Introduction About COLIZEST 25MG ORAL SUSPENSION

COLIZEST 25MG ORAL SUSPENSION contains colistin, which belongs to the group of medicines called Antibiotics. It is used in infants and in children to manage bacterial infections of the gut (stomach and intestines).

Colistin is a polypeptide antibiotic. It binds to the susceptible bacteria and disrupts the composition (lipids and proteins) of the bacterial cell membrane. As a result, it makes the contents of the bacterial cell leak out, which subsequently leads to bacterial killing. It may also inactivate the toxins produced by the bacteria.

Before starting the therapy with COLIZEST 25MG ORAL SUSPENSION, inform your doctor if your child has any kidney problems. Your doctor would prescribe a low dose of colistin to your child and constantly monitor their kidney functions to avoid the risk of side effects. You must also inform your doctor if your child has any inherited blood or muscle disorders before starting the therapy with COLIZEST 25MG ORAL SUSPENSION.

Do not give COLIZEST 25MG ORAL SUSPENSION to your child if your child is allergic to any of its ingredients. The most common side effects of taking COLIZEST 25MG ORAL SUSPENSION are stomach upset, nausea, vomiting, or dizziness. Contact your doctor if any of these side effects worsen in your child.

Uses Of COLIZEST 25MG ORAL SUSPENSION

• Manages bacterial infections of the gut in infants and in children

How COLIZEST 25MG ORAL SUSPENSION Works

COLIZEST 25MG ORAL SUSPENSION kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and proteins) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out, which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.

How to use COLIZEST 25MG ORAL SUSPENSION

Use COLIZEST 25MG ORAL SUSPENSION as advised by your physician. Reconstitute the medicine with the sterile water given along with the package or with boiled, cooled water before administration. Close the bottle tightly and shake the mixture vigorously for at least 10-15 minutes until it forms a uniform mixture. Measure the medicine using the measuring cup given along with the package and administer it to your child.

Your doctor will decide the correct dose, quantity (ml), and duration of therapy for your child depending upon their age, body weight, and severity of infection. Shake the medicine well before each use. Do not stop giving COLIZEST 25MG ORAL SUSPENSION to your child without consulting your doctor, even if they feel better after a few days of therapy. Continue to give COLIZEST 25MG ORAL SUSPENSION for the stipulated duration mentioned by your doctor to achieve maximum benefits.

Side Effects Of COLIZEST 25MG ORAL SUSPENSION

How To Manage Side Effects

Dizziness Or Drowsiness

Make your child rest and relax. Restrict them from playing outdoors. Avoid indulging them in activities that require proper concentration, such as riding a bicycle. Consult your doctor if dizziness worsens in your child.

Nausea And Vomiting

Give COLIZEST 25MG ORAL SUSPENSION to your child along with meals or after a snack. Provide them only with simple meals. Restrict your children from oil-rich or spicy food. Contact your doctor if nausea worsens in your child.

Warning & Precautions

Driving and Using Machines

Contraindicated

COLIZEST 25MG ORAL SUSPENSION may cause dizziness. Therefore, restrict your child from playing outdoors. Avoid indulging them in activities that require proper concentration, such as riding a bicycle.

Kidney

Use with Caution

COLIZEST 25MG ORAL SUSPENSION should be used with caution in children with kidney problems. Therefore, inform your doctor before administering it to your child.

Allergy

Contraindicated

Inform your doctor before starting the therapy with COLIZEST 25MG ORAL SUSPENSION if your child is allergic to colistin or other polymyxin antibiotics.

Use In Pediatrics

Consult your doctor

COLIZEST 25MG ORAL SUSPENSION can be used in infants and in children. However, it should be used only if prescribed by the physician. Therefore, consult your doctor before giving it to your child.

Interactions

A. Drug-Drug Interaction:

Before giving COLIZEST 25MG ORAL SUSPENSION to your child, inform your doctor if your child is taking any of the following medicines such as:

• other antibiotics such as aminoglycosides (Ex. netilmicin, gentamicin, amikacin, and tobramycin), cephalosporins (Ex. cefixime, ceftriaxone), macrolides (Ex. azithromycin, clarithromycin, or erythromycin), or fluoroquinolones (ofloxacin, norfloxacin, and ciprofloxacin)

Overdosage:

If your child or anyone else accidentally took more COLIZEST 25MG ORAL SUSPENSION, consult your doctor immediately.

Synopsis

More Information

FAQs About COLIZEST 25MG ORAL SUSPENSION

Q: What is the use of COLIZEST 25MG ORAL SUSPENSION?

A: COLIZEST 25MG ORAL SUSPENSION is an antibiotic used to manage bacterial infections of the gut in infants and in children. It acts by killing the susceptible bacteria that causes infection.

Q: What COLIZEST 25MG ORAL SUSPENSION does to my child?

A: COLIZEST 25MG ORAL SUSPENSION kills the susceptible bacteria in your child that causes infection. It acts by disrupting the composition (lipids and proteins) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out, which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.

Q: What are the side effects of COLIZEST 25MG ORAL SUSPENSION?

A: The most common side effects of receiving COLIZEST 25MG ORAL SUSPENSION are stomach upset, nausea, vomiting, or dizziness. Contact your doctor if any of these side effects worsen in your child.

Q: How to use COLIZEST 25MG ORAL SUSPENSION?

A: Use COLIZEST 25MG ORAL SUSPENSION as advised by your physician. Reconstitute the medicine with the sterile water given along with the package or with boiled, cooled water before administration. Close the bottle tightly and shake the mixture vigorously for at least 10-15 minutes until it forms a uniform mixture. Measure the medicine using the measuring cup given along with the package and administer it to your child. Shake the medicine well before each use.

Q: Can COLIZEST 25MG ORAL SUSPENSION be used in children?

A: Yes. COLIZEST 25MG ORAL SUSPENSION can be used in infants and in children if prescribed by the physician. Therefore, consult your doctor before using.

Q: What precautions do I need to follow while taking COLIZEST 25MG ORAL SUSPENSION?

A: Before starting the therapy with COLIZEST 25MG ORAL SUSPENSION, inform your doctor if your child has any kidney problems. Your doctor would prescribe a low dose of colistin to your child and constantly monitor their kidney functions to avoid the risk of side effects. You must also inform your doctor if your child has any inherited blood or muscle disorders before starting the therapy with COLIZEST 25MG ORAL SUSPENSION. Do not give COLIZEST 25MG ORAL SUSPENSION to your child if your child is allergic to any of its ingredients.

Q: What medicines should I avoid while taking COLIZEST 25MG ORAL SUSPENSION?

A: Avoid giving other antibiotics to your child along with COLIZEST 25MG ORAL SUSPENSION without consulting your doctor. Concomitant use of antibiotics along with COLIZEST 25MG ORAL SUSPENSION may potentiate the effects of COLIZEST 25MG ORAL SUSPENSION and may lead to unwanted side effects.

Q: Is COLIZEST 25MG ORAL SUSPENSION safe?

A: COLIZEST 25MG ORAL SUSPENSION is generally safe when used in the doses recommended by your doctor. Therefore, carefully follow your doctor's instructions and inform your doctor immediately if your child experiences any unpleasant side effects after taking COLIZEST 25MG ORAL SUSPENSION.

Q: Can I take COLIZEST 25MG ORAL SUSPENSION during pregnancy?

A: COLIZEST 25MG ORAL SUSPENSION is intended for use only in infants and in children. It is not suitable for use in pregnant women. Therefore, consult your doctor before taking it.

Q: Can I stop giving COLIZEST 25MG ORAL SUSPENSION to my child without consulting the doctor?

A: Do not stop giving COLIZEST 25MG ORAL SUSPENSION to your child without consulting your doctor, even if they feel better after a few days of therapy. Continue to give COLIZEST 25MG ORAL SUSPENSION for the stipulated duration mentioned by your doctor to achieve maximum benefits.

Q: What should I do if I forget to take a dose of COLIZEST 25MG ORAL SUSPENSION?

A: If a dose of COLIZEST 25MG ORAL SUSPENSION is missed, take it as soon as you remember. However, if it is time for the next dose of COLIZEST 25MG ORAL SUSPENSION, skip the missed dose and give the next one regularly to your child. Do not give a double dose of COLIZEST 25MG ORAL SUSPENSION to compensate for the missed ones.

References

1. K.D. Tripathi. Macrolide and other antibacterial antibiotics. Essentials of Medical Pharmacology. Seventh Edition. Page – 759.

2. Ferdinando F. Andrade, Daniela Silva, Acacio Rodrigues, and Cidalia Pina-Vaz. National Library of Medicine. Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges. NIH. National Library of Medicine. National Centre of Biotechnology Information. PMC PubMed Central. November 2020. [Accessed on 21st August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692639/

3. MK Medicine. [Accessed on 21st August 2024] https://www.mkmedicine.in/colistin-sulphate-12.5-mg-dry-syrup.html

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