Introduction About TRILOSAR 6.25MG TABLET

TRILOSAR 6.25MG TABLET is a combination of Amlodipine, Chlorthalidone and Losartan which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure). It can also be used to manage angina (chest pain), heart failure or stroke and can protect the function of kidneys particularly in patients who have both hypertension and type II diabetes mellitus.

It can also reduce the chances of fluid retention (edema) in the body that occurs due to some kidney or liver diseases. Take this medicine preferably in the mornings with food. While taking TRILOSAR 6.25MG TABLET, do not drink alcohol/grapefruit juice or go for a low-salt diet, as they may make further reduce your blood pressure. Consult your doctor for the best diet that can suit your health condition.

Before taking TRILOSAR 6.25MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, high blood cholesterol levels, dehydration, or very low blood sodium, potassium or magnesium levels as a precaution.

TRILOSAR 6.25MG TABLET is not recommended for use in patients with other severe heart problems such as narrowing of heart valves or cardiogenic shock. It is also not suitable for use in patients with severe hypotension (low blood pressure).

Do not take TRILOSAR 6.25MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby or breastfeeding without consulting your doctor.

The most common side effects of taking TRILOSAR 6.25MG TABLET are headache, dizziness, sleepiness, tiredness, muscle cramps, low blood potassium or sodium levels, impotence in men and low sex drive. Contact your doctor if any of these side effects trouble you.

Uses Of TRILOSAR 6.25MG TABLET

It is used to manage and prevent:

• Hypertension (high blood pressure)
• Heart failure, Stroke
• Angina (Prinzmetal angina)
• Edema (fluid retention)
• Kidney damage among diabetic patients

How TRILOSAR 6.25MG TABLET Works

TRILOSAR 6.25MG TABLET relaxes the blood vessels supplying various organs (such as heart, kidney, brain or others) which allows blood to flow more smoothly across the blood vessels. It also removes the excess fluids and electrolytes (sodium and water) from the body in the form of urine which helps in reducing edema and blood thickness. Collectively, these actions improve blood flow, reduces the strain on the heart and helps the heart to pump more blood with less pressure.

How to use TRILOSAR 6.25MG TABLET

Always take TRILOSAR 6.25MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. TRILOSAR 6.25MG TABLET is preferably taken during the mornings with food.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking TRILOSAR 6.25MG TABLET without consulting your doctor.

Side Effects Of TRILOSAR 6.25MG TABLET

How To Manage Side Effects

Nausea and vomiting:

Take TRILOSAR 6.25MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Warning & Precautions

Pregnancy

TRILOSAR 6.25MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, consult your doctor before taking it.

Breastfeeding

TRILOSAR 6.25MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk and harm the nursing infant. Therefore, consult your doctor before taking it.

Driving and Using Machines

Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking TRILOSAR 6.25MG TABLET.

Alcohol

Avoid consumption of alcohol while taking TRILOSAR 6.25MG TABLET as it might make you feel dizzier and drowsier.

Kidney

TRILOSAR 6.25MG TABLET is not recommended for use in patients with severe kidney problems (such as kidney stones, renal artery stenosis, dialysis). It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.

Liver

TRILOSAR 6.25MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with mild to moderate liver diseases. Therefore, consult your doctor before taking it.

Allergy

Do not take TRILOSAR 6.25MG TABLET if you are allergic to Amlodipine, Chlorthalidone or Losartan.

Heart Disease

TRILOSAR 6.25MG TABLET is not recommended for use in patients with severe heart problems such as heart failure, aortic stenosis (narrowing of arteries) or cardiogenic shock (inability of heart to pump blood). It should be used with caution in patients having a history of recent heart, heart failure, irregular heartbeat, coronary heart disease or problems related with heart muscle or valves). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking TRILOSAR 6.25MG TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to reduce elevated blood pressure and other heart problems (Ex. atenolol, propranolol, enalapril, lisinopril, amlodipine, nifedipine, diltiazem, verapamil, methyldopa, guanethidine)
• ketoconazole, itraconazole (used to manage fungal infections)
• ritonavir, indinavir, nelfinavir (used in management of HIV infections)
• rifampicin, erythromycin, clarithromycin (used to manage bacterial infections)
• dantrolene (a medicine used to manage muscle spasms)
• medicines used to control elevated cholesterol levels (Ex. simvastatin, cholestyramine)
• medicines used to manage graft rejection and to suppress immune functions (such as tacrolimus, sirolimus, temsirolimus, everlimus, cyclosporine)
• St. John’s wort (an herbal medicine used to manage depression)
• corticosteroids (used to manage pain and inflammation) Ex. prednisolone, betamethasone
• corticotropin (a medicine used to correct hormone problems)
• medicines used for cancer (Ex. temsirolimus, cyclophosphamide, methotrexate)
• medicines used to manage asthma (such as salbutamol, formoterol)
• amphotericin B (a medicine used to manage fungal infections)
• carbenoxolone (a medicine used to manage mouth ulcers)
• anticholinergics (used to manage stomach muscle spasms) such as atropine, hyoscine
• lithium (a medicine used to manage various mental health problems)
• digoxin (a medicine used to manage irregular heartbeat)
• allopurinol (a medicine used to manage gout)
• amantadine (a medicine used for parkinsonism or viral infections)
• non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
• calcium and vitamin D supplements
• tricyclic antidepressants (used to manage depression) Ex. amitriptyline, nortriptyline, imipramine
• antipsychotics (used to manage mental illness) Ex. chlorpromazine
• baclofen (a medicine used for relaxing muscles)
• amifostine (a kidney protectant used along with chemotherapeutic agents)

B. Drug-Food interaction:

Avoid drinking grapefruit juice while taking TRILOSAR 6.25MG TABLET, as it could further decrease your blood pressure.

Overdosage:

If you or anyone else accidentally took more TRILOSAR 6.25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin, and shortness of breath.

Synopsis

More Information

• Keep TRILOSAR 6.25MG TABLET out of the sight and reach of children
• Store TRILOSAR 6.25MG TABLET at room temperature

FAQs About TRILOSAR 6.25MG TABLET

Q: What are the uses of TRILOSAR 6.25MG TABLET?

A: TRILOSAR 6.25MG TABLET is used to manage hypertension (high blood pressure). It can also be used to manage angina (chest pain), heart failure or stroke and can protect the function of kidneys particularly in patients who have both hypertension and type II diabetes mellitus. It can also reduce the chances of fluid retention (edema) in the body that occurs due to some kidney or liver diseases.

Q: What type of a medicine is TRILOSAR 6.25MG TABLET?

A: TRILOSAR 6.25MG TABLET relaxes the blood vessels supplying various organs (such as heart, kidney, brain or others) which allows blood to flow more smoothly across the blood vessels. It also removes the excess fluids and electrolytes (sodium and water) from the body in the form of urine. Collectively, these actions decrease fluid retention, improves blood flow, reduces the strain on the heart and helps the heart to pump more blood with less pressure.

Q: What happens when I stop taking TRILOSAR 6.25MG TABLET?

A: Do not stop taking TRILOSAR 6.25MG TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take TRILOSAR 6.25MG TABLET for the stipulated duration recommended by your doctor to achieve maximum results.

Q: What is the best time to take TRILOSAR 6.25MG TABLET?

A: Take this medicine preferably in the mornings with food. However, consult your doctor for advice.

Q: What to do if I forgot to take a dose of TRILOSAR 6.25MG TABLET?

A: If you have missed a dose of TRILOSAR 6.25MG TABLET, take it as soon as you remember. However, if it is time for the next dose of TRILOSAR 6.25MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of TRILOSAR 6.25MG TABLET to compensate the missed ones.

Q: What precautions should be followed while taking TRILOSAR 6.25MG TABLET?

A: Before taking TRILOSAR 6.25MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have severe high or low blood pressure, or other heart problems (such as narrowing of the arteries, cardiogenic shock or a recent heart attack). Do not take TRILOSAR 6.25MG TABLET if you are pregnant and breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.

Q: Can I consume alcohol while taking TRILOSAR 6.25MG TABLET?

A: Avoid consumption of alcohol while taking TRILOSAR 6.25MG TABLET as it might make you feel dizzier and drowsier.

Q: What happens if I accidentally take more TRILOSAR 6.25MG TABLET?

A: If you or anyone else accidentally took more TRILOSAR 6.25MG TABLET, consult your doctor immediately. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin and shortness of breath.

Q: Can I take TRILOSAR 6.25MG TABLET daily?

A: Take TRILOSAR 6.25MG TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take TRILOSAR 6.25MG TABLET every day or not.

Q: What are the side effects of TRILOSAR 6.25MG TABLET?

A: The most common side effects of taking TRILOSAR 6.25MG TABLET are headache, dizziness, tiredness, muscle cramps, low blood potassium or sodium levels, impotence in men and low sex drive. Contact your doctor if any of these side effects trouble you.

Q: Can I stop taking TRILOSAR 6.25MG TABLET once my symptoms subside?

A: No. Do not stop taking TRILOSAR 6.25MG TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take TRILOSAR 6.25MG TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.

Q: Can TRILOSAR 6.25MG TABLET causes electrolyte imbalance?

A: Yes. TRILOSAR 6.25MG TABLET may alter the levels of certain electrolytes (sodium or potassium) in the body. To avoid this, your doctor will closely monitor the electrolytes levels in the blood periodically. However, if you experience any unusual symptoms such as chest pain, muscle weakness, irregular heartbeat, confusion, drowsiness, nausea, or vomiting, consult your doctor for advice.

Q: Can the use of TRILOSAR 6.25MG TABLET affect my sexual life?

A: Yes. TRILOSAR 6.25MG TABLET may cause impotence in men and low sex drive in both men and women. Consult your doctor if they trouble you.

Q: Can TRILOSAR 6.25MG TABLET be taken during pregnancy?

A: TRILOSAR 6.25MG TABLET is not recommended for use in pregnant women as it may harm the growing baby. Therefore, consult your doctor before taking it.

Q: Is TRILOSAR 6.25MG TABLET safe to use in kidney disease?

A: TRILOSAR 6.25MG TABLET is not recommended for use in patients with severe kidney problems (such as kidney stones, renal artery stenosis, dialysis). It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.

Q: Can the use of TRILOSAR 6.25MG TABLET affect the liver?

A: Yes. TRILOSAR 6.25MG TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.

Q: Does TRILOSAR 6.25MG TABLET cause frequent urination?

A: Yes. TRILOSAR 6.25MG TABLET may cause frequent urination. It is because TRILOSAR 6.25MG TABLET contains a medicine called chlorthalidone which is a diuretic (water pill). It excretes the excess water from the body in the form of urine. Therefore, it is advised to take TRILOSAR 6.25MG TABLET at least 5 hours before bedtime to avoid the urge at night to urinate.

References

1. KD Tripathi. Antianginal and Other Anti-ischaemic Drugs. Antihypertensive Drugs. Diuretics. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 549, 562, 559 & 583. 561 & 562.

2. Comparison of Fixed-dose Combinations of Amlodipine/Losartan Potassium/Chlorthalidone and Amlodipine/Losartan Potassium in Patients With Stage 2 Hypertension Inadequately Controlled With Amlodipine/Losartan Potassium: A Randomized, Double-blind, Multicenter, Phase III Study. Clinical Therapeutics. October 2017. [Accessed on 2nd January 2023] https://www.sciencedirect.com/science/article/pii/S0149291817309025

3. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.3478.pdf

4. Bristol Laboratories Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/product/11442/smpc#DOCREVISION

5. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2019] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.9045.pdf

6. Atlantic Pharma. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.11982.pdf

7. Torrent Pharmaceuticals Ltd. Trilosar. [Revised in August 2020]. [Accessed on 2nd January 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2960.pdf

Useful Diagnostic Tests

• Kidney function test