Introduction About COMXTIN ORAL SUSPENSION

COMXTIN ORAL SUSPENSION contains colistin, which belongs to the group of medicines called Antibiotics. It is used in infants and in children to manage bacterial infections of the gut (stomach and intestines).

Colistin is a polypeptide antibiotic. It binds to the susceptible bacteria and disrupts the composition (lipids and proteins) of the bacterial cell membrane. As a result, it makes the contents of the bacterial cell leak out, which subsequently leads to bacterial killing. It may also inactivate the toxins produced by the bacteria.

Before starting the therapy with COMXTIN ORAL SUSPENSION, inform your doctor if your child has any kidney problems. Your doctor would prescribe a low dose of colistin to your child and constantly monitor their kidney functions to avoid the risk of side effects. You must also inform your doctor if your child has any inherited blood or muscle disorders before starting the therapy with COMXTIN ORAL SUSPENSION.

Do not give COMXTIN ORAL SUSPENSION to your child if your child is allergic to any of its ingredients. The most common side effects of taking COMXTIN ORAL SUSPENSION are stomach upset, nausea, vomiting, or dizziness. Contact your doctor if any of these side effects worsen in your child.

Uses Of COMXTIN ORAL SUSPENSION

• Manages bacterial infections of the gut in infants and in children

How COMXTIN ORAL SUSPENSION Works

COMXTIN ORAL SUSPENSION kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and proteins) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out, which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.

How to use COMXTIN ORAL SUSPENSION

Use COMXTIN ORAL SUSPENSION as advised by your physician. Reconstitute the medicine with the sterile water given along with the package or with boiled, cooled water before administration. Close the bottle tightly and shake the mixture vigorously for at least 10-15 minutes until it forms a uniform mixture. Measure the medicine using the measuring cup given along with the package and administer it to your child.

Your doctor will decide the correct dose, quantity (ml), and duration of therapy for your child depending upon their age, body weight, and severity of infection. Shake the medicine well before each use. Do not stop giving COMXTIN ORAL SUSPENSION to your child without consulting your doctor, even if they feel better after a few days of therapy. Continue to give COMXTIN ORAL SUSPENSION for the stipulated duration mentioned by your doctor to achieve maximum benefits.

Side Effects Of COMXTIN ORAL SUSPENSION

How To Manage Side Effects

Dizziness Or Drowsiness

Make your child rest and relax. Restrict them from playing outdoors. Avoid indulging them in activities that require proper concentration, such as riding a bicycle. Consult your doctor if dizziness worsens in your child.

Nausea And Vomiting

Give COMXTIN ORAL SUSPENSION to your child along with meals or after a snack. Provide them only with simple meals. Restrict your children from oil-rich or spicy food. Contact your doctor if nausea worsens in your child.

Warning & Precautions

Driving and Using Machines

Contraindicated

COMXTIN ORAL SUSPENSION may cause dizziness. Therefore, restrict your child from playing outdoors. Avoid indulging them in activities that require proper concentration, such as riding a bicycle.

Kidney

Use with Caution

COMXTIN ORAL SUSPENSION should be used with caution in children with kidney problems. Therefore, inform your doctor before administering it to your child.

Allergy

Contraindicated

Inform your doctor before starting the therapy with COMXTIN ORAL SUSPENSION if your child is allergic to colistin or other polymyxin antibiotics.

Use In Pediatrics

Consult your doctor

COMXTIN ORAL SUSPENSION can be used in infants and in children. However, it should be used only if prescribed by the physician. Therefore, consult your doctor before giving it to your child.

Interactions

A. Drug-Drug Interaction:

Before giving COMXTIN ORAL SUSPENSION to your child, inform your doctor if your child is taking any of the following medicines such as:

• other antibiotics such as aminoglycosides (Ex. netilmicin, gentamicin, amikacin, and tobramycin), cephalosporins (Ex. cefixime, ceftriaxone), macrolides (Ex. azithromycin, clarithromycin, or erythromycin), or fluoroquinolones (ofloxacin, norfloxacin, and ciprofloxacin)

Overdosage:

If your child or anyone else accidentally took more COMXTIN ORAL SUSPENSION, consult your doctor immediately.

Synopsis

More Information

FAQs About COMXTIN ORAL SUSPENSION

Q: What is the use of COMXTIN ORAL SUSPENSION?

A: COMXTIN ORAL SUSPENSION is an antibiotic used to manage bacterial infections of the gut in infants and in children. It acts by killing the susceptible bacteria that causes infection.

Q: What COMXTIN ORAL SUSPENSION does to my child?

A: COMXTIN ORAL SUSPENSION kills the susceptible bacteria in your child that causes infection. It acts by disrupting the composition (lipids and proteins) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out, which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.

Q: What are the side effects of COMXTIN ORAL SUSPENSION?

A: The most common side effects of receiving COMXTIN ORAL SUSPENSION are stomach upset, nausea, vomiting, or dizziness. Contact your doctor if any of these side effects worsen in your child.

Q: How to use COMXTIN ORAL SUSPENSION?

A: Use COMXTIN ORAL SUSPENSION as advised by your physician. Reconstitute the medicine with the sterile water given along with the package or with boiled, cooled water before administration. Close the bottle tightly and shake the mixture vigorously for at least 10-15 minutes until it forms a uniform mixture. Measure the medicine using the measuring cup given along with the package and administer it to your child. Shake the medicine well before each use.

Q: Can COMXTIN ORAL SUSPENSION be used in children?

A: Yes. COMXTIN ORAL SUSPENSION can be used in infants and in children if prescribed by the physician. Therefore, consult your doctor before using.

Q: What precautions do I need to follow while taking COMXTIN ORAL SUSPENSION?

A: Before starting the therapy with COMXTIN ORAL SUSPENSION, inform your doctor if your child has any kidney problems. Your doctor would prescribe a low dose of colistin to your child and constantly monitor their kidney functions to avoid the risk of side effects. You must also inform your doctor if your child has any inherited blood or muscle disorders before starting the therapy with COMXTIN ORAL SUSPENSION. Do not give COMXTIN ORAL SUSPENSION to your child if your child is allergic to any of its ingredients.

Q: What medicines should I avoid while taking COMXTIN ORAL SUSPENSION?

A: Avoid giving other antibiotics to your child along with COMXTIN ORAL SUSPENSION without consulting your doctor. Concomitant use of antibiotics along with COMXTIN ORAL SUSPENSION may potentiate the effects of COMXTIN ORAL SUSPENSION and may lead to unwanted side effects.

Q: Is COMXTIN ORAL SUSPENSION safe?

A: COMXTIN ORAL SUSPENSION is generally safe when used in the doses recommended by your doctor. Therefore, carefully follow your doctor's instructions and inform your doctor immediately if your child experiences any unpleasant side effects after taking COMXTIN ORAL SUSPENSION.

Q: Can I take COMXTIN ORAL SUSPENSION during pregnancy?

A: COMXTIN ORAL SUSPENSION is intended for use only in infants and in children. It is not suitable for use in pregnant women. Therefore, consult your doctor before taking it.

Q: Can I stop giving COMXTIN ORAL SUSPENSION to my child without consulting the doctor?

A: Do not stop giving COMXTIN ORAL SUSPENSION to your child without consulting your doctor, even if they feel better after a few days of therapy. Continue to give COMXTIN ORAL SUSPENSION for the stipulated duration mentioned by your doctor to achieve maximum benefits.

Q: What should I do if I forget to take a dose of COMXTIN ORAL SUSPENSION?

A: If a dose of COMXTIN ORAL SUSPENSION is missed, take it as soon as you remember. However, if it is time for the next dose of COMXTIN ORAL SUSPENSION, skip the missed dose and give the next one regularly to your child. Do not give a double dose of COMXTIN ORAL SUSPENSION to compensate for the missed ones.

References

1. K.D. Tripathi. Macrolide and other antibacterial antibiotics. Essentials of Medical Pharmacology. Seventh Edition. Page – 759.

2. Ferdinando F. Andrade, Daniela Silva, Acacio Rodrigues, and Cidalia Pina-Vaz. National Library of Medicine. Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges. NIH. National Library of Medicine. National Centre of Biotechnology Information. PMC PubMed Central. November 2020. [Accessed on 21st August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692639/

3. MK Medicine. [Accessed on 21st August 2024] https://www.mkmedicine.in/colistin-sulphate-12.5-mg-dry-syrup.html

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