Introduction About REXIZOLE CREAM

REXIZOLE CREAM contains Clotrimazole, which belongs to the group of medicines called Antifungals. It is used in the management of fungal skin infections such as ringworm (fungal infection of the skin or scalp), athlete’s foot (fungal infection between the toes), fungal nappy rash (skin rash affecting the nappy area), and fungal sweat rash. It also relieves irritation of the vulva (external thrush) or at the end of the penis, which may be associated with thrush.

Before applying REXIZOLE CREAM, inform your doctor about your previous existing disease conditions. REXIZOLE CREAM is not recommended for use in patients who are allergic to clotrimazole. Avoid smoking or going near flames and wearing fabrics that catch fire easily due to the increased risk of severe burns.

REXIZOLE CREAM can be used in pregnant and breastfeeding women. Avoid using latex contraceptives (condoms or diaphragms), as this medicine may reduce the effectiveness of such contraceptives. Use alternative precautions for at least five days after using the medicine. Consult your doctor immediately if you experience any unusual effects.

Uses Of REXIZOLE CREAM

• Manage fungal skin infections (such as ringworm, athlete’s foot, fungal nappy rash, and sweat rash)
• Relieves irritation of the vulva or at the end of the penis (which may be associated with thrush)

How REXIZOLE CREAM Works

REXIZOLE CREAM acts by specifically inhibiting the biosynthesis of ergosterol and other sterols (enzymes) required for cell membrane production; therefore, it inhibits the division and growth of fungi, eventually leading to cell death, which further manages fungal growth.

How to use REXIZOLE CREAM

Always apply REXIZOLE CREAM as directed by your physician. It is for external use only. Clean and dry the affected surface before applying the medicine. Apply and rub gently a thin layer of this medicine on the affected area. Wash your hands before and after applying the medicine. Do not use REXIZOLE CREAM on your face, eyes, or large area. Do not use under bandages or for a long time without consulting your doctor. Your doctor will decide the duration and time interval for application depending on the type of infection.

Side Effects Of REXIZOLE CREAM

Warning & Precautions

Pregnancy

Safe

REXIZOLE CREAM can be used during pregnancy. Consult your doctor before applying it.

Breastfeeding

Safe

REXIZOLE CREAM can be used during breastfeeding. Consult your doctor before applying it.

Driving and Using Machines

Safe

REXIZOLE CREAM does not affect your ability to drive or use machines.

Allergy

Contraindicated

Do not apply REXIZOLE CREAM if you are allergic to Clotrimazole or any other ingredients of this medicine.

Use In Pediatrics

Consult your doctor

The safety and effectiveness of REXIZOLE CREAM are not established in children. Consult the child's doctor for advice.

Interactions

A. Drug-Drug interactions:

Before applying REXIZOLE CREAM, inform your doctor if you have recently taken or take any other medicines, including non-prescription medicines, and using:

• Latex contraceptives (such as condoms or diaphragms) used to manage pregnancy

Overdosage:

There is no risk of acute intoxication from topical administration. If you or anyone else accidentally ingest REXIZOLE CREAM, consult your doctor immediately or visit the nearby hospital. Symptoms include dizziness, nausea, or vomiting.

Synopsis

More Information

FAQs About REXIZOLE CREAM

Q: What is REXIZOLE CREAM used for?

A: REXIZOLE CREAM is used in the management of fungal skin infections such as ringworm (fungal infection of the skin or scalp), athlete’s foot (fungal infection between the toes), fungal nappy rash (skin rash affecting the nappy area), and fungal sweat rash. It also relieves irritation of the vulva (external thrush) or at the end of the penis, which may be associated with thrush. 

Q: How does REXIZOLE CREAM work?

A: REXIZOLE CREAM acts by specifically inhibiting the biosynthesis of ergosterol and other sterols (enzymes) required for cell membrane production; therefore, it inhibits the division and growth of fungi, eventually leading to cell death, which further manages fungal growth. 

Q: What are the side effects of REXIZOLE CREAM?

A: The side effects that can be associated with the use of REXIZOLE CREAM are itching, rash, blisters, burning, discomfort, swelling, irritation, tingling or prickling sensation, redness, and peeling of the skin. Consult your doctor immediately if any of the side effects get worse.

Q: Can REXIZOLE CREAM be used in children?

A: No, the safety and effectiveness of REXIZOLE CREAM are not established in children. Consult the child’s doctor to select a suitable alternative therapy for your child depending upon the type of infection.

Q: Does REXIZOLE CREAM cause an allergic reaction?

A: REXIZOLE CREAM may cause allergic reactions rarely in some individuals. Signs include rash, swelling of the lips, throat, tongue, or face, feeling faint or dizzy, weakness, nausea, and swallowing or breathing problems. If you experience this effect, consult your doctor immediately.

Q: Is REXIZOLE CREAM safe during pregnancy?

A: REXIZOLE CREAM can be used during pregnancy. Consult your doctor before applying it.

Q: Who should not use REXIZOLE CREAM?

A: Do not apply REXIZOLE CREAM if you are allergic to Clotrimazole or if you have nail or scalp infections. Consult your doctor before using it.

Q: What precautions must be taken while using REXIZOLE CREAM?

A: Before using REXIZOLE CREAM, inform your doctor if you have liver, kidney, heart disease, or any other pre-existing disorders.

Q: How should I use REXIZOLE CREAM?

A: Always apply REXIZOLE CREAM as directed by your physician. It is for external use only. Clean and dry the affected surface before applying the medicine. Apply and rub gently a thin layer of this medicine on the affected area. Wash your hands before and after applying the medicine. Do not use REXIZOLE CREAM on your face, eyes, or large area. Do not use under bandages or for a long time without consulting your doctor. Your doctor will decide the duration and time interval for application depending on the type of infection.

Q: Is REXIZOLE CREAM safe for private parts?

A: Always use REXIZOLE CREAM as advised by your doctor. It is for external use only. It can be applied to the external genital area to relieve irritation of the vulva or at the end of the penis (which may be associated with thrush). Consult your doctor for advice.

References

1. K. D. Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page No- 792

2. Dan Zhao, Bing Chen, Ying-Ting Wang, Chuan-Hua Jiao. Topical clotrimazole cream for the treatment of tinea cruris. NIH. National Library of Medicine, National Center for Biotechnology Information. PubMed Central. November 2020 [Accessed on 26th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676513/

3. P R Sawyer, R N Brogden, R M Pinder, T M Speight, Avery. Clotrimazole: A review of its antifungal activity and therapeutic efficacy. NIH National Library of Medicine, National Center for Biotechnology Information. Pubmed.gov. 1975. [Accessed on 26th July 2024] https://pubmed.ncbi.nlm.nih.gov/1097234/

4. Mylan UK Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 26th July 2024] https://www.medicines.org.uk/emc/files/pil.2598.pdf

5. Glenmark Pharmaceuticals Ltd. DailyMed; National Library of Medicine. National Institute of Health. [Revised in September 2014] [Accessed on 26th July 2024] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f6898117-14f3-42d2-bc0e-d296add3ad70&type=display

6. Palsons Derma. Kanel-DS Gel/Lotion (clotrimazole) [Accessed on 26th July 2024] https://www.palsonsderma.com/kansel-ds-gel-ds-lotion

7. Albatross Pharma. (Clotrimazole 1, 2% topical gel) [Accessed on 26th July 2024] http://www.albatrosspharma.com/PDFs/canitross-DS.pdf

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Identification Of Fungal Elements
• Fungal Culture
• Infection Checkup Profile
• Healthy Midlife Checkup
• Men Health Checkup - Advanced
• Complete Women Checkup
• Full Body Checkup - Gold
• Elderly Checkup - Female
• Elderly Checkup - Male

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 29 Jul 2024 | 05:36 PM(IST)