INTRODUCTION

ENVAS contains Enalaprilat which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure) when oral therapy is not suitable.

While undergoing therapy with ENVAS, follow the diet and lifestyle modification (such as low-salt diet, weight loss, quitting smoking or alcohol) as instructed by your doctor to achieve effective control of blood pressure.

Before receiving ENVAS inform your doctor if you have liver, kidney or heart problems. You must also inform your doctor if you have diabetes or are severely dehydrated due to vomiting or diarrhea before receiving ENVAS.

ENVAS is not recommended for use in patients with very a low blood pressure and in women who are pregnant or breastfeeding due to increased risk of side effects. Stop taking ENVAS and inform your doctor immediately if you become pregnant while undergoing therapy with ENVAS.

ENVAS may make you feel dizzy while standing up suddenly or changing positions, especially during the initial days of the therapy. Therefore, do not drive or operate any heavy tools or machines as a precaution. Also, contact your doctor immediately if you feel extremely dizzy.

ENVAS may reduce your blood sugar levels and electrolyte levels. Therefore, your doctor will constantly monitor your blood sugar levels and kidney functions during the therapy to avoid the risk of unwanted side effects.

Other most common side effects of receiving ENVAS are dizziness, headache, tiredness, and weakness. Consult your doctor if any of these side effect worsens.

USES OF ENVAS

• Manages hypertension (high blood pressure) when oral therapy is not suitable

HOW ENVAS WORKS

ENVAS is an antihypertensive agent. It works by blocking the actions of an enzyme called angiotensin-converting enzyme, that causes narrowing of blood vessels and increase in blood pressure. This results in widening of blood vessels supplying the various vital organs (such as heart, brain or kidneys) and makes the heart to pump blood more smoothly with less pressure.

DIRECTIONS FOR USE

ENVAS will be given to you only by a doctor or a trained health care professional into a vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.

SIDE EFFECTS OF ENVAS

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before receiving ENVAS, inform your doctor if you are taking any of the following medicines:

• lithium (used to manage mental illnesses such as depression and bipolar disorder)
• celecoxib and valdecoxib (used to relieve pain and swelling)
• aliskiren (a medicine used to reduce blood pressure)
• sodium aurothiomalate (a gold compound used to manage arthritis)
• potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels)
• diuretics (used to reduce edema and blood pressure) such as furosemide, chlorothiazide, torsemide
• other medicines used to reduce blood pressure such as angiotensin receptor blockers (such as olmesartan, telmisartan, losartan, valsartan)
• medicines used to manage diabetes (such as insulin, metformin)

Overdosage:  

ENVAS will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include lightheadedness or dizziness due to a sudden or excessive drop in blood pressure

SYNOPSIS

MORE INFORMATION

• Keep ENVAS out of reach of children
• Store ENVAS at room temperature
• Protect ENVAS from direct sunlight

FAQs ABOUT ENVAS

Is ENVAS safe to use in diabetic patients?

ENVAS may alter the blood sugar levels in your body. It can also hide the symptoms of low blood sugar. Therefore, it is necessary to inform your doctor if you have diabetes before taking ENVAS as a precaution. Your doctor will closely monitor your blood sugar levels to avoid the risk of side effects. Also, inform your doctor if you experience any unusual tiredness, hunger or thirst while undergoing therapy with ENVAS. 

What precautions should be followed while taking ENVAS?

Before receiving ENVAS inform your doctor if you have any kidney or heart problems. You must also inform your doctor if you have diabetes or are severely dehydrated. Regularly visit your doctor and take all the necessary tests which your doctor recommends to you without fail. Consult your doctor before receiving ENVAS if you have any severe liver or heart diseases (such as low blood pressure). If you are pregnant or become pregnant while receiving ENVAS inform your doctor immediately.

Can I consume alcohol while receiving ENVAS?

Avoid consumption of alcohol while receiving ENVAS as it might make you feel dizzier and drowsier.

What happens if I accidentally take more ENVAS?

ENVAS will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include lightheadedness or dizziness due to a sudden or excessive drop in blood pressure.

Can I receive ENVAS daily?

Your doctor will evaluate your health condition and suggests whether can you receive ENVAS every day or not.

Can I stop receiving ENVAS if my blood pressure reduces?

Do not stop therapy with ENVAS without consulting your doctor as your blood pressure may raise once again. Make sure to receive ENVAS for the stipulated duration recommended by your doctor to achieve maximum results.

What are the uses of ENVAS?

ENVAS is used to manage hypertension when oral therapy is not suitable.

What type of a medicine is ENVAS?

ENVAS is an antihypertensive medicine. It is used to manage hypertension when oral therapy is not suitable.

How ENVAS works?

GBNKEYWORD] is an antihypertensive agent. It works by blocking the actions of an enzyme called angiotensin-converting enzyme, that causes narrowing of blood vessels and increase in blood pressure. This results in widening of blood vessels supplying the various vital organs (such as heart, brain or kidneys) and makes the heart to pump blood more smoothly with less pressure.

What are the side effects of ENVAS?

The most common side effects of receiving ENVAS are dizziness, headache, tiredness, weakness and low blood sugar levels. Consult your doctor if any of these side effect worsens.

REFERENCES

1. KD. Tripathi. Cardiovascular drugs. Drugs affecting Renin-angiotensin system. Essentials of medical pharmacology. 8th Edition. 2019. Page – 532.

2. Francheska Marte, Graham D. Dersnah, Manouchkathe Cassagnol. NIH National Library of Medicine, National center for biotechnology information. Enalaprilat. [Revised in April 2022] [Accessed on 8th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK534299/

3. Syed Imran Ayaz, Craig M. Sharkey, Gregory M. Kwiatkowski, Suprat Saely Wilson, Reba S. John, Rosa Tolomello, Arushi Mahajan, Scott Millis, and Phillip D. Levy. NIH National Library of Medicine, National center for biotechnology information. Intravenous enalaprilat for management of acute hypertensive heart failure in the emergency department. December 2016. [Accessed on 8th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195922/

4. Sandoz Canada Inc. Angiotensin-Converting Enzyme Inhibitor [Revised in September 2013] [Accessed on 8th September 2022] https://www.sandoz.ca/sites/www.sandoz.ca/files/Vasotec_IV_PMe_20130920.doc.pdf

5. West-Ward Pharmaceuticals Corp. U.S. National Library of Medicine. [Revised in December 2018] [Accessed on 8th September 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=eabae489-e254-4987-ab90-7cda20a6f856&type=display

USEFUL DIAGNOSTIC TESTS

• Kidney function test