METAPOL XL 25MG TABLET is used in the management of high blood pressure, angina pectoris (chest pain), heart failure, arrhythmias or palpitations, heart attacks and migraine headaches. It contains Metoprolol which is a beta-blocker that works by controlling heart functions and reduces strain on the heart.

Uses Of METAPOL XL 25MG TABLET

• High blood pressure
• Angina pectoris (chest pain)
• Arrhythmias or palpitations
• Heart attack and heart failure
• Migraine

How METAPOL XL 25MG TABLET Works

In hypertension, METAPOL XL 25MG TABLET works by blocking the effect of adrenaline on the heart and decreasing cardiac output, also reducing the outflow of sympathetic neurons, and suppressing renin activity (normally responsible for the increase in blood pressure). Together, these actions lower blood pressure effectively.

In angina pectoris, METAPOL XL 25MG TABLET works by blocking adrenaline effects on the heart and decreases the heart rate, blood pressure, and extent of heart contraction. It also reduces the oxygen requirements of the heart, providing relief from angina.

In heart failure, METAPOL XL 25MG TABLET slows down the heart rate and makes it easier for the heart to pump blood around the body.

How to use METAPOL XL 25MG TABLET

• Take this medicine exactly as prescribed by your doctor. The dose depends on your condition (like high blood pressure or heart-related issues) and response to the treatment
• It is usually recommended to take metoprolol with or immediately after a meal to enhance absorption and reduce side effects like dizziness
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Take the tablet at the same time each day, as this helps maintain consistent levels of the medication in your body
• If you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed one. Do not double the dose
• Do not stop taking metoprolol abruptly, as it can worsen your condition. Always follow your doctor’s advice when discontinuing
• Always consult your healthcare provider for personalized instructions

Side Effects Of METAPOL XL 25MG TABLET

Common side effects of METAPOL XL 25MG TABLET:

• feeling faint on standing because of low blood pressure
• tiredness, drowsiness
• cold hands and feet
• palpitations
• dizziness, headache
• diarrhoea, constipation, abdominal pain
• fluid retention (swelling)
• pins and needles
• muscle cramps
• weight gain, increased sweating
• depression, reduced concentration
• difficulty in sleeping
• shortness of breath
• skin rash

Stop taking METAPOL XL 25MG TABLET and contact your physician immediately if you experience any of the following side effects:

• symptoms of an allergic reaction such as skin rash, itching, flushing, swelling of the face, lips, tongue or throat, difficulty in breathing or swallowing

Warning & Precautions

Pregnancy

Contraindicated

METAPOL XL 25MG TABLET is not recommended for use in pregnant women.

Breastfeeding

Contraindicated

It is not recommended for use in breastfeeding women, as metoprolol may pass through the breast milk.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy and tired after taking this medicine.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking this medicine as it will make you feel dizzier.

Kidney

Use with Caution

METAPOL XL 25MG TABLET should be used with caution in patients with kidney diseases such as abnormal function.

Liver

Use with Caution

It should be used with caution in patients with liver diseases.

Allergy

Contraindicated

Do not take METAPOL XL 25MG TABLET if you are allergic to Metoprolol or any other ingredients in this medicine.

Lungs

Contraindicated

METAPOL XL 25MG TABLET is not recommended for use in patients with bronchospastic diseases like asthma or COPD.

Heart Disease

Consult your doctor

METAPOL XL 25MG TABLET is not recommended for use in patients with severe bradycardia, low blood pressure, second or third-degree heart block, cardiogenic shock, decompensated cardiac failure, or sick sinus syndrome (unless a permanent pacemaker is present) and should be used with caution in patients with 1st-degree heart block, myocardial infarction, angina pectoris, heart failure, diseases of the heart valve, or enlarged heart muscle.

Use In Pediatrics

Contraindicated

There is limited data on the use of metoprolol in children and adolescents. Therefore, the use of metoprolol is not recommended.

Use In Geriatrics

Use with Caution

This medicine should be used with caution in elderly patients aged 65 years or above.

Interactions

A. Drug-Drug interactions:

Before taking this medicine inform your doctor if you are taking any of the following medicine:

• other antihypertensive agents (such as reserpine, clonidine, hydralazine, alpha methyldopa, guanfacine, diltiazem, and verapamil)
• Anti-arrhythmic agents (such as quinidine, amiodarone, propafenone, disopyramide)
• Antidepressants
• digitalis (a medicine used to manage heart failure)
• cimetidine (a medicine used to manage ulcers)
• terbinafine (a medicine used to manage fungal infection)
• hydroxychloroquine (a medicine used to manage malaria)
• Antipsychotics (Ex. chlorpromazine, triflupromazine, chlorprothixene)
• diphenhydramine (medicines used to manage allergies)
• celecoxib, indomethacin (medicines used to manage pain)
• rifampicin (medicines used to manage tuberculosis)
• other beta-blockers, Ex.  timolol eye drops
• adrenaline, noradrenaline (medicines used to manage shock)
• Antidiabetic agents (such as glimepiride)
• lidocaine (a medicine used to induce numbness)

Overdosage:

If you or anyone else has accidentally taken too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are nausea, vomiting, bluish discolouration of the skin, severe bradycardia, low blood pressure (fatigue, dizziness), atrioventricular block, heart failure, bronchospasm or shortness of breath.

Synopsis

More Information

To know more about this medicine: 

FAQs About METAPOL XL 25MG TABLET

References

1. K D Tripathi. Cardiovascular drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page - 523, 545, 564.

2. Bethesda (MD). Metoprolol. National Institute of Health. NLM. National Centre for Biotechnology Information. PubMed, 2006. [Accessed on 30th June 2022] click here

3. Aralez Pharmaceuticals US Inc. Metoprolol. [Revised in December 2016] [Accessed on 30th June 2022] click here

4. Dr Reddy’s Laboratories Limited. Metoprolol. [Revised in April 2016] [Accessed on 30th June 2022] click here

5. STADA Arzneimittel AG. Metoprolol. [Accessed on 30th June 2022] click here

User Feedback

Useful Diagnostic Tests

• Kidney function test (KFT)
• Cardiac Risk Profile

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 20 Nov 2024 | 12:06 PM(IST)