Introduction About TOKO 500 TABLET

TOKO 500 TABLET contains Citicoline which belongs to a group of medicines called Psychostimulants. TOKO 500 TABLET is used to manage cerebral insufficiency (such as dizziness, memory loss, poor circulation, disorientation) that occurs due to head trauma/brain injury in affected individuals.

TOKO 500 TABLET is also used to manage cognitive dysfunction that occurs due to Alzheimer’s disease (brain disease that affects memory and thinking skills) and other cerebrovascular disease. It is also indicated for use in acute and recovery phase of cerebral infarction (condition that occurs due to poor blood supply to the brain) and Parkinson’s disease (age related degenerative brain condition) in affected individuals.

TOKO 500 TABLET is not recommended for use in patients allergic to Citicoline. It is also not recommended for use in patients suffering from hypertonia (muscle overactivity).

Before taking TOKO 500 TABLET, inform your doctor if you are scheduled for any surgery, and/or have persistent intracranial haemorrhage, kidney/liver disease.

TOKO 500 TABLET should be used with caution in pregnant and breastfeeding women only if necessary. It is also advised to be used with caution in children and adolescents (aged below 18 years) if necessary. The medicine is also advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.

The most common side effects of taking TOKO 500 TABLET are nausea, vomiting, constipation, headache, low blood pressure, and/or agitation. Consult your doctor if any of these symptoms worsens.

Uses Of TOKO 500 TABLET

• Manage cerebral insufficiency that occurs due to head trauma/brain injury
• Manage cognitive dysfunction that occurs due to Alzheimer’s disease and other cerebrovascular disease
• Manage Parkinson’s disease
• Helps in the acute and recovery phase of cerebral infarction/ischemic stroke in affected individuals

How TOKO 500 TABLET Works

TOKO 500 TABLET works by increasing the synthesis of phosphatidylcholine (chemical that produces acetylcholine, responsible for memory and other bodily functions) which leads to improved cerebral function and cognitive function in Alzheimer’s disease and Parkinson’s disease. It also works by repairing neuronal membranes and damaged cholinergic neurons via potentiation of acetylcholine production and reduction of free fatty acid accumulation at stroke-induced nerve damage site which results in the management neuronal cell death thus helping in the recovery phase of cerebral infarction in affected individuals.

How to use TOKO 500 TABLET

Tablet:

Take TOKO 500 TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Orally Disintegrating Tablet:

Take TOKO 500 TABLET as advised by your physician. Place TOKO 500 TABLET inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of TOKO 500 TABLET

How To Manage Side Effects

Nausea and vomiting:

Take TOKO 500 TABLET with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.

Constipation:

Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.

Headache:

If TOKO 500 TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking TOKO 500 TABLET. If it lasts more than a week or severe, inform your doctor.

Warning & Precautions

Pregnancy

TOKO 500 TABLET should be used with caution during pregnancy only if it is clearly necessary. Consult your doctor before taking TOKO 500 TABLET.

Breastfeeding

TOKO 500 TABLET should be used with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before taking TOKO 500 TABLET.

Driving and Using Machines

Do not drive/operate machines while taking TOKO 500 TABLET since it may affect your ability to drive/operate machines.

Kidney

TOKO 500 TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking TOKO 500 TABLET.

Liver

TOKO 500 TABLET should be used with caution in patients with liver disease. Consult your doctor before taking TOKO 500 TABLET.

Allergy

Do not take TOKO 500 TABLET if you are allergic to Citicoline, and/or any other ingredients of this medicine.

Interactions

A. Drug - Drug interactions:

Before taking TOKO 500 TABLET, inform your doctor if you are taking any of the following medicine:

• levodopa (medicine used to manage Parkinson’s disease)
• meclofenoxate (used as a dietary supplement to manage dementia)

Overdosage:

If you or anyone else accidentally take too much of TOKO 500 TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep TOKO 500 TABLET out of the sight and reach of children.
• Do not store TOKO 500 TABLET above 30°C

FAQs About TOKO 500 TABLET

What is TOKO 500 TABLET is used for?

TOKO 500 TABLET is used to manage cerebral insufficiency that occurs due to head trauma/brain injury in affected individuals. It is also used to manage cognitive dysfunction that occurs due to Alzheimer’s disease (brain disease that affects memory and thinking skills) and other cerebrovascular disease. It is also indicated for use in acute and recovery phase of cerebral infarction (condition that occurs due to poor blood supply to the brain) and Parkinson’s disease (age related degenerative brain condition) in affected individuals.

What are the side effects of TOKO 500 TABLET?

The most common side effects of taking TOKO 500 TABLET are nausea, vomiting, constipation, headache, low blood pressure, and/or agitation. Consult your doctor if any of these symptoms worsens.

How TOKO 500 TABLET works?

TOKO 500 TABLET works by increasing the synthesis of phosphatidylcholine (chemical that produces acetylcholine, responsible for memory and other bodily functions) which leads to improved cerebral function and cognitive function in Alzheimer’s disease and Parkinson’s disease. It also works by repairing neuronal membranes and damaged cholinergic neurons via potentiation of acetylcholine production and reduction of free fatty acid accumulation at stroke-induced nerve damage site which results in the management neuronal cell death thus helping in the recovery phase of cerebral infarction in affected individuals.

What happens if more than required dosage of TOKO 500 TABLET is taken?

If you or anyone else accidentally take too much of TOKO 500 TABLET, consult your doctor immediately or visit the nearby hospital to manage the overdose symptoms.

Can TOKO 500 TABLET be used in pregnant and breastfeeding women?

Yes, TOKO 500 TABLET can be used but with caution in pregnant and breastfeeding women only if it is clearly necessary. Consult your doctor before taking TOKO 500 TABLET.

References

1. KD. Tripathi. CNS Stimulants and Cognition Enhancers. Essentials of medical pharmacology. Seventh edition. 2013. Page - 491.

2. Cochrane Stroke Group, Arturo J Martí-Carvajal, Claudia Valli, Cristina Elena Martí-Amarista, Ivan Solà, Joan Martí-Fàbregas, Xavier Bonfill Cosp. Citicoline for treating people with acute ischemic stroke. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in August 2020] [Accessed on 6th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406786/

3. Antonino Maria Cotroneo, Alberto Castagna, Salvatore Putignano, Roberto Lacava, Fausto Fantò, Francesco Monteleone,5 Filomena Rocca, Alba Malara, Pietro Gareri. Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in February 2013] [Accessed on 6th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569046/

4. UniLab, Inc. Citicoline. [Revised in June 2015] [Accessed on 6th May 2022] https://www.unilab.com.ph/products/cholinerv

5. Vidhyasha Pharmaceuticals.  Citipro 250. [Accessed on 6th May 2022] http://vidhyasha.in/tablets-capsules-approved-list/#

6. Actiza Pharmaceutical Private Limited. Citicoline Tablets. [Accessed on 6th May 2022] https://www.actizapharma.com/products/citicoline/

7. Alpha Drugs. COLCIT -500. [Accessed on 6th May 2022] https://www.alphadrug.in/product/colcit-500/

8. StayHappi Pharmacy.  Citicoline Tablets IP. [Accessed on 6th May 2022] https://www.stayhappi.com/stayhappi-generics/citicoline-500-mg-tablet-10s-8708

9. Cipla Ltd. COGNOLIN 500 Tablets. [Accessed on 6th May 2022] https://www.ciplamed.com/content/cognolin-500-tablets

Useful Diagnostic Tests

• Magnetic resonance imaging (MRI)
• Dopamine transporter (DAT) scan

Author Details

Written By Dr. K .AZEEM HUSSAIN - B.D.S

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 25 Nov 2022 | 05:43 PM(IST)