INTRODUCTION

VINPOTAG 5MG contains Vinpocetine which belongs to the group of medicines called Nootropics. It is indicated in adults to manage the symptoms caused by circulatory disorders in the brain (ischemic hypoperfusion and various forms of ischemic hypoperfusion conditions). Ischemic hypoperfusion is a condition in which there is an inadequate blood flow to the brain. It is characterized by symptoms such as difficulty speaking, weakness in one arm or leg, dizziness, vertigo, double vision or loss of coordination.

Before taking VINPOTAG 5MG inform your doctor if you have liver or kidney insufficiency, heart conditions (such as severe coronary heart disease, cardiac arrhythmia, prolonged QT intervals), lowered blood pressure, current eye inflammation or lactose intolerance. VINPOTAG 5MG is not recommended for use in pregnant and breast-feeding women.

Also, it is not recommended for use in children and adolescents under 18 years of age. Consult with your doctor for advice. Some of the side effects of taking VINPOTAG 5MG are headache, abdominal pain, constipation, diarrhoea and vomiting. Contact your physician if any of the symptoms of VINPOTAG 5MG gets worse.

USES OF VINPOTAG 5MG

• Manages symptom caused by circulatory disorders in the brain (ischemic hypoperfusion)

HOW VINPOTAG 5MG WORKS

VINPOTAG 5MG works by inhibiting the voltage-dependent neuronal sodium channels, which in turn enhances a chemical messenger in the brain. Thus, increases blood flow within the brain, as a result it protects the destruction of nerve cells (neurons) and protects the brain. Thus, helps in enhanced function of nervous system.

DIRECTIONS FOR USE

Take VINPOTAG 5MG as advised by your doctor. Swallow VINPOTAG 5MG with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration of VINPOTAG 5MG for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF VINPOTAG 5MG

HOW TO MANAGE SIDE EFFECTS

Vomiting:

VINPOTAG 5MG can be taken with or after meals. Simple meals are preferred. Oil rich foods or spicy foods should be avoided. Consult your doctor if the symptom does not improve.

Headache:

Apply hot or cold-water bag on your head. Try taking rest in a quiet and dark room. Apply pain-relieving balm on your forehead if required. Consult your doctor if the symptom does not improve.

Stomach pain:

Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain worsens.

Constipation:

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if constipation does not improve.

Diarrhea:

Increase the intake of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own to manage diarrhea without consulting your doctor. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking VINPOTAG 5MG, inform your doctor if you are taking any of the following medicines:

• aspirin, clopidogrel, dalteparin, enoxaparin, heparin and warfarin (used to manage blood clots)
• diclofenac, ibuprofen and naproxen (used to manage pain)
• antiarrhythmics Ex. amiodarone (used to manage heart rhythm disorders)
• antihypertensive drugs Ex. nifedipine (used to manage high blood
  pressure)
• medicinal products acting on the central nervous system (Ex. citalopram, escitalopram) (used to manage depression and anxiety)
• cayenne peppers, garlic, cassia cinnamon, gingko biloba, grape seed extract, dong quai and feverfew (blood thinning herbal medicines)
• medicinal products known to cause QT prolongation like clarithromycin (used to manage bacterial infections)

Overdosage:

If you or anyone else accidentally takes too much of VINPOTAG 5MG, contact your doctor or visit the nearby hospital immediately.

SYNOPSIS

MORE INFORMATION

• Keep VINPOTAG 5MG out of reach of children
• Store at room temperature

FAQs ABOUT VINPOTAG 5MG

Can I take VINPOTAG 5MG while having a heart condition?

VINPOTAG 5MG is not recommended for use if you have certain heart conditions such as severe coronary disease and severe arrhythmia and it should be used with caution if you have prolonged QT interval. Consult with your doctor before taking VINPOTAG 5MG.

How does VINPOTAG 5MG work in the body?

VINPOTAG 5MG works by inhibiting the voltage-dependent neuronal sodium channels, which in turn enhances a chemical messenger in the brain. Thus, increases blood flow within the brain, as a result it protects the destruction of nerve cells (neurons) and protects the brain. Thus, helps in enhanced function of nervous system.

Is VINPOTAG 5MG safe to use in patients with kidney problems?

VINPOTAG 5MG should be used with caution if you have kidney impairment. Your doctor may adjust the dose or select a suitable alternative management depending upon kidney function. Inform and consult with your doctor before taking VINPOTAG 5MG.

Can VINPOTAG 5MG be used in pregnant or breast-feeding women?

VINPOTAG 5MG is not recommended for use in pregnant and breast-feeding women. Consult with your doctor before taking VINPOTAG 5MG if you are pregnant or planning to have a baby or if you are a breast-feeding woman.

Who should not take VINPOTAG 5MG?

VINPOTAG 5MG is not recommended for use in patients having short term haemorrhagic cerebral (brain) blood flow stroke, intracranial hypertension (pressure inside the skull will be increased) or in patients who recently had bleeding in the brain. Inform and consult with your doctor before taking VINPOTAG 5MG.

REFERENCES

1. Sean C Sweetman. Supplementary Drugs and Other Substances. Martindale: The Complete Drug Reference. 36th edition. 2009. Page - 2414.

2. Yi-shuai Zhang, Jian-dong Li, and Chen Yan. An update on Vinpocetine: New discoveries and clinical implications. NIH. National Library of Medicine. National center for biotechnology information. PMC. Pubmed Central. January 2019 [Accessed on June 3rd 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766389/

3. Nyakas C, Felszeghy K, Szabo R, Keijser JN, Luiten PG, Szombathelyi Z, Tihanyi K. Neuroprotective Effects of Vinpocetine and its Major Metabolite Cis-apovincaminic Acid on NMDA-Induced Neurotoxicity in a Rat Entorhinal Cortex Lesion Model. National Institute of Health. NLM. National Centre for Biotechnology Information. PMC. Pubmed Central. May 2009. [Accessed on June 3rd 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494022/

4. B Kiss, E Karpati. Mechanism of action of vinpocetine. National Institute of Health. NLM. National Centre for Biotechnology Information. Pubmed.gov. September 1996. [Accessed on June 3rd 2022] https://pubmed.ncbi.nlm.nih.gov/9082841/#:~:text=Vinpocetine%20has%20been%20shown%20to,and%20increase%20of%20cerebral%20flow.

5. Covex S.A. Atreiza tablet (Vinpocetine). Heads of Medical Agency (HMA) [Revised in October 2020] [Accessed on June 3rd 2022] https://file.wuxuwang.com/hma/LV_H_0166_001_FinalPL.pdf

USEFUL DIAGNOSTIC TESTS

• Activated partial thromboplastin time
• Complete blood count
• Prothrombin time