Introduction About TINIBA 500MG TABLET

TINIBA 500MG TABLET is used in the management of post-operative infections caused by anaerobic bacteria, especially those associated with colonic, gastrointestinal and gynecological surgery. It is also used to manage intraperitoneal infections, gynecological infections, bacterial septicemia, post-operative wound infections, skin and soft tissue infections, upper and lower respiratory tract infections, non-specific vaginitis, acute ulcerative gingivitis, urogenital trichomoniasis in both male and female patients, giardiasis, intestinal amebiasis, amebic involvement of the liver. It contains Tinidazole which belongs to the group of medicines known as Anti-protozoals. It works against anaerobic bacteria and protozoa is believed to involve the penetration of the medicine into the cell of the microorganism and subsequent damage of DNA strands or inhibition of their synthesis.

TINIBA 500MG TABLET is not recommended for patients with organic neurological disorders and blood dyscrasias. TINIBA 500MG TABLET should be used with caution in patients with liver disease. It is not recommended for patients with first trimester in pregnancy. TINIBA 500MG TABLET is not recommended for use in breastfeeding mother.

There is no proper data available for the use of TINIBA 500MG TABLET in children and adolescents below 12 years of age. The most common side effect of taking TINIBA 500MG TABLET are decreased appetite, headache, vertigo, vomiting, diarrhoea, nausea or abdominal pain. Consult your doctor if the side effects worsens or persists for a longer duration.

Uses Of TINIBA 500MG TABLET

It is used in the management of:

• post-operative infections caused by anaerobic bacteria, especially those associated with colonic, gastrointestinal and gynecological surgery
• intraperitoneal infections
• gynecological infections
• bacterial septicemia
• post-operative wound infections
• skin and soft tissue infections
• upper and lower respiratory tract infections
• non-specific vaginitis
• acute ulcerative gingivitis
• urogenital trichomoniasis in both male and female patients
• giardiasis
• intestinal amebiasis
• amebic involvement of the liver

How TINIBA 500MG TABLET Works

TINIBA 500MG TABLET contains Tinidazole which is a 5-nitroimidazole derivative of the substituted imidazole compounds and possesses antimicrobial activity against anaerobic bacteria and protozoa. The mode of action of tinidazole against anaerobic bacteria and protozoa is believed to involve the penetration of the drug into the cell of the microorganism and subsequent damage of DNA strands or inhibition of their synthesis.

How to use TINIBA 500MG TABLET

Take TINIBA 500MG TABLET as advised by your physician. Swallow this medicine with a glass of water. Do not crush or chew the medicine. It is recommended that TINIBA 500MG TABLET should be taken during or after a meal. Your doctor will decide the correct dose and duration of TINIBA 500MG TABLET for you depending upon your age, body weight and disease condition.

Side Effects Of TINIBA 500MG TABLET

How To Manage Side Effects

Diarrhea

Drink lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own to manage without consulting your doctor.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Nausea And Vomiting

Take TINIBA 500MG TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals. Consult your doctor if your symptom does not improve.

Stomach Pain

Try to rest and relax. Try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.

Warning & Precautions

Pregnancy

Contraindicated

The use of TINIBA 500MG TABLET during the first trimester is contraindicated. There is no evidence that the medicine is harmful during the latter stages of pregnancy, but its use during the second and third trimesters requires that the potential benefits be weighed against the possible hazards to the mother or fetus. Consult your doctor before taking the medicine.

Breastfeeding

Contraindicated

TINIBA 500MG TABLET is not recommended for use in breastfeeding women. Consult your doctor for advice before taking TINIBA 500MG TABLET.

Driving and Using Machines

Use with Caution

There is no evidence to suggest that TINIBA 500MG TABLET may affect these abilities.

Alcohol

Contraindicated

Concurrent use of TINIBA 500MG TABLET and alcohol may produce a disulfiram-like reaction and should be avoided.

Kidney

Use with Caution

Dosage adjustment in patients with impaired renal function are generally not necessary. However, because TINIBA 500MG TABLET is easily removed by haemodialysis, patients may require additional doses of TINIBA 500MG TABLET to compensate. Consult your doctor before taking the medicine.

Liver

Use with Caution

TINIBA 500MG TABLET should be used with caution in patients with hepatic impairment. Consult your doctor before taking the medicine.

Allergy

Contraindicated

Do not take TINIBA 500MG TABLET if you are allergic to Tinidazole or any other ingredients of this medicine.

Use In Pediatrics

Consult your doctor

There is no proper data available for the use of TINIBA 500MG TABLET in children and adolescents below 12 years of age.

Interactions

A. Drug-Drug interactions:

Before taking TINIBA 500MG TABLET, inform your doctor if you are taking any of the following medicines:

• Anticoagulants (Ex. warfarin, acenocoumarol, dicumarol, anisindione, phenindione, phenprocoumon)

Overdosage:

If you or anyone else accidentally takes too much of TINIBA 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Treatment is symptomatic and supportive. Gastric lavage may be useful.

Synopsis

More Information

FAQs About TINIBA 500MG TABLET

Q: What precautions do I need to follow while taking TINIBA 500MG TABLET?

A: TINIBA 500MG TABLET is not recommended for patients with organic neurological disorders and blood dyscrasias. TINIBA 500MG TABLET should be used with caution in patients with liver disease. It is not recommended for patients with first trimester in pregnancy. TINIBA 500MG TABLET is not recommended for use in breastfeeding mother.

Q: What happens if I stop taking TINIBA 500MG TABLET?

A: Do not stop taking TINIBA 500MG TABLET without talking to your doctor first. Consult your doctor for advice.

Q: Is TINIBA 500MG TABLET safe to use in patients with kidney problems?

A: Dosage adjustment in patients with impaired renal function are generally not necessary. However, because TINIBA 500MG TABLET is easily removed by haemodialysis, patients may require additional doses of TINIBA 500MG TABLET to compensate. Consult your doctor before taking the medicine.

Q: How long should TINIBA 500MG TABLET be taken?

A: Take TINIBA 500MG TABLET as advised by your physician. It is recommended that TINIBA 500MG TABLET should be taken during or after a meal.

Q: Can I take TINIBA 500MG TABLET milk?

A: Take TINIBA 500MG TABLET with food, including with milk, to lower your risk of stomach discomfort. But keep in mind that dairy products, like milk, are high in fat, which might cause some people to feel nauseous. This might worsen the side effects of the medicine. Consult your doctor for advice.

Q: How long does TINIBA 500MG TABLET stay in the body?

A: It can take between 2-3 days for most of TINIBA 500MG TABLET to leave the body. It is estimated based on the half-life of TINIBA 500MG TABLET. The medication stays in your system can also depend on your age and your health conditions, so it can be different for each individual person.

Q: Is TINIBA 500MG TABLET a strong antibiotic?

A: Yes. TINIBA 500MG TABLET is an antibiotic effective against various bacterial infections in the intestines and vagina.

Q: Can TINIBA 500MG TABLET cure yeast infections?

A: It is not typically used to manage yeast infections. It is primarily effective against bacterial infections. Consult your doctor if you experience vaginal itching or discharge.

Q: Can TINIBA 500MG TABLET be taken with alcohol?

A: Avoid consuming alcohol while taking TINIBA 500MG TABLET and for at least 3 days after completing the course, as it may cause severe reactions like nausea, vomiting, and headache.

References

1. Pfizer Limited. [Revised on July 2021] [Accessed on August 28th 2024] https://labeling.pfizer.com/ShowLabeling.aspx?id=14826

2. GRACURE Pharmaceuticals Ltd. [Revised on August 2016] [Accessed on August 28th 2024] https://exphar.com/wp-content/uploads/2021/02/TINAZOL-SmPC.pdf

3. GoodRx. [Accessed on August 28th 2024] https://www.goodrx.com/tinidazole/what-is

4. Medicover hospitals. Tinidazole. [Accessed on August 28th 2024] https://www.medicoverhospitals.in/medicine/tinidazole

Useful Diagnostic Tests

• Complete blood count
• Bacterial culture test