Pulmosil 10mg Injection 12.5ml
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INTRODUCTION
PULMOSIL 10MG contains Sildenafil which belongs to the group of medicines called Phosphodiesterase type 5 (PDE 5) inhibitors. It is used in adults to manage pulmonary arterial hypertension (PAH). PAH can be defined as an increased blood pressure in the blood vessels that supplies the lungs. It can be caused due to narrowing of blood vessels (arteries) supplying the heart and the lungs. Symptoms of PAH might include shortness of breath, tiredness, weakness, and feeling faint.
Sildenafil reduces blood pressure within the lungs by relaxing the blood vessels supplying the lungs. This enhances blood flow and oxygen supply to the lungs which ultimately reduces pressure within the lungs and improves its functions. PULMOSIL 10MG should be used in patients who temporarily cannot take any medicines orally to manage pulmonary arterial hypertension.
Before receiving PULMOSIL 10MG inform your doctor if you have any liver, kidney, or heart problems. It should be used with caution in patients with eye problems, stomach problems, anemia, or penile deformity. Avoid consuming grapefruit juice just before receiving PULMOSIL 10MG, as it may increase the risk of side effects.
PULMOSIL 10MG should be used in pregnant or breastfeeding women only if it is considered necessary by the physician. Women of childbearing potential should use suitable contraceptive method to avoid pregnancy while undergoing therapy with PULMOSIL 10MG. It is also not recommended for use in children and adolescents (below 18 years).
The most common side effects of PULMOSIL 10MG are headache, muscle pain or stiffness, dizziness, blurred vision, or flushing. Consult your doctor if any of the side effect troubles you. Also inform your doctor if you experience any painful or prolonged erections after receiving PULMOSIL 10MG.
USES OF PULMOSIL 10MG
- Manages pulmonary arterial hypertension in adults
HOW PULMOSIL 10MG WORKS
PULMOSIL 10MG reduces blood pressure within the lungs, where sildenafil acts by blocking the effects of certain enzymes (PDE5) which limits blood flow to the lungs. As a result, it causes widening of blood vessels (arteries) supplying the lungs, improves blood supply to the lungs and enhances pulmonary functions.
DIRECTIONS FOR USE
PULMOSIL 10MG will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF PULMOSIL 10MG
COMMON
- flushing, fever
- headache, shaking and migraine
- effects on nose (nosebleed, stuffy nose, runny nose and inflammation of sinuses)
- effects on vision (includes light sensitivity, blurred vision, color tinge to vision, visual disturbance, eye irritation, red eyes)
- nausea
- low blood pressure
- pain in legs, arms, back and muscles
- night sweats
- infection under skin and redness
- decreased number of RBCs
- flu-like symptoms
- anxiety
- difficulty in sleeping
- retention of fluid
- reduced sense of touch or pricking of pins and needles sensation
- vertigo (spinning sensation)
- dry mouth
- digestive system issues (stomach pain, outward swelling of the stomach, indigestion, heartburn and piles)
- cough
- diarrhea
UNCOMMON
- eye problems (reduced sharpness of vision, double vision and abnormal sensation in the eye)
- breast enlargement in men
- presence of blood in semen/ urine
- penile bleeding
RARE
Consult your doctor immediately if you experience any of the following side effects after receiving PULMOSIL 10MG:
- prolonged or painful erection
- decreased or loss of vision in one or both eyes
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
PULMOSIL 10MG is generally not recommended for use in pregnant unless considered necessary by the physician. Therefore, consult your doctor before receiving it. Women of child-bearing potential should use proper contraceptive method to avoid pregnancy while undergoing therapy with PULMOSIL 10MG.
BREASTFEEDING
PULMOSIL 10MG should be used with caution for use in breastfeeding women. Therefore, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience dizziness or blurred vision after receiving PULMOSIL 10MG.
ALCOHOL
Avoid consumption of alcohol while receiving PULMOSIL 10MG as it may reduce the effectiveness of PULMOSIL 10MG.
KIDNEY
PULMOSIL 10MG should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
LIVER
PULMOSIL 10MG is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Therefore, consult your doctor before receiving it.
ALLERGY
Do not receive PULMOSIL 10MG if you are allergic to Sildenafil.
LUNGS
PULMOSIL 10MG should be used with caution in patients with pulmonary hypertension caused due to narrowing or blockade of veins (instead of arteries). Consult your doctor before receiving it.
HEART DISEASE
PULMOSIL 10MG is not recommended for use in patients with severe heart diseases (such as any recent heart attack or stroke, or severe low blood pressure). It should be used with caution in patients with other heart problems (such as problems in heart chambers or valves, low blood pressure at rest). Therefore, consult your doctor before receiving it.
OTHERS
PULMOSIL 10MG is not recommended for use if you:
- previously had loss of vision due to non-arteritic anterior ischaemic optic neuropathy (NAION; a type of nerve damage caused due to lack of blood and oxygen supply to the eye)
Before receiving PULMOSIL 10MG inform your doctor if you:
- have sickle cell anaemia (an inherited blood disorder characterized by low RBC count)
- have any type of rare inherited eye diseases (such as retinitis pigmentosa)
- have cancers of blood (leukaemia) or bone marrow (multiple myeloma)
- have penile deformation
- have Peyronie’s disease (development of fibrous scar tissue that results in painful erection)
- have stomach ulcer or bleeding disorder such as haemophilia
- have nosebleeds
- have dehydration due to diarrhoea, fever, or less intake of fluids or increased sweating
Use in pediatrics:
PULMOSIL 10MG is not recommended for children and adolescents (under the age of 18 years). Therefore, consult your doctor before receiving.
Use in geriatrics:
PULMOSIL 10MG should be used with caution in elderly patients. Therefore, consult your doctor before receiving.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving PULMOSIL 10MG, inform your doctor if you are taking any of the following:
- nitrates or amyl nitrites (used for reliving chest pains) Ex. nitroglycerin and isosorbide dinitrite
- other medicines used to manage PAH (Ex. riociguat, bosentan or iloprost)
- medicines used to manage prostate problems or blood pressure such as alpha-blocker (Ex. silodosin, doxazosin)
- ketoconazole or itraconazole (used to manage fungal infections)
- St. John’s wort or nefazodone (used to manage depression)
- antibiotics (used to manage bacterial infections) Ex. erythromycin, clarithromycin and telithromycin
- rifampicin (used in management of tuberculosis)
- saquinavir and ritonavir (used to manage HIV infections)
- medicines used for blood thinning (Ex. warfarin)
- medicines used to manage epilepsy (Ex. carbamazepine, phenytoin, and phenobarbital)
- medicines used to manage erectile dysfunction (Ex. tadalafil)
B. Drug-Food Interactions:
Avoid drinking grapefruit juice while receiving PULMOSIL 10MG as it may increase the risk of side effects.
Overdosage:
PULMOSIL 10MG will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms contact your doctor immediately.
SYNOPSIS
| Drug | : | Sildenafil |
| Pharmacological Category | : | Phosphodiesterase type 5 inhibitors |
| Therapeutic Indication | : | Pulmonary Arterial Hypertension |
| Dosage Forms | : | Tablet, Capsule, Oral Disintegrating Strips, Oral Jelly, Injection, Effervescent Tablet, Spray |
MORE INFORMATION
- Keep PULMOSIL 10MG out of reach of children
- Store PULMOSIL 10MG at room temperature
FAQs ABOUT PULMOSIL 10MG
What are the uses of PULMOSIL 10MG?
PULMOSIL 10MG is used to manage pulmonary arterial hypertension (PAH) in adults. It reduces blood pressure within the lungs by relaxing the blood vessels supplying the lungs.
What does PULMOSIL 10MG do?
PULMOSIL 10MG reduces blood pressure within the lungs, where sildenafil acts by blocking the effects of certain enzymes (PDE5) which limits blood flow to the lungs. As a result, it causes widening of blood vessels (arteries) supplying the lungs, improves blood supply to the lungs and enhances pulmonary functions.
How to take PULMOSIL 10MG?
PULMOSIL 10MG is not meant for self-administration. It will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Can elderly men receive PULMOSIL 10MG ?
Yes. PULMOSIL 10MG should be used with caution in elderly patients, especially if they have any pre-existing heart conditions and taking medicines for it. Consult your doctor before receiving.
Can PULMOSIL 10MG be used in women?
Yes. PULMOSIL 10MG can be used in women for manageing pulmonary arterial hypertension. However, it should be used in pregnant or breastfeeding women only if considered necessary by the physician. Therefore, consult your doctor before receiving it. Women of child-bearing potential should use proper contraceptive method to avoid pregnancy while undergoing therapy with PULMOSIL 10MG.
Can PULMOSIL 10MG manage erectile dysfunction?
No. PULMOSIL 10MG is not meant for manageing erecrtile dysfunction. It is used for manageing pulmonary arterial hypertension in adults. If you wish to manage erectile dysfunction, consult your doctor for advice. Your doctor would either prescribe a higher dose of sildenafil or suggest an alternative therapy based on your medical condition.
What are the side effects of PULMOSIL 10MG?
The most common side effects of PULMOSIL 10MG are headache, dizziness, blurred vision, or flushing. Consult your doctor if any of the side effect troubles you. Also inform your doctor if you experience any painful or prolonged erections after receiving PULMOSIL 10MG.
Can PULMOSIL 10MG affect sexual performance?
No. PULMOSIL 10MG is used to reduce increased blood pressure in the lungs. It may have influence on erection but cannot improve sexual performance.
Can PULMOSIL 10MG cause painful erections?
Yes. PULMOSIL 10MG may cause painful and prolonged erections. Inform your doctor if you experience any such effects.
What medicines should I avoid while taking PULMOSIL 10MG?
Before receiving PULMOSIL 10MG, inform your doctor about all the medicines that you use to manage your current illnesses. Avoid concomittant use of similar medicines which can relaxes your blood pressure such as nitrates (Ex. nitroglycerin). It is also important to inform your doctor about the use of antibiotics (Ex. erythromycin, clarithromycin, telithromycin, rifampicin), antivirals (Ex. saquinavir and ritonavir) and antiepiletic drugs (Ex. carbamazepine, phenytoin) before undergoing management with PULMOSIL 10MG.
Can I consume alcohol before receiving PULMOSIL 10MG?
No. Consumption of alcohol before receiving PULMOSIL 10MG may reduce the effectiveness of this medicine. Avoid alcohol to achieve maximum benefits of PULMOSIL 10MG.
REFERENCES
1. K.D. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page – 303-304.
2. Sukhdeep Bhogal, Ola Khraisha, Mohammad Al Madani, Jennifer Treece, Steven Baumrucker and Timir K Paul. Sildenafil for Pulmonary Arterial Hypertension. NIH National Library of Medicine, National center for biotechnology information. Jul/Aug 2019. [Accessed on 6th May 2022] https://pubmed.ncbi.nlm.nih.gov/30946047/
3. Yen-Chun Lai, Karin C. Potoka, Hunter C. Champion, Ana L. Mora and Mark T. Gladwin. Pulmonary Arterial Hypertension: The Clinical Syndrome. June 2014. [Accessed on 6th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096686/pdf/nihms598840.pdf
4. Pfizer Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 18th April 2022] https://www.medicines.org.uk/emc/files/pil.458.pdfc
5. Upjohn UK Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 18th April 2022] https://www.medicines.org.uk/emc/product/458/smpc#gref
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
