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Introduction About TENDIA P TABLET
TENDIA P TABLET is a combination of Pioglitazone and Teneligliptin which belongs to the group of medicines called Antidiabetic agents. It is used in the management of type 2 diabetes in adult patients.
Pioglitazone effectively controls blood sugar levels. It contains pioglitazone which is PPAR-gamma and PPAR-alpha agonist. Following administration, it activates certain receptors (PPAR-gamma and PPAR-alpha) in the body which are involved in metabolizing glucose. This makes our body utilize insulin for digesting the circulating blood glucose which in turn decreases blood sugar levels. Additionally, TENDIA P TABLET can also reduce the glucose produced by the liver. Teneligliptin is a dipeptidyl peptidase (DPP)-4 inhibitor. It lowers blood glucose levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that regulates the secretion of insulin in the body. As a result, it improves insulin production and helps in the digestion of circulating blood glucose. It can also regulate blood sugar post meal by controlling glucagon secretion.
Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking TENDIA P TABLET as it may aggravate your existing condition. TENDIA P TABLET is not recommended for use in patients with diabetes ketoacidosis (increased ketone bodies in the blood) or bladder cancer, type I diabetes mellitus and serious traumatic injury, pregnancy and breast feeding women. The most common side effects of taking TENDIA P TABLET are Hypoglycemia, Headache, dizziness, Constipation and Diarrhoea. Contact your doctor if any of the symptoms worsen.
Uses Of TENDIA P TABLET
- Used in the management of type 2 diabetes in adult patients
How TENDIA P TABLET Works
Pioglitazone effectively controls blood sugar levels. It contains pioglitazone which is PPAR-gamma and PPAR-alpha agonist. Following administration, it activates certain receptors (PPAR-gamma and PPAR-alpha) in the body which are involved in metabolizing glucose. This makes our body utilize insulin for digesting the circulating blood glucose which in turn decreases blood sugar levels. Additionally, TENDIA P TABLET can also reduce the glucose produced by the liver. Teneligliptin is a dipeptidyl peptidase (DPP)-4 inhibitor. It lowers blood glucose levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that regulates the secretion of insulin in the body. As a result, it improves insulin production and helps in the digestion of circulating blood glucose. It can also regulate blood sugar post meal by controlling glucagon secretion.
How to use TENDIA P TABLET
Take TENDIA P TABLET preferably with meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Side Effects Of TENDIA P TABLET
Common
- Hypoglycemia (low blood sugar levels causing dizziness, shakiness, or hunger)
- Headache, dizziness
- Abnormal vision
- Joint pain, back pain, muscle pain
- Impotence
- Shortness of breath, anaemia
- Flatulence
- Respiratory infection, sinus infection, sore throat
- Weight gain
- Numbness
- Constipation
- diarrhoea
- Fever
Uncommon
- Difficulty in sleeping (insomnia)
- Sugar in urine
- Proteins in urine
- Spinning sensation (vertigo)
- Sweating, tiredness
- Increased appetite
Stop taking TENDIA P TABLET and contact your physician immediately if you experience any of the following side effects:
- Symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
- Signs and symptoms of bladder cancer (such as blood in your urine, pain while urinating or urgent need to pee)
- Increased risk of fractures (especially in the bones of hand, upper arm or foot in women)
- Blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
- Serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- Signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
How To Manage Side Effects
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Diarrhea
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-manage diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Hypoglycemia
Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Consult your doctor if there is no improvement in your condition.
Warning & Precautions
Pregnancy
ContraindicatedTENDIA P TABLET is not recommended for use during pregnancy. Consult your doctor before taking it.
Breastfeeding
ContraindicatedTENDIA P TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if you experience abnormal vision and dizziness after taking TENDIA P TABLET.
Alcohol
Consult your doctorAvoid alcohol consumption while taking TENDIA P TABLET as it may increase the risks of side effects.
Liver
Consult your doctorTENDIA P TABLET is not recommended for use in patients with severe liver problems. TENDIA P TABLET should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take TENDIA P TABLET if you are allergic to Pioglitazone and Teneligliptin or any of the other ingredients of this medicine.
Heart Disease
Consult your doctorTENDIA P TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedTENDIA P TABLET is not recommended for use in children and adults under 18 years of age. Consult your doctor before taking it.
Use In Geriatrics
Use with CautionTENDIA P TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
Others
TENDIA P TABLET is not recommended for use if you:
- Have diabetic ketoacidosis (increased levels of ketone bodies in the blood)
- Have bladder cancer
- Pass bloody urine
- Have diabetic coma or precoma
- Have type I diabetes mellitus
- Have serious traumatic injury
Before taking TENDIA P TABLET, inform your doctor if you:
- Have fluid retention and swelling
- Have other urinary problems
- Smoke
- Have special type of diabetic eye disease called macular oedema (swelling of the back of the eye with worsening of your vision)
- Have cysts on your ovaries (polycystic ovary syndrome
- Previous had stroke
- Have anemia (low RBC in blood)
- Have any bone problems or at risk of developing bone fractures
- Are a premenopausal woman
- Have pituitary insufficiency or adrenal insufficiency
- Are malnourished, starved, on an irregular diet, or feeling weak
- Perform extreme muscle exercises
- Have a history of abdominal operation or intestinal obstruction
- Have hypokalaemia (low blood potassium levels)
Interactions
A. Drug-Drug interactions:
Before taking TENDIA P TABLET, inform your doctor if you are taking any of the following medicines, such as:
- Non-steroidal anti-inflammatory medicines (used for pain relief) such as celecoxib or etoricoxib
- Gemfibrozil (a medicine used to lower blood cholesterol levels)
- Rifampicin (a medicine used to manage tuberculosis)
- Other medicines used to manage diabetes (such as glimepiride, exenatide, acarbose, metformin, pioglitazone, repaglinide, empagliflozin or insulin)
- Beta blockers (medicines used to manage high blood pressure) Ex. atenolol, propranolol
- Salicylic acid (a medicine used to manage skin problems like acne)
- Medicines used to manage depression (Ex. phenelzine, selegiline)
- Adrenaline (a medicine used to manage shock caused by allergic reactions or collapse)
- Thyroid hormones (used for thyroid deficiency) Ex. levothyroxine, liothyronine
- Medicines used for irregular heartbeats (Ex. quinidine, procainamide, amiodarone, sotalol)
Overdosage:
If you or anyone else accidentally took more TENDIA P TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include hypoglycemia which may cause increased hunger, sweating, shakiness, weakness or an irregular heartbeat.
Synopsis
| Drug | : | Pioglitazone, Teneligliptin |
| Pharmacological Category | : | PPAR-gamma and PPAR-alpha agonists, Dipeptidyl Peptidase-4 Inhibitors |
| Therapeutic Indication | : | Type II Diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep TENDIA P TABLET out of the sight and reach of children
- Store TENDIA P TABLET below 30°C
FAQs About TENDIA P TABLET
Q: Does TENDIA P TABLET cause bone fractures?
A: Yes. TENDIA P TABLET may cause bone fractures in some individuals. Therefore, it is important for you to inform your doctor before taking TENDIA P TABLET if you have any bone problems or at risk of developing any bone fractures (such as menopause).
Q: Does TENDIA P TABLET cause weight gain?
A: Yes. TENDIA P TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and regular physical activity as advised by your physician. However, if you experience any weight gain due to swelling of body parts (such as in face, legs or hands), consult your doctor immediately.
Q: How much TENDIA P TABLET should I take?
A: TENDIA P TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Q: What should I do if I experience low blood sugar after taking TENDIA P TABLET?
A: Low blood sugar is a common side effect of taking TENDIA P TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Wait for some time. If you cannot any improvement in your condition or if your condition worsen, contact your doctor.
Q: Can TENDIA P TABLET cause dizziness?
A: Yes. Dizziness is a common side effect of using TENDIA P TABLET. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking TENDIA P TABLET.
Q: Can TENDIA P TABLET cause constipation?
A: Yes. Constipation is a common side effect of using TENDIA P TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if you experience constipation for a long time.
References
1. K.D. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 277.
2. Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey. Diabetes Mellitus. Pharmacotherapy- A Pathophysiologic Approach. Eighth edition. Page- 1263, 1264.
3. Cyrus V. Desouza1,2 and Vijay Shivaswamy1,2. Pioglitazone in the Treatment of Type 2 Diabetes: Safety and Efficacy Review. NIH: National Library of Medicine, National center for biotechnology information. PMC. PubMed Central.3 Aug 2010. [Accessed on 27th December 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411525/
4. Mitra, A., & Ray, S. Evaluation of the Safety and Efficacy of Teneligliptin at a Higher Dose in Indian Type 2 Diabetes Patients: A Retrospective Analysis. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. January 2020. [Accessed on 27th December 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047936/
5. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 27th December 2023] https://www.medicines.org.uk/emc/files/pil.8836.pdf
6. Takeda Pharmaceuticals America, Inc. U.S. Food & Drug Administration. [Revised in July 2011] [Accessed on 27th December 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021073s043s044lbl.pdf
7. Torrent Pharmaceutical Ltd. Teneligliptin. [Revised in April 2021] [Accessed on 27th December 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2991.pdf
8. Mitsubishi Tanabe Pharma Factory Ltd. Teneligliptin. [Revised in April 2020] [Accessed on 27th December 2023] http://ndi.fda.moph.go.th/uploads/drug_detail_corporation/doc/word/1163/2f4b9cbb0657cbd755ecd3d5f00d6b99-a1.pdf
Useful Diagnostic Tests
- HbA1C, also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Jaanch Diabetic Profile Basic
Author Details
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
