Temodal 100mg Capsule 5'S
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Introduction About TEMODAL 100MG CAPSULE
TEMODAL 100MG CAPSULE contains Temozolomide, which belongs to the group of medicines called Antineoplastic agents. It is used for specific forms of brain tumours in adults with newly diagnosed glioblastoma multiforme, which is used first together with radiotherapy as a concomitant phase of therapy and then used alone as a monotherapy. It is also used in children (above 3 years) and adults to manage malignant gliomas, such as glioblastoma multiforme or anaplastic astrocytoma, if they return or get worse after standard management.
Glioblastoma multiforme is an aggressive type of cancer that affects the brain or spinal cord and is generally characterized by symptoms such as headache, nausea, drowsiness, blurred vision, personality changes, and seizures.
Along with this management, your doctor might advise you to take liver function tests to assess the hepatotoxicity and function of your liver. Before taking TEMODAL 100MG CAPSULE, inform your doctor if you have or ever had a hepatitis B infection (serious liver infection).
TEMODAL 100MG CAPSULE is not recommended for use if you have certain kinds of blood cells that are severely reduced, such as white blood cells and platelet count. TEMODAL 100MG CAPSULE should be used with caution during pregnancy only if it is clearly necessary and not recommended for use in breastfeeding women. It is not recommended for use in children below 3 years of age and should be used with caution in children and adolescents (from 3 to 18 years of age). Consult your doctor before taking TEMODAL 100MG CAPSULE. The most common side effects of taking TEMODAL 100MG CAPSULE are loss of appetite, difficulty while speaking, headache, vomiting, nausea, diarrhea, and constipation. Consult and inform your doctor if any of these symptoms get worse.
Uses Of TEMODAL 100MG CAPSULE
It is used for:
- Specific forms of brain tumours in newly diagnosed glioblastoma multiforme (in adults)
- Malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma (in adults and children)
How TEMODAL 100MG CAPSULE Works
TEMODAL 100MG CAPSULE works by damaging the genetic material (DNA and RNA) of the cancer cells inside the brain cells and works against the cell growth and multiplication.
How to use TEMODAL 100MG CAPSULE
Take TEMODAL 100MG CAPSULE as advised by your physician. Swallow TEMODAL 100MG CAPSULE with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Side Effects Of TEMODAL 100MG CAPSULE
Common
- Loss of appetite
- Difficulty while speaking
- Headache
- Vomiting, nausea
- Diarrhea
- Constipation
- Rash
- Hair loss
- Tiredness
- Infections
- Feeling sick, extreme tiredness, loss of appetite (signs of neutropenia)
- Fever, cough, runny nose (signs of lymphopenia)
- Prolonged cuts, bleeding from gums, blood in urine (signs of thrombocytopenia)
- Allergic reactions
- Memory impairment
- Depression, anxiety, confusion, sleeplessness
- Difficulty concentrating
- Dizziness
- Visual disturbances
- Deafness, ringing in the ears, earache
- Blood clot in the lung or legs
- High blood pressure
- Shortness of breath
- Bronchitis
- Cough and cold
- Inflammation of sinuses
- Stomach or abdominal pain
- Dry skin, itching
- Muscle damage, muscle aches and pain, muscle weakness
- Joint and back pain
- Frequent urination
- Fever
- Flu-like symptoms such as chills, cough, fever, and muscle aches
- Pain
- Fluid retention
- Weight gain or loss
- Radiation injury such as weakness, hair loss, and bloody vomit
Uncommon
- New or reactivated cytomegalovirus infections such as chickenpox, herpes simplex
- Signs of reactivated hepatitis B virus infections such as abdominal pain, dark urine, fever, and joint pain
- Secondary cancers, including leukemia (blood cancer)
- Reduced blood cell counts, such as pancytopenia
- Red spots under the skin
- Signs of diabetes insipidus
- Piles
- Dry mouth
- Blisters on body or in mouth
- Skin peeling, skin eruption, painful reddening of the skin, severe rash with skin swelling
- Increased sensitivity to sunlight
- Urticaria (red, itchy skin)
- Increased sweating
- Change in skin colour
- Vaginal bleeding or irritation
- Absent or heavy menstrual periods
- Breast pain
- Sexual impotence
- Shivering
Stop taking TEMODAL 100MG CAPSULE and contact your doctor if you experience any of the following side effects:
- Signs of a severe allergic (hypersensitive) reaction such as itchy red skin, wheezing, or other breathing difficulty
- Uncontrolled bleeding
- Seizures (fits)
- Fever and symptoms of infections such as cough, chills, sweat
- Chills
- Severe headache
How To Manage Side Effects
Constipation
Try to eat high-fiber foods such as vegetables, cereals, and fresh fruit, and drink plenty of water. Consult and inform your doctor about receiving alternate management for constipation.
Diarrhea
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea; consult and inform your doctor if the symptom gets worse.
Dizziness Or Drowsiness
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom does not improve.
Headache
If TEMODAL 100MG CAPSULE causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking TEMODAL 100MG CAPSULE. If headaches last more than a week or are severe, consult and inform your doctor.
Nausea And Vomiting
Try to take TEMODAL 100MG CAPSULE with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Warning & Precautions
Pregnancy
Monitoring requiredTEMODAL 100MG CAPSULE should be used in pregnant women only if it is clearly necessary. Women with childbearing potential should use effective contraceptive precautions, which should be continued for at least 6 months following the completion of> management. Consult your doctor before taking TEMODAL 100MG CAPSULE.
Breastfeeding
ContraindicatedTEMODAL 100MG CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking TEMODAL 100MG CAPSULE.
Driving and Using Machines
ContraindicatedTEMODAL 100MG CAPSULE may cause tiredness or sleepiness. If you experience any such effects, avoid driving and using machines. Consult your doctor before taking TEMODAL 100MG CAPSULE.
Kidney
Use with CautionTEMODAL 100MG CAPSULE should be used with caution in patients with kidney problems such as severe renal impairment. Consult your doctor for advice before taking TEMODAL 100MG CAPSULE.
Liver
Use with CautionTEMODAL 100MG CAPSULE should be used with caution in patients with mild, moderate, and severe hepatic impairment. Consult your doctor for advice before taking TEMODAL 100MG CAPSULE.
Allergy
ContraindicatedDo not take TEMODAL 100MG CAPSULE if you are allergic to Temozolomide or any of the other ingredients of this medicine.
Lungs
Use with CautionTEMODAL 100MG CAPSULE should be used with caution in patients with lung disease such as pneumocystis jirovecii pneumonia (serious fungal infection of lungs). Consult your doctor before taking TEMODAL 100MG CAPSULE.
Use In Pediatrics
ContraindicatedTEMODAL 100MG CAPSULE is not recommended for use in children below 3 years of age. There is limited information in patients over 3 years of age who have taken TEMODAL 100MG CAPSULE. Consult your doctor before taking TEMODAL 100MG CAPSULE.
Use In Geriatrics
Use with CautionTEMODAL 100MG CAPSULE should be used with caution in elderly patients (aged 70 years or above). Consult your doctor before taking TEMODAL 100MG CAPSULE.
Others
TEMODAL 100MG CAPSULE is not recommended for use if you:
- Have certain kinds of blood cells that are severely reduced, such as white blood cells and platelet count
Before taking TEMODAL 100MG CAPSULE, inform your doctor if you:
- Have signs of anemia (low red blood cell count)
- Have signs of low platelet count
- Have a risk of other changes in blood cells, such as leukemia (blood cancer)
Interactions
A. Drug-Drug Interactions:
Before taking TEMODAL 100MG CAPSULE, inform your doctor if you are taking any of the following medicines:
- Dacarbazine (used for cancer of the lymph system and malignant melanoma)
Overdosage:
If you or anyone else accidentally takes too much of TEMODAL 100MG CAPSULE, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Temozolomide |
| Pharmacological Category | : | Antineoplastic agents |
| Therapeutic Indication | : | Glioblastoma multiforme, Anaplastic astrocytoma |
| Dosage Forms | : | Capsule, Tablet, Injection |
More Information
Storage
- Keep the medicine out of reach of children
- Store TEMODAL 100MG CAPSULE at room temperature
FAQs About TEMODAL 100MG CAPSULE
Q: What TEMODAL 100MG CAPSULE is used for?
A: TEMODAL 100MG CAPSULE is used for specific forms of brain tumours in adults with newly diagnosed glioblastoma multiforme, which is used first together with radiotherapy as a concomitant phase of therapy and then used alone as a monotherapy. It is also used in children (above 3 years) and adults to manage malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma, if they return or get worse after standard management.
Q: How should TEMODAL 100MG CAPSULE be taken?
A: Take TEMODAL 100MG CAPSULE as advised by your physician. Swallow TEMODAL 100MG CAPSULE with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q: What are the side effects of TEMODAL 100MG CAPSULE?
A: The most common symptoms of taking TEMODAL 100MG CAPSULE are loss of appetite, difficulty while speaking, headache, vomiting, nausea, diarrhea, and constipation. Consult and inform your doctor if any of these symptoms get worse.
Q: What happens if you forget to take TEMODAL 100MG CAPSULE?
A: If you forget to take TEMODAL 100MG CAPSULE at the usual time, take your dose as soon as possible and then continue with your medication at the usual times. Avoid taking a double dose to make up for forgotten individual doses. Consult and inform your doctor before taking TEMODAL 100MG CAPSULE if you have queries on the missed dose.
Q: Is TEMODAL 100MG CAPSULE safe to use in children?
A: TEMODAL 100MG CAPSULE is not recommended for use in children below 3 years of age. There is limited information in patients over 3 years of age who have taken TEMODAL 100MG CAPSULE. Consult your doctor before taking TEMODAL 100MG CAPSULE.
Q: How does TEMODAL 100MG CAPSULE work?
A: TEMODAL 100MG CAPSULE works by damaging the genetic material (DNA and RNA) of the cancer cells inside the brain cells and works against cell growth and multiplication.
Q: Is TEMODAL 100MG CAPSULE safe during pregnancy?
A: TEMODAL 100MG CAPSULE should be used in pregnant women only if it is clearly necessary. Women with childbearing potential should use effective contraceptive precautions, which should be continued for at least 6 months following the completion of> management. Consult your doctor before taking TEMODAL 100MG CAPSULE.
Q: Who should not take TEMODAL 100MG CAPSULE?
A: TEMODAL 100MG CAPSULE is not recommended for use if you have certain kinds of blood cells that are severely reduced, such as white blood cells and platelet count, or if you are allergic to temozolomide or any of the other ingredients of this medicine.
Q: What precautions must be taken while using TEMODAL 100MG CAPSULE?
A: TEMODAL 100MG CAPSULE should be used with caution in patients with kidney problems such as severe renal impairment, mild, moderate, and severe hepatic impairment, lung disease such as pneumocystis jirovecii pneumonia (serious fungal infection of lungs), signs of anemia (low red blood cell count), signs of low platelet count, or have a risk of other changes in blood cells such as leukemia (blood cancer). Consult your doctor for advice before taking TEMODAL 100MG CAPSULE.
Q: When should I stop taking TEMODAL 100MG CAPSULE?
A: Stop taking TEMODAL 100MG CAPSULE and contact your doctor if you experience any of the following side effects, such as signs of a severe allergic reaction such as itchy red skin, wheezing or other breathing difficulty, uncontrolled bleeding, seizures (fits), fever, and symptoms of infections such as cough, chills, sweat, chills, and severe headache.
References
1. KD. Tripathi. Anticancer Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page 858.
2. J.R. Wesolowski, P. Rajdev, and S.K. Mukherji. Temozolomide (Temodar). NIH National Library of Medicine, National Center for Biotechnology Information. PMC PubMed Central. September 2010 [Accessed on 15th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966084/
3. SP Labo N.V. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 15th July 2024] https://www.medicines.org.uk/emc/files/pil.1463.pdf
4. Merck & Co., Inc. TEMODAR. [Revised in November 2019] [Accessed on 15th July 2024] https://www.merck.com/product/usa/pi_circulars/t/temodar_capsules/temodar_pi.pdf
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Liver Function Test (LFT)
- Cancer Screening Package For Male
- Cancer Screening Package For Female
- Jaanch Tumor Panel (Female)
- Jaanch Tumor Panel (Male)
Author Details
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