Introduction About ORATIL 125 ORAL SUSPENSION

ORATIL 125 ORAL SUSPENSION contains Cefuroxime which belongs to the group of medicines called Antibiotics. It is used to manage bacterial infections such as pharyngitis and tonsillitis (upper respiratory tract infection), acute bacterial otitis media (infection of the middle ear), cystitis (infection of the urinary bladder), pyelonephritis (infection affecting the kidneys), acute bacterial maxillary sinusitis (infection of the nasal cavity and sinuses), and impetigo (infection of the skin).

Before starting the management, your doctor may want to do some tests to know the type of bacteria causing the infection and monitor bacterial sensitivity to ORATIL 125 ORAL SUSPENSION during the management. Before giving ORATIL 125 ORAL SUSPENSION to your child, inform your doctor if your child is allergic (hypersensitive) to cefuroxime, any other group of cephalosporins and penicillin antibiotics.

Before giving ORATIL 125 ORAL SUSPENSION to your child, inform your doctor if your child have or had any heart problems, liver or kidney problems. During the therapy, your doctor would regularly monitor your child’s health to avoid the risk of side effects.

Your doctor will prescribe the right dose and duration depends on the child’s age, body weight and health condition, so stick to the dose, time, and duration prescribed by the doctor.  Minor and temporary side effects may be experienced after the intake of this medicine. These includes dizziness, diarrhoea and sickness.

Generally, these effects subside once the child’s body adapts to the medicine. However, in case of prolonged or bothersome events, consult your doctor immediately without any delay. Inform your doctor about your child’s complete medical history including any previous episodes of allergies.

Uses Of ORATIL 125 ORAL SUSPENSION

It is used to manage:

• respiratory tract infections
• ear nose and throat infections
• skin and skin structure infections
• urinary tract infections
• intra-abdominal infections

How ORATIL 125 ORAL SUSPENSION Works

ORATIL 125 ORAL SUSPENSION is a second-generation cephalosporin that interferes with the production of the bacterial cell wall by blocking its binding to specific binding proteins located inside the bacterial cell wall. This leads to breaking down the cell wall of the bacteria and reducing its stability, thus causing cell damage, and eventually causing bacterial elimination.

How to use ORATIL 125 ORAL SUSPENSION

Take ORATIL 125 ORAL SUSPENSION as advised by your physician. Shake well before use. It is for pediatric use only. Your doctor will prescribe the right dose depends on your child’s age body weight and disease condition.

Side Effects Of ORATIL 125 ORAL SUSPENSION

How To Manage Side Effects

Diarrhea

Give lots of fluids, such as water or fruit juices to keep your child hydrated. Avoid giving any medicine on your own for managing diarrhoea. Consult your doctor if the symptom did not improve.

Headache

Give plenty of water and apply a wet or cold cloth on child’s forehead. Apply pain balm to head to ease off the pain. If there is no improvement in the symptom, contact your doctor.

Stomach Pain

Give your child smaller and frequent meals. Keep a heating pad on the stomach. If the symptom does not improve, contact your doctor.

Warning & Precautions

Driving and Using Machines

Use with Caution

Do not allow your child drive or play outdoors, as ORATIL 125 ORAL SUSPENSION may cause dizziness or blurry vision. Consult your doctor before giving ORATIL 125 ORAL SUSPENSION.

Kidney

Use with Caution

ORATIL 125 ORAL SUSPENSION should be used with caution if the child have kidney disease. Consult your doctor before giving ORATIL 125 ORAL SUSPENSION.

Liver

Use with Caution

ORATIL 125 ORAL SUSPENSION should be used with caution if the child have liver disease. Consult your doctor before giving ORATIL 125 ORAL SUSPENSION.

Allergy

Contraindicated

Do not give ORATIL 125 ORAL SUSPENSION if your child is allergic (hypersensitive) to Cefuroxime or other cephalosporins and antibiotics such as penicillins, monobactams and carbapenems.

Lungs

Use with Caution

ORATIL 125 ORAL SUSPENSION should be used with caution if the child have any lung problems. Consult your doctor before giving ORATIL 125 ORAL SUSPENSION.

Heart Disease

Use with Caution

ORATIL 125 ORAL SUSPENSION should be used with caution if your child have any heart disease. If needed, dose will be adjusted accordingly. Consult your doctor for advice.

Use In Pediatrics

Consult your doctor

ORATIL 125 ORAL SUSPENSION is not recommended in children below 3 months of age as the safety and effectiveness are not known in this age group. Your doctor will give the right dose depends on your child’s age, body weight and disease condition.

Interactions

A. Drug-Drug interactions:

Before using ORATIL 125 ORAL SUSPENSION, inform your doctor if your child is taking any medicines including prescription, non-prescription and herbal supplements.

Overdosage:

If your child accidentally takes too much of ORATIL 125 ORAL SUSPENSION, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep out of reach of children
• Store at room temperature

FAQs About ORATIL 125 ORAL SUSPENSION

Q: Is ORATIL 125 ORAL SUSPENSION the same as penicillin?

A: No, ORATIL 125 ORAL SUSPENSION belongs to the second-generation class of cephalosporins and is active against numerous gram-positive and gram-negative bacteria, including those who show resistance to other antibiotics such as penicillin.

Q: What if my child takes too much ORATIL 125 ORAL SUSPENSION?

A: ORATIL 125 ORAL SUSPENSION is unlikely to cause harm if you give an extra dose by mistake. However, you must still tell your child’s doctor immediately.

Q: Can other medicines be given at the same time as ORATIL 125 ORAL SUSPENSION?

A: ORATIL 125 ORAL SUSPENSION may interact with other medicines or substances. Tell your doctor about any other medicines your child is taking before starting ORATIL 125 ORAL SUSPENSION. Also, check with your child’s doctor before giving any medicine to your child.

Q: For how long should I give ORATIL 125 ORAL SUSPENSION?

A: Your doctor might advise you on how long your child should continue to take ORATIL 125 ORAL SUSPENSION. You will need to consult your doctor from time to time to review the child’s management and assess the symptoms.

Q: Can ORATIL 125 ORAL SUSPENSION be taken in new born babies?

A: No, ORATIL 125 ORAL SUSPENSION is not recommended for children younger than 3 months of age. Consult your doctor for advice before giving the medicine.

References

1. KD Tripathi. Second-generation cephalosporins. Essentials of Medical Pharmacology. Eighth edition. Page - 777.

2. Scott LJ, Ormrod D, Goa KL. Cefuroxime axetil: an updated review of its use in the management of bacterial infections. Drugs. 2001.National Library of Medicine. Pubmed.gov. [Accessed on 10th September 2022] https://pubmed.ncbi.nlm.nih.gov/11558834/

3. GlaxoSmithKline. [Revised in January 2007] [Accessed on 10th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050605s042lbl.pdf

4. Glaxo Wellcome UK Limited. Electronic Medicines Compendium (emc) [Revised in November 2019] [Accessed on 10th September 2022] https://www.medicines.org.uk/emc/files/pil.3814.pdf

5. Chiros Pharma. [Revised in February 2019] [Accessed on 10th September 2022] https://www.nafdac.gov.ng/wp-content/uploads/Files/SMPC/GORBACEF%20125%20(Cefuroxime%20Powder%20for%20Oral%20Suspension).pdf

6. Unichem Industries Ltd. [Revised in October 2019] [Accessed on 10th September 2022] https://fdaghana.gov.gh/img/pils/Kefrox%20125mg_5ml%20Oral%20Suspension%20(Cefuroxime%20Axetil%20Oral%20Suspension).pdf

7. GlaxoSmithKline (Ireland) Ltd. Electronic Machine Compendium [Revised in January 2018] [Accessed on 10th September 2022] https://gskpro.com/content/dam/global/hcpportal/en_MT/PDF/Homepage/Products/zinnat/Zinnat%20125mg.pdf

Useful Diagnostic Tests

• Complete Blood Count