VORINZ 200 Tablet 4's
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Introduction About VORINZ 200 TABLET
VORINZ 200 TABLET contains Voriconazole which belongs to the group of medicines called Antifungal agents. It is used to manage various fungal infections (such as invasive aspergillosis, candidaemia, invasive Candida sp. infections) in both adults and in children (aged 2 years or above). It can also be used to manage fungal infections in high-risk bone marrow transplant recipients.
VORINZ 200 TABLET should be taken at least 1 hour before or after meals. It is highly intended for patients with worsening or life-threatening fungal infections. It is important to complete the full course of therapy with VORINZ 200 TABLET to achieve better control over infection.
Before taking VORINZ 200 TABLET inform your doctor if you have any liver or heart problems. Do not take VORINZ 200 TABLET if you are pregnant or breast-feeding without consulting your doctor.
Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with VORINZ 200 TABLET. During management with VORINZ 200 TABLET, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors.
The most common side-effects of taking VORINZ 200 TABLET are visual impairment, fever, rash, nausea, vomiting, diarrhoea, headache, swelling of the extremities, stomach pain and breathing difficulties. Consult your doctor if any of these side effect troubles you.
Uses Of VORINZ 200 TABLET
It is used in adults and in children (aged 2 years or older) to:
- Manage and manage severe fungal infections
How VORINZ 200 TABLET Works
VORINZ 200 TABLET is an antifungal medication. It effectively controls fungal infections within the body. It disrupts the fungal cell membrane by blocking the production of certain chemicals (ergosterol) within the cell which is required for its survival. As a result, it stops the fungal cell from multiplication, thereby managing the further spread of infection.
How to use VORINZ 200 TABLET
Take VORINZ 200 TABLET 1 hour before or after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking VORINZ 200 TABLET without consulting your doctor.
Side Effects Of VORINZ 200 TABLET
Common
- vision problems (such as blurred vision, colour changes, light sensitivity)
- fever, chills, weakness
- headache, dizziness, sleepiness
- nausea, vomiting, diarrhoea, stomach pain
- constipation, indigestion
- swelling of the extremities
- inflammation of the sinuses
- low RBC, WBC and platelet count in blood
- low blood sugar levels, low blood pressure
- low blood potassium or sodium levels
- breathing difficulties
- anxiety, depression, inability to sleep
- fits
- hair loss
Uncommon
- enlarged lymph glands
- problems in adrenal gland
- underactive thyroid gland
- feeling shaky
- abnormal sense of taste
- hearing difficulties, vertigo, ringing in the ears
- increased blood cholesterol and urea levels
Rare
Stop taking VORINZ 200 TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as severe skin rash with itching, blistering and peeling of the skin, mouth, eyes, throat, genitals, swelling of the face and tongue, bleeding under the skin causing appearance of red-pin point dots on the skin, skin swelling, along with fever, tiredness, confusion or jaundice)
- skin rashes, sun burn
- bone pain, inflammation of the tissue surrounding the bone
- skin cancer
- red, scaly patches or ring-shaped skin lesions
- jaundice (yellowing of the skin and whites of the eye)
- signs of adrenal insufficiency (such as severe tiredness, weak muscles, loss of appetite, weight loss, stomach pain)
- signs of Cushing’s syndrome (such as round face, weight gain, fatty hump between the shoulders, dark skin, skin thinning, easy bruising, high blood sugar levels, excessive hair growth and excessive sweating)
How To Manage Side Effects
Nausea or vomiting:
Try to take VORINZ 200 TABLET with or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
VORINZ 200 TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with VORINZ 200 TABLET.
Breastfeeding
VORINZ 200 TABLET should be used with caution in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you experience vision problems after taking VORINZ 200 TABLET.
Liver
VORINZ 200 TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take VORINZ 200 TABLET if you are allergic to Voriconazole or to any other azole antifungal agents (such as fluconazole, ketoconazole).
Heart Disease
VORINZ 200 TABLET should be used with caution in patients with heart problems (such as cardiomyopathy, irregular or slow heart rate, prolong QT interval). Therefore, consult your doctor before taking it.
Others
Use in paediatrics:
VORINZ 200 TABLET is not recommended for use in children under 2 years of age. Therefore, consult your doctor before taking it.
Use in geriatrics:
VORINZ 200 TABLET can be used with caution in elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug – Drug Interactions:
Before taking VORINZ 200 TABLET, inform your doctor if you are taking any of the following medicines such as:
- medicines used for allergy (Ex. terfenadine, astemizole)
- medicines used for symptoms of chronic heart failure (Ex. ivabradine)
- medicines used for stomach problems (Ex. cisapride)
- medicines used for managing mental illness (Ex. pimozide, phenytoin, phenobarbital, midazolam, triazolam and lurasidone)
- carbamazepine, phenytoin (medicines used to manage fits)
- medicines used for irregular heartbeat (Ex. quinidine)
- medicines used for managing tuberculosis (Ex. rifampicin, rifabutin)
- medicines used for managing HIV (Ex. efavirenz, ritonavir, efavirenz, delavirdine, nevirapine)
- medicines used for migraine (Ex. ergotamine, dihydroergotamine)
- medicines used in transplant patients (Ex. sirolimus, ciclosporin, tacrolimus)
- St. John’s Wort (herbal supplement used to manage depression)
- medicines used to manage constipation (Ex. naloxegol)
- medicines used to manage hyponatremia (Ex. tolvaptan)
- medicines used in managing patients with blood cancer (Ex. venetoclax)
- medicines used for managing cancer (Ex. glasdegib, vincristine, vinblastine)
- warfarin (a medicine used to manage blood clotting)
- medicines used for diabetes (Ex. tolbutamide, glipizide, glyburide)
- medicines used for lowering cholesterol (Ex. atorvastatin, simvastatin)
- medicines used for managing stomach ulcers (Ex. omeprazole)
- oral contraceptives (used to manage pregnancy) Ex. ethinylestradiol
- medicines used to manage drug addiction (Ex. methadone)
- painkillers used for surgical procedures (Ex. alfentanil, fentanyl, sufentanil)
- medicines used to manage moderate to severe pain (Ex. oxycodone, hydrocodone, ibuprofen, diclofenac)
- other medicines used to manage fungal infections (Ex. fluconazole)
- medicines used for managing advanced kidney cancer and in transplant patients (Ex. everolimus)
- medicine used for managing cytomegalovirus (CMV) disease after bone marrow transplant (Ex. letermovir)
- medicines used to manage cystic fibrosis (Ex. ivacaftor)
Overdosage:
If you or anyone else accidentally took more VORINZ 200 TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Voriconazole |
| Pharmacological Category | : | Azole Antifungal agents |
| Therapeutic Indication | : | Fungal Infections |
| Dosage Forms | : | Tablet, Injection, Eye Drops |
More Information
- Keep VORINZ 200 TABLET out of reach of children
- Store VORINZ 200 TABLET at room temperature
FAQs About VORINZ 200 TABLET
What is the use of VORINZ 200 TABLET?
VORINZ 200 TABLET is used to manage various fungal infections (such as invasive aspergillosis, candidaemia, invasive Candida sp. infections) in both adults and in children (aged 2 years or above). It can also be used to manage fungal infections in high-risk bone marrow transplant recipients.
How VORINZ 200 TABLET works?
VORINZ 200 TABLET is an antifungal medication. It effectively controls fungal infections within the body. It disrupts the fungal cell membrane by blocking the production of certain chemicals (ergosterol) within the cell which is required for its survival. As a result, it stops the fungal cell from multiplication, thereby managing the further spread of infection.
How to take VORINZ 200 TABLET?
Take VORINZ 200 TABLET 1 hour before or after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
How long should I take VORINZ 200 TABLET?
You need to take VORINZ 200 TABLET for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
What to do if I forgot to take a dose of VORINZ 200 TABLET?
If you forgot to take a dose of VORINZ 200 TABLET, take it as soon as you remember. However, if it is time for the next dose of VORINZ 200 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of VORINZ 200 TABLET to compensate the missed ones.
Is VORINZ 200 TABLET safe?
VORINZ 200 TABLET is safe at doses prescribed by the physician. Therefore, do not alter the dose of VORINZ 200 TABLET without consulting your doctor.
Can I stop taking VORINZ 200 TABLET without consulting your doctor?
No. You should not stop taking VORINZ 200 TABLET without consulting your doctor as it may reduce its effectiveness. Therefore, take VORINZ 200 TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
What happens if I take too more of VORINZ 200 TABLET?
If you or anyone else accidentally took more VORINZ 200 TABLET, consult your doctor immediately or visit the nearby hospital.
Will taking a higher dose of VORINZ 200 TABLET be more effective?
No, taking a higher dose of VORINZ 200 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can VORINZ 200 TABLET be used in pregnant women?
VORINZ 200 TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
How much VORINZ 200 TABLET should I take?
VORINZ 200 TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
References
1. KD. Tripathi. Anti-Fungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 795.
2. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Voriconazole. [Accessed on 22nd November 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Voriconazole
3. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2022]. [Accessed on 22nd November 2022] https://www.medicines.org.uk/emc/files/pil.4415.pdf
Useful Diagnostic Tests
- Complete Blood Count
- Liver Function Test
- Kidney Function Test
Author Details
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