Introduction About PEGALUP ORAL SOLUTION

PEGALUP ORAL SOLUTION is a combination of Polyethelene glycol, Potassium chloride, Sodium chloride, and Sodium hydrogen carbonate which belongs to the group of medicines called laxatives. It is used to manage long-standing constipation as well as faecal impaction (very bad constipation).

Constipation is a condition that occurs when bowel movements become less frequent and stools become difficult to pass, which generally occurs due to changes in diet or inadequate intake of fiber-rich foods. It is characterized by symptoms such as hard, dry, or lumpy stools that are painful or difficult to pass, or having the feeling that a stool has not passed at all.

Faecal impaction is a condition characterized by the formation of hardened stools that remain stuck to the rectum or lower colon due to long-standing constipation. It is characterized by symptoms such as stomach cramps, bloating, and stool leakage.

PEGALUP ORAL SOLUTION is not recommended for use if you are allergic to polyethelene glycol, sodium chloride, potassium chloride, or sodium hydrogen carbonate. PEGALUP ORAL SOLUTION is not recommended for use in patients with obstruction in the gut, perforated gut wall, and severe inflammatory bowel diseases such as ulcerative colitis, Crohn´s disease, toxic megacolon, or ileus.

PEGALUP ORAL SOLUTION should be used with caution in patients with hepatic encephalopathy, renal impairment, and impaired heart function. PEGALUP ORAL SOLUTION should be used with caution in pregnant and breastfeeding women. PEGALUP ORAL SOLUTION is not recommended for use by children (below 12 years). PEGALUP ORAL SOLUTION should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking it.

The common side effects associated with the use of PEGALUP ORAL SOLUTION are stomach ache, cramps, diarrhoea, vomiting, nausea, stomach rumbles, and gas problems in the gut. Contact your doctor or a nearby hospital if any of the conditions worsen.

Uses Of PEGALUP ORAL SOLUTION

• Manage long-standing constipation as well as faecal impaction (very bad constipation)

How PEGALUP ORAL SOLUTION Works

PEGALUP ORAL SOLUTION helps in relieving constipation. Polyethelene glycol, potassium chloride, sodium chloride, and sodium hydrogen carbonate work by increasing the volume of faeces as they bind with water, which results in increased motility in the intestines, thereby increasing the movement of the softened stools and easing defecation. The salts present in the formulation also help in maintaining the body´s normal salt and water balance.

How to use PEGALUP ORAL SOLUTION

Take PEGALUP ORAL SOLUTION as advised by your physician. Empty 1 sachet with 12 glasses of water (about 125 ml) and mix well. Stir the mix until the powder is dissolved, and then drink. If you wish to take it with fruit juice or fruit syrup, then add it immediately before drinking. Your doctor will determine the correct dose and duration for you depending upon your age, body weight, and disease condition.

Side Effects Of PEGALUP ORAL SOLUTION

How To Manage Side Effects

Diarrhea

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.

Headache

Take rest and plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching the screen for a long time. Consult your doctor if the condition persists for a long or gets worsened.

Nausea And Vomiting

Try to take PEGALUP ORAL SOLUTION with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

Warning & Precautions

Pregnancy

Use with Caution

PEGALUP ORAL SOLUTION should be used with caution if you are pregnant or planning to have a baby. Consult and inform your doctor before taking it.

Breastfeeding

Use with Caution

PEGALUP ORAL SOLUTION should be used with caution in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Safe

PEGALUP ORAL SOLUTION has no or negligible effect on your ability to drive or use machines.

Kidney

Use with Caution

PEGALUP ORAL SOLUTION should be used with caution in patients with renal impairment. Consult your doctor for advice before taking it.

Liver

Use with Caution

PEGALUP ORAL SOLUTION should be used with caution in patients with hepatic encephalopathy (inability of the liver to remove toxins properly). Consult your doctor before taking it.

Allergy

Contraindicated

PEGALUP ORAL SOLUTION is not recommended for use if you are allergic to polyethelene glycol, sodium chloride, potassium chloride, sodium hydrogen carbonate or any of the other ingredients of this medicine.

Heart Disease

Use with Caution

PEGALUP ORAL SOLUTION should be used with caution in patients with impaired heart function. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

PEGALUP ORAL SOLUTION is not recommended for use in children (below 12 years). Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

PEGALUP ORAL SOLUTION should be used with caution in elderly patients (above 65 years). Consult your doctor before taking it.

Interactions

A. Drug-Drug Interactions:

Before taking PEGALUP ORAL SOLUTION, inform your doctor, if you are taking any of the following medicine:

• anti-epileptics (medicines used to manage epilepsy) Ex. sodium valproate, carbamazepine

Overdosage:

If you or anyone else accidentally takes too much of PEGALUP ORAL SOLUTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are severe diarrhoea or vomiting. 

Synopsis

More Information

• Keep the medicine out of reach of children
• Store PEGALUP ORAL SOLUTION at room temperature

FAQs About PEGALUP ORAL SOLUTION

Q: What is PEGALUP ORAL SOLUTION used for?

A: PEGALUP ORAL SOLUTION is used to manage long-standing constipation as well as faecal impaction (very bad constipation), which is characterized by symptoms such as hard, dry, or lumpy stools that are painful or difficult to pass, or having the feeling that a stool has not passed at all. Consult your doctor before taking PEGALUP ORAL SOLUTION.

Q: What happens if you take more PEGALUP ORAL SOLUTION than your required dose?

A: If you or anyone else accidentally takes too much PEGALUP ORAL SOLUTION, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are severe diarrhoea or vomiting.

Q: What side effects are seen with PEGALUP ORAL SOLUTION?

A: The common side effects associated with the use of PEGALUP ORAL SOLUTION are stomachache, cramps, diarrhoea, vomiting, nausea, stomach rumbles, and gas problems in the gut. Contact your doctor or a nearby hospital if any of the conditions worsen.

Q: Who should avoid taking PEGALUP ORAL SOLUTION?

A: PEGALUP ORAL SOLUTION is not recommended for use if you are allergic to polyethelene glycol, sodium chloride, potassium chloride, or sodium hydrogen carbonate. It is not recommended for use in patients with obstruction in the intestine (gut), a perforated gut wall, or severe inflammatory bowel diseases such as ulcerative colitis, Crohn´s disease, toxic megacolon, or ileus. It is not recommended for use in children (aged below 12 years). Consult your doctor before taking PEGALUP ORAL SOLUTION.

Q: Is PEGALUP ORAL SOLUTION safe to use in children or elderly patients?

A: PEGALUP ORAL SOLUTION is not recommended for use by children (below 12 years). It should be used with caution in elderly patients (over 65 years of age). Consult your doctor before taking PEGALUP ORAL SOLUTION.

Q: How does PEGALUP ORAL SOLUTION work?

A: PEGALUP ORAL SOLUTION helps in relieving constipation. Polyethelene glycol, potassium chloride, sodium chloride, and sodium hydrogen carbonate work by increasing the volume of faeces as they bind with water, which results in increased motility in the intestines, thereby increasing the movement of the softened stools and easing defecation. The salts present in the formulation also help in maintaining the body´s normal salt and water balance.

Q: How to use PEGALUP ORAL SOLUTION?

A: Take PEGALUP ORAL SOLUTION as advised by your physician. Empty 1 sachet with 12 glasses of water (about 125 ml) and mix well. Stir the mix until the powder is dissolved, and then drink. If you wish to take it with fruit juice or fruit syrup, then add it immediately before drinking. Your doctor will determine the correct dose and duration for you depending upon your age, body weight, and disease condition.

Q: What if I forget to take my PEGALUP ORAL SOLUTION dose?

A: If you forgot to take your PEGALUP ORAL SOLUTION dose, take it as early as possible. Do not double up the dose to make up for the forgotten one. Consult your doctor before taking PEGALUP ORAL SOLUTION.

Q: When should I stop taking PEGALUP ORAL SOLUTION?

A: Stop taking PEGALUP ORAL SOLUTION and contact your doctor if you experience swelling, shortness of breath, tiredness, signs of dehydration (increased thirst, dry mouth, and weakness), heart problems, or signs of serious allergic reactions such as difficulty breathing or swelling (typically in the face, lips, tongue, or throat).

Q: Is PEGALUP ORAL SOLUTION safe to use in liver and kidney patients?

A: PEGALUP ORAL SOLUTION should be used with caution in patients with hepatic encephalopathy (inability of the liver to remove toxins properly) and renal impairment. Consult your doctor before taking PEGALUP ORAL SOLUTION.

References

1. William L. Henrich. Principles and Practice of Dialysis. Gastrointestinal Complications in End Stage Renal Disease. 2009. Page – 425.

2. Manhal Izzy, Anju Malieckal, Erin Little, Sury Anand. Review of efficacy and safety of laxatives use in geriatrics. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. May 2016. [Assessed 26th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848256/

3. Mengting Li, Zhijie Zhang, Qiao Chen, Xiaoling Zhou, Diankui Shui, PhD, Jiean Huang. Comparative Effectiveness and Safety of Polyethylene Glycol Electrolyte Solution Versus Lactulose for Treatment of Hepatic Encephalopathy. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. January 2022. [Assessed 26th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647701/

4. Klocke Pharma-Service GmbH. Electronic Medicines Compendium (EMC). [Revised in May 2020] [Assessed 26th August 2022] https://www.medicines.org.uk/emc/files/pil.9648.pdf