helping to control autoimmune and inflammatory conditions.

Mechanism of Action of Saaz Tablet

Sulfasalazine is a prodrug metabolized in the colon to its active components—5-aminosalicylic acid (5-ASA) and sulfapyridine, which exert local and systemic anti-inflammatory effects by inhibiting pro-inflammatory mediators.

Immunomodulatory Effects of Saaz Tablet

Saaz Tablet suppresses immune system overactivity by inhibiting the transcription factor NF-kappa B (NF-kB), reducing the production of inflammatory cytokines such as TNF-alpha, and promoting immune cell apoptosis.

Role of Sulfasalazine Metabolites in Action

The active metabolites, 5-ASA and sulfapyridine, work synergistically: 5-ASA primarily acts locally in the colon to decrease inflammation, while sulfapyridine contributes to systemic immunomodulation.

NF-kB Pathway and Saaz Tablet

By inhibiting the NF-kB pathway, Saaz Tablet blocks the transcription of pro-inflammatory genes, leading to decreased inflammation and symptom relief in joints and bowel tissues.

Local Action in the Colon

Bacterial cleavage in the colon releases 5-ASA, which acts directly on the intestinal lining to reduce inflammation, making Saaz Tablet effective in managing ulcerative colitis and other bowel disorders.

Pharmacokinetics and Activation of Saaz Tablet

Sulfasalazine is minimally absorbed in the small intestine; its metabolites reach peak plasma levels several hours after oral administration, with sulfapyridine being well absorbed and 5-ASA acting locally.

Impact on Inflammatory Pathways

Saaz Tablet inhibits multiple inflammatory pathways by blocking cytokine release, reducing leukocyte accumulation, and modulating osteoclast formation, contributing to its anti-arthritic and anti-inflammatory effects.

Saaz Tablet as a Disease-Modifying Agent

Classified as a disease-modifying antirheumatic drug (DMARD), Saaz Tablet slows disease progression by targeting underlying immune dysfunctions rather than just alleviating symptoms.

How to use SAAZ TABLET

How to Take Saaz Tablet Safely

Take Saaz Tablet exactly as prescribed by your doctor, swallowing the tablet whole with water. It can be taken with or without food, but taking it after meals may reduce stomach upset. Avoid crushing or chewing the tablet for optimal effect.

Saaz Tablet Dosage and Administration

Dosage varies based on the condition managed and patient response. It is usually given in divided doses throughout the day, spaced evenly to maintain stable blood levels and minimize side effects.

Dosage Guidelines for Rheumatoid Arthritis

Start with 500 mg once daily, gradually increasing to 1,000 mg twice daily over a few weeks. The typical maintenance dose is 2,000 mg per day, taken in divided doses. Doses up to 3,000 mg may be considered, if necessary, under medical supervision.

Dosage Guidelines for Ulcerative Colitis

Initial doses typically range from 3 to 4 g daily in divided doses, gradually reduced to 2 g per day for maintenance once symptoms improve. Regular monitoring is advised to adjust dosing as needed.

Saaz Tablet Dosage for Crohn’s Disease

Management often starts at 3 to 6 g per day divided into several doses, continued up to 16 weeks or as directed by the physician based on clinical response.

Pediatric Dosage Information

For children aged 6 and above with juvenile rheumatoid arthritis, dosing is weight-based at 30 to 50 mg/kg/day divided into two doses. The usual maximum dose is 2 g per day.

Important Administration Tips

Maintain a consistent dosing schedule, avoid missing doses, and complete the full prescribed course. Drink plenty of fluids during management to reduce the risk of kidney-related side effects.

Maximum Recommended Dose of Saaz Tablet

The maximum dose generally should not exceed 4 g per day to minimize toxicity risk, unless closely monitored by a healthcare provider.

Adjusting Saaz Tablet Dosage

Your doctor may adjust the dose based on management response and side effects. Start with low doses to minimize gastrointestinal discomfort, increasing gradually as tolerated.

Side Effects Of SAAZ TABLET

Like all medicines, Saaz Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Saaz Tablet are:

• Nausea
• Headache
• Vomiting
• Gastrointestinal discomfort
• Dizziness
• Oligospermia (low sperm count)

When to consult your doctor?

• Severe allergic reactions symptoms such as difficulty breathing or swallowing, fast heartbeat, swelling of face/throat/tongue, hives, or severe itching.
• Severe skin reactions: Blistering, peeling skin, painful red or purple skin, rash with blisters on mouth, nose, or genitals (signs of Stevens-Johnson Syndrome or toxic epidermal necrolysis).
• Liver or kidney problems symptoms such as yellowing of the skin or eyes (jaundice), dark-colored urine, severe abdominal/stomach pain, change in urine output, or pain while urinating.
• Blood disorders such as unusual bleeding or bruising, pale skin, frequent sore throats, or unusual tiredness/weakness (possible signs of low blood cell counts or anemia).
• Signs of severe infection such as high temperature, fever, sore throat, persistent cough, pain when urinating, cuts that will not heal, or feeling very unwell.
• Heart problems symptoms such as chest pain, increased or irregular heartbeat, swelling in feet/ankles, or shortness of breath.

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or Lie Down: If you feel dizzy, sit down, or lie down immediately to reduce falling. Keep your head still and close your eyes if needed.
• Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
• Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
• Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
• Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Rest and Relax: Find a quiet, comfortable place to rest and avoid sudden movements to help reduce nausea.
• Stay Hydrated: Sip small amounts of clear fluids like water, oral rehydration solutions, or herbal teas frequently to reduce dehydration.
• Eat Light, Bland Foods: When ready, try eating plain foods such as crackers, toast, or bananas that are easy on the stomach.
• Avoid Strong Odors and Spicy Foods: These can worsen nausea and should be avoided until symptoms improve.
• Use Over-the-Counter Remedies: Anti-nausea medications may help but consult your doctor before use.
• Practice Deep Breathing: Gentle breathing exercises can help calm your stomach and reduce discomfort.

Warning & Precautions

Pregnancy

Consult your doctor

Before starting Saaz Tablet, inform the doctor if pregnant or planning pregnancy. Saaz Tablet is generally considered safe during pregnancy, but it can lower folic acid levels, so a high dose of folic acid supplementation (5mg daily) is recommended before and during pregnancy. Always follow medical advice for medication use while pregnant.

Breastfeeding

Use with Caution

Use caution if breastfeeding on Saaz Tablet. Small amounts of sulfasalazine can enter breast milk, and rare cases of diarrhea or blood in the baby's stools have been reported. Consult a healthcare provider before breastfeeding while on this medication, and monitor the infant for any unusual symptoms.

Driving and Using Machines

Use with Caution

Saaz Tablet is unlikely to affect your ability to drive or operate heavy machinery. However, if you experience dizziness or any unusual side effects, avoid such activities until you feel normal. 

Kidney

Use with Caution

This medicine should be taken with caution in patients with kidney problems. Regular monitoring may be required. Always consult your doctor before taking this medicine.

Liver

Use with Caution

Patients with liver disease should use Saaz Tablet with caution. Medical supervision and periodic liver function tests may be necessary during management. Always consult your doctor before taking this medicine.

Allergy

Contraindicated

Do not take Saaz Tablet if you are allergic to sulfasalazine or salicylates (such as aspirin) or sulfonamides (a type of antibiotic), or any ingredient in the medicine. Allergic reactions can be serious, so seek medical help immediately if symptoms occur.

Lungs

Use with Caution

Patients with a history of asthma or lung-related conditions should take Saaz Tablet with caution. Always consult your doctor before taking this medicine. 

Use In Pediatrics

Consult your doctor

Saaz Tablet is not recommended for children below 2 years of age, and in older children it should be given strictly under a doctor’s supervision. Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

Saaz Tablet 10’s should be used with caution in elderly patients, as age-related organ decline may increase the risk of side effects. Consult your doctor before taking it.

Other Warnings for SAAZ TABLET

Before taking SAAZ TABLET, inform your doctor if you:

• Have a history of blood disorders (such as low blood cell counts or anaemia).
• Have glucose-6-phosphate dehydrogenase (G6PD) deficiency, an inherited enzyme deficiency.
• Suffer from recurring or chronic infections.
• Are giving this medicine to your child for arthritis management

Who should not take [GBNKEYWORD

SAAZ TABLET is not recommended for use if you:

• Have porphyria, a rare inherited blood pigment disorder.
• Suffer from jaundice or any history of yellowing of the skin and eyes.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Saaz Tablet:

1. Methotrexate

Interaction: Taking methotrexate with Saaz Tablet may increase the risk of gastrointestinal side effects such as nausea and stomach upset.
Effects: Increased gastrointestinal irritation and potential toxicity.
Management: Close monitoring by your doctor is advised. Dose adjustments may be required to minimize side effects and toxicity.

2. Digoxin

Interaction: Saaz Tablet can reduce the absorption of digoxin, a heart medication.
Effects: Reduced effectiveness of digoxin, potentially leading to irregular heart rhythms or worsening heart failure symptoms.
Management: Monitor digoxin blood levels regularly. Your doctor may adjust the digoxin dosage accordingly.

3. Warfarin

Interaction: Concurrent use with warfarin may increase the risk of bleeding due to enhanced anticoagulant effects.
Effects: Increased bleeding risk, including bruising and hemorrhage.
Management: Frequent monitoring of INR (International Normalized Ratio) and blood clotting parameters is necessary. Dose adjustments of warfarin may be required.

4. NSAIDs (e.g., Ibuprofen, Naproxen)

Interaction: Using Saaz Tablet with nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of kidney damage and gastrointestinal irritation.
Effects: Higher risk of kidney problems, stomach ulcers, or bleeding.
Management: Use the lowest effective doses under medical supervision. Regular kidney function tests and gastrointestinal monitoring are advised.

5. Folic Acid

Interaction: Saaz Tablet decreases the absorption of folic acid (vitamin B9).
Effects: Risk of folate deficiency which can lead to anemia and other blood problems.
Management: Your doctor may recommend folic acid supplements to manage deficiency during management.

6. Sulfa Drugs and Salicylates (e.g., Aspirin)

Interaction: Concurrent use can increase the risk of allergic reactions and side effects like rash or blood disorders.
Effects: Increased chances of hypersensitivity reactions and blood abnormalities.
Management: Avoid using together unless advised. Patients should be monitored for allergic symptoms and blood counts.

Synopsis

More Information

01. What is the composition and dosage strengths of Saaz Tablet compared to Saaz?DS and other sulfasalazine brands?

02. What diet should I follow while taking Saaz Tablet 10’s?

FAQs About SAAZ TABLET

References

1. KD Tripathi. Drugs for Constipation and Diarrhea. Essentials of medical pharmacology. Eighth Edition. 2019. Page –734-735.

2. Jaehwa Choi, Ardy Fenando. Sulfasalazine. [Revised on June 2021] [Accessed on 26th Aug 2025] 

3. Sanford L. Taffet MD & Kiron M. Das. Adverse effects and desensitization. [Accessed on 26th Aug 2025] 

4. Pfizer Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 26th Aug 2025]

5. Sulfasalazine. Drugs.com. [Revised in June 2022] [Accessed on 26th Aug 2025]

Useful Diagnostic Tests

• Complete Blood Count (CBC)
• Urine Culture
• Kidney Function Test (KFT)
• Liver Function Test (LFT)
• Rheumatoid Factor (RA Test) – Qualitative
• Autoimmune Arthiritis Panel

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 26 Aug 2025 | 12:24 PM(IST)