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Quality Checked ProductsIntroduction About QLAIRA TABLET
QLAIRA Tablet is used to stop pregnancy and manage heavy menstrual bleeding (not caused by any disease of the womb) in women who wish to use oral contraception. It is a combination of Estradiol valerate and Dienogest, which belongs to the group of medicines called Oral contraceptives.
Take one tablet every day with water, with or without food. Do not crush or chew the tablet.
QLAIRA Tablet is not recommended to take if you have or have had blood clots, heart problems, diabetes, migraine, liver disease, tumours, or vaginal bleeding. Before taking QLAIRA Tablet, inform your doctor if you have or had jaundice, diabetes, depression, tumours, liver, kidney, gall bladder disease, a high level of fat in your blood, Crohn’s disease, sickle cell anemia, vein inflammation, epilepsy, or trouble with a previous pregnancy.
Your doctor might check your blood pressure and carry out other tests before giving you this tablet.
QLAIRA Tablet is used only by women. It is not recommended for use in women whose periods have not yet started or in women after menopause. QLAIRA Tablet is not recommended for use by pregnant or breastfeeding women. Do not smoke while taking QLAIRA Tablet.
The most common side effects of taking QLAIRA Tablet are headaches, nausea, abdominal pain, acne, and weight gain. Consult your doctor if the symptoms worsen.
If you experience mood changes and depressive symptoms, contact your doctor for further medical advice as soon as possible.
Uses Of QLAIRA TABLET
- It is used to stop pregnancy
- To manage heavy menstrual bleeding (not caused by any disease of the womb)
How QLAIRA TABLET Works
QLAIRA Tablet is a combination of Estradiol valerate and Dienogest, which works by stopping pregnancy by suppressing ovulation (the release of eggs). Changes in the integrity of the endometrium (the lining shed during periods) and cervical mucus may occur, resulting in unfavourable conditions for the penetration of sperm and a reduced likelihood of implantation.
How to use QLAIRA TABLET
Take QLAIRA with or without meals, or as advised by your physician. It can be taken with or without food. Swallow one tablet daily with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Side Effects Of QLAIRA TABLET
Common
- headache
- abdominal pain, nausea
- acne
- no periods, breast discomfort, painful periods, irregular bleeding (heavy irregular bleeding)
- weight gain
Uncommon
- fungal infections, fungal infection of the vulva and vagina, vaginal infection
- increased appetite
- depression, depressed mood, emotional disorder, problems sleeping, decreased interest in sex, mental disorder, mood swings
- dizziness, migraine
- hot flush, high blood pressure
- diarrhoea, vomiting
- hair loss
- excessive sweating (hyperhidrosis), itching, and rash
- muscle cramps
- swollen breasts, lumps in the breast, abnormal cell growth on the neck of the womb (cervical dysplasia), dysfunctional genital bleeding, pain with intercourse, fibrocystic breast disease, heavy periods, menstrual disorders, ovarian cyst, pelvic pain, premenstrual syndrome, growth in the uterus, contractions of the uterus, uterine/vaginal bleeding, spotting, vaginal discharge, vulvovaginal dryness
- fatigue, irritability, swelling of parts of your body, Ex. ankles (oedema)
- weight loss, and blood pressure changes
Rare
- fungal infections, urinary tract infections, and bacterial inflammation of the vagina
- aggression, anxiety, feelings of unhappiness, increased interest in sex, nervousness, nightmare, restlessness, problems sleeping, stress
- reduced attention, “pins and needles,” giddiness
- contact lens intolerance, dry eye, eye swelling
- heart attack (myocardial infarction), palpitations
- bleeding in a varicose vein, low blood pressure, inflammation of superficial veins, painful veins
- harmful blood clots in a vein or artery in the heart, lungs, etc
- constipation, dry mouth, indigestion, and heartburn
- liver nodules (focal nodular hyperplasia), chronic inflammation of the gallbladder
- allergic skin reactions, golden brown pigment patches (chloasma) and other pigmentation disorders, male pattern hair growth, excessive hair growth, skin conditions such as dermatitis and neurodermatitis, dandruff and oily skin (seborrhoea), and other skin disorders
- back pain, pain in the jaw, sensation of heaviness
- urinary tract pain
- abnormal withdrawal bleeding, benign breast nodules, breast cancer in early stages, breast cysts, breast discharge, polyp on the neck of the womb, reddening on the neck of the womb, bleeding during intercourse, spontaneous milk flow, genital discharge, lighter periods, delayed periods, rupture of an ovarian cyst, vaginal odour, burning sensation in the vulva and vagina, vulvovaginal discomfort
- swollen lymph nodes
- asthma, difficulty breathing, and nose bleeding
- chest pain, tiredness, feeling generally unwell, and fever
- abnormal smear from the neck of the womb
Stop taking QLAIRA and contact your doctor immediately if you experience any of the following side effects, such as:
- severe allergic reaction (such as swollen face, tongue, or throat and/or difficulty swallowing or hives, together with difficulty breathing)
- suicidal thoughts
- signs and symptoms of deep vein thrombosis, such as swelling of one leg or along a vein in the leg or foot, especially when accompanied by pain or tenderness in the leg, which may be felt only when standing or walking, increased warmth in the affected leg, and a change in colour of the skin on the leg, such as turning pale, red, or blue
- signs and symptoms of pulmonary embolism such as sudden unexplained breathlessness or rapid breathing, sudden cough along with blood, sharp chest pain that may increase with deep breathing, severe lightheadedness or dizziness, rapid or irregular heartbeat, and severe pain in your stomach
- signs and symptoms of retinal vein thrombosis (blood clots in the eye), such as immediate loss of vision and painless blurring of vision, which can progress to loss of vision
- signs and symptoms of a heart attack include chest pain, discomfort, pressure, heaviness, sensation of squeezing or fullness in the chest, arm, or below the breastbone, fullness, indigestion or choking feeling, upper body discomfort radiating to the back, jaw, throat, arm, and stomach, sweating, nausea, vomiting, or dizziness, extreme weakness, anxiety, or shortness of breath, rapid or irregular heartbeats.
- signs and symptoms of stroke such as sudden weakness or numbness of the face, arm, or leg, especially on one side of the body, sudden confusion, trouble speaking or understanding, sudden trouble seeing in one or both eyes, sudden trouble walking, dizziness, loss of balance or coordination, sudden, severe, or prolonged headache with no known cause, loss of consciousness or fainting with or without seizure
- signs and symptoms of blood clots blocking other blood vessels, such as swelling and slight blue discolouration of an extremity and severe pain in your stomach
How To Manage Side Effects
Headache
Ensure adequate fluid intake, as dehydration can cause headaches. Maintain a consistent sleep schedule, aiming for 7-9 hours of quality sleep per night. Eat balanced meals at regular intervals to avoid blood sugar fluctuations that can trigger headaches. Practice relaxation techniques such as meditation, yoga, or deep breathing exercises to reduce stress levels. Engage in regular physical exercise, which can help reduce the frequency and severity of headaches. Apply a cold pack or warm compress to the forehead or neck to alleviate pain. Consult your doctor if a headache persists.
Nausea And Vomiting
Stay hydrated with small sips of clear fluids like water, ginger ale, or electrolyte solutions. Avoid consuming large meals; instead, opt for bland, easy-to-digest foods. Ginger, peppermint, or chamomile tea may help soothe the stomach. Rest in a comfortable position, preferably with your head elevated, to ease symptoms. Consult your doctor if nausea persists.
Skin Conditions
Wash your face twice daily with a gentle, non-comedogenic cleanser. Avoid scrubbing too hard, as this can irritate the skin and worsen acne. Use a moisturizer suitable for acne-prone skin, preferably oil-free and non-comedogenic. Use a gentle exfoliant once or twice a week to remove dead skin cells that can clog pores. Look for products with salicylic acid or glycolic acid.
Stomach Pain
Avoid spicy or fatty foods, caffeine, or alcohol that may exacerbate symptoms. Eat a bland diet consisting of easily digestible foods like rice, bananas, applesauce, and toast. Applying a heating pad or taking a warm bath can also help soothe abdominal muscles and alleviate discomfort. Drink plenty of fluids to stay hydrated, but avoid excessive consumption to prevent further irritation. If stomach pain persists, consult your doctor.
Weight Gain
Focus on a diet rich in fruits, vegetables, lean proteins, whole grains, and healthy fats. Limit your intake of processed foods, sugary beverages, and high-fat snacks. Be mindful of portion sizes to avoid overeating. Use smaller plates and bowls to help control portions. Eat regular meals and snacks to maintain energy levels and prevent overeating later in the day. Avoid skipping meals.
Warning & Precautions
Pregnancy
ContraindicatedDo not take QLAIRA Tablet if you are pregnant. If you become pregnant while taking QLAIRA Tablet, stop taking it immediately and contact your doctor. If you want to become pregnant, you can stop taking QLAIRA Tablet at any time.
Breastfeeding
ContraindicatedQLAIRA Tablet is not recommended for use by breastfeeding women. Consult your doctor if you wish to take.
Driving and Using Machines
SafeThere is no effect on driving or using machines after taking the QLAIRA Tablet.
Kidney
Use with CautionQLAIRA Tablet should be used with caution in patients with kidney insufficiency or hemolytic uraemic syndrome. Therefore, consult your doctor before taking QLAIRA Tablet.
Liver
Consult your doctorQLAIRA Tablet is not recommended for use in patients with liver diseases or tumour in the liver. It should be used with caution in patients with liver problems such as jaundice. Therefore, consult your doctor before taking.
Allergy
ContraindicatedDo not take QLAIRA Tablet if you are allergic to Estradiol valerate, Dienogest, or any other ingredients in this medicine.
Lungs
ContraindicatedQLAIRA Tablet is not recommended for use if you have blood clots in the blood vessels of the lungs. Therefore, consult your doctor before taking QLAIRA Tablet.
Heart Disease
Consult your doctorQLAIRA Tablet is not recommended for use in patients with severe heart diseases (such as any recent heart attack or stroke, angina pectoris, transient ischaemic attack, or severe high blood pressure). It should be used with caution in patients with heart problems (valve disorder, disturbance of the rhythm called atrial fibrillation), and cardiac insufficiency. Therefore, consult your doctor before taking QLAIRA Tablet.
Use In Pediatrics
ContraindicatedQLAIRA Tablet is not recommended for use in females whose periods have not started. There is no information available on the use of QLAIRA Tablet in children under 18 years of age. Consult your doctor before taking.
Use In Geriatrics
ContraindicatedQLAIRA is not recommended for use by women who have reached menopause. Consult your doctor before taking.
Others
QLAIRA Tablet is not recommended for use if you:
- have (or have ever had) a blood clot in a blood vessel of your legs (deep vein thrombosis), your lungs (pulmonary embolus), or other organs
- have a disorder affecting your blood clotting (for instance, protein C deficiency, protein S deficiency, antithrombin-III deficiency, Factor V Leiden, or antiphospholipid antibodies)
- need an operation, or if you have been off your feet for a long time
- have any of the following diseases that may increase your risk of a clot in the arteries: severe diabetes with blood vessel damage; a very high level of fat in the blood (cholesterol or triglycerides); (a condition known as hyperhomocysteinaemia)
- have (or have ever had) a type of migraine called ‘migraine with aura.
- have (or have ever had) cancer or suspected cancer of the breast or genital organs
- have any unexplained bleeding from the vagina
Before taking QLAIRA Tablet, inform your doctor:
- if a close relative has or has ever had breast cancer
- if you have a disease of the gall bladder
- if you have diabetes
- if you have depression
- if you have Crohn’s disease or ulcerative colitis (chronic inflammatory bowel disease)
- if you have systemic lupus erythematosus (SLE – a disease affecting your natural defense system)
- intolerant to certain sugars
- if you have sickle cell anaemia (an inherited disease of the red blood cells)
- if you have elevated levels of fat in the blood (hypertriglyceridemia) or a positive family history for this condition.
- if you need an operation or are off your feet for a long time
- if you have just given birth, you are at an increased risk of blood clots
- if you have inflammation in the veins under the skin (superficial thrombophlebitis).
- if you have varicose veins.
- if you have epilepsy
- if you have a disease that first appeared during pregnancy or earlier use of sex hormones (for example, hearing loss, porphyria, gestational herpes, or Sydenham’s chorea)
- if you have (or have ever had) golden brown pigment patches, so-called “pregnancy patches,” especially on the face (Chloasma)
- if you have hereditary or acquired angioedema
- if you smoke
- if you are overweight
- if a member of your immediate family has had a heart attack or stroke at a young age (less than about 50)
- if you, or someone in your immediate family, has a high level of fat in the blood (cholesterol or triglycerides)
Interactions
A. Drug-drug interactions
- Antiepileptics (Ex. primidone, lamotrigine, phenytoin, barbiturates, carbamazepine, oxcarbazepine, topiramate, and felbamate)
- Antituberculosis (Ex. rifampicin)
- Other contraceptives
- Antivirals (such as ritonavir, nevirapine, efavirenz, ombitasvir/paritaprevir/ritonavir with or without dasabuvir, as well as the regimen glecaprevir/pibrentasvir)
- Antifungals (Ex. griseofulvin, ketoconazole)
- Antidepressant (Ex. St. John's wort)
- Immunosuppressant (Ex. cyclosporin)
Overdosage:
If you or anyone else accidentally took more QLAIRA, consult your doctor or visit the nearby hospital. Symptoms of overdosage include feeling sick, throwing up, and bleeding from the vagina, as well as severe diarrhea.
Synopsis
| Drug | : | Estradiol valerate, Dienogest |
| Pharmacological Category | : | Estrogen, Progesterone |
| Therapeutic Indication | : | Stop pregnancy and severe menstrual bleeding |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep QLAIRA out of the reach of children
- Store QLAIRA at room temperature
FAQs About QLAIRA TABLET
Q: How does QLAIRA work?
A: QLAIRA stops pregnancy primarily by inhibiting ovulation (the release of an egg from the ovary). It also thickens the cervical mucus to hinder sperm movement and alters the uterine lining to prevent implantation.
Q: How should I take QLAIRA?
A: Start on the first day of your menstrual period. Take one tablet daily, following the order on the blister pack. Take the tablet at the same time each day with water. QLAIRA packs contain 28 pills with varying hormone levels, so follow the sequence as indicated. Do not skip any pills between packs.
Q: What if I miss a pill?
A: Less than 12 hours late: Take the missed pill as soon as you remember. Continue taking the next pills at your usual time. More than 12 hours late: Take the missed pill immediately and the next one at your usual time, even if it means taking two pills in one day. Use additional contraception (e.g., condoms) for the next 9 days. Specific instructions for missed pills vary based on which week of the pack the pill was missed; consult the package insert for detailed guidance.
Q: What are the benefits of QLAIRA?
A: Effective contraception when taken as directed. May reduce menstrual bleeding and associated pain. Potential improvement in menstrual cycle regularity.
Q: What are the side effects of QLAIRA?
A: The most common side effects of taking QLAIRA are headaches, nausea, abdominal pain, acne, and weight gain. Consult your doctor if the symptoms worsen.
Q: Who should not take QLAIRA?
A: QLAIRA is not recommended to take if you have or have had blood clots, heart problems, diabetes, migraine, liver disease, tumours, or vaginal bleeding.
Q: Can QLAIRA interact with other medications?
A: Yes, certain medications can reduce the effectiveness of QLAIRA, including some antibiotics (e.g., rifampicin), anti-epileptic drugs (e.g., phenytoin, carbamazepine), and herbal supplements like St. John’s Wort. Always inform your healthcare provider about all the medications and supplements you are taking.
Q: What should I do if I experience severe side effects?
A: Seek immediate medical attention if you experience symptoms of a blood clot (e.g., sudden chest pain, difficulty breathing, severe leg pain, or swelling). Signs of a stroke (e.g., sudden weakness or numbness, difficulty speaking, vision changes), Severe headache or migraine. Yellowing of the skin or eyes (jaundice).
Q: Can I use QLAIRA if I am breastfeeding?
A: QLAIRA is not recommended for breastfeeding mothers as it may reduce milk production and pass hormones to the baby. Consult your healthcare provider for alternative contraception methods.
Q: What should I do if I want to stop taking QLAIRA?
A: If you decide to stop taking QLAIRA, you can do so at any time. However, if you want to avoid pregnancy, use another form of contraception immediately. Discuss with your healthcare provider to choose the best alternative method.
Q: Can I buy QLAIRA online?
A: To purchase QLAIRA Tablet online, visit an online pharmacy website like Netmeds, search for the product, add it to your cart, and proceed to checkout. If you wish to buy QLAIRA Tablet on Netmeds, you need a prescription from a registered medical practitioner. Netmeds has made buying online medicines more easy for consumers and is one of India's leading online pharmacies.
References
1. K.D. Tripathi. Androgens and Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 303-304.
2. What role for Qlaira in contraception? NIH National Library of Medicine, National Center for Biotechnology Information. PubMed. September 2010. [Accessed on 20th May 2024] https://pubmed.ncbi.nlm.nih.gov/20810709/
3. Uche Anadu Ndefo and Nina Mosely, Estradiol Valerate and Estradiol Valerate/Dienogest (Natazia) Tablets. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. November 2010. [Accessed on 20th May 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993067/
4. Bayer Weimar GmbH und Co. Electronics Medicines Compendium (EMC). [Revised In April 2022] [Accessed on 20th May 2024] https://www.medicines.org.uk/emc/files/pil.6536.pdf https://www.medicines.org.uk/emc/product/6536/smpc#about-medicine
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Liver Function Test (LFT)
- Healthy Midlife Checkup
- Men Health Checkup - Advanced
- Complete Women Checkup
- Full Body Checkup - Gold
- Elderly Checkup – Female
- Elderly Checkup - Male
- Full Body Checkup – Silver
Author Details
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