INTRODUCTION

EFIPRES 30MG contains Ephedrine which belongs to the group of medicines called Sympathomimetics. It is used to manage hypotension (low blood pressure) which commonly occurs following a spinal anesthesia. It raises blood pressure by temporarily narrowing the blood vessels supplying the heart.

During management with EFIPRES 30MG your doctor will constantly monitor your heart function and blood pressure to avoid any unwanted side effects.

Inform your doctor before receiving EFIPRES 30MG if you are taking or taken any medicines used to manage depression such as monoamine oxidase inhibitors (such as phenelzine, selegiline, isocarboxazid) in the last 14 days.

You must also inform your doctor if you have any heart problems (such as angina or irregular heartbeat), hypertension, diabetes, glaucoma, hyperthyroidism, or prostate enlargement.

EFIPRES 30MG is not recommended for use in breastfeeding women and it should be used in pregnant women only if considered necessary by the physician. It is not suitable for use in children (aged below 18 years) due to lack of safety data.

The common side effect of receiving EFIPRES 30MG are nausea, headache, weakness, shortness of breath. Consult your doctor immediately if the symptoms worsen.

USES OF EFIPRES 30MG

• Manages hypotension (low blood pressure) following spinal anesthesia

HOW EFIPRES 30MG WORKS

EFIPRES 30MG is an adrenergic agonist. It works by binding to the alpha and beta receptors of the adrenergic system. This action stimulates the heart, improves heart functions, and increases blood pressure by temporarily narrowing the blood vessels supplying the heart. As a result, it restores blood pressure in patients having hypotension following spinal anesthesia.

DIRECTIONS FOR USE

EFIPRES 30MG will be given to you by a doctor or by a health care professional into the vein (intravenously). Your doctor will decide the correct dose, duration of therapy and frequency of administration depending upon your age, body weight and health condition.

SIDE EFFECTS OF EFIPRES 30MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Try to take rest. Apply a pain-relieving balm on your forehead. If the symptom does not improve, consult with your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Before receiving EFIPRES 30MG, inform your doctor if you are taking any of the following medicines:

• other medicines act on the adrenergic system such as used to manage blocked nose, cough, breathing problems or heart problems (such as phenylpropanolamine, phenylephrine, pseudoephedrine, xylometazoline, adrenaline, noradrenaline, isoprenaline, methoxamine, salbutamol)
• methylphenidate (a medicine used to manage attention deficit hyperactivity disorder)
• oxytocin (a medicine used to induce labor)
• inhaled general anesthetics (used to cause loss of consciousness) such as halothane or cyclopropane
• antidepressants (used to manage depression) such as monoamine oxidase inhibitors (Ex. phenelzine, selegiline, isocarboxazid) or tricyclic antidepressants (Ex. imipramine, amitriptyline)
• linezolid (an antibiotic used to manage bacterial infections)
• sibutramine (a medicine used to reduce appetite)
• theophylline (a medicine used to manage severe asthma or other breathing difficulties)
• corticosteroids (used to manage pain or inflammation) Ex. methylprednisolone, prednisone, dexamethasone
• medicines used to manage epilepsy (such as phenytoin, carbamazepine, valproic acid)
• doxapram (a medicine used to stimulate breathing)
• medicines used to manage high blood pressure (such as guanethidine, reserpine and methyldopa)
• other ergot alkaloids (such as methysergide or ergotamine) used to manage migraine
• cardiac glycosides (used to manage abnormal heart rhythm) such as digoxin

Overdosage:

EFIPRES 30MG will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

MORE INFORMATION

• Keep EFIPRES 30MG out of reach of children
• Store EFIPRES 30MG at room temperature
• Protect EFIPRES 30MG from direct sunlight

FAQs ABOUT EFIPRES 30MG

What is the use of EFIPRES 30MG?

EFIPRES 30MG is used to manage hypotension (low blood pressure) which commonly occurs following a spinal anesthesia. It raises blood pressure by temporarily narrowing the blood vessels supplying the heart.

Is EFIPRES 30MG safe?

EFIPRES 30MG is safe when used under proper medical supervision and at the prescribed doses.

What EFIPRES 30MG does to my heart?

EFIPRES 30MG is a powerful cardiac stimulant. It works by binding to the alpha and beta receptors of the adrenergic system. This action stimulates the heart, improves heart functions, and increases blood pressure by narrowing the blood vessels supplying the heart. As a result, it restores blood pressure in patients having hypotension following spinal anesthesia.

What precautions do I need to follow while taking EFIPRES 30MG?

Patients receiving EFIPRES 30MG must inform their doctor about their pre-existing disease conditions such as high blood pressure, diabetes, glaucoma, liver problems, kidney problems, heart problems or thyroid problems. It is also important to inform your doctor if you are pregnant or breastfeeding before receiving EFIPRES 30MG.

How EFIPRES 30MG is administered?

EFIPRES 30MG will be given only by a doctor or by a trained healthcare professional into the vein (intravenously).

Can EFIPRES 30MG cause high blood pressure?

Yes. EFIPRES 30MG can be used to increase blood pressure in patients suffering from low blood pressure caused due spinal anesthesia. Therefore, should be used with caution in patients with hypertension. Therefore, inform your doctor before receiving it.

Is EFIPRES 30MG safe for use during pregnancy?

EFIPRES 30MG should be used in pregnant women only if considered necessary by the physician. Therefore, inform your doctor before receiving EFIPRES 30MG if you are pregnant or think you may be pregnant or planning to have a baby.

Can EFIPRES 30MG be used in children?

EFIPRES 30MG is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before receiving it.

Is EFIPRES 30MG safe for use in patients with diabetes?

EFIPRES 30MG should be used with caution if you are diabetic. Your doctor may also advise regular monitoring of your blood sugar level during the management. Therefore, consult your doctor for advice.

REFERENCES

1. KD. Tripathi. Adrenergic transmission and adrenergic drugs. Essentials of medical pharmacology. 8th Edition. 2019. Page – 147.

2. Alec K. Statler; Christopher V. Maani; Arpan Kohli. Ephedrine. NIH National Library of Medicine, National center for biotechnology information. [Revised on May 2022] [Accessed on 8th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK547661/

3. Eric Wooltorton and Barbara Sibbald. Ephedra/ephedrine: cardiovascular and CNS effects. NIH National Library of Medicine, National center for biotechnology information. [Revised in July 2002] [Accessed on 8th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99410/

4. Hameln pharma ltd. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 8th September 2022] https://www.medicines.org.uk/emc/files/pil.9291.pdf