ROBILINK DSR CAPSULE is used to manage Gastro-Esophageal Reflux Disease (GERD) among patients who have not responded adequately to rabeprazole alone. It is a combination of Domperidone and Rabeprazole which belongs to the group of medicines called Dopamine Antagonists and Proton pump inhibitors respectively. It can also be used to manage peptic ulcers caused by H. pylori infection or NSAIDs use.

Uses Of ROBILINK DSR CAPSULE

It is used to manage:

• peptic ulcer
• Gastro-Esophageal Reflux Disease (GERD)

How ROBILINK DSR CAPSULE Works

ROBILINK DSR CAPSULE reduces stomach ulcers and acid reflux, where Rabeprazole acts by inhibiting the secretions of stomach acid and Domperidone acts by increasing bowel movements and facilitating gastric emptying, thus leading to rapid symptom relief and healing of stomach ulcers and esophageal lesions.

How to use ROBILINK DSR CAPSULE

• Take ROBILINK DSR CAPSULE as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition

Side Effects Of ROBILINK DSR CAPSULE

Common side effects of ROBILINK DSR CAPSULE:

• nausea, vomiting
• diarrhea, constipation, stomach pain, flatulence
• cough, sore throat, runny nose
• back pain
• headache, dizziness
• dry mouth
• benign polyps in the stomach
• indigestion, belching in the stomach (excess air accumulation in the stomach)
• urinary tract infection

Stop taking ROBILINK DSR CAPSULE and contact your doctor immediately if you experience the following side effects:

• severe allergic reaction (sudden wheezing, swelling of lips, face or body, rash, fainting or difficulties swallowing)
• symptoms of liver problems (yellow skin, dark urine and tiredness)
• severe skin reactions such as erythema multiforme, stevens-johnson syndrome or toxic epidermal necrolysis (reddening of skin with blisters or peeling and may be associated with a high fever and joint pains, also severe blisters and bleeding in the lips, eyes, mouth, nose and genitals)
• seizures
• involuntary movements of the face or arms and legs, excessive trembling, excessive muscle stiffness or muscle spasm
• heart rhythm disorders (rapid or irregular heartbeat)

Warning & Precautions

Pregnancy

Contraindicated

ROBILINK DSR CAPSULE is not recommended for use in pregnant women.

Breastfeeding

Contraindicated

ROBILINK DSR CAPSULE is not recommended for use in breast-feeding women.  

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience sleepiness, confusion or less control over your movements.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking ROBILINK DSR CAPSULE, as it could aggravate your existing condition.

Kidney

Contraindicated

ROBILINK DSR CAPSULE is not recommended for use in patients with kidney impairment.  

Liver

Consult your doctor

ROBILINK DSR CAPSULE is not recommended for use in patients with moderate or severe liver impairment and it should be used with caution in patients with liver problems.

Allergy

Contraindicated

Do not take ROBILINK DSR CAPSULE if you are allergic to Domperidone or Rabeprazole or any other ingredients of this medicine.

Heart Disease

Contraindicated

ROBILINK DSR CAPSULE is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure.

Use In Pediatrics

Contraindicated

ROBILINK DSR CAPSULE is not recommended for use in children and adolescents (aged less than 18 years) due to lack of safety and effectiveness.  

Use In Geriatrics

Use with Caution

ROBILINK DSR CAPSULE should be taken with caution in elderly patients (aged 65 years or above).  

Interactions

A. Drug-Drug interactions:

Before taking the medicine, inform to your doctor if you are taking any of these medicines:

• Prokinetic agent (Ex. Cisapride, dolasetron, prucalopride, diphemanil)
• Cardiac glycosides (Ex. Digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
• Ant-viral agents (Ex. Atazanavir, nelfinavir, saquinavir, Telaprevir)
• Antipsychotics (Ex. Haloperidol, pimozide, sertindole)
• Antidepressants (Ex. Escitalopram or citalopram)
• Antibiotics (Ex. Moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin)
• Antimalarials (Ex. Halofantrine, lumefantrine)
• Antihistamines (Ex. Mizolastine, mequitazine)
• Nonsteroidal antiestrogens (Ex. Toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
• Antimetabolites (Ex. Methotrexate)
• Antihypertensives (Ex. Bepridil)
• Opioid narcotics (Ex. Methadone)
• Iron salts
• Immunosuppressants (Ex. Tacrolimus or mycophenolate mofetil)
• Antifungals (Ex. Ketoconazole, itraconazole)
• Anti-infective (Ex. Pentamidine)
• Anticoagulants (Ex. Warfarin)

Overdosage:

If you or anyone else take too much of ROBILINK DSR CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms are altered consciousness, agitation, convulsions, disorientation, sleepiness and extrapyramidal reactions (such as rigidity, tremor, drooling).

Synopsis

More Information

FAQs About ROBILINK DSR CAPSULE

References

1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page-666 & 651-653.

2. Keith A. Sharkey and John L. Wallace. Treatment of disorders of bowel motility and water flux; Antiemetics; Agents used in biliary and pancreatic disease and Pharmacotherapy of gastric acidity, peptic ulcer and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page-1326 & 1317-1320.

3. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page-1232 & -3337.

4. Janssen Research & Development, LLC. A Pharmacokinetics, Pharmacodynamics and Safety Study of Rabeprazole in Newborn Infants with Gastroesophageal Reflux Disease (GERD). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2013] [Accessed on 1st October 2021] click here

5. Savita Shahani, Prabha Sawant, Preen Dabholkar. Rabeprazole plus domperidone: the answer for gastro-esophageal reflux disease. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 2008. [Accessed on 1st October 2021] click here

6. K Semmanaselvan, Qayum I Mukaddam, Manoj Naik. An Open Label, Prospective, Single Centre Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Rabeprazole (Enteric-Coated, EC) 20 mg + Domperidone (Sustained Release, SR) 30 mg Capsule in Treatment of Patients with Laryngopharyngeal Reflux Disease. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. July 2015. [Accessed on 1st October 2021] click here

7. Cipla Ltd. Rabicip D Capsules (Rabeprazole sodium + Domperidone). Ciplamed.com. [Revised in January 2020] [Accessed on 1st October 2021] click here

Useful Diagnostic Tests

• Complete Blood Count (CBC)
• Stool Complete Analysis

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 20 Nov 2024 | 12:04 PM(IST)