Introduction About VERTIGIL TABLET

VERTIGIL TABLET is a combination of Cinnarizine and Domperidone which belongs to the group of medicines called Anti histamines and Anti-emetic agents. It is used to manage vertigo or meniere’s disease, nausea and vomiting due to motion sickness. It is also used for the management of vestibular disorders.

Cinnarizine is an antihistaminic and blocks the calcium channels, inhibiting smooth muscle contraction and improves microcirculation to inner ear and relieves vertigo or spinning sensation. Domperidone is a prokinetic agent that works on the upper digestive tract and increase the movement of food through stomach and intestine more quickly. It also works by blocking dopamine (a chemical which is responsible for feeling of nausea or vomiting) in the brain. Therefore, relieving vertigo associated with nausea and vomiting

Before taking VERTIGIL TABLET inform your doctor if you have liver, kidney or heart disease. VERTIGIL TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking it. VERTIGIL TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it. VERTIGIL TABLET is not recommended for use in children. Contact your doctor before taking. VERTIGIL TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking. The most common side effects of this medicine are nausea, dryness in mouth, Indigestion, Sleepiness, and, Weight gain. Contact your doctor if any of the symptoms worsen.

Uses Of VERTIGIL TABLET

Manage:

• vertigo or meniere’s disease,
• motion sickness,
• vestibular disorders

How VERTIGIL TABLET Works

VERTIGIL TABLET helps to relieve vertigo associated with nausea and vomiting, where Cinnarizine works by blocking the calcium channels, inhibiting smooth muscle contraction and improves microcirculation to inner ear and domperidone is a prokinetic agent that works on the upper digestive tract and increase the movement of food through stomach and intestine more quickly. It also works by blocking dopamine (a chemical which is responsible for feeling of nausea or vomiting) in the brain.

How to use VERTIGIL TABLET

Take this medicine as advised by your physician. Swallow this medicine as whole with a glass of water and do not crush or chew the medicine.

Side Effects Of VERTIGIL TABLET

How To Manage Side Effects

Indigestion

Eat smaller meals but take frequently. Eat and exercise regularly. Contact your doctor if the symptom does not improve.

Nausea And Vomiting

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.

Warning & Precautions

Pregnancy

Monitoring required

VERTIGIL TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking.

Breastfeeding

Contraindicated

VERTIGIL TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate machinery if you feel drowsy or sleepiness after taking VERTIGIL TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking VERTIGIL TABLET because it might make you drowsy.

Kidney

Use with Caution

VERTIGIL TABLET should be used with caution in patients with kidney disease. Contact your doctor before taking

Liver

Contraindicated

VERTIGIL TABLET is not recommended for use in patients with moderate to severe liver disease. Contact your doctor before taking.

Allergy

Contraindicated

Do not take VERTIGIL TABLET if you are allergic to cinnarizine, domperidone, or to other ingredients of this medicine.

Heart Disease

Contraindicated

VERTIGIL TABLET is not recommended for use in patients with heart diseases such as heart failure, heart rhythm disorders like prolonged QT interval. Contact your doctor before taking.

Interactions

A. Drug-Drug interactions:

Inform your physician, if you are using,

• digoxin (medicine used for heart failure)
• aspirin (medicine used to manage blood clots)
• paracetamol (medicine used to manage fever)
• diazepam (medicine used to manage anxiety)
• phenothiazines (medicines used to manage psychotic disorders)
• antimuscarinic agents Ex. atropine, hyoscamine (medicine used to manage overactive bladder syndrome, bradycardia etc.)
• opiods  Ex. codeine (medicine used for severe pain)
• suxamethonium (medicine used in anaesthesia)
• medicines used to manage psychoses (haloperidol, pimozide, sertindole)
• citalopram, escitalopram (medicines used for depression)

Overdosage: If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of Overdosage include nausea, stomach upset, drowsiness or sleepiness, unusual eye movements, tongue or uncontrollable muscle spasms, weakness, prolonged QT interval and seizures in young children.

Synopsis

More Information

• Keep out of reach of children
• Store at room temperature

FAQs About VERTIGIL TABLET

Does VERTIGIL TABLET cause drowsiness?

Yes. VERTIGIL TABLET cause drowsiness or sleepiness. Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Avoid consumption of alcohol as it can aggravate your dizziness. Contact your doctor if the symptom persists for longer time.

For what conditions VERTIGIL TABLET is used?

VERTIGIL TABLET is used to manage vertigo or meniere’s disease, nausea and vomiting due to motion sickness. It is also used for the management of vestibular disorders. Contact your doctor before taking.

How VERTIGIL TABLET works?          

VERTIGIL TABLET helps to relieve vertigo associated with nausea and vomiting, where Cinnarizine works by blocking the calcium channels, inhibiting smooth muscle contraction and improves microcirculation to inner ear and domperidone is a prokinetic agent that works on the upper digestive tract and increase the movement of food through stomach and intestine more quickly. It also works by blocking dopamine (a chemical which is responsible for feeling of nausea or vomiting) in the brain.

What are the possible side effects of taking VERTIGIL TABLET?

The most common side effects of this medicine are nausea, dryness in mouth, Indigestion, Sleepiness, and, Weight gain. Contact your doctor if any of the symptoms worsen.

Can I use VERTIGIL TABLET in pregnancy?

No. VERTIGIL TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking.

References

1. K.D.Tripathi. Autocoids and related drugs, Antiemetic, prokinetic and digestant drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page- 168,663, 666

2. Tanvi S. Tambawala, Pranav J. Shah, Shailesh A. Shah. Uses of Cinnarizine and domperidone. International Journal of Pharmaceutical Sciences and Technology and Management. 2015. [Accessed on 1st June 2022] https://pharmacy.nmims.edu/docs/orally-disintegrating-article-09.pdf

3. Milind Vasant Kirtane, Anita Bhandari, Prashant Narang, Ravi Santani. Mechanism of cinnarizine: A contemporaray review. Indian Journal of otolaryngology and Head and Neck Surgery. April 2017. [Accessed on 1st June  2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841794/#:~:text=Mechanism%20of%20Action,Cinnarizine%2C%20developed%20as&text=Cinnarizine%20inhibits%20smooth%20muscle%20cell,dopamine%20D2%20receptors%20%5B6%5D.

4. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised on January 2021] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.2607.pdf

5. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised on March 2021] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.556.pdf

6. Cinnarizine and Domperidone. Mims.com. [Accessed on 1st June 2022] https://www.mims.com/india/drug/info/cinnarizine%20+%20domperidone?type=full&mtype=generic

7. Cinnarizine and Domperidone. Leeford healthcare. [Accessed on 1st June 2022] https://www.leeford.in/product/802/sinadom

8. Cinnarizine and Domperidone. Vibcare. [Accessed on 1st June 2022] https://vibcare.co.in/cinnarizine-domperidone/

9. Cinnarizine and Domperidone. Somacare.co.in. [Accessed on 1st June 2022] https://www.somacare.co.in/product/domperidone-10mg-cinnarizine-25mg

10. Cinnarizine and Domperidone. Neuraclelife. [Accessed on 1st June 2022] https://www.neuraclelife.com/product/cinnarizine-domperidone-tablet/

11. Cinnarizine and Domperidone. DM pharma. [Accessed on 1st June 2022] https://dmpharma.co.in/Cinnarizine%20and%20Domperidone%20Tablet.html

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 30 Jan 2023 | 03:57 PM(IST)