Introduction About ZOLDONAT 4MG INJECTION

Along with management with ZOLDONAT 4MG INJECTION, your doctor might ask you to make some lifestyle changes, such as eating a balanced diet rich in calcium and vitamin D. Prior to starting management with ZOLDONAT 4MG INJECTION, your doctor might want you to take some diagnostic tests to understand the existing condition.

Before receiving ZOLDONAT 4MG INJECTION, inform your doctor if you have had or have pain, swelling or numbness of the jaw, a feeling of heaviness in the jaw or loosening of teeth, kidney disease, are having dental management, or are due to undergo dental surgery.

ZOLDONAT 4MG INJECTION is not recommended for use in pregnant and breast-feeding women. ZOLDONAT 4MG INJECTION is not recommended for use in children and adolescents (under 18 years of age) and should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving ZOLDONAT 4MG INJECTION.

The most common side effects of receiving ZOLDONAT 4MG INJECTION are headache, nausea, vomiting, loss of appetite, conjunctivitis, and anemia (a low number of red blood cells). Inform your doctor if any of the symptoms worsen.

• Manage bone complications such as fractures and bone metastases
• Helps to reduce the amount of calcium in the blood (tumour-induced hypercalcaemia (TIH))

Before receiving ZOLDONAT 4MG INJECTION, inform your doctor if you have received, are receiving, or are taking any of the following medicines:

• Aminoglycosides such as gentamicin
• Calcitonin
• Loop diuretics such as chlorthalidone and indapamide
• Other calcium-lowering medicines
• Anticancer agents like thalidomide
• Any other bisphosphonates, such as risedronate
• Anti-angiogenic medicines such as bevacizumab and axitinib

Overdosage:

ZOLDONAT 4MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms, such as serum electrolyte abnormalities (Ex. abnormal levels of calcium, phosphorus, and magnesium) and/or changes in kidney function, including severe kidney impairment, consult your doctor immediately.

A: Inform your doctor if you have any kidney problems, low calcium levels, or any other medical conditions. Ensure adequate hydration before the infusion. Calcium and vitamin D supplements may be recommended to prevent low calcium levels.

Q. Can ZOLDONAT 4MG INJECTION interact with other medications?

A: Yes, ZOLDONAT 4MG INJECTIONcan interact with medications such as aminoglycosides (which can also affect kidney function) and other drugs that may affect calcium levels. Always inform your doctor about all medications you are taking.

Q. How should ZOLDONAT 4MG INJECTIONbe stored?

A: ZOLDONAT 4MG INJECTION should be stored in a refrigerator (2-8°C) and protected from light. It should not be frozen.

Q. What should I do if I experience side effects?

A: Report any side effects to your healthcare provider. Immediate medical attention may be needed for severe reactions.

Q. Is ZOLDONAT 4MG INJECTION safe for long-term use?

A: Your doctor will evaluate the benefits and risks of long-term use based on your specific condition. Regular monitoring of kidney function and other parameters will be necessary during treatment. For any further questions or concerns, always consult your healthcare provider for personalized advice.

Q: How long should I receive ZOLDONAT 4MG INJECTION?

A: ZOLDONAT 4MG INJECTION should be received in the dose and duration as advised by your doctor. The medicine takes around 6 months to show its maximum benefits for bones. However, in some cases, the doctor may suggest ZOLDONAT 4MG INJECTION for a longer duration. The exact duration will depend on the condition you are being managed for.

Q: How is ZOLDONAT 4MG INJECTION administered?

A: ZOLDONAT 4MG INJECTION will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of ZOLDONAT 4MG INJECTION for you depending upon your age, body weight, and disease condition.

Q: What are the lifestyle changes I should follow while receiving ZOLDONAT 4MG INJECTION?

A: To get maximum benefit from this medicine, there are certain lifestyle changes that you must adhere to. Include some calcium- or vitamin-D-rich foods for bone strength. Try to spend more time in sunlight to get natural vitamin D. Quit smoking and reduce alcohol consumption, as they may harm your bones. You can take up an exercise regime such as walking and low-impact aerobics, as they are good for your bones. Similarly, you can try strength-training exercises where you use your own body weight, which in turn improves bone health.

Q: Can ZOLDONAT 4MG INJECTION cause constipation?

A: Yes, ZOLDONAT 4MG INJECTION may cause constipation in some individuals. To manage this effect, try to eat more high-fiber foods such as fresh fruit, vegetables, and cereals, and drink plenty of water. If this does not help, inform your doctor about receiving alternate management for constipation.

Q: Is ZOLDONAT 4MG INJECTION safe to use in pregnant or breast-feeding women?

A: ZOLDONAT 4MG INJECTION is not recommended for use in pregnant and breast-feeding women. Consult your doctor before receiving ZOLDONAT 4MG INJECTION if you are pregnant, planning to be pregnant, or breast-feeding.

2. R Berenson. Zoledronic acid in cancer patients with bone metastases: results of Phase I and II trials. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. April 2001. [Accessed on 8th July 2024] https://pubmed.ncbi.nlm.nih.gov/11346862/

3. Ali Haidar, Morten Jonler, Troels B Folkmar, Lars Lund. Bisphosphonate (zoledronic acid)-induced osteonecrosis of the jaw. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 2009. [Accessed on 8th July 2024] https://pubmed.ncbi.nlm.nih.gov/19903091/

4. Seacross Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 8th July 2024] https://www.medicines.org.uk/emc/files/pil.7205.pdf