Introduction About BUPRON XL 300MG TABLET

BUPRON XL 300MG TABLET contains Bupropion which belongs to a group of medicines called Antidepressants. BUPRON XL 300MG TABLET is used to manage major depressive disorder (persistent depresstion) and manage seasonal affective disorder (depression that occurs due to seasonal changes) in affected individuals.

Before taking BUPRON XL 300MG TABLET, inform your doctor if you are diabetic, have/ever had head injury, seizures, depression, suicidal thoughts, tumor in brain/spine, high blood pressure, heart, kidney, and/or heart problems.

BUPRON XL 300MG TABLET should be used with caution during pregnancy and in women planning for pregnancy only if it is clearly necessary. It is also used advised to be used with caution in breast-feeding women only if it is necessary since the medicine may pass through breast milk.

BUPRON XL 300MG TABLET is generally not recommended for use in children and adolescents (aged below 18 years) unless it is clearly considered necessary. The medicine is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.  

The most common side effects of taking BUPRON XL 300MG TABLET are weight loss, dry mouth, skin rash, nausea, stomach pain, anxiety, and/or dizziness. Contact your doctor if any of the symptoms worsens.

Uses Of BUPRON XL 300MG TABLET

• Manage major depressive disorder
• Prevents seasonal affective disorder in affected individuals

How BUPRON XL 300MG TABLET Works

BUPRON XL 300MG TABLET works by managing the reuptake of three neurotransmitters, dopamine (responsible for pleasure), serotonin (responsible for cognitive functions such as memory, learning), and norepinephrine (responsible for fight/flight response during stress) in the brain which helps in managing the occurrence of depression by decreasing the level of three neurotransmitters in the brain (which are usually needed to cause depression) thus managing major depressive disorder and managing seasonal affective disorder in affected individuals.

How to use BUPRON XL 300MG TABLET

Take BUPRON XL 300MG TABLET as advised by your physician. Swallow BUPRON XL 300MG TABLET with a glass of water. Do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of BUPRON XL 300MG TABLET

How To Manage Side Effects

Dry mouth:

Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult your doctor if the symptom gets worse.

Nausea:

Take BUPRON XL 300MG TABLET with or just after a meal. Stick to simple meals. Avoid eating oil-rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.

Constipation:

Try to eat high-fibre foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.

Warning & Precautions

Pregnancy

BUPRON XL 300MG TABLET should be used with caution during pregnancy and in women planning for pregnancy only if it is clearly necessary. Consult your doctor before taking BUPRON XL 300MG TABLET

Breastfeeding

BUPRON XL 300MG TABLET should be used with caution in breastfeeding women only if it is clearly necessary as the medicine may pass through breast milk. Consult your doctor before taking BUPRON XL 300MG TABLET.

Driving and Using Machines

Do not drive/operate machines if your ability to drive/operate machines is impaired after taking BUPRON XL 300MG TABLET.

Alcohol

Avoid consumption of alcohol while taking BUPRON XL 300MG TABLET since it may alter the effect of the medicine.

Kidney

BUPRON XL 300MG TABLET should be used with caution in patients with kidney problems such as renal impairment. Consult your doctor before taking the medicine.

Liver

BUPRON XL 300MG TABLET should be used with extreme caution in patients with liver problems such as severe hepatic cirrhosis, mild to moderate hepatic impairment. Consult your doctor before taking the medicine.

Allergy

Do not take BUPRON XL 300MG TABLET if you are allergic to Bupropion, and/or any other ingredients in this medicine.

Heart Disease

BUPRON XL 300MG TABLET should be used with caution in patients with heart problems such as heart attack, unstable heart disease, left ventricular dysfunction. Consult your doctor before taking BUPRON XL 300MG TABLET.

Interactions

A. Drug-Drug Interactions:

Before taking BUPRON XL 300MG TABLET, inform your doctor, if you are taking any of the following medicine:

• zyban (medicine used to help people stop smoking)
• monoamine oxidase inhibitor (medicine used for depression) Ex. phenelzine sulfate, tranylcypromine sulfate, isocarboxazid
• insulin/other medicines to control your blood sugar (Ex.glimepiride,gliclazide, glipizide)

Overdosage:

If you or anyone else accidentally takes too much of BUPRON XL 300MG TABLET, contact your doctor immediately or go to a hospital straight away. Symptoms of overdose are seizure, hallucinations, loss of consciousness, sinus tachycardia (fast heartbeat), arrhythmias (irregular heartbeat), fever, muscle rigidity, rhabdomyolysis (muscle death), low blood pressure, stupor (unconsciousness), coma, and respiratory failure.

Synopsis

More Information

• Keep BUPRON XL 300MG TABLET out of reach in children
• Store BUPRON XL 300MG TABLET at room temperature

FAQs About BUPRON XL 300MG TABLET

Can BUPRON XL 300MG TABLET be used with other antidepressant medications?

No. BUPRON XL 300MG TABLET should not be used with other antidepressant medications since it may cause unwanted side effects. Consult your doctor before taking BUPRON XL 300MG TABLET who might monitor the effect of the drug and alter the dosage based on the necessity of usage of the medicine if needed to be used with other antidepressant drugs.

What happens if BUPRON XL 300MG TABLET is taken more than its required dosage?

If you or anyone else accidentally takes too much of BUPRON XL 300MG TABLET, contact your doctor immediately or go to a hospital straight away. Symptoms of overdose can be seizure, hallucinations, loss of consciousness, sinus tachycardia (fast heartbeat), arrhythmias (irregular heartbeat), fever, muscle rigidity, rhabdomyolysis (muscle death), low blood pressure, stupor (unconsciousness), coma, and respiratory failure.

Is BUPRON XL 300MG TABLET safe to use in children?

BUPRON XL 300MG TABLET should be used with caution in children and adolescents (less than 18 years of age) only if the  potential risks justify the clinical need considering the safety and effectiveness of the drug. Your doctor might monitor the effects of the drug for any possible side effects especially on suicidality, and unusual changes in behavior during the initial few months of a course of the drug therapy. Consult your doctor before taking BUPRON XL 300MG TABLET.

What side effects are seen with BUPRON XL 300MG TABLET?

The most common side effects of taking BUPRON XL 300MG TABLET are weight loss, dry mouth, skin rash, nausea, stomach pain, anxiety, dizziness, sweating, ringing in the ears, shakiness, muscle pain, fast heartbeat and frequent urination. Rare side effect that may occur taking BUPRON XL 300MG TABLET is  acute generalized exanthematous pustulosis which is a rare severe skin disease characterized by pustules (white or red elevations with pus) on skin). Contact your doctor if any of the symptoms worsen.

Can [GBNKEYWORD] be used in elderly patients?

Yes, but BUPRON XL 300MG TABLET should be used with caution in elderly patients (aged 65 years or above) as they are more likely to have decreased renal or kidney function who might be advised for regular kidney function tests to monitor the kidney function. Consult your doctor before taking BUPRON XL 300MG TABLET.

References

1. KD. Tripathi. Anticholinergic Drugs and Drugs Acting on Autonomic Ganglia. Essentials of medical pharmacology. Seventh edition. 2013. Page – 122

2. GlaxoSmithKline. Study to Evaluate the Efficacy, Safety and Tolerability of Bupropion Hydrochloride Extended-release Tablet, and Escitalopram Oxalate Capsule in Subjects with Major Depressive Disorder. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in February 2020] [Accessed on 4th May 2022] https://www.clinicaltrials.gov/ct2/show/NCT02191397

3. J A Ascher , J O Cole, J N Colin, J P Feighner, R M Ferris, H C Fibiger, R N Golden, P Martin, W Z Potter, E Richelson. Bupropion: a review of its mechanism of antidepressant activity. NIH National Library of Medicine, National center for biotechnology information. PubMed.gov. September 1995 [Accessed on 4th May 2022] https://pubmed.ncbi.nlm.nih.gov/7665537/

4. Hasan Tak,  Cengiz Koçak,  Gülben Sarici, Nazli Dizen Namdar, and Mehtap Kidir. An Uncommon Side Effect of Bupropion: A Case of Acute Generalized Exanthematous Pustulosis. NIH National Library of Medicine, National center for biotechnology information. PMC Pubmed Central. November 2015 [Accessed on 4th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672104/\

5. IMPAX Laboratories, Inc.U.S. Food & Drug Administration. [Revised in February 2011] [Accessed on 4th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/anda/2011/077415Orig1s017.pdf

Useful Diagnostic Tests

• Kidney function test
• Liver function test