INTRODUCTION

TRIVON 10MG contains Tranylcypromine which belongs to the group of medicines called Antidepressants. It is used in adults for the management of moderate to severe depression and helps to come out of the fear that may be associated with it. Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest in day-to-day activities. Other symptoms of depression include feeling of worthlessness, sleep disturbances, tiredness, anxiety, mood swings, fear to face crowd, crying, loss of appetite, suicidal thoughts, etc. TRIVON 10MG is often used when other types of antidepressant medicines have not worked effectively.

GBNKEYWORD] is not recommended for use in children and adolescents (below 18 years of age) and in patients with severe heart diseases, overactive thyroid glands, kidney tumours, porphyria (hereditary blood disorder), or those who takes other medicines such as monoamine oxidase inhibitors (MAOIs) or have taken within the last two weeks. Before initiating and during management with TRIVON 10MG, your doctor may advice you to undergo few psychiatric assessment tests to understand your mental health status better.

TRIVON 10MG should be used with caution in pregnant and breast-feeding women. Before taking TRIVON 10MG, inform your doctor if you are suffering from mild heart problems, fits, or planning to have any surgery in the upcoming week or have serious mental condition (have or had suicidal tendency or tendency to harm yourself). The common side effects of taking TRIVON 10MG are headache, tiredness, disturbed sleep, dry mouth, constipation and altered vision. Consult your doctor if any of the symptom worsens.

USES OF TRIVON 10MG

• To manage moderate to severe depression

HOW TRIVON 10MG WORKS

TRIVON 10MG is a monoamine oxidase inhibitor (MAOIs) that works by blocking an enzyme called monoamine oxidase, which is responsible for degradation of the chemicals in the brain such as serotonin, dopamine, and norepinephrine in the central nervous system of the body. [GNKEYWORD] prevents the breakdown of serotonin and noradrenaline, which helps to regulate mood, anxiety and activity, thus ultimately aids in overcoming depression.

DIRECTIONS FOR USE

Take TRIVON 10MG exactly as advised by your doctor. Swallow the medicine with a glass of water and should be taken preferably after meals. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and severity of the condition. Do not stop taking TRIVON 10MG without the advice of your doctor.

SIDE EFFECTS OF TRIVON 10MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Drink plenty of fluids and stay hydrated. Avoid consuming alcohol and skipping meals. Try to be relaxed and stress free. Get adequate sleep and rest. Apply a pain-relieving balm on the forehead if necessary. Consult your doctor if the symptom does not improve.

Dry Mouth:

Try to drink plenty of cold water. Sip on cold unsweetened drinks and use lip balm if your lips are dry. Try to brush your teeth twice a day and use mouthwash. Consult your doctor if the symptom gets worse.

Constipation:

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom gets worse.

Tiredness:

Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug – Drug interactions

Before taking TRIVON 10MG inform your doctor if you have received or taken or taking any of the following medicines:

• medicines used to manage heart problems (Ex. adrenaline, noradrenaline, dopamine)
• medicines used to manage asthma (Ex. ephedrine, pseudoephedrine)
• medicine used to stop smoking (Ex. bupropion)
• medicine used to manage parkinson’s disease (Ex. levodopa)
• medicines used to control hunger (Ex. amphetamine, fenfluramine)
• medicines used to relieve pain (Ex. nefopam, pethidine, codeine)
• medicine used for sedation in surgery (Ex. propofol)
• medicines used to manage depression (Ex. amitriptyline, imipramine, tryptophan, isocarboxazid, sertraline)
• medicine used to manage anxiety (Ex. buspirone)
• metrizamide (used as radiocontrast agent)
• medicine used to manage fits (Ex. carbamazepine)
• medicine to manage sleeping problems (Ex. amylobarbitone)
• medicines to manage diabetes (Ex. insulin, metformin)
• medicine used to manage allergy (Ex. cetirizine)
• medicines used to manage hypertension (Ex. reserpine, methyldopa)
• natural health products or OTC supplements containing tyramine

B. Drug- Food interactions:

Avoid eating foods (such as processed and matured cheeses (Ex. cheddar cheese), yeast extracts (Ex. marmite, bovril), meat, fish and poultry which are not fresh or has been pickled, broad bean pods, most soybean products (including soy sauce and tofu), sauerkraut, banana skins and chocolate) while taking TRIVON 10MG as it may increase the risk of developing high blood pressure.

Overdosage:

If you or anyone else accidentally take too much of TRIVON 10MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose includes mental confusion with reduced awareness of surroundings (delirium) and low platelet levels in the blood (thrombocytopenia), increased heartbeat, sweating, fever, restlessness, and excitement. Tremors, depression, and coma may also be present or develop. Blood pressure may increase, but it also could drop lower than normal.

SYNOPSIS

MORE INFORMATION

• Keep TRIVON 10MG out of reach of children
• Store TRIVON 10MG at room temperature

FAQs ABOUT TRIVON 10MG

What is TRIVON 10MG used for?

TRIVON 10MG is used to manage moderate to severe depression. It helps you to come out of the fear that may be associated with depression. TRIVON 10MG is often used when other types of antidepressant medicines have not worked effectively. Consult your doctor before taking it.

What are the most common side effects of taking TRIVON 10MG?

The common side effects of taking TRIVON 10MG are headache, tiredness, disturbed sleep, dry mouth, sedation, constipation, tremor and altered vision. Consult your doctor before taking it.

What are the foods to be avoided while taking TRIVON 10MG?

Avoid eating foods (such as processed and matured cheeses (Ex. cheddar cheese), yeast extracts (Ex. marmite, bovril), meat, fish and poultry which are not fresh or has been pickled, broad bean pods, most soybean products (including soy sauce and tofu), sauerkraut, banana skins, natural food products containing tyramine and chocolate) while taking TRIVON 10MG as it may increase the risk of developing high blood pressure. Consult your doctor before taking it.

Is TRIVON 10MG safe to use in patients with heart problems?

TRIVON 10MG is not recommended for use in patients with severe heart disease. TRIVON 10MG should be used with caution in patients with mild heart problem that restricts your activity. Consult your doctor before taking it.

Can TRIVON 10MG be used during pregnancy?

TRIVON 10MG is not recommended for use if you are pregnant unless clearly advised by the doctor. Consult your doctor before taking TRIVON 10MG if you are pregnant or planning to get pregnant.

REFERENCES

1. KD Tripathi. Autocoids and related drugs. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 482.

2. Chatterjee, A., and M. C. Tosyali. Thrombocytopenia and delirium associated with tranylcypromine overdose. Chatterjee, A., and M. C. Tosyali. "Thrombocytopenia and delirium associated with tranylcypromine overdose." Journal of clinical psychopharmacology (1995). [Accessed on 1st August 2022] https://psycnet.apa.org/record/1995-44137-001

3. New York State Psychiatric Institute. Tranylcypromine Management of Bipolar Depression. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in March 2018] [Accessed on 1st August 2022] https://clinicaltrials.gov/ct2/show/NCT01430455

4. Cenexi. Electronic Medicines Compendium (EMC). [Revised in June 2022] [Accessed on 1st August 2022] https://www.medicines.org.uk/emc/files/pil.2788.pd

5. Concordia Pharmaceuticals Inc. U.S. Food and Drug Administration (USFDA) [Revised in January 2018] [Accessed on 1st August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/012342s064lbl.pdf

6. Marlex Pharmaceuticals, Inc.Tranylcypromine. [Revised in May 2022] [Accessed on 1st August 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=df892a65-52e4-8eb2-e053-2a95a90aa25f

7. Amdipharm Mercury (Australia) Pty Ltd. Tranylcypromine [Revised in March 2020] [Accessed on 1st August 2022] https://www.medsafe.govt.nz/Consumers/cmi/p/parnate.pdf

8. GlaxoSmithKline Inc. Tranylcypromine [Revised in November 2019] [Accessed on 1st August 2022] https://ca.gsk.com/media/6197/parnate.pdf