Introduction About ZEBLONG T 40 TABLET

ZEBLONG T 40 TABLET is a combination of Azelnidipine and Telmisartan which belongs to the group of medicines called Antihypertensive agents. It is used in adults to manage stage II hypertension (high blood pressure) when management with single agents is not effective.

Hypertension (also known as high blood pressure) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high, and as a result it may lead to severe damage to the blood vessels supplying several vital organs, such as heart, kidney, or brain. If left unmanageed, it may cause serious complications such as heart attack, heart failure, stroke or even blindness.

By lowering blood pressure, ZEBLONG T 40 TABLET can also reduce the risk of heart attack (myocardial infarction) and stroke. During management with ZEBLONG T 40 TABLET your doctor will constantly monitor your kidney functions, blood pressure and blood sugar levels to avoid the risk of unwanted side effects.

Before taking ZEBLONG T 40 TABLET inform your doctor if you have any heart, liver, or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure or are severely dehydrated due to excessive vomiting or diarrhea. Avoid taking grapefruit juice while taking this medicine as it may reduce the risk of side effects.

ZEBLONG T 40 TABLET is also not suitable for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby. Stop taking ZEBLONG T 40 TABLET and inform your doctor immediately if you become pregnant while undergoing therapy with ZEBLONG T 40 TABLET.

The most common side effects of taking ZEBLONG T 40 TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles, and flushing. Contact your doctor if any of these side effect worsens.

Uses Of ZEBLONG T 40 TABLET

• Manage Stage II Hypertension (high blood pressure)
• Prevents the risk of heart attack and stroke

How ZEBLONG T 40 TABLET Works

ZEBLONG T 40 TABLET effectively controls blood pressure in patients with hypertension. It contains two medicines namely, Azelnidipine and telmisartan. Telmisartan blocks the actions of certain hormones (angiotensin-II) in the body that causes narrowing of blood vessels and increase in blood pressure.

Azelnidipine is a vasodilator. It relaxes the blood vessels by blocking the entry of certain ions (calcium ions) within them that causes narrowing. This allows blood to flow more smoothly across the blood vessels. Collectively, they reduce the strain on the heart and helps the heart to pump blood more smoothly with less pressure.

How to use ZEBLONG T 40 TABLET

Take ZEBLONG T 40 TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Try to take ZEBLONG T 40 TABLET at the same time each day. ZEBLONG T 40 TABLET can be taken with or without food.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking ZEBLONG T 40 TABLET without consulting your doctor.

Side Effects Of ZEBLONG T 40 TABLET

How To Manage Side Effects

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea And Vomiting

Take ZEBLONG T 40 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Warning & Precautions

Pregnancy

Contraindicated

ZEBLONG T 40 TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking ZEBLONG T 40 TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with ZEBLONG T 40 TABLET, stop taking it and consult your doctor immediately.

Breastfeeding

Contraindicated

ZEBLONG T 40 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking ZEBLONG T 40 TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking ZEBLONG T 40 TABLET as it might make you feel dizzier and drowsier.

Kidney

Use with Caution

ZEBLONG T 40 TABLET should be used with caution in patients with kidney problems (such as kidney transplant, narrowing of renal arteries). Therefore, consult your doctor before taking it.

Liver

Consult your doctor

ZEBLONG T 40 TABLET is not recommended for use in patients with severe liver impairment (such as cholestasis, jaundice, biliary obstruction). It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take ZEBLONG T 40 TABLET if you are allergic to Azelnidipine or Telmisartan.

Heart Disease

Use with Caution

ZEBLONG T 40 TABLET should be used with caution in patients with heart problems (such as irregular heart rhythm, heart failure, recent heart attack, and problems with heart muscle or valves). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking ZEBLONG T 40 TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to manage elevated blood pressure (such as aliskiren, captopril, enalapril, lisinopril, verapamil, diltiazem, losartan, valsartan)
• potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
• non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
• heparin (a medicine used to manage or manage blood clots)
• medicines used to manage bacterial infections (Ex. trimethoprim)
• medicines to suppress immune system (Ex. cyclosporin, tacrolimus, sirolimus, temsirolimus and everolimus)
• medicine used to manage HIV infection (Ex. indinavir, ritonavir, saquinavir)
• medicines used to manage fungal infections (Ex. itraconazole, ketoconazole and fluconazole)
• digoxin (a medicine used to manage irregular heartbeat)
• cimetidine (a medicine used for stomach ulcers)
• imatinib (a medicine used for cancer)
• rifampicin (a medicine used to manage tuberculosis)
• phenytoin (a medicine used to manage fits)
• lithium (a medicine used for depression)
• medicines that can make you feel sleepy (such as alprazolam, midazolam, imipramine, amitriptyline, morphine)

B. Drug-Food interactions:

Do not eat grapefruit or drink grapefruit juice while taking ZEBLONG T 40 TABLET as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally took more ZEBLONG T 40 TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, and dizziness.

Synopsis

More Information

• Keep ZEBLONG T 40 TABLET out of reach of children
• Store ZEBLONG T 40 TABLET at room temperature

FAQs About ZEBLONG T 40 TABLET

Q: What are the uses of ZEBLONG T 40 TABLET?

A: ZEBLONG T 40 TABLET is used to manage hypertension in adults. It can also be used to manage the risk of heart attack and stroke.

Q: What type of a medicine is ZEBLONG T 40 TABLET?

A: ZEBLONG T 40 TABLET is an antihypertensive medicine. It is a combination of two medicines namely Azelnidipine and telmisartan. Azelnidipine is a calcium channel blocker and telmisartan is an angiotensin-II receptor blocker. They both reduces strain on the heart, relaxes blood vessels and makes the heart to pump more blood with lesser force.

Q: What happens when I stop taking ZEBLONG T 40 TABLET?

A: Do not stop taking ZEBLONG T 40 TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take ZEBLONG T 40 TABLET for the stipulated duration recommended by your doctor to achieve maximum results.

Q: What is the best time to take ZEBLONG T 40 TABLET?

A: ZEBLONG T 40 TABLET can be taken with or without meals. Your doctor will decide the best time for you to take ZEBLONG T 40 TABLET based on your age, body weight and disease condition.

Q: What to do if I forgot to take a dose of ZEBLONG T 40 TABLET?

A: If you forgot to take a dose of ZEBLONG T 40 TABLET, take it as soon as you remember. However, if it is time for the next dose of ZEBLONG T 40 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of ZEBLONG T 40 TABLET to compensate the missed ones.

Q: What precautions should be followed while taking ZEBLONG T 40 TABLET?

A: Before taking ZEBLONG T 40 TABLET, inform your doctor if you have any heart, liver or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure volume or are severely dehydrated. Stop taking ZEBLONG T 40 TABLET and consult your doctor immediately if you become pregnant. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.

Q: Can I consume alcohol while taking ZEBLONG T 40 TABLET?

A: Avoid consumption of alcohol while taking ZEBLONG T 40 TABLET as it might make you feel dizzier and drowsier.

Q: What happens if I accidentally take more ZEBLONG T 40 TABLET?

A: If you or anyone else accidentally took more ZEBLONG T 40 TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, fainting, drowsiness, nausea, vomiting or confusion.

Q: Can I take ZEBLONG T 40 TABLET daily?

A: Take ZEBLONG T 40 TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take ZEBLONG T 40 TABLET every day or not.

Q: Is ZEBLONG T 40 TABLET safe to use in diabetic patients?

A: ZEBLONG T 40 TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking ZEBLONG T 40 TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.

Q: What are the side effects of ZEBLONG T 40 TABLET?

A: The most common side effects of taking ZEBLONG T 40 TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles, and flushing. Contact your doctor if any of these side effect worsens.

Q: Can I stop taking ZEBLONG T 40 TABLET once my symptoms subside?

A: No. Do not stop taking ZEBLONG T 40 TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take ZEBLONG T 40 TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.

Q: Can ZEBLONG T 40 TABLET be taken during pregnancy?

A: ZEBLONG T 40 TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking ZEBLONG T 40 TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with ZEBLONG T 40 TABLET, stop taking it and consult your doctor immediately.

Q: Is ZEBLONG T 40 TABLET safe to use in kidney disease?

A: ZEBLONG T 40 TABLET should be used with caution in patients with kidney diseases (such as those having renal artery stenosis, kidney transplant or in those undergoing haemodialysis). Your doctor will access your health condition and suggest a suitable dose for you. Therefore, it is important to inform your doctor if you have any kidney problems before taking ZEBLONG T 40 TABLET as a precaution.

Q: Can the use of ZEBLONG T 40 TABLET affect the liver?

A: Yes. ZEBLONG T 40 TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Consult your doctor before taking it.

References

1. KD Tripathi. Antihypertensive drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 561 & 562.

2. Bi-Lian Chen, Yin-Zhuang Zhang, Jian-Quan Luo, and Wei Zhang. Clinical use of azelnidipine in the treatment of hypertension in Chinese patients. NIH. National Library of Medicine. National Center of Biotechnology Information. PMC. PubMed Central. February 2015. [Accessed on 4th February 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348133/

3. Glenmark Arzneimittel GmbH. Electronic Medicines Compendium (EMC). [Revised in November 2019] [Accessed on 4th February 2023] https://www.medicines.org.uk/emc/files/pil.9981.pdf

4. La Renon Healthcare Pvt Ltd. Azeliren (Azelnidipine 8mg and 16mg Tablet). [Accessed on 4th February 2023] https://www.larenon.com/wp-content/uploads/2020/10/AZELIREN-LBL.pdf

5. Torrent Pharmaceuticals Ltd. Uniaz-T. [Revised in September 2020]. [Accessed on 4th February 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/3006.pdf

Useful Diagnostic Tests

• Kidney Function Test

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 04 Feb 2023 | 05:13 PM(IST)