Introduction About OPIME XP 1.125 INJECTION

OPIME XP 1.125 INJECTION is a fixed-dose combination of cefepime and tazobactam which belongs to the group of medicines called antibiotics. It is used to manage several bacterial infections like lower respiratory tract infections such as pneumonia, acute bacterial exacerbation causing breathing difficulties, urinary tract infections, pyelonephritis, skin infections, abdominal and biliary tract infections, vaginal infections, bacteraemia, and bacterial meningitis in infants and children.

OPIME XP 1.125 INJECTION is also used along with other antibacterial agents in the management of neutropenia caused by bacterial infection. Pneumonia is an infection that causes inflammation in the air sac, producing a cough with phlegm and shortness of breath. Pyelonephritis is a urinary tract infection affecting the urinary bladder that later spreads to the kidneys.

Bacteremia is an infectious condition indicating the presence of bacteria in the bloodstream. Bacterial meningitis is an infection caused by bacteria in the region surrounding the brain. Neutropenic means low levels of neutrophils (a type of white blood cell) in our body.

OPIME XP 1.125 INJECTION should not be used in patients allergic to penicillin antibiotics, cefepime, tazobactam and other beta-lactam antibiotics. OPIME XP 1.125 INJECTION should be used with caution in patients with kidney and liver diseases. Avoid using other aminoglycoside antibiotics and diuretics, and OPIME XP 1.125 INJECTION.

There is no proper information regarding the use of OPIME XP 1.125 INJECTION in pregnant women and so it should be used with caution in pregnant women. OPIME XP 1.125 INJECTION should be used with caution in breastfeeding women. OPIME XP 1.125 INJECTION should be used with caution in children above 2 months and elderly people. The common side effect of OPIME XP 1.125 INJECTION is injection site reactions such as pain and inflammation. Consult your doctor if any of your symptoms get worse or persist.

Uses Of OPIME XP 1.125 INJECTION

It is used to manage:

• lower respiratory tract infections, such as pneumonia, and acute bacterial exacerbation causing breathing difficulties
• uncomplicated and complicated urinary tract infections and pyelonephritis
• skin and subcutaneous infections
• intra-abdominal infections, including peritonitis and biliary tract infections
• gynaecological infections
• bacteraemia associated with other infections
• bacterial meningitis in infants and children

How OPIME XP 1.125 INJECTION Works

OPIME XP 1.125 INJECTION works by destroying the bacterial growth responsible for causing infections. OPIME XP 1.125 INJECTION has two antibiotics cefepime a cephalosporin antibiotic and tazobactam a beta-lactam antibiotic. Cefepime works by interrupting wall formation by binding with the enzymes responsible for cell wall synthesis. This binding causes defects in the cell wall leading to cell death and causing the death of the organism. Tazobactam present in OPIME XP 1.125 INJECTION is responsible for the irreversible termination of enzymbeta-lactamasesases) that protect the organism from antibiotics. Tazobactam produces fewer anti-bacterial actions when given alone so it’s always used in combination with other antibiotics. Thus, both substances work by managing cell growth and function inhibit biting bacterial growth.

How to use OPIME XP 1.125 INJECTION

OPIME XP 1.125 INJECTION must be given by a doctor or nurse into the vein (intravenously)or the muscle (intramuscularly). Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition. If you have any doubts regarding the doses, consult your doctor.

Side Effects Of OPIME XP 1.125 INJECTION

How To Manage Side Effects

Injection Site Reactions

Try using a warm water compress to reduce swelling. keeping the affected area elevated can help reduce the swelling. Not applying pressure to the affected area will help reduce pain and manage further damage. Add food substances like garlic, onion, ginger, and pineapple as they help in reducing inflammations. Consult your doctor if the symptom gets worse or persist.

Warning & Precautions

Pregnancy

Consult your doctor

There is no proper information regarding the use of OPIME XP 1.125 INJECTION in pregnant women and so it should be used with caution in pregnant women. Consult your doctor before taking it.

Breastfeeding

Use with Caution

OPIME XP 1.125 INJECTION should be used with caution in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or handle heavy machines if you experience side effects like dizziness, drowsiness, tiredness, or if you have blurred vision while taking GBNKEYWORD].

Alcohol

Contraindicated

Consumption of alcohol is not recommended during management with OPIME XP 1.125 INJECTION.

Kidney

Use with Caution

OPIME XP 1.125 INJECTION should be used with caution in patients with kidney diseases. Consult your doctor before taking it.

Liver

Use with Caution

OPIME XP 1.125 INJECTION should be used cautiously in patients with liver diseases and with abnormal liver tests.  Consult your doctor before taking it.

Allergy

Contraindicated

Do not take OPIME XP 1.125 INJECTION if you are allergic to cefepime, cephalosporins, penicillins or other drugs of the beta-lactam class.

Interactions

A. Drug-Drug interactions:

Before taking OPIME XP 1.125 INJECTION, inform your doctor if you are taking any of the following medicine:

• other aminoglycoside antibiotics used to manage bacterial infections Ex. gentamycin, streptomycin, neomycin, amikacin
• medicines used to manage fluid accumulation Ex. furosemide

Overdosage:

If you or anyone else accidentally took more of OPIME XP 1.125 INJECTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include encephalopathy (symptoms: unconsciousness, confusion, hallucinations, and coma), seizures, neuromuscular excitability, and prolonged seizure.

Synopsis

More Information

• Keep OPIME XP 1.125 INJECTION out of reach from children
• Store at room temperature

FAQs About OPIME XP 1.125 INJECTION

Q: Does OPIME XP 1.125 INJECTION cause any side effects?

A: Stop taking OPIME XP 1.125 INJECTION and contact your doctor immediately if you experience any of the following side effects: Swelling of the face, tongue, and throat, which can make breathing difficult, neurological effects such as encephalopathy (symptoms include unconsciousness, confusion, hallucinations, and coma), aphasia (inability to speak), seizures, and Clostridium difficile-associated diarrhoea.

Q: Will OPIME XP 1.125 INJECTION manage a COVID infection?

A: No, OPIME XP 1.125 INJECTION is not intended to manage COVID-19. OPIME XP 1.125 INJECTION is used widely in the management of bacteria, while the COVID-19 infection is a viral infection.

Q: Will OPIME XP 1.125 INJECTION manage different bacterial infections?

A: Yes, OPIME XP 1.125 INJECTION is indicated to manage several bacterial infections, such as lower respiratory tract infections, such as pneumonia, acute bacterial exacerbations causing breathing difficulties, uncomplicated and complicated urinary tract infections, and pyelonephritis. skin and subcutaneous infections, intra-abdominal infections, including peritonitis and biliary tract infections, gynaecological infections, bacteraemia associated with other infections, and bacterial meningitis in infants and children, and it is used along with other antibacterial agents in the management of neutropenia caused by bacterial infection.

Q: Can OPIME XP 1.125 INJECTION be used by children?

A: Yes, it is safe to use OPIME XP 1.125 INJECTION in children above 2 months of age; dose adjustments are necessary when used in children. Your doctor will decide the correct dose for your child depending on your child’s age and weight.

Q: How should I store OPIME XP 1.125 INJECTION?

A: Keep OPIME XP 1.125 INJECTION out of reach of children. Store at room temperature, no higher than 30 °C. Do not freeze OPIME XP 1.125 INJECTION.

Q: How will OPIME XP 1.125 INJECTION manage my infection?

A: OPIME XP 1.125 INJECTION works by destroying the bacterial growth responsible for causing infections. OPIME XP 1.125 INJECTION has two antibiotics: cefepime, a cephalosporin antibiotic, and tazobactam, a beta-lactam antibiotic. Cefepime works by interrupting cell wall formation by binding with the enzymes responsible for cell wall synthesis. This binding causes defects in the cell wall, leading to cell death and the death of the organism. Tazobactam, present in OPIME XP 1.125 INJECTION, is responsible for the irreversible termination of enzymes (beta-lactamases) that protect the organism from antibiotics. Tazobactam produces fewer anti-bacterial actions when given alone, so it’s always used in combination with other antibiotics. Thus, both substances work by managing cell growth and function by inhibiting bacterial growth.

Q: How long will OPIME XP 1.125 INJECTION take to manage bacterial infections?

A: OPIME XP 1.125 INJECTION will start working once it is injected into the bloodstream. It will work faster compared with oral antibiotics as it is injected directly into the bloodstream. However, the full course of antibiotics should be given to obtaining its efficacy. Your doctor will decide the dose adjustments and termination of the medicine depending on your health condition.

References

1. KD Tripathi Beta-Lactam Antibiotics Page no -729, 725 Essentials of Pharmacology seventh edition Page no: 637.

2. Agarwal R, Agarwal V, Tewari A, Upadhyay P. Cefepime/tazobactam as a new treatment option for multidrug-resistant gram-negative bacilli, international Journal of Research in Medical Sciences June 2019. [Accessed on 24th May 2022] https://www.researchgate.net/publication/333460567_Cefepimetazobactam_as_a_new_treatment_option_for_multidrug_resistant_gram_negative_bacilli/fulltext/5cef491a4585153c3da54936

3. O'Connor A, Lopez MJ, Eranki AP. Cefepime. NCBI: National Library of Medicine, PubMed articles. [Revised on February 2022] [Accessed on 24th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK542232/#article-19092.s3

4. Eric Scholar, in pharm: The Comprehensive Pharmacology Reference, 2007, science direct https://www.sciencedirect.com/topics/chemistry/tazobactam

5. Biocon Biologics India Limited, [Revised on September 2019] [Accessed on 24th May 2022] https://www.biocon.com/docs/domestic-market-pi/ccd/CELRIM%20TZ.pdf

6. Akums Drugs and Pharmaceuticals Ltd, Cipla med. [Revised on August 2019] [Accessed on 24th May 2022] https://www.ciplamed.com/content/forpar-xp-injection

7. Zuventus healthcare Ltd. [Accessed on 24th May 2022] file:///C:/Users/VITLAP109/Downloads/Scud%20XP%20250%20mg,%20500%20mg%20&%201g%20Injection%20Pack%20Insert%20-%20A4%20Size%20(06-11-2020) ....pdf

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 30 Jan 2023 | 03:55 PM(IST)