ZENSITA M 1000 Tablet 15's
ZENSITA M 1000 Tablet 15's

ZENSITA M 1000 Tablet 15's

15 Tablet(s) in a Strip Mkt: Zuventus Healthcare Ltd Country of Origin: India
Diabetes Rx required
₹152.28
MRP ₹173.05 Save 12 %
Inclusive of all taxes
ZENSITA M 1000 Tablet 15's ₹152.28
MRP ₹173.05 Save 12 %
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Generic Name
Metformin 1000 mg+Sitagliptin 50 mg
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How ZENSITA M TABLET Works

ZENSITA M TABLET is an antidiabetic medicine. It contains two medicines, namely metformin and sitagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells utilize more of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduce its absorption in the body. Sitagliptin inhibits DPP-4 which leads to increased levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), decreased levels of glucagon, and a stronger insulin response to glucose.

How to use ZENSITA M TABLET

  • Take ZENSITA M TABLET, preferably after meals or as advised by your physician
  • Swallow the medicine with a glass of water. Do not crush or chew the medicine
  • Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition
  • Do not stop taking unless your doctor advises you to stop

Side Effects Of ZENSITA M TABLET

Common side effects of ZENSITA M TABLET:

  • hypoglycemia (low blood sugar)
  • flatulence, diarrhea, constipation, stomach pain, and loss of appetite
  • swelling of the hands and legs (edema)
  • metallic taste
  • drowsiness, dizziness
  • dry mouth

Stop taking and consult your doctor immediately if you experience any of the following side effects:

  • serious allergic reaction (such as hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing)
  • severe blistering of the skin (signs of an allergic skin reaction called bullous pemphigoid)
  • signs of pancreatitis (severe and persistent pain in the stomach areas that might reach through to your back with or without nausea and vomiting)
  • signs of lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)

Warning & Precautions

Pregnancy

Contraindicated

ZENSITA M TABLET is not recommended for use by pregnant women. Therefore, inform your doctor before taking this medicine if you are pregnant, think you may be pregnant, or are planning to have a baby.

Breastfeeding

Contraindicated

ZENSITA M TABLET is not recommended for use by breastfeeding women.  

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking ZENSITA M TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking ZENSITA M TABLET, as it may increase the risk of unwanted side effects.

Kidney

Contraindicated

ZENSITA M TABLET is not recommended for use in patients with severely reduced kidney functions.

Liver

Consult your doctor

ZENSITA M TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gallstones.

Allergy

Contraindicated

Do not take ZENSITA M TABLET if you are allergic to metformin or sitagliptin or any other ingredients of this medicine.

Heart Disease

Contraindicated

ZENSITA M TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure or a recent heart attack).  

Use In Pediatrics

Contraindicated

ZENSITA M TABLET is not recommended for use in children and adolescents (aged below 18 years).  

Use In Geriatrics

Use with Caution

ZENSITA M TABLET should be used with caution in elderly patients (aged above 65 years).

Others

It is not recommended for use if you:

  • have severe, uncontrollable diabetes
  • have nausea, vomiting, diarrhea, or rapid weight loss
  • have lactic acidosis or ketoacidosis (a buildup of lactic acid or ketones in the body)
  • are dehydrated
  • have any severe systemic infection
  • have shock or problems in blood circulation
  • have problems in breathing
  • are an alcoholic
  • are scheduled for any X-rays in the upcoming days

Before taking the medicine, inform your doctor if you:

  • have or ever had pancreatitis (inflammation of the pancreas)
  • have alcohol dependence
  • have high blood lipid levels
  • have type I diabetes mellitus (insulin-dependent diabetes)
  • are about to have a major surgery
  • are fasting
  • are malnourished, starved, on an irregular diet, or feeling weak
  • perform extreme muscle exercises
  • have a vitamin B12 deficiency

Interactions

A. Drug-Drug interactions:

Before taking ZENSITA M TABLET, inform your doctor if you are taking any of the following medicines, such as:

  • Anti-diabetics (Ex. glimepiride, glyburide, gliclazide, teneligliptin, rosiglitazone, pioglitazone)
  • iodine contrast medium
  • Bronchodilators (Ex. salbutamol or terbutaline)
  • corticosteroids Ex. hydrocortisone, prednisolone)
  • diuretics (Ex. furosemide, hydrochlorothiazide)
  • NSAID’s (Ex. ibuprofen and celecoxib)
  • Antihypertensives (Ex. atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, and telmisartan)
  • alcohol-containing medicines (such as cough syrups)
  • H2 blockers (Ex. cimetidine)
  • Anti-viral agents (Ex. dolutegravir)
  • Anti-Anginal agents (Ex. ranolazine)
  • Antibiotics (Ex. trimethoprim)
  • Cardiac glycosides (Ex. digoxin)

Overdosage:

If you or anyone else accidentally took more ZENSITA M TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps, and fast breathing.

Synopsis

Drug :   Metformin, Sitagliptin
Pharmacological Category :   Biguanides, DPP-4 Inhibitors
Therapeutic Indication :   Type II diabetes mellitus          
Dosage Forms :   Tablet, Capsule, Combi pack

More Information

 

 

FAQs About ZENSITA M TABLET

Q: What is ZENSITA M TABLET used for?

A: It is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with type II diabetes mellitus.

Q: How and when to take ZENSITA M TABLET?

A: Take ZENSITA M TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Q: How long should I take ZENSITA M TABLET?

A: You need to take as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Q: What is the best time to take ZENSITA M TABLET?

A: It must be taken with meals to avoid gastrointestinal side effects.

Q: What should I do if I forget to take a dose of ZENSITA M TABLET?

A: If you forgot to take a dose of ZENSITA M TABLET, take it as soon as you remember. However, if it is time for the next dose, skip the missed dose and take the next one regularly.

Q: What are the most common side effects of taking ZENSITA M TABLET?

A: The most common side effects are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in the mouth, sore throat, stuffy nose, and joint pain.

Q: Can I stop taking ZENSITA M TABLET without consulting your doctor?

A: No. You should not stop taking ZENSITA M TABLET without consulting your doctor because it may lead to a reversal of symptoms.

Q: Will taking a higher dose of ZENSITA M TABLET be more effective?

A: No, taking a higher dose will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking ZENSITA M TABLET?

A: Before taking ZENSITA M TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections, or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results.

Q: Can I take medication for high blood pressure along with ZENSITA M TABLET?

A: It is not advisable to take medicines to control blood pressure while taking ZENSITA M TABLET without consulting your doctor.

Q: What should I do if I experience low blood sugar after taking ZENSITA M TABLET?

A: Low blood sugar is a common side effect. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat), consume a sugary snack or sugar drink immediately.

Q: Can ZENSITA M TABLET be taken with insulin?

A: Co-administration of ZENSITA M TABLET with insulin is considered risky as it increases the chance of hypoglycemia (decreased blood sugar levels.

Q: Can ZENSITA M TABLET be used in pregnant women?

A: No. it is not recommended for use by pregnant women.

Q: How much ZENSITA M TABLET should I take?

A: It should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body condition, and severity of the disease.

Q: Can ZENSITA M TABLET cause constipation?

A: Yes. Constipation is a common side effect. Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals, as well as drink plenty of water and exercise more regularly when taking this medicine.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-274 & 275.

2. Erin L. St. Onge, Shannon Miller and Elizabeth Clements. Sitagliptin/Metformin (Janumet) as Combination Therapy in the Treatment of Type-2 Diabetes Mellitus. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 19th January 2024] click here

3. Chitrabhanu Ballav and Stephen C.L. Gough. Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus. Libertas Academica. 2013. [Accessed on 19th January 2024]  click here

4. Merck Sharp & Dohme (UK) Limited. Electronic Medicines Compendium (EMC) [Revised in February 2022] [Accessed on 19th January 2024] click here

5. Merck & Co., Inc. JANUMET® (sitagliptin and metformin hydrochloride) tablets, for oral use. [Revised in July 2022] [Accessed on 19th January 2024] click here

6. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 19th January 2024] click here

7. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 19th January 2024] click here

8. Organon Pharma (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 19th January 2024] click here

User Feedback

 

 

Author Details

Written By Srilekha. R - B.Pharm
Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile
Last updated on 18 Nov 2024 | 12:26 PM(IST)
    Net Qty
    1 N
    Shelf Life
    720 Days
    Item Weight
    17.5 g
    Ingredient
    Metformin 1000 mg+Sitagliptin 50 mg
    Hsn Code
    30049099
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