INTRODUCTION

PLANEP 50MG contains Eplerenone, which belongs to the group of medicines called Selective Aldosterone blocking agents. It is used for the management of mild to moderate hypertension (condition in which the force of the blood against the artery walls is too high) and heart failure in adults. Heart failure is a chronic condition in which the heart doesn't pump blood properly to meet the body’s demand.

PLANEP 50MG is not recommended for use in patients with severe liver disease, severe kidney disease, or high potassium levels in the blood etc. It should be used with caution in patients with other kidney or liver diseases etc. Consult your doctor before taking PLANEP 50MG. Before taking PLANEP 50MG inform your doctor if you are pregnant or planning to get pregnant or breast-feeding women.

PLANEP 50MG is not recommended for use in children and growing adults. It should be used with caution in elderly patients. Consult your doctor before taking PLANEP 50MG. The most common side effects of taking PLANEP 50MG are nausea, vomiting, diarrhoea, constipation, high potassium level, low blood pressure, fainting, dizziness, headache etc. Consult your doctor if any of the symptom worsens.

USES OF PLANEP 50MG

• Manages mild to moderate hypertension
• Manages heart failure

HOW PLANEP 50MG WORKS

PLANEP 50MG works by inhibiting the action of aldosterone, a hormonal substance produced within the body that controls blood pressure and heart function. As a result, it effectively regulates blood pressure and improves heart function.

DIRECTIONS FOR USE

Take PLANEP 50MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF PLANEP 50MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Take rest and relax. Drink plenty of fluids such as water or fruit juices. Apply a pain-relieving balm on the forehead if necessary. Consult your doctor if the symptom does not improve.

Nausea and vomiting:

Take PLANEP 50MG with or just after a meal. Stick to simple meals. Avoid eating oily or spicy foods. Do not lie down immediately after eating. Consult your doctor if the symptom does not improve.  

Diarrhoea:

Drink lot of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for manageing diarrhoea. Consult your doctor if the symptom does not improve.

Constipation:

Eat plenty of fiber-rich foods in your diet such as fresh fruits, vegetables, and cereals. Drink plenty of water and exercise more regularly. Consult your doctor if the symptom does not improve.

Dizziness:

Lie down until dizziness passes away and then move slowly and carefully. Take rest and drink plenty of fluids. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking PLANEP 50MG, inform your doctor if you are taking any of the following medicines:

• itraconazole, ketoconazole and fluconazole (used to manage fungal infections)
• ritonavir, nelfinavir and saquinavir (used to manage HIV infection)
• clarithromycin, telithromycin, trimethoprim, erythromycin and rifampicin (used to manage bacterial infections)  
• nefazodone and tricyclic antidepressants like amitriptyline, and amoxapine (used to manage depression)  
• potassium-sparing diuretics such as spironolactone (used to manage high blood pressure)
• potassium supplements (salt tablets) (used to increase potassium levels in the blood)
• angiotensin converting enzyme (ACE) inhibitors such as lisinopril, ramipril and angiotensin receptor blockers (ARB) such as losartan, olmesartan (used to manage high blood pressure, heart disease or some kidney conditions)
• lithium (used to manage bipolar disorder)
• cyclosporine or tacrolimus (used to manage skin diseases such as psoriasis or eczema and prevent rejection after organ transplantation)
• non-steroidal anti-inflammatory drugs such as ibuprofen (used to relieve pain and inflammation)
• alpha blockers such as prazosin or alfuzosin (used to manage high blood pressure and particular prostate conditions)
• antipsychotics such as chlorpromazine or haloperidol (used to manage psychiatric disorders)
• amifostine (used to protect kidneys during cancer management)
• baclofen (used to manage muscle spasms)
• glucocorticoids Ex. hydrocortisone or prednisone (used to manage inflammation and certain skin conditions)
• tetracosactide (used to manage disorders of the adrenal cortex)
• digoxin (used to manage heart conditions)
• warfarin (used to prevent and manage blood clots)
• amiodarone, diltiazem and verapamil (used to manage heart problems and high blood pressure)
• st. john's wort (herbal medicine used to manage depression),
• medicines used to manage seizures (Ex. carbamazepine, phenytoin, and phenobarbital)

Overdosage:

If you or anyone else accidentally takes too much of PLANEP 50MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include low blood pressure (causing light-headedness, dizziness, blurred vision, weakness, acute loss of consciousness) or high levels of potassium in the blood (signs include muscle cramps, diarrhoea, nausea, dizziness or headache).

SYNOPSIS

MORE INFORMATION

• Keep PLANEP 50MG out of reach of children
• Store at room temperature

FAQs ABOUT PLANEP 50MG

How does PLANEP 50MG work?

PLANEP 50MG works by inhibiting the action of aldosterone, a hormonal substance produced within the body that controls blood pressure and heart function. As a result, it effectively regulates blood pressure and improves heart function.

Is PLANEP 50MG safe to use in patients with liver disease?

PLANEP 50MG is not recommended for use in patients with severe liver disease. It should be used with caution in patients with other liver diseases. Consult your doctor before taking PLANEP 50MG.

Can PLANEP 50MG cause dizziness?   

Yes, this medicine may cause dizziness in some individuals. Try to rest and relax. Get enough sleep. Avoid driving or operating any machines if you feel dizzy after taking PLANEP 50MG. Do not consume alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom does not improve or gets worse.

What is PLANEP 50MG used for?

PLANEP 50MG is used to manage mild to moderate hypertension (condition in which the force of the blood against the artery walls is too high) and heart failure in adults. Heart failure is a chronic condition in which the heart doesn't pump blood properly to meet the body’s demand.           

Is PLANEP 50MG safe to use in patients with kidney disease?

PLANEP 50MG is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with other kidney diseases. Consult your doctor before taking PLANEP 50MG.

REFERENCES

1. KD Tripathi. Diuretics. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page-589.

2. Jennifer Craft. Eplerenone (Inspra), a new aldosterone antagonist for the management of systemic hypertension and heart failure. NIH. National Library of Medicine. National Center center of biotechnology Information. PMC Pubmed Central. April 2004. [Accessed on June 3rd 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200656/

3. Faiez Zannad, John J V McMurray, Henry Krum, Dirk J van Veldhuisen, Karl Swedberg, Harry Shi, John Vincent, Stuart J Pocock, Bertram Pitt, EMPHASIS-HF Study Group. Eplerenone in patients with systolic heart failure and mild symptoms. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 2011. [Accessed on June 3rd 2022] https://pubmed.ncbi.nlm.nih.gov/21073363/

4. Central Drugs Standard Control Organisation (CDSCO). Eplerenone Tablet (25mg/50mg). [Accessed on June 3rd 2022] https://cdscoonline.gov.in/CDSCO/Drugs

5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on June 3rd 2022] https://www.medicines.org.uk/emc/files/pil.7055.pdf

USEFUL DIAGNOSTIC TESTS

• Kidney function test
• Liver function test
• Electrocardiogram (ECG)