Introduction About ZON XP 1.125 INJECTION

ZON XP 1.125 INJECTION is a combination of Ceftriaxone and Tazobactam which belongs to the group of medicines called Antibiotics. It is used to manage several bacterial infections like lower respiratory tract infections such as pneumonia, acute bacterial otitis media lower respiratory tract infections, pneumonia, infection in the ear, skin, urinary tract infections, gonorrhoea, pelvic inflammatory disease, bacterial septicaemia, bone and joint infections, intra-abdominal infections, including peritonitis and biliary tract infections, bacterial meningitis, surgical prophylaxis (pre-operative antibiotics, infections in neutropenic patients).

Pneumonia is an infection which causes inflammation in the air sac producing cough with phlegm and shortness of breath. Urinary tract infection affects the urinary bladder later gets spreads to the kidneys. Bacteraemia is an infectious condition indicating presence of bacteria in the blood stream. Bacterial meningitis is an infection caused by bacteria in the region surrounding the brain. Neutropenic is low levels of neutrophils (a type of white blood cells) in our body.

Inform your doctor or your health- care professional before any laboratory tests as ZON XP 1.125 INJECTION will interact with medical investigations. Inform your doctor if you are allergic to any antibiotics or to any other medicines.

ZON XP 1.125 INJECTION should not be used in patients allergic to penicillin antibiotics, cefepime, tazobactam and other beta-lactam antibiotics.

ZON XP 1.125 INJECTION should be used with caution in patients with or history of allergic reactions, diarrhoea, gastrointestinal disease (colitis) kidney and liver diseases.

Avoid concomitant use of other antibiotics and diuretics along with ZON XP 1.125 INJECTION. ZON XP 1.125 INJECTION should be used with caution in pregnant and breast-feeding women. Consult your doctor before receiving the medicine.

ZON XP 1.125 INJECTION should be used with caution in new-borns, children and adolescents. ZON XP 1.125 INJECTION is not recommended for use in pre-mature babies and in children with or history of jaundice and hyperbilirubinemia. Consult your doctor before receiving the medicine.

ZON XP 1.125 INJECTION should be used with caution in elderly people. The common side effect of receiving ZON XP 1.125 INJECTION are diarrhoea, nausea, vomiting and skin allergies. Consult your doctor if any of the above side effects worsen or persist for a longer duration.

Uses Of ZON XP 1.125 INJECTION

It is used to manage bacterial infections such as:

• lower respiratory tract infections
• pneumonia
• infection in the ear
• skin infections
• complicated and uncomplicated urinary tract infections
• sexually transmitted disease (gonorrhoea affecting cervix, urethra and rectal)
• pelvic inflammatory disease (infection affecting reproductive organs)
• bacterial septicaemia
• bone and joint infections
• intra-abdominal infections (peritonitis and biliary tract infections)
• bacterial meningitis
• surgical prophylaxis (pre-operative antibiotics)
• infections in neutropenic patients

How ZON XP 1.125 INJECTION Works

ZON XP 1.125 INJECTION works by destroying the bacterial growth responsible for causing infections. ZON XP 1.125 INJECTION have combination of Ceftriaxone and Tazobactam where Ceftriaxone works by interrupting the cell wall formation by binding with the enzymes responsible for cell wall synthesis. This binding causes defects in the cell wall leading to cell death causing death of the organism. Tazobactam present in ZON XP 1.125 INJECTION is responsible for the irreversible termination of enzymes (beta- lactamases) that protect the organism from antibiotics. Thus, produces less anti-bacterial actions when given alone so it’s always used in combination with other antibiotics. Thus, both the substances works by inhibiting the bacterial growth.

How to use ZON XP 1.125 INJECTION

ZON XP 1.125 INJECTION will be administered into the vein (intravenously) or into the muscle (intramuscularly) by your doctor or nurse. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of ZON XP 1.125 INJECTION

How To Manage Side Effects

Nausea or Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods. Avoid fried, greasy or sweet foods. Eat slowly and eat smaller, more frequent meals, drinking gradually larger amounts of clear liquids, avoid solid food until the vomiting episode has passed, take rest. If the symptom does not improve, contact your doctor.

Warning & Precautions

Pregnancy

ZON XP 1.125 INJECTION should be used with caution in pregnant women only if clearly needed. Consult your doctor before taking ZON XP 1.125 INJECTION.

Breastfeeding

ZON XP 1.125 INJECTION should be used with caution in breastfeeding women as it may pass into the breast milk. Consult your doctor before taking ZON XP 1.125 INJECTION.

Driving and Using Machines

Do not drive or handle heavy machines if you experience side effects like dizziness, drowsiness, tired or if you have blurred vision while taking this ZON XP 1.125 INJECTION.

Alcohol

Consumption of alcohol is not recommended during management with ZON XP 1.125 INJECTION.

Kidney

ZON XP 1.125 INJECTION should be used with caution in patients with kidney disease. Consult your doctor before taking ZON XP 1.125 INJECTION.

Liver

ZON XP 1.125 INJECTION should be used with caution in patients with liver disease. Consult your doctor before taking ZON XP 1.125 INJECTION.

Allergy

Do not take if you are allergic to Ceftriaxone, Tazobactam, other beta- lactam or any other ingredients of this medicine.

Lungs

ZON XP 1.125 INJECTION should be used with caution in patients with pneumonia. Consult your doctor before taking.

Interactions

A. Drug-Drug interactions:

Before taking ZON XP 1.125 INJECTION, inform your doctor if you are taking any of the following medicine:

• other antibiotics used to manage bacterial infections (Ex. chloramphenicol)
• medicines used to manage fluid accumulation (Ex. furosemide)
• probenecid (used to manage gout)
• disulfiram (used to manage alcohol dependence)
• medicines used to manage pregnancy (Ex. ethinyl estradiol, estradiol)

Overdosage:

If you or anyone else accidentally took more of ZON XP 1.125 INJECTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include nausea, vomiting and diarrhoea.

Synopsis

More Information

• Keep ZON XP 1.125 INJECTION out of reach of children
• Store at room temperature below 30°C

FAQs About ZON XP 1.125 INJECTION

References

1. K.D. Tripathi Beta-Lactam Antibiotics Essentials of Pharmacology seventh edition 2013 Page no -727, 725.

2. S.M. Shrivastava Comparative study of efficacy of fixed dose combination of ceftriaxone sulbactam and ceftriaxone tazobactam October 2009 Journal of Pure and Applied Microbiology. [Accessed on 14th June 2022] https://www.researchgate.net/publication/288200470_Comparative_study_of_efficacy_of_fixed_dose_combination_of_ceftriaxone_sulbactam_and_ceftriaxone_tazobactam

3. Biocon Limited. [Accessed on 14th June 2022] https://www.biocon.com/docs/prescribing_information/ccd/supravatz_pi.pdf

4. Cipla med. [Revised in March 2014] [Accessed on 14th June 2022] https://www.ciplamed.com/print-product-pdf/23645

5. Cipla med. [Revised in November 2013] [Accessed on 14th June 2022] https://www.ciplamed.com/print-product-pdf/24155

6. Zuventus healthcare Ltd. [Accessed on 14th June 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=76

7. Abbott. [Accessed on 14th June 2022] https://www.abbott.in/products.f.html#tabsComp