Premarin 0.3mg Tablet 28'S
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INTRODUCTION
PREMARIN 0.3MG contains Conjugated estrogens which belongs to the group of medicines called Hormone Replacement Therapy. It is used among postmenopausal women to relieve menopausal symptoms such as hot flushes, sleep problems, irritability, and depression.
It can also be used to prevent osteoporosis (bone loss and fragility) among postmenopausal women who are at risk of developing fractures easily. PREMARIN 0.3MG should be used only in women who do not have their period at least for the past 6 months.
Conjugated estrogen is a synthetic derivative of a female sex hormones called estrogen. It supplements our body with sufficient levels of estrogens which usually becomes deficient during menopause. As a result, it provides relief from postmenopausal symptoms such as hot flushes, sleep problems, irritability, depression, and bone loss.
PREMARIN 0.3MG is not a contraceptive (birth control pill), therefore it cannot prevent you from becoming pregnant. Women who are in pre-menopause (less than 6 months from last periods) or aged below 50 years must use a suitable contraceptive method to prevent pregnancy.
During management with PREMARIN 0.3MG, your doctor will instruct you to have periodic blood tests and regular physical examination (breast examination) to avoid the risk of unwanted side effects. Avoid drinking grapefruit juice while taking PREMARIN 0.3MG as it may interfere with the effects of PREMARIN 0.3MG.
Do not take PREMARIN 0.3MG if you have or previously had breast cancer, uterine cancer, unexplained vaginal bleeding, heart problems or blood clots. Before taking PREMARIN 0.3MG inform your doctor if you have any liver or kidney problems, diabetes, migraine headache, asthma, or epilepsy.
PREMARIN 0.3MG is not intended for use in pregnant and breastfeeding women. The most common side effects of taking PREMARIN 0.3MG are stomach pain, headache, vaginal infection, or vaginal discharge, weight gain, memory loss and changes in libido. Consult your doctor if any of these side effect worsens.
Also, inform your doctor if you experience any changes in your breast such as breast pain, tenderness, discharge from the nipple, or lump growth in the breasts, heavy menstrual bleeding, pain, swelling, redness of the legs, sudden chest pain or difficulty in breathing.
USES OF PREMARIN 0.3MG
It is used in postmenopausal women to:
- relieve menopausal symptoms
- prevent osteoporosis
HOW PREMARIN 0.3MG WORKS
PREMARIN 0.3MG supplements our body with sufficient levels of female sex hormones (estrogen). This helps in manageing problems associated with hormonal deficiency states such as menopause. As a result, it provides relief from postmenopausal symptoms such as hot flushes, sleep problems, irritability, depression, and bone loss.
DIRECTIONS FOR USE
Take PREMARIN 0.3MG strictly as advised by your physician. Swallow PREMARIN 0.3MG with a glass of water. Do not crush or chew the medicine. Try to take PREMARIN 0.3MG at the same time each day.
Do not miss any dose of PREMARIN 0.3MG in between the therapy, as it may reduce its effectiveness. In case if you have missed a dose of PREMARIN 0.3MG take it as soon as you remember. Avoid taking a double dose of PREMARIN 0.3MG to compensate the missed dose it may lead to bleeding or spotting. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
SIDE EFFECTS OF PREMARIN 0.3MG
COMMON
- irregular menstrual bleeding
- vaginal infection (thrush)
- nausea, vomiting, bloating, abdominal pain
- headache, dizziness
- changes in mood such as depression, anxiety, and irritability
- memory loss
- joint pain, leg cramps
- increased or decreased libido (interest in sex)
- visible swelling of the face or ankles
- acne, rash, itchiness, and dark or red patches on the skin
- hair loss or excessive hair growth
- changes in weight
RARE
Stop taking PREMARIN 0.3MG and contact your doctor immediately if you experience any of the following side effects:
- unexplained vaginal bleeding
- signs of abdominal uterine bleeding (such as changes in menstrual flow, breakthrough bleeding or spotting, pelvic pain, vaginal inflammation, and vaginal discharge)
- signs of blood clots such as pain, swelling and redness of the legs, sudden chest pain, and difficulty in breathing
- signs of liver problems (such as yellowing of the skin or the whites of the eyes (jaundice))
- signs of high blood pressure (such as headache, tiredness, dizziness)
- migraine-like headache happening for the first time
- signs of allergic reaction (such as skin rash, itching, shortness of breath, difficulty in breathing, and a swollen face)
- inflammation of the colon (part of the intestine) which may present as lower left sided abdominal pain and/or bloody diarrhea
- growth of benign meningioma (a tumor of the membranes around the brain or spinal cord)
- signs of breast cancer (breast pain or tenderness, swollen breasts, discharge from the nipples and changes in breast tissue)
HOW TO MANAGE SIDE EFFECTS
Nausea and Vomiting:
Take PREMARIN 0.3MG with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
PREMARIN 0.3MG is not intended for use in pregnant women. However, if you are in pre-menopause (less than 6 months from last periods) or aged below 50 years, you must use a suitable contraceptive method to prevent pregnancy. Stop taking PREMARIN 0.3MG and consult your doctor immediately if you accidentally become pregnant while taking PREMARIN 0.3MG.
BREASTFEEDING
PREMARIN 0.3MG is not intended for use in breastfeeding women. Consult your doctor before taking.
DRIVING AND USING MACHINES
PREMARIN 0.3MG is unlikely to affect your ability to drive or to use machines. However, do not drive or operate any heavy tools or machines if your ability is affected by PREMARIN 0.3MG.
ALCOHOL
Avoid consumption of alcohol while taking PREMARIN 0.3MG, as it may increase the risk of side effects.
KIDNEY
PREMARIN 0.3MG should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.
LIVER
PREMARIN 0.3MG is not recommended for use in patients with severe liver diseases (Ex. benign liver tumor). Therefore, consult your doctor before taking it.
ALLERGY
Do not take PREMARIN 0.3MG if you are allergic to Conjugated estrogens.
LUNGS
PREMARIN 0.3MG is not recommended for use in patients having blood clots in their lungs (pulmonary embolism). It should be used with caution in patients having asthma. Therefore, consult your doctor before taking it.
HEART DISEASE
PREMARIN 0.3MG is not recommended for use in patients with heart problems (as heart attack). Therefore, consult your doctor before taking it.
OTHERS
PREMARIN 0.3MG is not recommended for use if you:
- have or previously had breast cancer
- have cancer in the uterus lining (endometrium), or if you are suspected of having it
- have any unexplained vaginal bleeding
- have unmanageed endometrial hyperplasia (excessive thickening of the layer of uterus)
- have or had blood clot in the veins (thrombosis, deep venous thrombosis, pulmonary embolism)
- have a blood clotting disorder (such as Protein C, Protein S, antithrombin deficiency)
- have porphyria (inherited disorder affecting RBC)
Before taking PREMARIN 0.3MG, inform your doctor if you:
- have fibroids (tumors growth in uterus)
- have endometriosis (a condition where inner lining of the uterus grows outside the uterus)
- have or had family history of breast cancer
- have diabetes
- have migraine (a neurological disease with symptoms of severe headache)
- have or ever had systemic lupus erythematosus (a serious disease in which immune system attacks its own body)
- have or ever had epilepsy
- have fluid retention
- have hypocalcemia (low blood calcium levels)
- have high blood fat levels
- have premature menopause
- have any blood tests to be done
- are overweight
- have or ever had hereditary and acquired angioedema
- have or ever had otosclerosis (disease affecting the eardrum and hearing)
- have any upcoming surgery
Use in pediatrics:
PREMARIN 0.3MG is generally not recommended for use in children and adolescents (aged below 18 years of age). Therefore, consult your doctor before taking it.
Use in geriatrics:
PREMARIN 0.3MG should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interaction:
Before taking PREMARIN 0.3MG, inform your doctor, if you are taking any of the following:
- medicines used to manage epilepsy (Ex. phenobarbital, phenytoin, carbamazepine)
- medicines used to manage tuberculosis (Ex. rifampicin, rifabutin)
- medicine used to manage HIV infection (Ex. nevirapine, efavirenz, ritonavir and nelfinavir)
- medicines used to manage bacterial infections (Ex. erythromycin, clarithromycin)
- medicines used to manage fungal infections (Ex. ketoconazole, itraconazole)
- St. john’s wort (an herbal medication used to manage depression)
- metyrapone (a medicine used to adrenal insufficiency)
- cimetidine (a medicine used to manage stomach ulcers)
- dexamethasone (a corticosteroid used to manage inflammation)
B. Drug-Food Interaction:
Avoid drinking grapefruit juice while taking PREMARIN 0.3MG as it may alter the effects of this medicine.
Overdosage:
If you or anyone else accidentally took more PREMARIN 0.3MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include nausea, breast tenderness, dizziness, stomach pain, drowsiness, weakness, and short periods of vaginal bleeding.
SYNOPSIS
| Drug | : | Conjugated Estrogens |
| Pharmacological Category | : | Synthetic Estrogen derivative |
| Therapeutic Indication | : | Menopausal symptoms, Osteoporosis |
| Dosage Forms | : | Tablet, Cream |
MORE INFORMATION
- Keep PREMARIN 0.3MG out of reach of children
- Store PREMARIN 0.3MG at room temperature
FAQs ABOUT PREMARIN 0.3MG
What is the use of PREMARIN 0.3MG?
PREMARIN 0.3MG is used to manage menopausal symptoms (such as hot flushes, sleep problems, irritability, or depression) and to prevent osteoporosis in postmenopausal women.
Can I stop taking PREMARIN 0.3MG once my symptoms subside?
No. Do not stop taking PREMARIN 0.3MG unless your doctor advises you to stop, because sudden termination of PREMARIN 0.3MG will not provide an expected result. Continue to take PREMARIN 0.3MG as advised by your doctor to achieve maximum benefits.
Can PREMARIN 0.3MG be used to prevent osteoporosis in healthy women?
PREMARIN 0.3MG is not used to prevent osteoporosis in healthy women. If you are at an increased risk of fractures due to osteoporosis and if other medicines are not suitable for you, then PREMARIN 0.3MG can be used to prevent osteoporosis after menopause.
What are the side effects of PREMARIN 0.3MG?
PREMARIN 0.3MG may cause few side effects like stomach pain, headache, vaginal infection, or vaginal discharge, weight gain, memory loss and changes in libido. Consult your doctor if any of these side effect worsens. Also, inform your doctor if you experience any changes in your breast such as breast pain, tenderness, discharge from the nipple, or lump growth in the breasts, heavy menstrual bleeding, pain, swelling, redness of the legs, sudden chest pain or difficulty in breathing.
What precautions need to be followed while taking PREMARIN 0.3MG?
Before taking PREMARIN 0.3MG inform your doctor if you have or previously had breast cancer, uterine cancer, unexplained vaginal bleeding, heart problems, blood clots, diabetes, or asthma. Take PREMARIN 0.3MG regularly as instructed by the physician without fail. Do not miss a dose of PREMARIN 0.3MG to achieve maximum benefits. Periodically undergo blood tests and breast examination as advised by your doctor without fail. Women aged below 50 years must use a suitable contraceptive method to avoid pregnancy while taking PREMARIN 0.3MG.
Can PREMARIN 0.3MG be used as a contraceptive?
No. PREMARIN 0.3MG is not a contraceptive (birth control pill) and therefore necessary safety measures must be followed to avoid pregnancy. If it is less than 12 months since your last menstrual period and you are under 50 years of age, you may still need to use an additional contraception to prevent pregnancy. In case if you become pregnant while taking PREMARIN 0.3MG stop taking PREMARIN 0.3MG and consult your doctor immediately.
Can PREMARIN 0.3MG be used to induce periods?
PREMARIN 0.3MG is not used to induce periods. It is intended for use in postmenopausal women to manage menopausal symptoms. It works by supplementing your body with sufficient female sex hormones.
Can PREMARIN 0.3MG be used in pregnant women?
No. PREMARIN 0.3MG not intended for use in pregnant women. It is used only in postmenopausal women to manage menopausal symptoms. Women taking PREMARIN 0.3MG must follow a suitable contraceptive method to avoid pregnancy. In case if you found to be pregnant stop taking PREMARIN 0.3MG and consult your doctor immediately.
Can PREMARIN 0.3MG cause cancer?
Current studies have shown that prolonged use of PREMARIN 0.3MG may lead to breast cancer. To avoid this, your doctor will constantly monitor your health condition through periodic blood tests and ultrasounds (breast examination). However, inform your doctor immediately if you experience any unusual symptoms such as severe breast pain or tenderness, purplish discoloration of breasts or discharge from nipples.
Can PREMARIN 0.3MG cause memory loss?
Yes. PREMARIN 0.3MG may cause memory loss in elderly women (above 60 years). Consult your doctor if you are experiencing forgetfulness or memory problems.
Who should not take PREMARIN 0.3MG?
PREMARIN 0.3MG is not recommended for use in patients who have or ever had breast cancer, or endometrial cancer (uterus cancer). It is also not recommended for use in patients having unexplained vaginal bleeding, increased thickening of uterus, or blood clot problems. Therefore, consult your doctor before taking it.
How to take PREMARIN 0.3MG?
Take PREMARIN 0.3MG strictly as advised by your physician. Swallow PREMARIN 0.3MG with a glass of water. Do not crush or chew the medicine. Try to take PREMARIN 0.3MG at the same time each day. Do not miss any dose of PREMARIN 0.3MG in between the therapy, as it may reduce its effectiveness. In case if you have missed a dose of PREMARIN 0.3MG take it as soon as you remember. Avoid taking a double dose of PREMARIN 0.3MG to compensate the missed dose as it may lead to bleeding or spotting.
REFERENCES
1. KD. Tripathi. Estrogens, Progestins and Contraceptives. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 310.
2. Marco Gambaccianicorresponding author1 and Marco Levancini1,2. Hormone replacement therapy and the prevention of postmenopausal osteoporosis. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 9 Sep 2014. [Accessed on 1st June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520366/
3. Pfizer Ireland Pharmaceuticals, Little Connell, Newbridge, County Kildare, Republic of Ireland. Electronic medicines compendium (EMC). [Revised in September 2020] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.5476.pdf
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