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Introduction About ZUKANORM SR 100 TABLET
ZUKANORM SR 100 TABLET is used in adults to manage type 2 diabetes which helps to control the blood sugar levels when diet and exercise becomes insufficient to control the disease. It contains Vildagliptin which belongs to group of medicines called Oral Anti-diabetics.
Take ZUKANORM SR 100 TABLET as advised by your physician. Do not crush or chew ZUKANORM SR 100 TABLET. Swallow the medicine with a glass of water.
Along management with ZUKANORM SR 100 TABLET, your doctor might advise you to follow the diet and/or exercise which is beneficial. Avoid consumption of alcohol because it might lead to low blood glucose levels. Before taking ZUKANORM SR 100 TABLET, inform your doctor if you are on dialysis or have diabetic ketoacidosis (serious complication of diabetes), pancreatic disease, heart failure and liver or kidney disease.
ZUKANORM SR 100 TABLET is not recommended for use in pregnant and breast-feeding women, which is also not recommended for use in children and adolescents (aged below 18 years). It should be used with caution in elderly patients (aged 65 years and above).
The side effects of taking ZUKANORM SR 100 TABLET are dizziness, headache, joint pain and constipation.
Uses Of ZUKANORM SR 100 TABLET
How ZUKANORM SR 100 TABLET Works
ZUKANORM SR 100 TABLET controls blood glucose level by acting on the pancreas to produce more insulin and less glucagon which leads to low production of blood sugar levels resulting in controlled blood glucose levels.
How to use ZUKANORM SR 100 TABLET
- Take ZUKANORM SR 100 TABLET as advised by your physician.
- Do not crush or chew ZUKANORM SR 100 TABLET.
- Swallow the medicine with a glass of water.
- Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of ZUKANORM SR 100 TABLET
Common Side Effects of ZUKANORM SR 100 TABLET:
- Dizziness
- Headache
- Blurred vision
- Constipation
- Nausea, vomiting
- Diarrhea
- rashes
Stop taking ZUKANORM SR 100 TABLET and contact your doctor immediately if you experience any of the following side effects:
- Signs of liver disease (hepatitis) such as loss of appetite or dark-colored urine, yellow skin and eyes, nausea
- Signs of inflammation of the pancreas such as severe and persistent pain in the abdomen (stomach area), nausea and vomiting
Warning & Precautions
Pregnancy
ContraindicatedZUKANORM SR 100 TABLET is not recommended for use in pregnant women.
Breastfeeding
ContraindicatedZUKANORM SR 100 TABLET is not recommended for use in breastfeeding women or women who plan to breast-feed.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizziness after taking ZUKANORM SR 100 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking ZUKANORM SR 100 TABLET because it might lead to hypoglycemia (lowering of blood glucose levels).
Kidney
Use with CautionZUKANORM SR 100 TABLET should be used with caution in patients with moderate or severe kidney disease and in patients who are undergoing dialysis.
Liver
Use with CautionZUKANORM SR 100 TABLET should be used with caution in patients with liver disease.
Allergy
ContraindicatedDo not take ZUKANORM SR 100 TABLET if you are allergic to Vildagliptin or any other ingredients of this medicine.
Heart Disease
Use with CautionZUKANORM SR 100 TABLET should be used with caution in patients suffering from heart failure.
Use In Pediatrics
ContraindicatedZUKANORM SR 100 TABLET is not recommended for use in children and adolescents up to 18 years of age.
Use In Geriatrics
Use with CautionZUKANORM SR 100 TABLET should be used with caution in elderly patients (aged 65 years and above).
Others
Before taking ZUKANORM SR 100 TABLET, inform your doctor if you:
- Have type 1 diabetes (i.e. your body does not produce insulin)
- Have a condition called diabetic ketoacidosis (serious complication of diabetes)
- Have intolerance to certain sugars
- Had or have a disease of the pancreas
Interactions
A. Drug-Drug interactions:
Before taking ZUKANORM SR 100 TABLET, inform your doctor if you are taking any of the following medicines:
- Oral antidiabetics (medicine used to manage type 2 diabetes) Ex. sulphonylureas such as gliclazide, glipizide
- Digoxin (used to manage heart failure)
- Warfarin (used to manage blood clot)
- Cardiac drugs (such as captopril, enalapril, fosinopril)
- Simvastatin (used to reduce high cholesterol levels)
- Thiazides or other diuretics (medicines used to manage high blood pressure) Ex. chlorothiazide, chlorthalidone, hydrochlorothiazide
- Corticosteroids (used to manage inflammation) Ex. prednisolone
- Certain medicines affecting nervous system such as antidepressants Ex. clomipramine, amitriptyline
- Thyroid medicines (used to lower thyroid levels) Ex. levothyroxine
Over dosage:
If you or anyone else accidentally takes too much of ZUKANORM SR 100 TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of ZUKANORM SR 100 TABLET are muscle pain, mild and transient paraesthesia (burning and prickling sensation in hands and legs), fever, oedema (swelling in arms and legs) and laboratory abnormalities such as transient increase in lipase levels, increases in creatine phosphokinase (CPK), aspartate aminotransferase (AST), C-reactive protein (CRP) and myoglobin levels.
Synopsis
| Drug | : | Vildagliptin |
| Pharmacological Category | : | Dipeptidyl peptidase-4 (DPP-4) inhibitors |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
FAQs About ZUKANORM SR 100 TABLET
Q: Can ZUKANORM SR 100 TABLET be used to manage diabetes mellitus?
A: Yes, ZUKANORM SR 100 TABLET lowers blood glucose levels and it is specifically used to manage type II diabetes mellitus which is a medical condition where the body does not make enough insulin or if the produced insulin that the body makes is not optimal leading to increased blood glucose levels in the body. Consult your doctor before taking ZUKANORM SR 100 TABLET.
Q: Can I take ZUKANORM SR 100 TABLET along with other hypoglycemic drugs like metformin or glimepiride?
A: Using ZUKANORM SR 100 TABLET along with other hypoglycemic drugs like metformin, glimepiride may drastically lower your blood glucose levels. So, be cautious and inform your doctor before taking any other anti-diabetic medicines.
Q: Does taking ZUKANORM SR 100 TABLET cause weight gain?
A: No, ZUKANORM SR 100 TABLET has no effect on weight gain. Moreover, these kinds of medicines delay gastric emptying and make you feel satiety (stomach fullness). These further decreases hunger. So, basically ZUKANORM SR 100 TABLET has no effect or it does not influence weight gain.
Q: How does ZUKANORM SR 100 TABLET work?
A: ZUKANORM SR 100 TABLET controls blood glucose level by acting on the pancreas to produce more insulin and less glucagon which leads to low production of blood sugar levels resulting in controlled blood glucose levels.
Q: Does ZUKANORM SR 100 TABLET cause dizziness?
A: Yes, ZUKANORM SR 100 TABLET may cause dizziness in some individuals. To manage this effect, lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor if the symptom gets worse.
Q: Can ZUKANORM SR 100 TABLET be used in children?
A: ZUKANORM SR 100 TABLET is not recommended for use in children and adolescents up to 18 years of age.
Q: What does ZUKANORM SR 100 TABLET contain?
A: It contains Vildagliptin which belongs to group of medicines called Oral Anti-diabetics.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-275.
2. B Ahren, A Schweizer, S Dejager, E B Villhauer, B E Dunning, J E Foley. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. NIH National Library of Medicine. National Center for Biotechnology Information.PubMed.gov. [Revised in September 2011] [Accessed on 16th October 2024] click here
3. Kalyan Kumar Gangopadhyay and Parminder Singh. Consensus Statement on Dose Modifications of Antidiabetic Agents in Patients with Hepatic Impairment. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in March 2017] [Accessed on 16th October 2024] click here
4. Novartis Europharm Limited. Electronic Medicines Compendium (EMC) [Revised in August 2023] [Accessed on 16th October 2024] click here
5. Novartis Pharma GmbH. European Medicines Agency (EMA). [Revised in July 2012] [Accessed on 16th October 2024] click here
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