Valprol Injection 5ml
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| Encorate 100mg Injection 5ml Prescription Epilepsy/Convulsion Rx required MRP ₹ 33.71 Get this at ₹ 26.97 > Mkt: Sun Pharmaceutical Industries Ltd |
| VALPOCARE Injection 5ml Prescription Epilepsy/Convulsion Rx required MRP ₹ 31.00 Get this at ₹ 24.80 > Mkt: Ikon Remedies Pvt Ltd |
Introduction About VALPROL INJECTION
VALPROL INJECTION contains Sodium valproate, which belongs to the group of medicines called Anti-convulsant. It is used in the management of epilepsy (fits). Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness. Symptoms include temporary confusion, staring spells, stiff muscles, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness, fear, anxiety or déjà vu.
VALPROL INJECTION is not recommended for use if you have porphyria (affecting metabolism), liver problems or Alpers-Huttenlocher syndrome. Before receiving VALPROL INJECTION inform your doctor if you have kidney, brain problems, carnitine palmitoyl transferase type II deficiency, diabetes, systemic lupus erythematosus, urea cycle disorder, a genetic problem caused by a mitochondrial disorder in your family.
Do not consume alcohol while receiving VALPROL INJECTION. VALPROL INJECTION is not recommended or used in pregnant women, inform your doctor if you are breastfeeding. VALPROL INJECTION should be used with caution in children and the elderly. The most common side effects of receiving VALPROL INJECTION are stomach pain, diarrhea, headache, feeling tired and weight gain. Consult your doctor if any of your symptoms become worse while taking VALPROL INJECTION.
Uses Of VALPROL INJECTION
- Manage epilepsy (fits)
How VALPROL INJECTION Works
VALPROL INJECTION increases concentrations of gamma-aminobutyric acid (GABA) which reduces neuronal excitability by inhibiting nerve transmission in the brain, probably due to inhibition of the enzymes responsible for the breakdown of GABA.
How to use VALPROL INJECTION
VALPROL INJECTION will be given to you only by a doctor or a nurse as a slow infusion into the veins (intravenously). Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
Side Effects Of VALPROL INJECTION
Common
- stomach pain, feeling or being sick
- diarrhea
- dry or sore mouth or swollen gums
- shakes (tremors) in a part of your body or unusual eye movements
- feeling tired or sleepy
- headache
- weight gain
- thinning hair or changes to the color or texture of your hair
- irregular or delayed periods
- pain at the injection site
Rare
Stop receiving VALPROL INJECTION and contact your doctor immediately if you experience any of the following side effects:
- thoughts of harming or killing yourself
- an allergic reaction (rash, joint pain, fever (systemic lupus erythematosus), swallowing or breathing problems, swelling of your lips, face, throat or tongue, lymph node enlargement and possible impairment of other organs
- liver problems and problems of the pancreas may show as a sudden illness (feeling and being sick many times; being very tired, sleepy and weak, stomach pain, jaundice, loss of appetite, swelling of legs, worsening of fits
- skin rash or skin lesions with a pink/red ring and a pale center which may be itchy, scaly or filled with fluid (on the palms or soles of your feet, can be erythema multiforme)
- blistering or bleeding of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever (Stevens-Johnson syndrome)
- severe blistering rash where layers of the skin may peel off to leave large areas of raw exposed skin over the body, unwell, fever, chills and aching muscles (toxic epidermal necrolysis)
- bruising more easily and getting more infections than usual (thrombocytopenia), blood clotting problems
- changes in mood, loss of memory, lack of concentration and coma
- hypothyroidism, which may cause tiredness or weight gain
- breathing difficulty and pain due to inflammation of the lungs
- changes in behavior including being very alert and sometimes also aggressive, hyperactive and unusual or inappropriate behavior
- changes in the amount of ammonia in the blood (being sick, problems with balance and co-ordination, feeling lethargic or less alert)
- feeling shaky (tremor), sleepy or unsteady when walking or jerky muscle movements.
- rapid, uncontrollable movement of the eyes
- increase in the number and severity of convulsions
- liver damage, inflammation of the pancreas, bedwetting, renal dysfunction, overgrowth of gum tissue, aggression, agitation, disturbance in attention, abnormal behavior, hyperactivity and learning disorder in children
- kidney disease or kidney problems (renal failure, tubulointerstitial nephritis and Fanconi syndrome) which may manifest as reduced urinary output or blood in the urine
- confusion, which could be due to decreased levels of sodium in your blood (Syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion)
How To Manage Side Effects
Stomach pain:
Try to rest and relax. Eat and drink slowly. Keep a heating pad. Consult your doctor if any of your symptoms get worse.
Diarrhea:
Drink lots of water or fruit juice to keep yourself hydrated. Consult your doctor if any of your symptoms get worse.
Feeling or being sick:
Stick to simple meals. Avoid eating oily or spicy meals. Consult your doctor if any of your symptoms get worse.
Headache:
Avoid bright lights, take enough rest and drink more water. Consult your doctor if any of your symptoms get worse.
Warning & Precautions
Pregnancy
VALPROL INJECTION is not recommended for use in pregnant women or if you are planning to have a baby as it can cause birth defects and behavioral/learning problems in the baby. if you are a woman able to have a baby, you must not take it unless you use an effective method of birth control (contraception) during your entire> management. Do not stop taking this medicine or contraception, until you have discussed this with your doctor. Consult your doctor before receiving VALPROL INJECTION.
Breastfeeding
Inform your doctor if you are breastfeeding before receiving VALPROL INJECTION as very little medicine might pass through the breastmilk. Consult your doctor if you can breastfeed or not receive the medicine during the> management.
Driving and Using Machines
Do not drive or use machines while receiving VALPROL INJECTION as it can make you sleepy.
Alcohol
Do not consume alcohol while receiving VALPROL INJECTION as it can worsen the side effects.
Kidney
VALPROL INJECTION should be used with caution in patients with kidney disease. The dose will be adjusted by your doctor. Consult your doctor before receiving VALPROL INJECTION.
Liver
VALPROL INJECTION is not recommended for patients with liver problems or with a family history of liver disease. Consult your doctor before receiving VALPROL INJECTION.
Allergy
Do not receive VALPROL INJECTION if you are allergic to Sodium valproate or any other ingredients of this medicine.
Others
VALPROL INJECTION is not recommended for use if you:
- have a rare illness called porphyria which affects metabolism
- have a known metabolic disorder, i.e., a urea cycle disorder
- have a genetic problem caused by a mitochondrial disorder (Alpers-Huttenlocher syndrome)
- are a woman of birth-giving age and not using contraceptives (birth control)
Before receiving VALPROL INJECTION, inform your doctor if you:
- have diabetes
- have a carnitine palmitoyl transferase type II deficiency
- have a brain disease or a metabolic condition affecting the brain
- have a ‘urea cycle disorder’ where too much ammonia builds up in the body.
- have an illness called systemic lupus erythematosus (SLE) (an immune system which affects skin, bones, joints and internal organs)
- genetic problem caused by a mitochondrial disorder in your family
Use in pediatrics:
VALPROL INJECTION should be used with caution in children only if recommended by your doctor. Consult your doctor for advice.
Use in geriatrics:
VALPROL INJECTION should be used with caution in the elderly only if recommended by your doctor. Consult your doctor for advice.
Interactions
A. Drug-Drug interactions:
Before receiving VALPROL INJECTION, inform your doctor if you are taking any of the following medicine:
- medicines used for pain and inflammation (salicylates) (Ex. aspirin)
- other medicines used to manage fits (Ex. phenobarbital, primidone, phenytoin, carbamazepine, rufinamide, topiramate, acetazolamide, lamotrigine and felbamate)
- medicines used for thinning the blood (Ex. warfarin).
- zidovudine, lopinavir and ritonavir (to manage HIV infection)
- temozolomide (to manage cancer)
- medicines for depression (monoamine oxidase inhibitors (MAOI) such as moclobemide, selegiline, linezolid)
- selegiline (used to manage Parkinson’s disease), linezolid (used to manage infections).
- medicines used to calm emotional and mental health problems (Ex. quetiapine, diazepam and olanzapine)
- nimodipine (to manage hemorrhage)
- propofol (used for anesthesia)
- oestrogen-containing products (including some birth control pills).
- medicines to manage malaria (Ex. mefloquine and chloroquine)
- cimetidine (for stomach ulcers)
- carbapenem agents (antibiotics used to manage bacterial infections) Ex. imipenem, meropenem, rifampicin and erythromycin
- cholestyramine is used to lower blood fat (cholesterol) levels.
- metamizole (to manage pain and fever)
Overdosage:
VALPROL INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like feeling sick or being sick, pupils of the eye become smaller, dizziness, loss of consciousness, weak muscles and poor reflexes, breathing problems, headaches, fits (seizures), confusion, memory loss and unusual or inappropriate behavior.
Synopsis
| Drug | : | Sodium Valproate |
| Pharmacological Category | : | Anti-convulsant |
| Therapeutic Indication | : | Epilsepsy (fits) |
| Dosage Forms | : | Tablet, Injection, Syrup, Oral solution |
More Information
- Keep VALPROL INJECTION out of reach from children
- Store at room temperature
FAQs About VALPROL INJECTION
What is VALPROL INJECTION used for?
VALPROL INJECTION is used in the management of epilepsy (fits). Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness.
Can pregnant women receive VALPROL INJECTION?
VALPROL INJECTIONis not recommended for use in pregnant women or if you are planning to have a baby as it can cause birth defects and behavioral/learning problems in the baby. Consult your doctor before receiving VALPROL INJECTION.
How does VALPROL INJECTION work?
VALPROL INJECTION increases concentrations of gamma-aminobutyric acid (GABA) which reduces neuronal excitability by inhibiting nerve transmission in the brain, probably due to inhibition of the enzymes responsible for the breakdown of GABA.
Can I drive while receiving VALPROL INJECTION?
Do not drive or use machines while receiving VALPROL INJECTION as it can make you sleepy and weaken your ability to drive. Consult your doctor for more information on VALPROL INJECTION.
Can VALPROL INJECTION be received by kidney patients?
VALPROL INJECTIONshould be used with caution in patients with kidney disease. The dose will be adjusted by your doctor. Consult your doctor before receiving VALPROL INJECTION.
References
1. KD Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 444.
2. Pubchem. Sodium Valproate. [Accessed on 15th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-valproate#:~:text=Valproate%20sodium%20is%20converted%20into,for%20the%20catabolism%20of%20GABA.
3. R. M. Pinder, R. N. Brogden, T. M. Speight & G. S. Avery. Sodium Valproate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Epilepsy. [Accessed on 15th July 2022] https://link.springer.com/article/10.2165/00003495-197713020-00001
4. Sanofi S.r.l. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 15th July 2022] https://www.medicines.org.uk/emc/files/pil.1445.pdf
5. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 15th July 2022] https://www.medicines.org.uk/emc/files/pil.1209.pdf
6. NHS. Sodium Valproate [Revised in August 2021] [Accessed on 15th July 2022] https://www.nhs.uk/medicines/sodium-valproate/
7. Mayoclinic. Sodium valproate. [Revised on October 2021] [Accessed on 15th July 2022] https://www.mayoclinic.org/diseases-conditions/epilepsy/symptoms-causes/syc-20350093#:~:text=Epilepsy%20is%20a%20central%20nervous,races%2C%20ethnic%20backgrounds%20and%20ages.
Useful Diagnostic Tests
- Blood tests
Author Details
VIDEOS
Sodium Valproate INJECTION - Drug Information
Sodium Valproate INJECTION : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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