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Introduction About ONGLYZA 5MG TABLET
ONGLYZA 5MG TABLET contains Saxagliptin which belongs to the group of medicines called Anti-diabetic drugs. It is used in adults (18 years and older) to manage type 2 diabetes that cannot be adequately controlled with one oral anti-diabetic medicine, diet, and exercise. It is used alone or together with insulin or other anti-diabetic medicines (Ex. metformin, sulfonylureas).
Type 2 diabetes is a condition in which your body does not make enough insulin (a hormone that helps control your blood sugar levels) or the insulin that is produced does not work to control glucose levels. It can show symptoms like increased thirst, urination, hunger, blurry vision, numbness in the hands or feet or tiredness.
Appropriate diet and exercise can help your body use its blood sugar better. Follow any advice given by your doctor regarding skin and foot care. Before taking ONGLYZA 5MG TABLET, inform your doctor if you have any serious kidney, liver, or heart problems, reduced immunity, type-1 diabetes, or pancreatic problems.
ONGLYZA 5MG TABLET is not recommended for use during pregnancy and breastfeeding. Therefore, consult your doctor before taking it. ONGLYZA 5MG TABLET is not recommended for use in children and adolescents under 18 years of age.
The most common side effects of taking ONGLYZA 5MG TABLET are upper respiratory and urinary tract infections and headaches. Contact your doctor if any of the symptoms worsen.
Uses Of ONGLYZA 5MG TABLET
- To manage type 2 diabetes
How ONGLYZA 5MG TABLET Works
ONGLYZA 5MG TABLET works by inhibiting Dipeptidyl Peptidaye-4 (DPP-4) enzyme activity and decreasing glucagon concentrations, thus increasing glucose-dependent insulin secretion from pancreatic beta cells.
How to use ONGLYZA 5MG TABLET
Take ONGLYZA 5MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of ONGLYZA 5MG TABLET
Serious
Stop taking ONGLYZA 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- low blood sugar (shaking, sweating, anxiety, blurred vision, tingling lips, paleness, mood change, vagueness, confusion, rapid heartbeat, hunger, or headache)
- serious allergic reaction (rash, raised red patches on your skin, swelling of the face, lips, tongue, and throat that may cause trouble breathing or swallowing)
- bullous pemphigoid symptoms such as skin blistering
- symptoms of heart failure (breathlessness, rapid increase in weight and swelling of the feet)
- pancreatitis (inflammation of the pancreas)
- prolonged severe abdominal pain which may be accompanied by vomiting
- severe disabling joint pain
Common
- upper respiratory tract infection
- urinary tract infection
- headache
- dizziness
- diarrhea
- stomach pain
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Dizziness Or Drowsiness
Lie down until the dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs.
Headache
Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for headaches.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.
Warning & Precautions
Pregnancy
ContraindicatedONGLYZA 5MG TABLET is not recommended for use by pregnant women. Consult your doctor before taking it.
Breastfeeding
ContraindicatedONGLYZA 5MG TABLET is not recommended for use by breastfeeding women as it is not known if it passes into human breast milk. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy (hypoglycemic) after taking ONGLYZA 5MG TABLET.
Kidney
Consult your doctorONGLYZA 5MG TABLET is not recommended for use in patients with end-stage renal disease who are on hemodialysis. ONGLYZA 5MG TABLET should be used with caution in patients with reduced kidney function. Consult your doctor before taking it.
Liver
Consult your doctorONGLYZA 5MG TABLET is not recommended for use in patients with severe liver problems. ONGLYZA 5MG TABLET should be used with caution in patients with moderate liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take ONGLYZA 5MG TABLET if you are allergic to Saxagliptin or any of the other ingredients of this medicine.
Heart Disease
Use with CautionONGLYZA 5MG TABLET should be used with caution in patients with heart failure. Consult your doctor before taking it.
Use In Pediatrics
ContraindicatedONGLYZA 5MG TABLET is not recommended for use in children and adolescents under 18 years of age. Consult your doctor before taking it.
Others
ONGLYZA 5MG TABLET is not recommended for use if you:
- have diabetes type 1 (your body does not produce any insulin)
- have diabetic ketoacidosis (high blood sugar, rapid weight loss, nausea, vomiting)
- diabetic pre-coma or diabetic coma
- hereditary diseases
- galactose intolerance
- lapp lactase deficiency
- glucose-galactose malabsorption
Before taking ONGLYZA 5MG TABLET, inform your doctor if you:
- have any condition that reduces your defense against infections, such as AIDS or from medicines that you might take after an organ transplant
- have or had inflamed pancreas
- have stress conditions (fever, infection, surgery, trauma)
Interactions
A. Drug-Drug interactions:
Before taking ONGLYZA 5MG TABLET, inform your doctor if you are taking any of the following medicine:
- carbamazepine, phenobarbital or phenytoin (used to control fits (seizures) or chronic pain)
- dexamethasone (used to manage inflammation)
- rifampicin (used to manage infections such as tuberculosis)
- ketoconazole (used to manage fungal infections)
- diltiazem (used to lower blood pressure)
Overdosage:
If you or anyone else accidentally use too much of ONGLYZA 5MG TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Saxagliptin |
| Pharmacological Category | : | Dipeptidyl Peptidase-4 Inhibitors |
| Therapeutic Indication | : | Type-2 Diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep ONGLYZA 5MG TABLET out of reach of children
- Store between 15-30°C
FAQs About ONGLYZA 5MG TABLET
Q: Can ONGLYZA 5MG TABLET cause heart failure?
A: Heart failure is seen in patients managed with ONGLYZA 5MG TABLET. You are at greater risk of heart failure if you have or have had any heart or blood vessel disease, like heart failure, a heart attack, or kidney disease.
Symptoms include tiredness, swollen ankles, a rapid increase in weight, and increased breathlessness, especially when lying down. You must talk to your doctor immediately or go to the nearest hospital if this happens to you.
Q: Can ONGLYZA 5MG TABLET be used on infants?
No, ONGLYZA 5MG TABLET is recommended for use by adults only and is not recommended for children and adolescents below 18 years of age, as its safety and effectiveness in children have not been studied. Your doctor will determine the correct dose or select a suitable alternative therapy for your child.
Q: Can ONGLYZA 5MG TABLET be crushed?
A: No. Do not break, split, crush, or chew ONGLYZA 5MG TABLET. Simply swallow it with a glass of water.
Q: What if I miss a dose of ONGLYZA 5MG TABLET?
A: If you miss a dose of ONGLYZA 5MG TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take the medicine twice to make up for the missed dose.
Q: Can ONGLYZA 5MG TABLET cause hypoglycemia?
A: Yes. ONGLYZA 5MG TABLET may cause hypoglycemia (low blood sugar levels). In such cases, have fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If you have not reached your optimum level, take another sugary snack or drink and check your blood sugar again.
Q: Can I stop taking ONGLYZA 5MG TABLET?
A: Do not stop taking ONGLYZA 5MG TABLET without consulting your doctor. Take it for as long as your doctor tells you to keep your sugar levels under control. If you have any more doubts regarding the use of ONGLYZA 5MG TABLET, ask your doctor.
References
1. Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey. Diabetes Mellitus. Pharmacotherapy- A Pathophysiologic Approach. Eighth edition. Page-1263, 1264.
2. Onglyza. NIH National Library of Medicine, National center for biotechnology information. PubChem. May 2022. [Accessed on 31st May 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Onglyza#section=Pharmacology-and-Biochemistry
3. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 30th May 2022] https://www.medicines.org.uk/emc/files/pil.6675.pdf
4. AstraZeneca Canada Inc. Saxagliptin. [Revised in June 2021] [Accessed on 30th May 2022] https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/onglyza-consumer-information-leaflet-en.pdf
Useful Diagnostic Tests
- Glucose-Fasting Blood
- Glucose-Postprandial Blood
- Glycosylated Hemoglobin
Author Details
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
