TOLAZ LA 300MG INJECTION is used in the management of Schizophrenia and its symptoms like rapid control of agitation and disturbed behaviour when oral therapy is not appropriate. It contains Olanzapine which belongs to the group of medicines called Antipsychotics.

Uses Of TOLAZ LA 300MG INJECTION

• Used in the management of Schizophrenia and its symptoms like rapid control of agitation and disturbed behaviour when oral therapy is not appropriate

How TOLAZ LA 300MG INJECTION Works

TOLAZ LA 300MG INJECTION exerts its action primarily on dopamine and serotonin. It blocks the action of dopamine which leads to a decrease in symptoms like hallucinations, delusions, and disorganized speech, thought, and behavior. It also blocks the action of serotonin helping in decrease of symptoms like poor speech, unable to express emotions, low motivation, and poor attention.

How to use TOLAZ LA 300MG INJECTION

TOLAZ LA 300MG INJECTION will be given to you only by a doctor or a nurse into the muscle in buttock region. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of TOLAZ LA 300MG INJECTION

Common side effects of TOLAZ LA 300MG INJECTION:

• weight gain
• sleepiness
• pain at the site of injection
• increases in levels of prolactin in the blood
• changes in the levels of some blood cells
• feel dizzy (with a slow heart rate), especially while getting up from a lying or sitting position
• restlessness, tremor, unusual movements (dyskinesias)
• constipation, abdominal distension
• dry mouth
• rashes
• loss of strength, extreme tiredness, feeling more hungry
• swelling of the hands, ankles, or feet
• fever, joint pain
• sexual dysfunctions (decreased libido in males and females or erectile dysfunction in males)
• syndrome of restless legs, problems with speech (stuttering)
• memory loss or forgetfulness
• changes in breasts in males and females like an abnormal production of breast milk or abnormal growth

Stop receiving TOLAZ LA 300MG INJECTION and contact your doctor immediately if you experience any of the following side effects:

• excessive sleepiness, dizziness, confusion, disorientation, difficulty talking and walking, muscle stiffness or shaking, weakness, irritability, aggression, anxiety, increase in blood pressure, or convulsions
• unusual movement of face or tongue
• blood clots in the veins, especially in the legs (swelling, pain, and redness in the legs), which may travel through blood vessels to the lungs, causing chest pain and difficulty in breathing
• a combination of fever, faster breathing, sweating, muscle stiffness and drowsiness

Warning & Precautions

Pregnancy

Use with Caution

TOLAZ LA 300MG INJECTION should be used with caution in pregnant women.

Breastfeeding

Contraindicated

TOLAZ LA 300MG INJECTION is not recommended for use in breastfeeding women as it can pass through breast milk.

Driving and Using Machines

Use with Caution

Do not drive and use machines after receiving TOLAZ LA 300MG INJECTION as it can make you feel drowsy.

Alcohol

Contraindicated

Do not drink alcohol while receiving TOLAZ LA 300MG INJECTION as it can make you feel drowsy.

Kidney

Use with Caution

TOLAZ LA 300MG INJECTION should be used with caution in patients with kidney disease.

Liver

Use with Caution

TOLAZ LA 300MG INJECTION should be used with caution in patients with liver disease.

Allergy

Contraindicated

Before receiving TOLAZ LA 300MG INJECTION inform your doctor if you are allergic to Olanzapine or any other ingredients of this medicine.

Heart Disease

Use with Caution

TOLAZ LA 300MG INJECTION should be used with caution in patients with heart disease, heart attack, sick sinus syndrome (abnormal heart rhythms), unstable angina or low blood pressure.

Use In Pediatrics

Contraindicated

TOLAZ LA 300MG INJECTION is not recommended for children and adolescents under 18 years of age.

Use In Geriatrics

Consult your doctor

TOLAZ LA 300MG INJECTION is not recommended for elderly patients above 75 years of age, especially patients with dementia. It should be used with caution in patients above 65 years of age. Consult your doctor before receiving TOLAZ LA 300MG INJECTION.

Interactions

A. Drug-Drug interactions:

Before receiving TOLAZ LA 300MG INJECTION, inform your doctor if you are taking any of the following medicine:

• diuretics
• antidepressants
• tranquillizers
• benzodiazepines
• Parkinson’s disease (Ex. carbamazepine, fluvoxamine)
• Antibiotics (Ex. ciprofloxacin)

Overdosage:

TOLAZ LA 300MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms like rapid beating of the heart, agitation, problems with speech, unusual movements (especially of the face or tongue), reduced level of consciousness, acute confusion, seizures. contact your doctor immediately.

Synopsis

FAQs About TOLAZ LA 300MG INJECTION

References

1. KD Tripathi. Drugs Used in Mental Illness: Antipsychotic and Antimanic Drugs. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page –469.

2. Kristina Thomas; Abdolreza Saadabadi. Olanzapine. [Revised on May 2022] [Accessed on 20th May 2022] click here

3. Lilly S.A. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 20th May 2022] click here

4. Olanzapine. Mayoclinic. [Revised in January 2020] [Accessed on 20th May 2022] click here

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 18 Nov 2024 | 03:12 PM(IST)