Introduction About TRIKON TABLET

TRIKON TABLET contains Trihexyphenidyl which belongs to the group of medicines called Central Anticholinergics. It is used to improve muscle control in patients with Parkinson’s disease. Parkinson’s disease is a long-term brain disorder that causes muscle stiffness, shaking, slow and unsteady movements, difficulty in walking and loss of balance. It happens due to loss of nerve cells at certain regions of brain (basal ganglia) that controls body movements.

TRIKON TABLET can also be used to control abnormal involuntary muscle movements (such as extreme restlessness or muscle spasms) in the body that is caused due to the use of certain medicines.

Trihexyphenidyl is a muscle relaxant. It reduces muscle stiffness and relaxes muscles by reducing the activity of a chemical messenger called acetylcholine in the brain. It also restores a balance between certain brain chemicals (dopamine and acetylcholine) that controls body movements.

Before taking TRIKON TABLET, inform your doctor if you have glaucoma, high blood pressure, stomach ulcer or problems in your prostate gland. You must also inform your doctor if you have any liver, kidney, or heart problems before taking TRIKON TABLET as a precaution.

Talk to your doctor before taking TRIKON TABLET if you have myasthenia gravis (muscle weakness) or tardive dyskinesia (unusual movements of face and tongue). Consult your doctor before taking TRIKON TABLET if you are pregnant or breastfeeding.

The most common side effects of taking TRIKON TABLET are dry mouth, constipation, dizziness, blurred vision, nausea, and vomiting. Consult your doctor if any of these side effect worsens.

Uses Of TRIKON TABLET

It is used to:

• Reduce muscle stiffness and improve muscle control in patients with Parkinson’s disease
• Manage drug-induced abnormal involuntary muscle movements (such as extreme restlessness or muscle spasms)

How TRIKON TABLET Works

TRIKON TABLET is an anticholinergic medicine with muscle relaxing properties. It reduces muscle stiffness and improves muscle control by reducing the activity of a chemical messenger called acetylcholine in the brain. It also regulates the release of a brain chemical called dopamine that regulates proper body movements and coordination. As a result, it reduces abnormal muscle movements associated with Parkinson’s disease and with the use of certain medicines.

How to use TRIKON TABLET

Take TRIKON TABLET as advised by your physician. Swallow TRIKON TABLET with a glass of water. Do not chew or crush the medicine. It must be taken with or just before meals.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take TRIKON TABLET for the stipulated duration as advised by your doctor without any interruption to achieve maximum benefits.

Side Effects Of TRIKON TABLET

How To Manage Side Effects

Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Dry Mouth

Drink plenty of water or fluids at regular intervals. Frequent small sips of water or the use of artificial saliva may be beneficial. However, if it bothers you or if your condition worsens contact your doctor.

Nausea And Vomiting

Take TRIKON TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.

Warning & Precautions

Pregnancy

Contraindicated

TRIKON TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.

Breastfeeding

Contraindicated

TRIKON TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking TRIKON TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking TRIKON TABLET.

Kidney

Use with Caution

TRIKON TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

Liver

Use with Caution

TRIKON TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take TRIKON TABLET if you are allergic to Trihexyphenidyl.

Heart Disease

Use with Caution

TRIKON TABLET should be used with caution in patients with heart problems (such as high blood pressure). Therefore, consult your doctor before taking it.

Use In Pediatrics

Use with Caution

TRIKON TABLET should be used with caution in children and adolescents (below 18 years). Therefore, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

TRIKON TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug Interactions:

Before taking TRIKON TABLET, inform your doctor, if you are taking any of the following medicines such as:

• aspirin (a medicine used to relieve pain and reduce fever)
• medicine used for depression such as monoamine oxidase inhibitors (Ex. moclobemide, tranylcypromine) or tricyclic antidepressants (Ex. amitriptyline)
• medicines used to manage mental illness (Ex. chlorpromazine, thioridazine, clozapine)
• antihistamines (medicines used to manage allergies) Ex. cetirizine, desloratadine, fexofenadine
• disopyramide (a medicine used to manage irregular heartbeat)
• levodopa (a medicine used to manage parkinson’s disease)
• amantadine (a medicine used for viral infections)
• nefopam (a medicine used for pain relief)
• metoclopramide or domperidone (medicines used for nausea and vomiting)
• parasympathomimetics (medicine used for urinary retention) ex. neostigmine, bethanechol

Overdosage:

If you or anyone else accidentally took more TRIKON TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include anxiety, depression, and behavioral changes.

Synopsis

More Information

• Keep TRIKON TABLET out of reach of children
• Store TRIKON TABLET at room temperature

FAQs About TRIKON TABLET

Q: How long does it take for TRIKON TABLET to start acting?

A: TRIKON TABLET begins to act within 1 hour following administration. It reaches its maximum action between 2-3 hours after administration. The effects of TRIKON TABLET can be there in your body for around 6-12 hours.

Q: What TRIKON TABLET is used for?

A: TRIKON TABLET is used to improve muscle control in patients with Parkinson’s disease. It can also be used to control abnormal involuntary muscle movements (such as extreme restlessness or muscle spasms) in the body that is caused due to the use of certain medicines.

Q: Is TRIKON TABLET safe to be taken by pregnant and breastfeeding women?

A: TRIKON TABLET is not recommended for use in pregnant or breastfeeding women. However, consult your doctor before taking.

Q: What are the side effects of TRIKON TABLET?

A: The most common side effects of taking TRIKON TABLET are dry mouth, constipation, dizziness, blurring of vision, nausea, and vomiting. Consult your doctor if any of these symptoms gets worse.

Q: Is it safe to drive after taking TRIKON TABLET?

A: TRIKON TABLET may cause dizziness and blurred vision in some individuals. If you experience these side effects, try to avoid driving or operating heavy machines.

Q: What happens if you take more TRIKON TABLET than your required dose?

A: If you or anyone else accidentally took more TRIKON TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are anxiety, depression, and behavioral changes.

Q: How long should I take TRIKON TABLET?

A: You are advised to take TRIKON TABLET until your doctor suggests you discontinue the medicine. Do not stop taking TRIKON TABLET without consulting your doctor as it may make your symptoms to reappear.

Q: Will taking a higher dose of TRIKON TABLET be more effective?

A: No. Do not take a higher dose of TRIKON TABLET than the prescribed one without consulting your doctor. Taking a higher dose of TRIKON TABLET may not be beneficial. Instead, it can cause serious side effects. If the prescribed dose is not effective for you, consult your doctor. Your doctor may prescribe a suitable higher dose or suggest an alternative therapy after evaluating your disease condition.

Q: What should I do if I forget to take a dose of TRIKON TABLET?

A: If your forgot to take a dose of TRIKON TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed one and take the regular dose. Do not take a double dose of TRIKON TABLET to compensate the missed dose.

Q: Can I stop taking TRIKON TABLET once my symptoms subside?

A: No. Do not stop taking TRIKON TABLET without consulting your doctor as it may cause the symptoms to reappear. Make sure to take TRIKON TABLET for the stipulated duration recommended by your doctor to achieve the maximum results.

References

1. KD. Tripathi. Antiparkinsonian Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 433

2. Children Marcia L. Buck, Pharm.D., FCCP, FPPAG. Trihexyphenidyl for the Management of Dystonia in Children. Pediatric Pharmacotherapy. June 2011. [Accessed on 13th July 2022] https://med.virginia.edu/pediatrics/wp-content/uploads/sites/237/2015/12/201106.pdf

3. Talha N. Jilani; Sarah Sabir; Sandeep Sharma. Trihexyphenidyl. NIH National Library of Medicine, National center for biotechnology information. February 2022 [Accessed on 3rd June 2022] https://www.ncbi.nlm.nih.gov/books/NBK519488/

4. B D BURNS, D DEJONG, O H SOLIS-QUIROGA. EFFECTS OF TRIHEXYPHENIDYL HYDROCHLORIDE (ARTANE) ON PARKINSON'S DISEASE. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Jan 1964 [Accessed on 3rd June 2022] https://pubmed.ncbi.nlm.nih.gov/14112442/

5. Thomton & Ross Ltd. Electronic medicines compendium (EMC). [Revised in July 2016] [Accessed on 3rd June 2022] https://www.medicines.org.uk/emc/files/pil.5271.pdf

6. Thomton & Ross Ltd. Electronic medicines compendium (EMC). [Revised in July 2018] [Accessed on 3rd June 2022] https://www.medicines.org.uk/emc/files/pil.5272.pdf

7. ACTAVIS PHARMA, INC. TRIHEXYPHENIDYL HYDROCHLORIDE tablet. DailyMed. NIH U.S. National Library of Medicine. [Revised in June 2015] [Accessed on 3rd June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a44d7803-164d-4a67-9356-581c45de8596

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 28 Mar 2023 | 04:08 PM(IST)