INTRODUCTION

RELGIN 0.5MG contains Rasagiline which belongs to the group of medicines called Anti- Parkinsonian agents. It is used to manage signs and symptoms of Parkinson's disease in adults. It is also used together with or without levodopa. Parkinson’s disease is a condition of the brain where there is a loss of cells that produce dopamine and it primarily affects the body movement. It is mainly characterized by symptoms such as shaking, muscle stiffness, slow and unsteady movement.

Avoid alcohol consumption while taking RELGIN 0.5MG as it increases the risk of side effects such as dizziness, drowsiness, or sudden onset of sleep. RELGIN 0.5MG is not recommended for use in patients with severe liver disease. Before taking RELGIN 0.5MG, inform your doctor if you have any liver or kidney problems, high blood pressure, skin cancer or if you smoke.

RELGIN 0.5MG is not recommended for use during pregnancy and it should be used with caution in breastfeeding women, so consult your doctor before taking it. RELGIN 0.5MG is not recommended for use in children and adolescents (less than 18 years of age). The most common side effects of taking RELGIN 0.5MG are involuntary movements, headache, stomach pain, allergy, fever, feeling generally unwell, neck pain and chest pain. Contact your physician if any of the symptoms worsen.

USES OF RELGIN 0.5MG

• Manages signs and symptoms of parkinson's disease in adults

HOW RELGIN 0.5MG WORKS

RELGIN 0.5MG works by increasing and maintaining the levels of certain natural substances such as dopamine, serotonin and norepinephrine in your brain, resulting in reduction of parkinson’s symptoms.

DIRECTIONS FOR USE

Take RELGIN 0.5MG as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking RELGIN 0.5MG unless your doctor advises you to stop.

SIDE EFFECTS OF RELGIN 0.5MG

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Lie down until dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids. Consult your doctor if the symptom does not improve.

Constipation:

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.

Stomach pain:

Try to take rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor. Consult your doctor if the symptom does not improve.

Loss of appetite:

Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein, such as dried fruit and nuts. Consult your doctor if the symptom does not improve.

Headache:

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Apply pain-relieving balm on your forehead if required. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking RELGIN 0.5MG, inform your doctor if you are taking any of the following medicines:

• medicines used to manage depression (Ex. venlafaxine, fluoxetine, fluvoxamine, amitriptyline, st. john’s wort (herbal medicine), phenelzine, selegiline, mirtazapine)
• ciprofloxacin (used to manage bacterial infections)
• dextromethorphan (used to manage cough)
• certain medicines present in eye drops (Ex. brimonidine), nasal and oral decongestants and cold medicine (Ex. ephedrine, pseudoephedrine, oxymetazoline)
• medicines used to manage severe pain (Ex. pethidine, meperidine)
• other medicines used to manage parkinson’s disease (Ex. bromocriptine, cabergoline, apomorphine)
• clozapine (used to manage schizophrenia)
• tyramine (used to regulate blood pressure)
• metoclopramide (used to manage nausea and vomiting)

B. Drug - Food interactions:

Avoid eating too much of foods rich in tyramine (Ex. aged cheese, red wine) while taking RELGIN 0.5MG as it could very rarely increase your blood pressure.

Overdosage:

If you or anyone else accidentally takes too much of RELGIN 0.5MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include slightly euphoric mood (light version of mania), extremely high blood pressure and serotonin syndrome.

SYNOPSIS

MORE INFORMATION

• Keep RELGIN 0.5MG out of reach of children
• Store at room temperature

FAQs ABOUT RELGIN 0.5MG

Can I take RELGIN 0.5MG with Fluoxetine?

No, before taking RELGIN 0.5MG inform your doctor if you are taking any other medicines. The use of this medicine with fluoxetine should be avoided. If you are starting management with RELGIN 0.5MG you should wait at least 5 weeks after stopping management with fluoxetine. If you are starting fluoxetine management, wait at least 14 days after stopping RELGIN 0.5MG management.

Can I smoke while taking RELGIN 0.5MG?

No, before taking RELGIN 0.5MG inform your doctor if you smoke or planning to stop smoking as it could decrease the amount of RELGIN 0.5MG in your blood and results in undesired therapeutic outcome

Is RELGIN 0.5MG safe to use in patients with liver disease?

RELGIN 0.5MG is not recommended for use in patients with severe liver problems. It should be used with caution in patients with any other liver problems. Consult your doctor before taking it.

What if I forget to take a dose of RELGIN 0.5MG?

If you forget to take a dose of RELGIN 0.5MG, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take the medicine twice to make up for a forgotten dose.

Can RELGIN 0.5MG cause constipation?

Yes, constipation is a common side effect of RELGIN 0.5MG. If it occurs, take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.

REFERENCES

1. KD. Tripathi. Antiparkinsonian Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 432.

2. Shimon Lecht, Simon Haroutiunian, Amnon Hoffman, Philip Lazarovici P. Rasagiline: a novel MAO B inhibitor in Parkinson's disease therapy. National Institute of Health. NLM. National Centre for Biotechnology Information. Pubmed.gov. June 2007. [Accessed on 2nd June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386362/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 2nd June 2022] https://www.medicines.org.uk/emc/files/pil.5094.pdf

4. Teva Pharmaceuticals USA. Rasagiline. [Revised in June 2020] [Accessed on 2nd June 2022] https://www.azilect.com/azilect.pdf

5. Teva Pharma Australia Pty Ltd. Rasagiline. [Revised in June 2021] [Accessed on 2nd June 2022] https://www.nps.org.au/assets/medicines/b37394f4-ecf6-4965-be8d-ab84006e2075.pdf

6. Central Drugs Standard Control Organization (CDSCO). [Accessed on 2nd June 2022] https://cdscoonline.gov.in/CDSCO/Drugs

USEFUL DIAGNOSTIC TESTS

• SPECT scan
• MRI scan