Introduction About PIONORM 15 TABLET

PIONORM 15 TABLET contains Pioglitazone, a medication used for type 2 diabetes management. It helps control blood sugar levels by increasing insulin sensitivity.

PIONORM 15 TABLET can be taken alone or with other diabetes medication. It is important to take it consistently at the same time each day for the best results.

Take PIONORM 15 TABLET as prescribed by your doctor, usually once daily with or without food. Regular monitoring of blood sugar levels, as well as blood tests to check blood cell counts and liver function, may be advised by your doctor.

PIONORM 15 TABLET should be part of a comprehensive management plan, including a healthy diet, regular exercise, and weight management, as recommended by your doctor.

Before taking PIONORM 15 TABLET, inform your doctor if you have a history of heart disease, thyroid disorders, or hormonal conditions, as it may not be suitable.

The most common side effects of taking PIONORM 15 TABLET are weight gain or swelling in legs. Consult your doctor if you experience above side effects worsen or persists for a longer duration.

Key Composition

Active Ingredient:

• Pioglitazone hydrochloride (15mg) – A thiazolidinedione (TZD) class drug that helps improve insulin sensitivity in type 2 diabetes patients

Inactive ingredients (excipients):

• Lactose monohydrate
• Microcrystalline cellulose
• Povidone (Polyvinylpyrrolidone, PVP)
• Sodium starch glycolate
• Magnesium stearate

Uses Of PIONORM 15 TABLET

• Type II diabetes mellitus

Benefits of PIONORM 15 TABLET

1. Controls blood sugar in type 2 diabetes:

• PIONORM 15 TABLET helps lower blood glucose levels by enhancing the body response to insulin
• Ensures better sugar utilization and reduces glucose production in the liver

2. Reduces insulin resistance:

• Pioglitazone improves insulin sensitivity in muscle and fat tissues, making it easier for cells to absorb glucose from the bloodstream
• This reduces the need for higher insulin levels and helps in reducing metabolic complications

3. Helps to reduce diabetes complications:

• Long-term use can lower the risk of diabetes-related complications, including nerve damage (neuropathy), kidney problems (nephropathy), and vision issues (retinopathy)
• PIONORM 15 TABLET may also provide cardiovascular protection by improving lipid levels and reducing inflammation

How PIONORM 15 TABLET Works

1. Reduces insulin resistance

• In type 2 diabetes, cells become resistant to insulin, meaning they do not efficiently absorb glucose
• Pioglitazone activates PPAR-γ (Peroxisome Proliferator-Activated Receptor Gamma), a protein that enhances insulin sensitivity in fat, muscle, and liver cells
• It reduces insulin resistance, allowing cells to better absorb glucose from the bloodstream

2. Enhances glucose utilization:

• Muscle and fat cells absorb more glucose, lowering blood sugar levels
• It reduces excess glucose production in the liver, reducing high fasting blood sugar levels

3. Protects against diabetes complications

• Reduces lipid abnormalities, improving heart health
• Lowers inflammation, which is beneficial for reducing complications like nerve damage, kidney disease, and vision issues

How long does it take for PIONORM 15 TABLET to show results?

• Initial effects: 1 to 2 weeks – some improvement in blood sugar levels may be observed
• Significant improvement: 4 to 8 weeks – insulin sensitivity improves, leading to better glucose control
• Full therapeutic effect: Up to 12 weeks – maximum benefits in reducing blood sugar levels and insulin resistance

How to use PIONORM 15 TABLET

PIONORM 15 TABLET is a prescription medicine which needs to be taken under medical supervision. Always consult your doctor or pharmacist if you have any questions or concerns about taking this medication.

What is the recommended dosage for PIONORM 15 TABLET?

• Adults: 15mg once daily
• Maximum dose: It can be increased up to 45mg per day based on blood sugar response
• Duration: As prescribed by the doctor, typically long-term for type 2 diabetes management

How should I take PIONORM 15 TABLET?

• Take once daily or as prescribed by your doctor
• Swallow the tablet whole with a glass of water. Do not crush, chew, or break it
• It can be taken with or without food, but taking it at the same time daily helps maintain steady blood sugar levels

What if I forgot to take PIONORM 15 TABLET

• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose
• Do not take two doses to make up for the missed one

Overdose

• PIONORM 15 TABLETcan lead to hypoglycemia (low blood sugar) or fluid retention
• Symptoms of overdose: severe hypoglycemia (dizziness, sweating, confusion, blurred vision, rapid heartbeat), fluid retention & swelling (edema), breathing difficulties, liver dysfunction or heart complications

What to do in case of overdose?

• Seek immediate medical help – call emergency services or visit the nearest hospital
• Monitor blood sugar – if experiencing hypoglycemia, consume sugar-rich foods like juice or glucose tablets
• Avoid self-medication – do not take insulin or other glucose-lowering drugs without medical advice

Side Effects Of PIONORM 15 TABLET

Common side effects:

• weight gain
• swelling in legs

When to consult a doctor?

• increased risk of heart failure  

How To Manage Side Effects

Swelling in legs:

• Limit salty foods like processed snacks, pickles, and canned foods and drink plenty of water to help flush excess sodium from the body
• Take short walks every hour if sitting for long periods and do gentle leg exercises (such as ankle rotations or toe flexing) help improve circulation
• Stay hydrated which helps flush out excess fluids, reduce intake of caffeinated and alcoholic drinks, which can worsen dehydration and swelling.

Warning & Precautions

Pregnancy

Contraindicated

Animal studies show adverse effects on fetal growth, but there are no well-controlled human studies. It may cause fetal growth restriction, delayed bone formation, and altered glucose metabolism in the baby. Pioglitazone is not recommended during pregnancy due to limited human studies and potential risks to fetal development. Most doctors recommend safer alternatives like insulin or metformin for managing diabetes during pregnancy.

Breastfeeding

Consult your doctor

Pioglitazone use during breastfeeding is not well studied in humans. It is unknown if Pioglitazone passes into breast milk. There is no sufficient clinical research on the safety of PIONORM 15 TABLET during breastfeeding. It is unclear whether the drug passes into breast milk and how it might affect the infant.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if you experience abnormal vision after taking PIONORM 15 TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking PIONORM 15 TABLETas it may increase the risks of side effects.

Liver

Consult your doctor

PIONORM 15 TABLET is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other liver problems.

Allergy

Contraindicated

Do not take PIONORM 15 TABLET if you are allergic to Pioglitazone or any other ingredients of this medicine.

Heart Disease

Consult your doctor

PIONORM 15 TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems.

Use In Pediatrics

Contraindicated

PIONORM 15 TABLET is not recommended for use in children and adolescents (aged below 18 years).

Use In Geriatrics

Use with Caution

PIONORM 15 TABLET should be used with caution in elderly patients (aged 65 years or above).

Other Warnings for PIONORM 15 TABLET

Before taking PIONORM 15 TABLET inform your doctor if you:

• have fluid retention and swelling
• have other urinary problems
• smoke
• have macular oedema
• have polycystic ovary syndrome
• had stroke
• have anemia
• have any bone problems or at risk of developing bone fractures
• are a premenopausal woman

Who should not take [GBNKEYWORD

PIONORM 15 TABLET is not recommended for use if you:

• have diabetic ketoacidosis
• have bladder cancer
• pass bloody urine

Diet and Lifestyle Advice

Best diet plan while taking PIONORM 15 TABLET for Diabetes control:

• Focus on Low-Glycemic Index (GI) foods – Helps to reduce blood sugar spikes
• Include High-Fiber foods – Improves digestion and regulates blood sugar
• Balance protein, healthy fats & complex carbs – Provides sustained energy
• Reduce processed & sugary foods – Reduces weight gain and insulin resistance
• Limit salt intake – Helps manage swelling (edema) caused by PIONORM 15 TABLET
• Drink plenty of water and fluids
• Exercise regularly (brisk walking, strength training)
• Monitor blood sugar levels and adjust diet accordingly
• Take PIONORM 15 TABLET as prescribed and maintain a consistent meal schedule

Top foods that help PIONORM 15 TABLET work effectively:

• Leafy greens
• Whole grains (quinoa, brown rice, oats, whole wheat)
• Legumes (lentils, chickpeas, kidney beans)
• Nuts & seeds (chia seeds, flaxseeds, almonds, walnuts)
• Fatty fish (salmon, mackerel, sardines)
• Skinless chicken or turkey
• Eggs
• Tofu & paneer (Indian cottage cheese)
• Greek yogurt
• Avocados, olive oil & coconut oil, nuts (almonds, walnuts, pistachios) and seeds (flaxseeds, sunflower seeds, pumpkin seeds)
• Berries, apples, pears, oranges, lemons, grapefruits, guava & papaya

"Ask a Pharmacist" Section – Answers common queries about PIONORM 15 TABLET

1. What happens if I miss a dose?

• Take the missed dose as soon as you remember
• Skip it if it is almost time for your next dose
• Never double the dose to make up for a missed one

2. Can I stop taking PIONORM 15 TABLET if my sugar levels are normal?

• No. Stopping suddenly may cause uncontrolled blood sugar spikes. Always consult your doctor before making changes

3. Can I drink alcohol while on PIONORM 15 TABLET?

• Limit alcohol intake, it increases the risk of low blood sugar and liver issues

Drug - Drug interaction

How PIONORM 15 TABLET interacts with other medications, including over-the-counter drugs and supplements:

1. Insulin & other diabetes medications: Metformin, glimepiride, gliclazide, insulin, sitagliptin

• Risk: It can cause excessive blood sugar drops (hypoglycemia)

• Solution: Your doctor may lower the dose of insulin or sulfonylureas when using PIONORM 15 TABLET.

2. Beta-Blockers (Heart Medications): Atenolol, metoprolol, propranolol

• Risk: It can mask symptoms of low blood sugar  
• Solution: Monitor blood sugar closely

 3. NSAIDs (Painkillers & Anti-Inflammatory Drugs): Ibuprofen, diclofenac, naproxen

• Risk: NSAID’s worsen swelling in legs & increase heart failure risk
• Solution: Use only under doctor’s advice

4. Corticosteroids: Prednisolone, dexamethasone, hydrocortisone

• Risk: It raises blood sugar levels & causes fluid retention
• Solution: It may need adjusted diabetes medication doses

5. Calcium channel blockers: Amlodipine, nifedipine, verapamil

• Risk: It may increase swelling (edema) when combined with PIONORM 15 TABLET

6. Diuretics: Furosemide, hydrochlorothiazide (HCTZ), spironolactone

• Risk: It may reduce PIONORM 15 TABLET ability to control blood sugar

7. Rifampin (Antibiotic for TB & Infections)

• Risk: Reduces PIONORM 15 TABLET effectiveness, requiring a higher dose

Over-the-Counter (OTC) drug interactions

• Cold & Flu Medications (Decongestants)
• Aspirin & Pain Relievers
• Antacids (Ranitidine, Omeprazole)

Herbal & dietary supplement interactions:

1. Ginseng, fenugreek, bitter melon, aloe vera, cinnamon

• Risk: Lowers blood sugar too much when combined with PIONORM 15 TABLET

2. St. John’s Wort

• Risk: It can reduce the effectiveness of PIONORM 15 TABLET

3. Omega-3 & fish oil supplements

• Risk: may increase fluid retention & swelling in some people

Synopsis

More Information

Glucose Monitoring Techniques: Best practices for using glucometers and understanding blood sugar readings:

• Wash hands before testing (removes food residue & dirt)
• Use a fresh lancet each time for accuracy & hygiene
• Prick the side of the fingertip (less painful than the center)
• Apply the blood sample properly (too little blood gives inaccurate results)
• Log your readings to track patterns over time

Blood sugar targets (for non-pregnant adults with diabetes)

HbA1c Testing: Why it matters in long-term diabetes control

• The HbA1c test (Glycated Hemoglobin Test) measures average blood sugar levels over the past 2-3 months

Why is HbA1c important?

• Helps assess long-term glucose control
• Predicts diabetes complications (nerve, kidney, heart damage)
• Shows if your medications PIONORM 15 TABLET are working

Ideal HbA1c levels

High HbA1c (>8%) = poor blood sugar control

PIONORM 15 TABLET vs. Metformin – Which is better?

PIONORM 15 TABLET vs. Voglibose - Which one should you take?

Top 5 Alternatives to PIONORM 15 TABLET for Diabetes Control:

• Pioglit 15mg Tablet
• Pioglar 15mg Tablet
• Pioglaz 15mg Tablet 10'S
• Piokind 15mg Tablet 10'S
• Piomed 15mg Tablet 10'S

Doctor-Recommended Tips for PIONORM 15 TABLET Users:

• Take it as prescribed
• Monitor your blood sugar regularly
• Watch for side effects
• Maintain a diabetes-friendly diet
• Stay active & exercise regularly
• Avoid alcohol & smoking
• Be cautious with other medications
• Regular health check-ups are important

FAQs About PIONORM 15 TABLET

Q: What is PIONORM 15 TABLET used for?

A: PIONORM 15 TABLET contains Pioglitazone, a medication used for type 2 diabetes management. It helps control blood sugar levels by increasing insulin sensitivity.

Q: How does PIONORM 15 TABLET work to control blood sugar?

A: PIONORM 15 TABLET reduces blood sugar levels by making the body to utilize the circulating insulin (a peptide hormone used for digesting glucose). It also reduces the production of glucose by the liver which eventually decreases blood glucose levels.

Q: Does PIONORM 15 TABLET cause weight gain?

A: Yes, PIONORM 15 TABLET (Pioglitazone) can cause weight gain in some users. This happens due to fluid retention (edema) and increased fat storage.

Q: Is PIONORM 15 TABLET safe during pregnancy?

A: PIONORM 15 TABLET is not recommended during pregnancy. It may cause harm to the unborn baby by affecting blood sugar levels and fetal development.

Q: Can PIONORM 15 TABLET be used by patients with liver disease?

A: It is generally not recommended for patients with liver disease. Pioglitazone is metabolized in the liver, and its use may worsen liver function in patients with pre-existing liver conditions. It can increase liver enzyme levels, potentially leading to liver damage or hepatitis in rare cases.

Q: Are there any heart-related risks associated with PIONORM 15 TABLET?

A: Yes, PIONORM 15 TABLET may increase the risk of heart-related issues, especially in certain patients.

Q: Are there any food restrictions with PIONORM 15 TABLET?

A: There are no strict food restrictions while taking PIONORM 15 TABLET, but following a diabetes-friendly diet can improve its effectiveness and reduce side effects.

Q: Can I drink coffee or alcohol while taking PIONORM 15 TABLET?

A: Coffee (caffeine) does not directly interact with PIONORM 15 TABLET. However, excessive caffeine may lead to blood sugar fluctuations (spikes & crashes). Alcohol is not recommended which may increase the risk of low blood sugar (hypoglycemia), especially if combined with other diabetes medications.

Q: What to do if you experience swelling or edema from PIONORM 15 TABLET?

A: Avoid salty foods, drink plenty of water, avoid sitting or standing for long hours and walk or do light exercises.

Q: Can I stop taking PIONORM 15 TABLET if my sugar levels are normal?

A: No, do not stop taking PIONORM 15 TABLET without consulting your doctor.

Q: Where to buy PIONORM 15 TABLET?

A:You can purchase PIONORM 15 TABLET from a reputable online pharmacy like Netmeds.

Q: What are the side effects of taking PIONORM 15 TABLET?

A: The most common side effects of taking PIONORM 15 TABLET are weight gain or swelling in legs. Consult your doctor if you experience above side effects worsen or persists for a longer duration.

Q: Can PIONORM 15 TABLET be taken with insulin?

A: Co-administration of PIONORM 15 TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels).

Q: Does PIONORM 15 TABLET cause low blood sugar (hypoglycemia)?

A: Yes. Low blood sugar is a common side effect of taking PIONORM 15 TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Wait for some time. If you cannot any improvement in your condition or if your condition worsen, contact your doctor.

Q: Can PIONORM 15 TABLET cause dizziness?

A: Dizziness is a common side effect of using PIONORM 15 TABLET. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents.

References

1.K.D. Tripathi. Insulin, oral hypoglycaemic drugs, and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 277.    

2.Cyrus V. Desouza1,2 and Vijay Shivaswamy1,2. Pioglitazone in the Treatment of Type 2 Diabetes: Safety and Efficacy Review. NIH: National Library of Medicine, National center for biotechnology information. PMC. PubMed Central. August 2010. [Accessed on 21st June 2025]

3.Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 21st Juneh 2025]

4.Takeda Pharmaceuticals America, Inc. U.S. Food & Drug Administration. [Revised in July 2011] [Accessed on 21st June 2025]

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (Rbs)
• Post Prandial Blood Sugar (PPBS)

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 21 Jun 2025 | 05:10 PM(IST)