Introduction About ZYMOFLAM TABLET

ZYMOFLAM TABLET is a combination of Bromelain, Rutoside, and Trypsin, which belongs to the group of medicines called Proteolytic enzymes and Flavonoids, respectively. It is used in the management of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, gout, joint issues related to inflammation, pain and swelling of joints, swelling associated with surgical wounds, pulmonary edema, ulcerative colitis, sports and accidental injuries, muscular cramps and spasms, tendinitis, bursitis, dental extraction, sinusitis, bronchitis, and rhinitis. 

Prior to starting the management with ZYMOFLAM TABLET, your doctor might want you to take several diagnostic tests to understand your existing condition and to safely use this medicine to manage the risk of any unusual effects. 

ZYMOFLAM TABLET is not recommended for use in patients with hemophilia (a disorder in which blood doesn't clot normally), liver or kidney disorders, or patients undergoing haemodialysis. ZYMOFLAM TABLET should be taken with caution in patients with any bleeding disorders and heart disease. 

ZYMOFLAM TABLET is not recommended for use in pregnant and breastfeeding women. There is no data on the use of ZYMOFLAM TABLET in children or elderly patients; hence, always consult your doctor for advice before taking this medicine. 

The most common side effects of taking ZYMOFLAM TABLET are nausea, diarrhea, stomach upset, tiredness, dry mouth, and skin rash. Consult your doctor if any of the side effects worsen.

Uses Of ZYMOFLAM TABLET

Used in the management of pain and inflammation associated with the following:

• Osteoarthritis, rheumatoid arthritis, gout
• Joint issues related to inflammation
• Pain and swelling of joints
• Swelling associated with surgical wounds
• Pulmonary edema
• Ulcerative colitis
• Sports and accidental injuries
• Muscular cramps and spasms
• Tendinitis and bursitis
• Dental extraction
• Sinusitis, bronchitis, and rhinitis

How ZYMOFLAM TABLET Works

ZYMOFLAM TABLET helps in managing pain and inflammation associated with various conditions where bromelain and trypsin are protease enzymes that decrease inflammation by inhibiting the substances that are responsible for it called proinflammatory prostaglandins. It also influences blood clotting by increasing the activity of a protein called fibrinogen. Rutoside is a flavonoid that works by enhancing the strength of blood vessels and decreasing their ability to break down. 

How to use ZYMOFLAM TABLET

Take ZYMOFLAM TABLET as advised by your physician. Swallow the medicine with enough water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of ZYMOFLAM TABLET for you depending on your age, body weight, and disease condition.

Side Effects Of ZYMOFLAM TABLET

How To Manage Side Effects

Constipation

Take fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole grain cereals, and drink plenty of fluids. Exercise regularly (such as walking) and stay active. Consult your doctor if the symptom does not improve. 

Diarrhea

Drink a lot of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Consult your doctor if the symptom does not improve. 

Dry Mouth

Sip water and other sugar-free liquids regularly. Do not use mouthwashes that contain alcohol because they can make your mouth dry; use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

Headache

Rest and relax. Drink plenty of fluids, such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much alcohol. Consult your doctor if the symptom does not improve.

Tiredness

Drink plenty of fluid, eat a balanced diet, and frequent meals. Do regular minimal exercise and follow a regular sleep schedule. Consult your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Contraindicated

ZYMOFLAM TABLET is not recommended for use in pregnant women. Consult your doctor before taking ZYMOFLAM TABLET.

Breastfeeding

Contraindicated

ZYMOFLAM TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking ZYMOFLAM TABLET.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking ZYMOFLAM TABLET.

Kidney

Contraindicated

ZYMOFLAM TABLET is not recommended for use in patients with kidney disorders and in patients undergoing haemodialysis. Consult your doctor before taking ZYMOFLAM TABLET.

Liver

Contraindicated

ZYMOFLAM TABLET is not recommended for use in patients with liver disorders. Consult your doctor before taking ZYMOFLAM TABLET.

Allergy

Contraindicated

Do not take ZYMOFLAM TABLET if you are allergic to Bromelain, Rutoside, and Trypsin.

Heart Disease

Use with Caution

ZYMOFLAM TABLET should be used with caution in patients with heart disease. Consult your doctor before taking it.

Interactions

A. Drug-Drug Interactions:

Before taking ZYMOFLAM TABLET, inform your doctor if you are taking any of the following medicines:

• Digoxin (used to manage heart problems)
• Ramipril (used to manage high blood pressure)

Overdosage:

If you or anyone else accidentally take too much of ZYMOFLAM TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

FAQs About ZYMOFLAM TABLET

Q: Does ZYMOFLAM TABLET cause stomach disturbances?

A: Yes, ZYMOFLAM TABLET can cause side effects like vomiting, nausea, diarrhea, indigestion, and stomach bloating. Do not take any medication on your own to manage the specific symptom. Consult your doctor if any of the side effects worsen or bother you.

Q: Can ZYMOFLAM TABLET be used in patients with kidney problems?

A: ZYMOFLAM TABLET is not recommended for use in patients with kidney disorders and in patients undergoing haemodialysis. Consult your doctor before taking it.

Q: Is ZYMOFLAM TABLET safe to use in pregnant women?

A: ZYMOFLAM TABLET is not recommended for use in pregnant women. Consult your doctor for advice before taking this medicine if you are pregnant or planning to get pregnant.

Q: Is ZYMOFLAM TABLET safe to use in patients with heart disease?

A: ZYMOFLAM TABLET should be used with caution in patients with heart disease because it may increase the risk of increased heart rate. Consult your doctor for advice before taking this medicine.

Q: Can ZYMOFLAM TABLET be given to children?

A: There is no information regarding the use of ZYMOFLAM TABLET in children. Your child’s doctor will select a suitable alternative therapy for your child to manage the specific condition.

Q: What is ZYMOFLAM TABLET used for?

A: ZYMOFLAM TABLET is used in the management of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, gout, joint issues related to inflammation, pain and swelling of joints, swelling associated with surgical wounds, pulmonary edema, ulcerative colitis, sports and accidental injuries, muscular cramps and spasms, tendinitis, bursitis, dental extraction, sinusitis, bronchitis, and rhinitis. 

Q: How does ZYMOFLAM TABLET work?

A: ZYMOFLAM TABLET helps in managing pain and inflammation associated with various conditions where bromelain and trypsin are protease enzymes that decrease inflammation by inhibiting the substances that are responsible for it called proinflammatory prostaglandins. It also influences blood clotting by increasing the activity of a protein called fibrinogen. Rutoside is a flavonoid that works by enhancing the strength of blood vessels and decreasing their ability to break down. 

Q: What are the side effects of ZYMOFLAM TABLET?

A: The most common side effects of taking ZYMOFLAM TABLET are nausea, diarrhea, stomach upset, tiredness, dry mouth, and skin rash. Consult your doctor if any of the side effects worsen.

Q: How should I take ZYMOFLAM TABLET?

A: Take ZYMOFLAM TABLET as advised by your physician. Swallow the medicine with enough water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of ZYMOFLAM TABLET for you depending on your age, body weight, and disease condition.

Q: Who should not take ZYMOFLAM TABLET?

A: ZYMOFLAM TABLET is not recommended for use in patients with hemophilia (a disorder in which blood doesn't clot normally), kidney disorders, patients undergoing haemodialysis, liver disorders, or if you are allergic to Bromelain, Rutoside and Trypsin. Consult your doctor before taking ZYMOFLAM TABLET.

Q: What precautions must be taken while using ZYMOFLAM TABLET?

A: Before taking ZYMOFLAM TABLET, inform your doctor if you have heart disease or any other bleeding disorder.

References

1. K.D. Tripathi. Drug Affecting Blood and Blood Formation, Autacoids and Related Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 616 & 204.

2. R.S. Satoskar, Nirmala N. Rege, S.D. Bhandarkar. Enzymes in Therapy. Pharmacology and Pharmacotherapeutics. Twenty Fourth Edition. 2015. Page – 1670, 1103.

3. Pavan R, Jain S, Shraddha, Kumar A. Properties and therapeutic applications of bromelain: a review. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. December 2012. [Accessed on 10th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/

4. Shah D, Mital K. The Role of Trypsin: Chymotrypsin in the Tissue Repair. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed.gov. January 2018. [Accessed on 10th July 2024] https://pubmed.ncbi.nlm.nih.gov/29209994/

5. Biobrick Pharma. Tryson-BR Tablets [Accessed on 10th July 2024] https://www.biobrickpharma.com/product/tryson-br-2/

6. DM Pharma. Kebon-3 Tablet. [Accessed on 10th July 2024] http://www.dmpharma.co.in/Trypsin_Bromelain_%20Rutoside_Tablets.html

7. BSA Pharma Inc. Inflabis BR Tablet. [Accessed on 10th July 2024] https://www.bsapharmainc.in/trypsinbromelainrutoside-tablets-inflabis-br/

8. Leogenic Health care. LeoTryps Tablet. [Accessed on 10th July 2024] https://www.leogenic.com/leotryps-trypsin-bromelain-rutoside-tablets/

9. Bionova. Reeca Forte Tablet. [Accessed on 10th July 2024] https://www.bionova.co.in/recca-forte.html

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Calcium
• Basic Arthritis Care
• Extended Arthritis Care
• Comprehensive Arthritis Care
• Frequent Pain Check Package
• Bone Strength Package
• Bone Profile – Advanced
• Autoimmune Arthritis Panel

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 12 Jul 2024 | 05:22 PM(IST)