Introduction About PENEGRA XPRESS 50MG TABLET

PENEGRA XPRESS 50MG TABLET is a FDA approved prescription medication for the management of erectile dysfunction. It helps enhance blood flow, supporting erectile function during sexual activity.

PENEGRA XPRESS 50MG TABLET can be taken with or without food but should always be used as directed by your doctor. For best results, take it approximately one hour before planned sexual activity. While the time it takes to work may vary from person to person, it usually starts acting within 30 minutes to an hour. This medicine works only when there is sexual stimulation. Do not exceed the recommended dose of one tablet in 24 hours.

Avoid alcohol consumption while taking this medicine, as it can increase the likelihood of experiencing side effects such as dizziness or headache and may decrease the effectiveness of PENEGRA XPRESS 50MG TABLET.

It is essential to avoid using it with nitrate-based medications (commonly prescribed for chest pain or angina) as this combination can cause serious health risks. Additionally, do not use PENEGRA XPRESS 50MG TABLET if you have severe heart or liver conditions, have recently experienced a heart attack or stroke, or have very low blood pressure. Always inform your doctor about your medical history before starting this medication.

The most common side effects of PENEGRA XPRESS 50MG TABLET include flushing (a warm sensation), headache, dizziness, blurred vision, muscle pain, indigestion, and rash. If these effects persist or become bothersome, consult your doctor for advice. They may adjust your dosage or suggest an alternative treatment. Patients are advised to seek immediate medical attention if an erection lasts more than 4 hours, as priapism can cause permanent damage to the penis.

Key Composition

• Sildenafil

Uses Of PENEGRA XPRESS 50MG TABLET

• Erectile Dysfunction (ED) in men

Benefits of PENEGRA XPRESS 50MG TABLET

• Clinically Approved for ED: PENEGRA XPRESS 50MG TABLET, has been demonstrated to improve erectile function in men with ED, aiding in achieving and maintaining optimum erection. USFDA approval
• Rapid Onset of Action: The medication typically begins to work within 30 to 60 minutes after ingestion.
• Non-Invasive Treatment Option: As an oral medication, PENEGRA XPRESS 50MG TABLET offers a convenient and less invasive alternative to other ED treatments, such as injections or surgical interventions.

PENEGRA XPRESS 50MG TABLET should only be taken under the supervision of a healthcare professional. USFDA insists that although PENEGRA XPRESS 50MG TABLET is approved for use as an ED pill, its usage is restricted to use only under the supervision of a licensed health care professional. 

PENEGRA XPRESS 50MG TABLET is effective only when sexually stimulated and should not be used recreationally or without a confirmed diagnosis of ED.

How PENEGRA XPRESS 50MG TABLET Works

PENEGRA XPRESS 50MG TABLET contains an active ingredient called sildenafil, a medication that works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5) in the body which restricts blood flow to the penis in men with ED. This action of sildenafil allows for increased blood flow to the penis, enabling an erection to occur and be maintained during sexual activity.

How to use PENEGRA XPRESS 50MG TABLET

• PENEGRA XPRESS 50MG TABLET is a prescription medicine which should be used only as advised by your doctor.
• Swallow the medicine with a glass of water. Do not crush or chew the medicine.

How to use PENEGRA XPRESS 50MG TABLET 100mg Tablet

• Take PENEGRA XPRESS 50MG TABLET exactly as prescribed by your doctor.
• Typically, it should be taken about 1 hour before planned sexual activity.
• You may take it with or without food but note that a high-fat meal may delay the onset of action.
• It is only effective when you are sexually stimulated, so it should not be used if you do not have erectile dysfunction.

PENEGRA XPRESS 50MG TABLET 100mg dosage instructions

The usual starting dose for ED is 50mg, but your doctor may adjust this based on your needs and tolerance. If the 50mg dose is ineffective or not working for you, your doctor may increase the dose to 100mg, the maximum recommended dose. PENEGRA XPRESS 50MG TABLET should not be taken more than once in a 24-hour period.

How often can I take PENEGRA XPRESS 50MG TABLET 100mg?

You should take PENEGRA XPRESS 50MG TABLET no more than once per day. If you feel the need to take it more often, consult your doctor for a proper evaluation and guidance.

Maximum daily dose of Sildenafil:

The maximum recommended dose of sildenafil (PENEGRA XPRESS 50MG TABLET) is 100mg per day. Exceeding this dose may increase the risk of side effects. Always follow the prescribed dosage by your doctor.

Can PENEGRA XPRESS 50MG TABLET be taken daily?

PENEGRA XPRESS 50MG TABLET is typically used as needed before sexual activity and is not intended for daily use. If you feel the need to use it daily, consult with your healthcare provider for a tailored treatment plan.

What if I forgot to take PENEGRA XPRESS 50MG TABLET

Taking too much sildenafil can lead to serious side effects, including an erection lasting more than 4 hours (priapism), sudden vision loss, or hearing problems. In the case of an overdose, seek immediate medical help.

Side Effects Of PENEGRA XPRESS 50MG TABLET

Like all medicines, PENEGRA XPRESS 50MG TABLET may cause some side effects in certain individuals, although not everybody gets them

Possible Side Effects of PENEGRA XPRESS 50MG TABLET:

• nausea
• facial flushing or hot flushes
• indigestion
• blurred vision, eye redness, visual disturbance
• nasal congestion, nasal allergies causing repeated sneezing or itching
• dizziness
• skin rashes
• pounding heartbeat
• muscle pain, arm pain
• upper abdominal pain, heartburn
• nosebleeds
• tiredness
• headache

What to do if you experience serious side effects of PENEGRA XPRESS 50MG TABLET?

Stop taking PENEGRA XPRESS 50MG TABLET and consult your doctor immediately if you experience any of the following serious (rare) side effects,

• Severe allergic reaction (causing difficulty in breathing or dizziness, swelling of the eyelids, face, lips or throat)
• Chest pains (typically during or after intercourse)
• Prolonged and sometimes painful erections (priapism)
• having an erection which lasts for more than 4 hours, you should contact a doctor immediately.
• A sudden decrease or loss of vision
• serious skin reactions with peeling or blistering of skin

How To Manage Side Effects

Headache

• Rest in a quiet, dark room: Sometimes, simply resting in a calm, dark place can help alleviate headache symptoms.
• Hydrate: Drinking plenty of water can also help relieve headache and prevent dehydration.
• If the headache persists, contact your doctor for advice

Hot Flushes

• Cool down: Use a cool cloth or take a cool shower to help reduce the sensation of warmth.
• Stay hydrated: Drink plenty of water to help flush out the medication and maintain hydration.
• Avoid alcohol: Alcohol can worsen flushing, so it is best to avoid it while taking PENEGRA XPRESS 50MG TABLET.
• Contact your doctor if flushing persists or becomes severe

Warning & Precautions

Pregnancy

Contraindicated

PENEGRA XPRESS 50MG TABLET is not indicated for use in women, as sildenafil 100 mg is primarily indicated for the management of erectile dysfunction in men. Contact your doctor for more.

Breastfeeding

Contraindicated

PENEGRA XPRESS 50MG TABLET is not indicated for use in women

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience dizziness or blurred vision after taking PENEGRA XPRESS 50MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking PENEGRA XPRESS 50MG TABLET, as it may make you feel drowsier.

Kidney

Use with Caution

This medicine should be used with caution in patients with kidney diseases. Proper dose adjustments and careful monitoring are required in such patients. Therefore, if you have any pre-existing kidney conditions, inform your doctor prior to starting PENEGRA XPRESS 50MG TABLET as a precaution.

Liver

Consult your doctor

PENEGRA XPRESS 50MG TABLET is not recommended for use in patients having severe liver diseases. It should be used with caution in patients with other minor liver problems. Therefore, inform your doctor about your liver conditions prior to taking PENEGRA XPRESS 50MG TABLET. Your doctor will suggest the suitable dose for you accordingly and carefully monitor your health status.

Allergy

Contraindicated

Do not take PENEGRA XPRESS 50MG TABLET if you are allergic to Sildenafil.

Lungs

Use with Caution

PENEGRA XPRESS 50MG TABLET should be used with caution in patients with pulmonary arterial hypertension. Therefore, consult your doctor before taking it.

Heart Disease

Consult your doctor

PENEGRA XPRESS 50MG TABLET should be used with caution in heart patients, especially those taking nitrate medications or those with a history of heart attack, stroke, or severe heart conditions. Combining PENEGRA XPRESS 50MG TABLET with nitrates can cause a dangerous drop in blood pressure. Always consult your doctor before using PENEGRA XPRESS 50MG TABLET if you have heart disease or low blood pressure to ensure safe use.

Use In Pediatrics

Contraindicated

PENEGRA XPRESS 50MG TABLET is not recommended for use in children and adolescents (below 18 years). Consult your doctor for advice.

Use In Geriatrics

Use with Caution

• PENEGRA XPRESS 50MG TABLET should be used with caution in elderly patients. As a precaution, elders must inform their health status and medications they take to their doctor prior to taking PENEGRA XPRESS 50MG TABLET.
• Older adults may be more sensitive to the medication, and a lower dose may be recommended to reduce the risk of side effects like dizziness, headache, or low blood pressure. It is essential for elderly patients to consult their doctor before using PENEGRA XPRESS 50MG TABLET to ensure it is appropriate for their individual health status.

Other Warnings for PENEGRA XPRESS 50MG TABLET

Before taking PENEGRA XPRESS 50MG TABLET, inform your doctor if you:

• Have sickle cell Anaemia
• Have cancers of the blood (leukemia) or bone marrow (multiple myeloma)
• Have penile deformation
• Have Peyronie’s disease 
• Have a stomach ulcer or bleeding disorder such as haemophilia

Who should not take [GBNKEYWORD

PENEGRA XPRESS 50MG TABLET is not recommended for use if you:

• Have any type of rare inherited eye disease
• Previously had vision loss due to non-arteritic anterior ischaemic optic neuropathy (nerve damage caused by a lack of blood and oxygen supply to the eye)

Safety Advice

Expert Advice to follow while taking PENEGRA XPRESS 50MG TABLET Tablet:

1. Follow Your Doctor's Instructions: Always take PENEGRA XPRESS 50MG TABLET exactly as prescribed by your healthcare provider. Avoid taking more than one dose in 24 hours.
2. Timing: Take the tablet about 1 hour before sexual activity, but it can be taken anywhere from 30 minutes to 4 hours in advance. Avoid taking it right after a large meal, as it may delay the effects.
3. Avoid Alcohol and Grapefruit: Limit alcohol intake and avoid grapefruit or grapefruit juice while using PENEGRA XPRESS 50MG TABLET, as they can interfere with its effectiveness.
4. Monitor for Side Effects: Watch for common side effects like headache, dizziness, or flushing. If you experience an erection lasting longer than 4 hours (priapism) or vision problems, seek immediate medical attention.
5. Stay Sexually Stimulated: PENEGRA XPRESS 50MG TABLET only works when sexually aroused. It doesn’t cause an erection on its own.
6. Check for Drug Interactions: Inform your doctor about any other medications you're taking, particularly nitrates for chest pain, as combining them with PENEGRA XPRESS 50MG TABLET can cause serious side effects.
7. Consult Your Doctor Regularly: Regularly check with your healthcare provider to ensure the medication is still appropriate for you, especially if you have heart disease, low blood pressure, or kidney problems.

By following these guidelines, you can use PENEGRA XPRESS 50MG TABLET safely and effectively. Always consult with your doctor for personalized advice based on your health needs.

Drug - Drug interaction

1. Medicines used for chest pain (also known as nitrates): Examples: glyceryl trinitrate, isosorbide mononitrate, isosorbide dinitrate

Effects on Interaction: When Sildenafil is taken with Nitrates, it could lead to a dangerous fall in blood pressure. Therefore, inform your doctor if you are previously taking any medicines for chest pain as a precaution.

2. Riociguat: Used for the management of pulmonary arterial hypertension

Effect on interaction: Taking Sildenafil with riociguat can cause a severe drop in blood pressure. To stay safe, inform your doctor if you are already using any medication for chest pain.

3. HIV Medicines

Effect on interaction: Taking Sildenafil with certain class of HIV medicines can severely reduce blood pressure. To stay safe, inform your doctor if you are already using any medication for HIV infection.

Other Drug-Drug interactions:

• Antibiotics and Antifungals such as itraconazole, ketoconazole and erythromycin
• Heartburn treatment (such as cimetidine)
• Alpha-blockers used for urinary problems or high blood pressure (such as alfuzosin, doxazosin or tamsulosin)
• Sacubitril/valsartan (used for heart failure)

Drug - Food interaction

Avoid taking PENEGRA XPRESS 50MG TABLET with:

• Alcohol: as it could potentially decrease your blood pressure
• Heavy meal: as it may take longer time for this medicine to start working
• Grape fruit juice: as it may make you dizzier

Synopsis

More Information

PENEGRA XPRESS 50MG TABLET 100mg reviews

Sildenafil (PENEGRA XPRESS 50MG TABLET) has received positive reviews for erectile dysfunction (ED), with many users reporting improved sexual function. Some users have expressed issues with effectiveness, such as not achieving a full erection or experiencing delayed ejaculation. As with any medication, it's important to consult a doctor for proper dosing and ensure it's suitable for individual health conditions.

Alternatives to PENEGRA XPRESS 50MG TABLET for ED: Buy now

• Caverta 100mg Tablet 4'S
• Suhagra 100mg Tablet 4'S
• Funtime 100mg Tablet 4'S
• Manforce 100mg Tablet 4'S

PENEGRA XPRESS 50MG TABLET vs Cialis for ED treatment:

Is PENEGRA XPRESS 50MG TABLET 50mg or 100mg better?

• PENEGRA XPRESS 50MG TABLET 50mg is typically recommended as the starting dose.
• PENEGRA XPRESS 50MG TABLET 100mg is a higher dose and may be more effective for some men, though it can increase the likelihood of side effects.
• Always follow a doctor’s advice to determine the appropriate dose for your needs.

FAQs About PENEGRA XPRESS 50MG TABLET

Q: What is PENEGRA XPRESS 50MG TABLET used for?

A: PENEGRA XPRESS 50MG TABLET is primarily used to manage erectile dysfunction (ED) in men by increasing blood flow to the penis, helping men achieve and maintain an erection during sexual activity.

Q: Can I take PENEGRA XPRESS 50MG TABLET without a prescription?

A: No, PENEGRA XPRESS 50MG TABLET is a prescription medication and should only be used under the supervision of a healthcare provider. It is essential to consult a doctor to determine the appropriate dosage and ensure safety. Do not self-use PENEGRA XPRESS 50MG TABLET or any ED pills without proper doctor consultation. FDA warns consumers not to use unapproved erectile dysfunction products as they may cause serious side effects like chest pain, fainting, etc.

Q: Is it safe to take PENEGRA XPRESS 50MG TABLET daily?

A: No, PENEGRA XPRESS 50MG TABLET should not be taken daily. It is typically used on an as-needed basis, with a recommended maximum dose of one tablet per day. Overuse can increase the risk of side effects.

Q: Is PENEGRA XPRESS 50MG TABLET effective for erectile dysfunction?

A: Yes, PENEGRA XPRESS 50MG TABLET is an effective for erectile dysfunction (ED) in men. It works by increasing blood flow to the penis, helping men achieve and sustain an erection when sexually stimulated.

Q: What is the best time to take PENEGRA XPRESS 50MG TABLET for better results?

A: The best time to take PENEGRA XPRESS 50MG TABLET is approximately 1 hour before sexual activity. However, it can be taken between 30 minutes and 4 hours in advance for optimal effectiveness. Avoid taking it right after a heavy meal, as it may delay its onset.

Q: How much PENEGRA XPRESS 50MG TABLET should I take in a day?

A: The maximum recommended dose of PENEGRA XPRESS 50MG TABLET is 100mg per day. Do not take more than one dose within a 24-hour period. Always follow your doctor’s recommendations.

Q: Can I split a PENEGRA XPRESS 50MG TABLET?

A: It is generally not recommended to split a PENEGRA XPRESS 50MG TABLET unless instructed by your doctor. If a lower dose is required, your doctor may prescribe a 50mg or 25mg dose instead.

Q: Can PENEGRA XPRESS 50MG TABLET cause heart problems?

A: PENEGRA XPRESS 50MG TABLET can cause a drop in blood pressure, which may be risky for people with certain heart conditions, especially if taken with nitrates or other medications for heart disease. Always consult a doctor before using PENEGRA XPRESS 50MG TABLET if you have a history of heart problems.

Q: Does PENEGRA XPRESS 50MG TABLET cause sudden vision loss?

A: In rare cases, PENEGRA XPRESS 50MG TABLET has been associated with sudden vision loss due to a condition called non-arteritic anterior ischemic optic neuropathy (NAION). If you experience sudden vision changes or loss, stop taking PENEGRA XPRESS 50MG TABLET and seek immediate medical attention.

Q: Is PENEGRA XPRESS 50MG TABLET safe for older adults?

A: PENEGRA XPRESS 50MG TABLET can be safe for older adults, but dosage adjustments may be necessary, especially if they have underlying health conditions like heart disease or liver problems. It’s important for older adults to consult their doctor before using PENEGRA XPRESS 50MG TABLET.

Q: Are there any specific PENEGRA XPRESS 50MG TABLET side effects in men?

A: Common side effects in men taking PENEGRA XPRESS 50MG TABLET may include headache, flushing, dizziness, blurred vision, and indigestion. If any side effects persist or cause discomfort, consult your doctor.

Q: How long does it take for PENEGRA XPRESS 50MG TABLET to work?

A: PENEGRA XPRESS 50MG TABLET typically starts working within 30 minutes to 1 hour after ingestion. The exact time may vary depending on factors like food intake, metabolism, and individual response.

Q: How long do the effects of PENEGRA XPRESS 50MG TABLET last for?

A: The effects of PENEGRA XPRESS 50MG TABLET generally last for about 4 to 5 hours. However, the duration may vary depending on the individual, and PENEGRA XPRESS 50MG TABLET will only work with sexual stimulation.

References

1. K.D. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page – 303-304.
2. N. Srikant, SV Kotwal. Sildenafil – Oral Medication for Erectile Dysfunction – A Review. NIH National Library of Medicine, National Center for Biotechnology Information. June 2017. [Accessed on 4th September 2025] 
3. Pfizer Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 4th September 2025] 
4. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 4th September 2025] 
5. USFDA Generic Approval for Viagra. Teva Pharmaceuticals, USA. 
6. FDA warns consumers not to use unapproved erectile dysfunction products advertised on the radio. 
7. Viagra (Sildenafil) Reviews and Ratings. Drugs.com. 
8. Viagra User Reviews. WebMD. 
9. Public Notification: U.S.A Viagra contains hidden drug ingredient. 

Useful Diagnostic Tests

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Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 04 Sep 2025 | 03:28 PM(IST)