Introduction About TONACT PLUS TABLET

TONACT PLUS TABLET is a combination of Atorvastatin and Nicotinic acid which belongs to the group of medicines called Hypolipidemic agents. It is used to manage raised cholesterol levels in the body.

Cholesterol is a waxy substance found in the blood, the body needs cholesterol to build healthy cells, but high levels of cholesterol can increase risk of heart disease and fatty deposits in the blood vessels.

Your doctor might want you to make certain lifestyle changes like low-fat diet, exercise, stopping smoking and alcohol.

Prior to the management your doctor might want to take certain blood tests to understand your existing condition.

Avoid consumption of grapefruit juice or alcohol while taking this medicine as it may lead to unwanted interactions.

Before taking TONACT PLUS TABLET inform your doctor if you have muscle aches or weakness, diabetes, seizures, low blood pressure, any surgery, thyroid, liver or kidney disease.

TONACT PLUS TABLET is not recommended for use in pregnant and breastfeeding women. Consult your doctor for advice.

The most common side effects of taking TONACT PLUS TABLET are nausea, constipation, stomach pain, muscle pain, weakness, and headache. Consult your doctor if any of the side effects worsen.

Uses Of TONACT PLUS TABLET

• Used to manage high cholesterol levels

How TONACT PLUS TABLET Works

TONACT PLUS TABLET works by reducing bad cholesterol (LDL) and triglycerides levels and reduce the risk of heart attack and stroke. Atorvastatin works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body. Nicotinic acid works by decreasing the catabolism of HDL (good cholesterol) in the liver and increase their concentration in the blood.

How to use TONACT PLUS TABLET

Take TONACT PLUS TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of TONACT PLUS TABLET

How To Manage Side Effects

Nausea or Vomiting:

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating rich or spicy food.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly.

Stomach pain:

Try to rest and relax. Try to have smaller and frequent meals. Keep a heat pad on your stomach.

Headache:

Avoid bright lights, take enough rest and drink lots of water. Consult your doctor if symptoms don’t improve.

Warning & Precautions

Pregnancy

TONACT PLUS TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.

Breastfeeding

TONACT PLUS TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

TONACT PLUS TABLET has negligible effect on driving or using machines. Consult your doctor for advice.

Alcohol

Avoid consumption of alcohol while taking TONACT PLUS TABLET as it may increase the side effects.

Kidney

TONACT PLUS TABLET should be used with caution in patients with kidney disease. Dose will be adjusted by your doctor. Consult your doctor before taking.

Liver

TONACT PLUS TABLET should be used with caution in patients with liver disease. Dose will be adjusted by your doctor. Consult your doctor before taking.

Allergy

Do not take TONACT PLUS TABLET if you are allergic to Atorvastatin or Nicotinic acid or any other ingredients of this medicine.

Interactions

A. Drug - Drug interactions:

Before taking TONACT PLUS TABLET, inform your doctor if you are taking any of the following medicine:

• immunosuppressant medicines (Ex. cyclosporine)
• cholesterol-lowering medicines (Ex. gemfibrozil)
• antifungal (Ex. itraconazole)
• antiviral/HIV medicine (Ex. ritonavir)
• medicines for heart disease (Ex. digoxin)
• blood thinner (Ex. warfarin)
• anti-hypertensive drugs (Ex. verapamil, diltiazem)

B. Drug - Food interaction:

Avoid consumption of grape juice while taking this medicine as it may cause unwanted side effects.

Overdosage:

If you or anyone else accidentally took too much of TONACT PLUS TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep TONACT PLUS TABLET out of reach of children
• Store below 30°C

FAQs About TONACT PLUS TABLET

Q: How does TONACT PLUS TABLET work?

A: TONACT PLUS TABLET works by reducing bad cholesterol (LDL) and triglycerides levels and reduce the risk of future heart attack and stroke.

Q: Can TONACT PLUS TABLET be used in pregnant women?

A: No, TONACT PLUS TABLET is unsafe for use in pregnant women. Consult your doctor for advice before taking the medicine.

Q: How to store and dispose TONACT PLUS TABLET?

A: TONACT PLUS TABLET should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

Q: Is TONACT PLUS TABLET used for lowering cholesterol?

A: Yes, TONACT PLUS TABLET comes under the class of drugs termed as statins and helps in decreasing the level of fats. It is used to lower cholesterol and triglycerides present in the blood. However, you must take a cholesterol-lowering diet during management.

Q: Can I stop taking TONACT PLUS TABLET?

A: Do not stop taking TONACT PLUS TABLET without informing your doctor. Completing the course of medication is necessary or it can worsen your condition.

References

1. KD Tripathi. Hypolipidemic Drugs. Essentials of medical pharmacology. Eighth Edition. 2019.Page –684-686.

2. Vaijinath S Kamanna, Moti L Kashyap. Mechanism of action of niacin. [Accessed on 8th June 2022] https://pubmed.ncbi.nlm.nih.gov/18375237/  

3. Atorvastatin, Nicotinic acid. Medicienet. [Revised in June 2016] [Accessed on 8th June 2022] https://www.medicinenet.com/lipitor_atorvastatin_vs_niacin_nicotinic_acid_b3/article.htm#lipitor_vs_niacin_whats_the_difference

4. Atorvastatin. Medlineplus. [Revised in August 2015] [Accessed on 8th June 2022] https://medlineplus.gov/druginfo/meds/a600045.html

5. Atorvastatin. Sciencedirect [Accessed on 8th June 2022] https://www.sciencedirect.com/topics/neuroscience/atorvastatin

6. Nicotinic acid. Sciencedirect. [Accessed on 8th June 2022] https://www.sciencedirect.com/topics/medicine-and-dentistry/niacin

7. Nicotinic acid. Mayoclinic. [Revised in November 2020] [Accessed on 8th June 2022] https://www.mayoclinic.org/drugs-supplements-niacin/art-20364984

8. Atorvastatin, Nicotinic acid. Mayoclinic. [Revised in July 2021] [Accessed on 8th June 2022] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/symptoms-causes/syc-20350800

Useful Diagnostic Tests

• Blood test