Introduction About TAZRET 0.05/ GEL(TOPICAL)

TAZRET 0.05/ GEL(TOPICAL) contains Tazarotene which belongs to the group of medicines called Retinoids. It is used to topically manage plaque psoriasis and acne vulgaris. Plaque psoriasis is a skin disease that causes dry, itchy, raised skin patches (plaques) covered with scales. Acne vulgaris is a common, usually self-limiting disease that causes inflammation of the sebaceous follicles of the face and upper body.

Before using TAZRET 0.05/ GEL(TOPICAL), inform your doctor if you have liver, kidney, or heart problems, eczema, or other skin problems. TAZRET 0.05/ GEL(TOPICAL) is not recommended for use among pregnant women. TAZRET 0.05/ GEL(TOPICAL) should be used with caution in breastfeeding women. Consult your doctor before using it.

It is not known if TAZRET 0.05/ GEL(TOPICAL) is safe and effective for use in children and adolescents under 12 years of age. TAZRET 0.05/ GEL(TOPICAL) for the management of acne has not been clinically evaluated in elderly patients (over 65 years).

The most common side effects of using TAZRET 0.05/ GEL(TOPICAL) are itching, burning, redness, worsening of psoriasis, irritation, skin pain, peeling, and dry skin. Contact your doctor if any of the symptoms worsen.

Uses Of TAZRET 0.05/ GEL(TOPICAL)

• Topically manage plaque psoriasis and acne vulgaris

How TAZRET 0.05/ GEL(TOPICAL) Works

TAZRET 0.05/ GEL(TOPICAL) is converted to its active form, tazarotenic acid, that binds to all three members of the retinoic acid receptor (RAR) family (RARa, RARβ, and RARγ) and may modify gene expression.

How to use TAZRET 0.05/ GEL(TOPICAL)

Apply TAZRET 0.05/ GEL(TOPICAL) as advised by your physician. It is for external use only. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of TAZRET 0.05/ GEL(TOPICAL)

Warning & Precautions

Pregnancy

Contraindicated

TAZRET 0.05/ GEL(TOPICAL) is not recommended for use in pregnancy as it may cause birth defects. Consult your doctor before using it.

Breastfeeding

Use with Caution

TAZRET 0.05/ GEL(TOPICAL) should be used with caution in breastfeeding women as it is not known if it passes into breast milk. Consult your doctor before using it.

Allergy

Contraindicated

Do not use TAZRET 0.05/ GEL(TOPICAL) if you are allergic to Tazarotene.

Use In Pediatrics

Consult your doctor

It is not known if TAZRET 0.05/ GEL(TOPICAL) is safe and effective in children and adolescents (under 12 years of age). Consult your doctor before using it.

Use In Geriatrics

Consult your doctor

TAZRET 0.05/ GEL(TOPICAL) for the management of acne has not been clinically evaluated in elderly patients (over 65 years). Consult your doctor before using it.

Interactions

A. Drug-Drug interactions:

Before using TAZRET 0.05/ GEL(TOPICAL), inform your doctor if you are using, have used, or might use any other medicine, including prescription, non-prescription or herbal medicine.

Overdosage:

If you or anyone else accidentally use too much of TAZRET 0.05/ GEL(TOPICAL), consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include marked redness, peeling, or discomfort.

Synopsis

More Information

• Keep TAZRET 0.05/ GEL(TOPICAL) out of reach of children
• Store between 20-25°C

FAQs About TAZRET 0.05/ GEL(TOPICAL)

Q: Is TAZRET 0.05/ GEL(TOPICAL) safe to use during pregnancy?

A: TAZRET 0.05/ GEL(TOPICAL) may cause birth defects if used in pregnancy. Women must not be pregnant when they start using or during management with this medicine. For women who get pregnant, your doctor will order a pregnancy test within 2 weeks before you begin management with TAZRET 0.05/ GEL(TOPICAL) to be sure that you are not pregnant.

Get safety advice from your doctor for using TAZRET 0.05/ GEL(TOPICAL) during a normal menstrual period. Discuss with your doctor about birth control options that may be used during the management. Stop using it and tell your doctor immediately if you become pregnant while using this medicine.

Q: What if TAZRET 0.05/ GEL(TOPICAL) accidentally gets into my eye?

A: Avoid getting TAZRET 0.05/ GEL(TOPICAL) in your eyes or eyelids. If it gets in or near your eyes, rinse them thoroughly with water. Call your doctor if you have persistent eye irritation. Wash your hands after applying TAZRET 0.05/ GEL(TOPICAL).

Q: What should I avoid while using TAZRET 0.05/ GEL(TOPICAL)?

A: While using TAZRET 0.05/ GEL(TOPICAL), avoid exposure to sunlight, including sunlamps. Use sunscreen and cover your skin if you have to be in the sun. Avoid using cosmetics or topical medicines that may make your skin more sensitive to the sun or dry. Avoid using it on unaffected skin or skin with eczema, as it may cause severe irritation.

Q: What if I accidentally swallow TAZRET 0.05/ GEL(TOPICAL)?

A: Avoid getting TAZRET 0.05/ GEL(TOPICAL) in your mouth. If you or anyone else swallows it, call your doctor or go to the nearest hospital immediately.

Q: Can TAZRET 0.05/ GEL(TOPICAL) cause itching?

A: Yes. TAZRET 0.05/ GEL(TOPICAL) may cause itching. In such a case, pat your skin instead of scratching it and hold something cool, like a damp towel, on it. Wear loose cotton clothes. Consult your doctor if you have persistent itching.

References

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Acne vulgaris. Pharmacotherapy Handbook. Ninth edition. Page- 135.

2. Allergan USA, Inc. U.S. Food & Drug Administration. [Revised in April 2018] [Accessed 26th May 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020600s010lbl.pdf

3. Almirall LLC. Tazarotene. [Revised in August 2019] [Accessed 26th May 2021] https://www.tazorachcp.com/static/tazorac-cream-pi-54115b39c03f775e241400f432307541.pdf

4. Almirall LLC. Tazarotene. [Revised in August 2019] [Accessed 26th May 2021] https://www.tazorachcp.com/static/tazorac-gel-pi-02a09c0c385acf94ad9c3227b66febfd.pdf

5. Drugbank. Tazarotene. [Accessed 26th May 2021] https://go.drugbank.com/drugs/DB00799

6. Mayo clinic. Psoriasis. [Accessed 26th May 2021] https://www.mayoclinic.org/diseases-conditions/psoriasis/symptoms-causes/syc-20355840

7. Itchy skin. NHS UK. [Revised in July 2020] [Accessed 26th May 2021] https://www.nhs.uk/conditions/itchy-skin/

Useful Diagnostic Tests

• Skin biopsy