Introduction About URALFIN TABLET

URALFIN TABLET contains Alfuzosin which belongs to the group of medicines called Alpha-1-blockers. It is used to provide relief from moderate to severe symptoms of benign prostatic hyperplasia in affected individuals.

Benign prostatic hyperplasia is a non-cancerous condition that increases the size of the prostate and it is generally characterized by symptoms such as increased urinary frequency, unusual urine color/smell, urinary urgency, weak/interrupted urine stream, and pain after urination/ejaculation.

URALFIN TABLET is not recommended for use in patients who are allergic to alfuzosin or equivalent substances (such as terazosin and doxazosin). It is also not recommended for use in patients with orthostatic hypotension (low blood pressure while standing up from a sitting or lying position), liver problems and should be used with caution in patients with kidney problems (such as mild, moderate and severe kidney problems).

URALFIN TABLET is not recommended for use in pregnant or breastfeeding women as it is used only in men. It is also not recommended for use in children and adolescents (aged below 18 years) and it should be used with caution in elderly patients (aged 65 and above).

The most common side effects of taking URALFIN TABLET are dizziness, headache, nausea, stomach pain, weakness and tiredness. Consult your doctor if any of the side effects worsens.   

Uses Of URALFIN TABLET

• Relieves moderate to severe symptoms of benign prostatic hyperplasia  

How URALFIN TABLET Works

URALFIN TABLET works by binding and inhibiting a receptor (alpha 1-adrenergic receptor) in the lower urinary tract, which results in the relaxation of muscles around the bladder, thus facilitating urine to flow more easily and thereby providing relief from symptoms of benign prostatic hyperplasia.

How to use URALFIN TABLET

Take URALFIN TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of URALFIN TABLET

How To Manage Side Effects

Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Try to avoid taking any medicine on your own to manage diarrhea and consult your doctor if the symptom gets worse.

Dizziness Or Drowsiness

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor if the symptom gets worse.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Stick to simple meals while taking this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.

Warning & Precautions

Pregnancy

Contraindicated

URALFIN TABLET is not for use in women as it is only recommended for use in men to manage symptoms of benign prostatic hyperplasia.   

Breastfeeding

Contraindicated

URALFIN TABLET is not for use in women as it is only recommended for use in men to manage symptoms of benign prostatic hyperplasia.   

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy or weak after taking URALFIN TABLET.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking URALFIN TABLET as it may cause orthostatic hypotension (low blood pressure that happens when standing up from sitting or lying position).

Kidney

Use with Caution

URALFIN TABLET should be used with caution in patients with kidney problems such as mild, moderate and severe kidney problems. Consult your doctor before taking URALFIN TABLET.

Liver

Contraindicated

URALFIN TABLET is not recommended for use in patients with liver problems. Consult your doctor before taking URALFIN TABLET.

Allergy

Contraindicated

Do not take URALFIN TABLET if you are allergic to Alfuzosin or other equivalent substances (such as terazosin, doxazosin) or any other ingredients of this medicine.

Heart Disease

Use with Caution

URALFIN TABLET should be used with caution in patients with heart disease and QT prolongation (abnormal heart’s electrical activity). Consult your doctor before taking URALFIN TABLET.   

Use In Pediatrics

Contraindicated

URALFIN TABLET is not recommended for use in children and adolescents (below 18 years of age). Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

URALFIN TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking URALFIN TABLET.

Interactions

A. Drug-Drug interactions:

Before taking URALFIN TABLET inform your doctor if you are taking any of the following medicines:   

• other alpha-blockers (medicines used to manage hypertension and benign prostatic hyperplasia) Ex. doxazosin, indoramin, prazosin, terazosin, tamsulosin, phenoxybenzamine
• antihypertensives (medicines used to manage high blood pressure) Ex. captopril, ramipril
• nitrates such as nitroglycerin (used to manage chest pain (angina))
• ketoconazole, itraconazole (used to manage fungal infections)
• ritonavir medicine (used to manage HIV infection)
• medicines used to manage bacterial infections (Ex. clarithromycin, telithromycin)
• medicines used to manage depression (Ex. nefazodone)
• general anesthetics such as propofol (medicines used to provide unconsciousness during surgery)

Overdosage:

If you or anyone else accidentally take too much of URALFIN TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep URALFIN TABLET out of reach of children
• Store the medicine at room temperature

FAQs About URALFIN TABLET

Q: What is URALFIN TABLET used for?

A: URALFIN TABLET is used to relax muscles around the urinary bladder and helps manage symptoms such as increased urinary frequency, unusual urine colour or smell, urinary urgency, a weak or interrupted urine stream, and pain after urination or ejaculation.

Q: How does URALFIN TABLET work?

A: URALFIN TABLET works by binding and inhibiting a receptor (alpha 1-adrenergic receptor) in the lower urinary tract, which results in the relaxation of muscles around the bladder, thus facilitating urine to flow more easily and thereby providing relief from symptoms of urinary difficulties.

Q: Can URALFIN TABLET be used in children?

A: No, URALFIN TABLET is not recommended for use in children and adolescents (below 18 years of age). If URALFIN TABLET is accidentally ingested by a child or adolescent, go to the hospital immediately and consult the doctor for further management.

Q: What are the common side effects of URALFIN TABLET?

A: The most common side effects of taking URALFIN TABLET are dizziness, headache, nausea, stomach pain, weakness, and tiredness. Consult your doctor if any of the side effects worsen.

Q: Is URALFIN TABLET safe to use in patients with kidney problems?

A: URALFIN TABLET should be used with caution in patients with kidney problems, such as mild, moderate, and severe kidney problems. Your doctor may regularly monitor your kidney function test to manage any unusual effects. Consult your doctor before taking it.

Q: How do I take URALFIN TABLET?

A: Take URALFIN TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

Q: Can I take URALFIN TABLET during pregnancy?

A: No, URALFIN TABLET is not for use in women, as it is only recommended for use in men to manage symptoms of urinary difficulties.

Q: Is URALFIN TABLET safe to use in patients with heart problems?

A: URALFIN TABLET should be used with caution in patients with heart problems and QT prolongation (abnormal heart’s electrical activity). Your doctor may regularly monitor your heart function to manage any unusual effects. Consult your doctor before taking URALFIN TABLET.

Q: What precautions must be followed while taking URALFIN TABLET?

A: Before taking URALFIN TABLET, inform your doctor if you have chest pain, painful erections of the penis (unrelated to sexual activity), or are scheduled for eye surgery because of a cataract (a cloudy area in the lens of the eye).

Q: Can I consume alcohol while taking URALFIN TABLET?

A: Avoid consumption of alcohol while taking URALFIN TABLET, as it may cause orthostatic hypotension (low blood pressure that happens when standing up from a sitting or lying position). To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Q: When is the best time to take URALFIN TABLET?

A: Take URALFIN TABLET as advised by your doctor. It is generally taken at bedtime with food to avoid injury from dizziness or fainting. Consult your doctor for more information.

References

1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 142.

2. Madhu S. Agrawal, Abhishek Yadav, Himanshu Yadav, Amit K. Singh, Prashant Lavania and Richa Jaiman. A prospective randomized study comparing alfuzosin and tamsulosin in the management of patients suffering from acute urinary retention caused by benign prostatic hyperplasia. NIH National Library of Medicine. National center for biotechnology information. Pubmed Central. December 2009. [Accessed on 26th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128060/

3. Sanofi. The Efficacy, Onset of Effect, and Safety of Alfuzosin Once Daily in the Treatment of Lower Urinary Tract Symptoms of Benign Prostatic Hyperplasia: A Randomized, Placebo-Controlled Trial Using an Acute International Prostate Score (ALF-ACUTE). Clinicaltrials.gov. [Revised in October 2007] [Accessed on 26th April 2022] https://clinicaltrials.gov/ct2/show/NCT00540891

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 26th April 2022] https://www.medicines.org.uk/emc/files/pil.7047.pdf

Useful Diagnostic Tests

• Prostate-specific antigen (PSA) blood test
• Urine analysis