INTRODUCTION

POLY B 500000IU contains Polymyxin B which belongs to the group of medicines called Antibiotics. It is used to manage certain forms of serious bacterial infections when other antibiotics are not suitable. It is used to manage infections of the urinary tract (Ex. urinary tract infections), brain (Ex. meningeal infections) or blood (Ex. bacteremia) caused by susceptible gram-negative bacteria such as Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae or Pseudomonas aeruginosa.

Polymyxin B is a polypeptide antibiotic. It binds to the susceptible bacteria and disrupts the composition (lipids and protein) of the bacterial cell membrane. As a result, it makes the contents of the bacterial cell to leak out which subsequently leads to bacterial killing. It may also inactivate the toxins produced by the bacteria.

POLY B 500000IU should be used only under constant medical supervision. It is very important to complete the full course of therapy with POLY B 500000IU to achieve the maximum benefits. Therefore receive POLY B 500000IU regularly as instructed by your doctor. Failure to complete the full course of therapy or skipping doses in between the therapy may make the bacteria more resistant against POLY B 500000IU.

Before receiving POLY B 500000IU inform your doctor if you have any kidney problems. Your doctor will carefully monitor your kidney functions during management with POLY B 500000IU to avoid the risk of side effects.

Also, inform your doctor if you are already taking any antibiotics (such as bacitracin, colistin, neomycin, amikacin, cephalosporins, streptomycin, kanamycin, gentamicin, tobramycin, paromomycin or viomycin) before receiving POLY B 500000IU as a precaution.

There is no proper information regarding the use of POLY B 500000IU in pregnant or breastfeeding women. Therefore, inform your doctor before receiving POLY B 500000IU if you are pregnant, think you may be pregnant or breastfeeding.

The most common side effects of receiving POLY B 500000IU are fever, diarrhea or pain and swelling at the site of injection. These side effects are usually temporary and disappears when therapy is discontinued. However, consult your doctor if they worsen or becomes uncontrollable. You must also inform your doctor if you have sensation of numbness in hands and feet, facial flushing, dizziness, drowsiness, breathing difficulty or see any kidney cells in the urine.

USES OF POLY B 500000IU

It is used to manage bacterial infections affecting the:

• urinary tract (Ex. urinary tract infections)
• brain (Ex. meningeal infections)
• blood stream (Ex. bacteremia)

HOW POLY B 500000IU WORKS

POLY B 500000IU kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and protein) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.

DIRECTIONS FOR USE

POLY B 500000IU will be given to you only by a doctor or by a trained health care professional into the vein (intravenously), muscles (intramuscularly) or into the spine (intrathecally). Your doctor will decide the suitable dose, length of the therapy and site of administration for you depending upon your age, body weight and site and severity of the infection.

Receive POLY B 500000IU regularly as instructed by your doctor. Failure to complete the course of therapy or skipping doses in between the therapy may make the bacteria more resistant against POLY B 500000IU.

SIDE EFFECTS OF POLY B 500000IU

HOW TO MANAGE SIDE EFFECTS

Skin rash:

Avoid taking hot showers, as it may further irritate your skin. Use protective clothes while going outdoors. Avoid scratching the affected area of the skin. Regularly moisturize your skin. Consult your doctor if your condition worsens.

Pain, inflammation or swelling at the site of injection:

Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.

Fever:

Rest and relax. Drink plenty of fluids. Avoid taking cold bath or showers. If the fever prolongs for a longer time, consult your doctor immediately.

Diarrhea:

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-manage diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interaction:

Before receiving POLY B 500000IU, inform your doctor if you are taking any of the following medicines such as:

• muscle relaxants (used to relaxing muscles before surgery) such as ether, tubocurarine, gallamine, sodium citrate, decamethonium
• other antibiotics (used to manage infections) such as bacitracin, colistin, neomycin, amikacin, cephalosporins, streptomycin, kanamycin, gentamicin, tobramycin, paromomycin or viomycin

Overdosage:

POLY B 500000IU will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

MORE INFORMATION

• Keep this medicine out of reach of children.
• Before reconstitution: store the medicine at room temperature
• After reconstitution: store in a refrigerator 2-8°C

FAQs ABOUT POLY B 500000IU

What is the use of POLY B 500000IU?

POLY B 500000IU is an antibiotic used to manage serious bacterial infections. It is used only when other antibiotics are not suitable for you. It acts by killing the susceptible bacteria that causes infection.

What POLY B 500000IU does to my body?

POLY B 500000IU kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and protein) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.

What are the side effects of POLY B 500000IU?

The most common side effects of receiving POLY B 500000IU are fever, diarrhea or pain and swelling at the site of injection. These side effects are usually temporary and disappears when therapy is discontinued. However, consult your doctor if they worsen or becomes uncontrollable.

How POLY B 500000IU is administered?

POLY B 500000IU will be given to you only by a doctor or by a trained health care professional into the vein (intravenously), muscles (intramuscularly) or into the spine (intrathecally). Your doctor will decide the suitable dose, length of the therapy and site of administration for you depending upon your age, body weight and site and severity of the infection.

Can POLY B 500000IU be used in children?

Yes. POLY B 500000IU can be used in children and adolescents (aged below 18 years) if prescribed by the physician. Your doctor will decide the suitable dose for your child based on their age, body weight and severity of infection.

What precautions do I need to follow while taking POLY B 500000IU?

Before receiving POLY B 500000IU, inform your doctor if you have any kidney problems. You must also inform your doctor if you are taking any other antibiotics to manage other infections or if you are pregnant or breastfeeding before receiving POLY B 500000IU. Complete the full course of antibiotic therapy as insisted by your doctor. Regularly check your kidney functions without fail while undergoing therapy with POLY B 500000IU. Consult your doctor if you experience any unusual side effects after receiving POLY B 500000IU.

What medicines should I avoid while taking POLY B 500000IU?

Avoid taking other antibiotics along with POLY B 500000IU without consulting your doctor. Concomitant use of antibiotics along with POLY B 500000IU may potentiate the effects of POLY B 500000IU and may lead to unwanted side effects.

Is POLY B 500000IU safe?

POLY B 500000IU is a very potent antibiotic. It is safe when used in the doses recommended by your doctor. Therefore, carefully follow your doctor's instructions and inform your doctor immediately if you experience any unpleasant side effects after receiving POLY B 500000IU.

Can I take POLY B 500000IU during pregnancy?

There is no proper information regarding the use of POLY B 500000IU in pregnant women. Therefore, inform your doctor before receiving POLY B 500000IU if you are pregnant or think you may be pregnant.

Can POLY B 500000IU cause numbness?

Yes. POLY B 500000IU may causes numbness. This happens due to nerve damage. If you experience any such side effects, consult your doctor immediately.

How long should I take POLY B 500000IU?

It is important to undergo therapy with POLY B 500000IU for the stipulated duration instructed by your doctor. Failure to complete the course of therapy or skipping doses in between the therapy may make the bacteria more resistant against POLY B 500000IU.

REFERENCES

1. K.D. Tripathi. Macrolide and Other antibacterial antibiotics. Essential of Medical Pharmacology. Seventh edition. Page – 759.

2. Alexandre Prehn Zavascki, Luciano Zubaran Goldani, Jian Li, Roger L. Nation. Polymyxin B for the management of multidrug-resistant pathogens: a critical review. Journal of Antimicrobial chemotherapy. Oxford Academic. December 2007. [Accessed on 1st July 2022] https://academic.oup.com/jac/article/60/6/1206/820740

3. X-Gen Pharmaceuticals, Inc. Polymyxin b for injection, USP For Parenteral and Ophthalmic Administration. Dailymed. [Revised in August 2014] [Accessed on 24th June 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a14373aa-c5fa-4f90-8e8f-fc9e2219039c&type=display

4. Ben Venue Laboratories, Inc. U.S. Food and Drug Administration. [Revised in June 2011] [Accessed on 24th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/060716Orig1s020Lbl.pdf

5. CIMS. Polymyxin B. [Accessed on 24th June 2022] https://www.mims.com/india/drug/info/polymyxin%20b?type=full&mtype=generi

6. Alniche Life Sciences Pvt. Ltd. Polymyxin Sulphate, Polypure. [Accessed on 24th June 2022] https://www.alniche.com/product/polypure/

USEFUL DIAGNOSTIC TESTS

• Complete Blood count