REKOOL INJECTION is used to manage acidity, heartburn, peptic ulcers, acid reflux, Zollinger-Ellison syndrome. It contains a medicine called Rabeprazole which is a Proton pump inhibitor that works by reducing gastric acid secretions.

Uses Of REKOOL INJECTION

REKOOL INJECTION is used to provide relief from following gastric conditions:

• Acidity, Heartburn, Acid reflux
• Peptic ulcers
• Inflammation of oesophagus
• Zollinger-Ellison syndrome

How REKOOL INJECTION Works

REKOOL INJECTION is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances for acid reflux into the oesophagus, heals peptic ulcers and esophageal lesions and manages its recurrence.

How to use REKOOL INJECTION

• Take REKOOL INJECTION as advised by your physician.
• Swallow the medicine with a glass of water. Do not crush or chew the medicine.
• It is preferably taken in the mornings or at any time of the day before meals, preferably 15-30 minutes prior to meals
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Side Effects Of REKOOL INJECTION

Common Side Effects of REKOOL INJECTION:

• mouth sores
• difficulty in sleeping
• headache, dizziness
• stomach pain, diarrhoea, flatulence, nausea, vomiting or constipation
• aches or back pain
• polyps in the stomach

Stop taking REKOOL INJECTION and contact your doctor immediately if you experience any of the following side effects:

• signs of frequent infections (such as chills, sore throat and fever)
• painful ulcers in the mouth or throat
• bruising or bleeding easily
• severe watery or bloody diarrhoea with fever, stomach pain or tenderness
• signs of vitamin B12 deficiency (such as pale skin, oral sores, disturbed vision, irritability, depression)
• signs of low magnesium levels (such as fits, tremor, muscle spasms, abnormal eye movements)

Warning & Precautions

Pregnancy

Monitoring required

REKOOL INJECTION should be used in pregnant women only if considered necessary by the physician.

Breastfeeding

Contraindicated

REKOOL INJECTION is generally not recommended for use in breastfeeding women.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel sleepy after taking REKOOL INJECTION.

Liver

Use with Caution

REKOOL INJECTION should be used with caution in patients who have or ever had any liver problems.

Allergy

Contraindicated

Do not take REKOOL INJECTION if you are allergic to Rabeprazole or to any other proton pump inhibitors (such as omeprazole, esomeprazole).

Use In Pediatrics

Contraindicated

REKOOL INJECTION is not recommended for use in children and adolescents (aged below 18 years).

Use In Geriatrics

Use with Caution

REKOOL INJECTION should be used with caution in elderly patients.

Interactions

A. Drug – Drug Interactions:

Before taking REKOOL INJECTION, inform your doctor if you are taking any of the following medicines such as:

• Antifungal agents (Ex. ketoconazole or itraconazole)
• Antiviral agents (Ex. atazanavir)
• Cancer medicines (Ex. methotrexate)
• corticosteroids (used to manage pain and inflammation) such as prednisolone

Overdosage:

If you or anyone else accidentally took more REKOOL INJECTION, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

To know more about this medicine:

FAQs About REKOOL INJECTION

Q: What are the uses of REKOOL INJECTION?

A: REKOOL INJECTION is used to manage Gastro-esophageal Reflux Disease (GERD), peptic ulcer and Zollinger-Ellison syndrome (tumours in the pancreas causing the stomach to secrete more acid).

Q: How REKOOL INJECTION works?

A: REKOOL INJECTION is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances for acid reflux into the oesophagus, heals peptic ulcers and esophageal lesions and manages its recurrence.

Q: How long will it take for REKOOL INJECTION to manage my disease?

A: The time taken for healing depends on the severity of the disease. You may notice improvement in your condition within 1-2 days of therapy with REKOOL INJECTION. However, it may take several weeks for REKOOL INJECTION to completely heal the ulcers.

Q: When should I take REKOOL INJECTION?

A: REKOOL INJECTION should be taken on an empty stomach at mornings. It can also be taken before a meal.

Q: What are the long-term side effects of REKOOL INJECTION?

A: Taking REKOOL INJECTION especially over the time of a year can slightly increase the risk of hip, wrist, or spine fracture. Inform your doctor if you suffer from osteoporosis or if you are taking corticosteroids which can increase the risk of osteoporosis. It may also cause vitamin B12 deficiency and low magnesium levels in the blood.

Q: Can I stop taking REKOOL INJECTION once my symptoms subside?

A: Do not stop taking REKOOL INJECTION without consulting your doctor even if you feel better during the midway of the therapy. Make sure to take REKOOL INJECTION for the stipulated duration recommended by your doctor to achieve complete healing of ulcers.

Q: What is the best time to take REKOOL INJECTION?

A: REKOOL INJECTION should be taken while you are on empty stomach in the morning. It can also be taken before a meal.

Q: What to do if I forgot to take a dose of REKOOL INJECTION?

A: If you have missed a dose of REKOOL INJECTION, take it as soon as you remember. However, if it is time for the next dose of REKOOL INJECTION, skip the missed dose and take the next one regularly. Do not take a double dose of REKOOL INJECTION to compensate the missed ones.

Q: What precautions should be followed while taking REKOOL INJECTION?

A: Before taking REKOOL INJECTION inform your doctor if you have any liver problems. You must also inform your doctor if you have vitamin B12 deficiency, osteoporosis or any tumors in your stomach. Do not take REKOOL INJECTION if you are pregnant or breastfeeding without consulting your doctor. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail. You must also inform your doctor immediately if you experience severe uncontrollable diarrhea with stomach pain or tenderness after taking REKOOL INJECTION.

Q: Can I consume alcohol while taking REKOOL INJECTION?

A: Avoid consumption of alcohol while taking REKOOL INJECTION as it could aggravate your ulcers and delays the healing process.

Q: Can I take REKOOL INJECTION daily?

A: Take REKOOL INJECTION as advised by your physician. Your doctor will evaluate your health condition and suggest whether can you take REKOOL INJECTION every day or not.

Q: Can the use of REKOOL INJECTION affect the liver?

A: Yes. REKOOL INJECTION may affect the way your liver work. Therefore, it should be used with caution in patients with liver problems.

Q: Can REKOOL INJECTION be taken during pregnancy?

A: REKOOL INJECTION is not recommended for use in pregnant women.

References

1. KD. Tripathi. Drugs for Peptic Ulcer and GERD. Essentials of medical pharmacology. Seventh edition. 2013. Page – 653

2. Seiichi Hayato, Setsuo Hasegawa, Seiichiro Hojo, Hiroki Okawa, Hiroaki Abe, Nobuyuki Sugisaki, Masahiro Munesue, Yukio Horai, Akihiro Ohnishi. Dose-response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes. NIH National Library of Medicine, National Center for biotechnology information. Pubmed.gov. May 2012. [Accessed on 1st October 2024]. click here

3. Eisai GmbH. Electronic Medicines Compendium (EMC). Revised in May2021. [Accessed on 10th May 2024]. click here

4. Eisai R&D Management Co., Ltd. U.S. Food and Drug Administration. [Revised in December 2014]. [Accessed on 1st October 2024]. click here

5. Veloz 40. Rabeprazole Gastro-resistant Tablet. Torrent Pharmaceutical Ltd. [Revised in June 2022]. [Accessed on 1st October 2024]. click here

Useful Diagnostic Tests

• Ultrasound
• Endoscopy
• Liver Function Test
• Complete Blood Count

Author Details

Written By Srilekha. R - B.Pharm

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 12 Nov 2024 | 03:43 PM(IST)