INTRODUCTION

PNV NEW contains Meclizine which belongs to the group of medicines called Antihistamine/Antiemetic agents. It is used to prevent and provide relief from nausea, dizziness and vomiting associated with motion sickness (illness caused by motion during travel). It is also used to manage vertigo (condition where a person experiences sensation of spinning movement or of surrounding objects moving when they are still in the same position) associated with diseases affecting the vestibular system in adults.

Meclizine works by suppressing vestibular stimulation by controlling the activity of hair cells in the inner ear and therefore helpful in manageing vertigo symptoms like dizziness and spinning sensation. It also reduces the activity of central nervous system (by anticholinergic effect) and reduces symptoms like nausea and vomiting sensation associated with motion sickness.

PNV NEW should be used with caution in patients with asthma, liver, or kidney disease, glaucoma and enlarged prostate gland. Contact your doctor before taking it. Before taking PNV NEW inform your doctor if you are pregnant or breast-feeding. PNV NEW is not recommended for use in children (under 12 years of age) and should be used with caution in elderly patients (above 65 years of age). Contact your doctor before taking it. Avoid consumption of alcohol during management with PNV NEW as it may increase the risk of unwanted effects. The most common side effects of taking PNV NEW are drowsiness, headache, fatigue, dry mouth and vomiting. Contact your physician if any of the symptoms worsen.

USES OF PNV NEW

Manages:

• motion sickness
• vertigo

HOW PNV NEW WORKS

PNV NEW works by suppressing vestibular stimulation by controlling the activity of hair cells in the inner ear and therefore helpful in manageing vertigo symptoms like dizziness and spinning sensation. It also reduces the activity of central nervous system (by anticholinergic effect) and reduces symptoms like nausea and vomiting sensation associated with motion sickness.

DIRECTIONS FOR USE

Take PNV NEW as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF PNV NEW

HOW TO MANAGE SIDE EFFECTS

Drowsiness:

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling drowsy. Do not drink alcohol, as it can aggravate your drowsiness. Consult your doctor if your symptom does not improve or worsens.

Headache:

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Consult your doctor if your symptom does not improve.

Vomiting:

Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Consult your doctor if your symptom does not improve.

Tiredness:

Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if your symptom does not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking PNV NEW, inform your doctor if you are taking any of the following medicines:

• tranquilizers such as alprazolam, diazepam (medicines used to manage anxiety and panic disorders)
• sedatives such as amobarbital, butabarbital (medicines used to manage insomnia)
• CYP2D6 inhibitor drugs such as amiodarone (medicines used to manage heart rhythm disorders), amitriptyline (used to manage depression) and terbinafine (medicines used to manage fungal infections)
• monoamine oxidase inhibitor (MAO) inhibitors Ex. selegiline (medicines used to manage parkinson’s disease)

Overdosage:

If you or anyone else accidentally take too much of PNV NEW, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are CNS depression with drowsiness, coma and fits. Low blood pressure, anticholinergic effects (such as dry mouth, dry eyes, constipation, etc.) and CNS stimulation (hallucinations, seizures, trouble sleeping) are more likely to occur.

SYNOPSIS

MORE INFORMATION

• Keep PNV NEW out of reach of children
• Store at room temperature

FAQs ABOUT PNV NEW

Can PNV NEW cause drowsiness?

Yes, PNV NEW may cause drowsiness. To manage this effect, try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling drowsy. Do not drink alcohol, as it can aggravate your drowsiness. Consult your doctor if your symptom does not improve or worsens.

What is PNV NEW used for?

PNV NEW is used to prevent and provide relief from nausea, dizziness and vomiting associated with motion sickness (illness caused by motion during travel). It is also used to manage vertigo (condition where a person experiences sensation of spinning movement or of surrounding objects moving when they are still in the same position) associated with diseases affecting the vestibular system in adults.

What are the common side effects of taking PNV NEW?

The most common side effects of taking PNV NEW are drowsiness, headache, tiredness, urinary retention, dry mouth and vomiting. Consult your doctor if any of the symptoms worsen.

Can I drink alcohol while taking PNV NEW?

No, avoid alcohol consumption while taking PNV NEW as it may increase the effect of drowsiness and central nervous system (CNS) depression (body's normal neurological functions slow down).

Can PNV NEW be used in elderly patients?

PNV NEW should be used with caution in elderly patients aged 65 years or above. Usually, the management will be initiated with the lowest effective dose depending upon vital organ functions and other concomitant disease states or other drug therapy. Contact your doctor before taking PNV NEW.

REFERENCES

1. K.D. Tripathi. Antiemetic, Prokinetic and Digestant drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page - 663.

2. Houston BT, Chowdhury YS. Meclizine. National Institute of Health. NLM. National Centre for Biotechnology Information. December 2021. [Accessed on 21st July 2022] https://www.ncbi.nlm.nih.gov/books/NBK560645/#:~:text=Mechanism%20of%20Action,its%20antiemetic%20and%20antivertigo%20properties.

3. Casper Pharma LLC. U.S. Food & Drug Administration. [Revised in June 2019] [Accessed on 21st July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/010721s063lbl.pdf

4. AvKare, Inc. Meclizine. DailyMed; National Library of Medicine; National Institute of Health. [Revised in January 2022] [Accessed on 21st July 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=af5d0c9b-a997-8033-afca-3c04221f2e76&version=7

5. Northwind Pharmaceuticals, LLC. Meclizine hydrochloride. [Revised in March 2015] [Accessed on 21st July 2022] https://fda.report/DailyMed/215AF966-1AB0-4C47-BCC8-C21E670A26E6.pdf

6. McNeil Consumer Healthcare. Meclizine. Product Monograph. [Revised in June 2011] [Accessed on 21st July 2022] https://pdf.hres.ca/dpd_pm/00013453.PDF

7. Memorial Sloan Kettering Cancer Center. Meclizine. [Revised in July 2022] [Accessed on 21st July 2022] https://www.mskcc.org/pdf/cancer-care/patient-education/meclizine-01