Introduction About ONDERO MET 2.5/500MG TABLET

Ondero Met 2.5/500mg Tablet is a fixed-dose combination of Linagliptin (2.5 mg) and Metformin Hydrochloride (500 mg), commonly used in adults with Type 2 Diabetes Mellitus who need additional support to manage blood sugar levels. It may be suggested when blood glucose is not controlled with Metformin alone, along with healthy eating and regular physical activity. This dual-ingredient tablet works through two different mechanisms—Linagliptin supports the body’s insulin response after meals, while Metformin reduces glucose production in the liver—offering complementary action for balanced glucose support.

This tablet is generally suitable for adults with Type 2 diabetes whose blood sugar levels are not adequately managed with a single agent. It may also be prescribed as a replacement therapy for those already taking Linagliptin and Metformin separately. The tablet is typically taken once or twice daily with food, as directed by a healthcare provider. Taking it with meals helps reduce stomach upset and supports consistent glucose response. It's important not to skip doses or stop the medicine suddenly without consulting a doctor.

Users should follow certain precautions while using this medication. Regular blood sugar monitoring, adherence to dietary guidelines, and routine follow-ups are advised. Those with kidney, liver, or heart conditions, or who consume alcohol frequently, should inform their doctor before starting. This medicine is not recommended during pregnancy or breastfeeding unless specifically advised by a healthcare provider. Dose adjustments or alternative options may be considered in such cases.

Some common side effects may include nausea, stomach discomfort, diarrhea, or a metallic taste. These are generally mild and may reduce over time. Rarely, users may experience symptoms like dizziness or low blood sugar, especially if taken with other sugar-lowering agents. Any unusual symptoms like shortness of breath, weakness, or severe abdominal pain should be reported to a doctor immediately. As with all medicines, Ondero Met 2.5/500mg should be used strictly under medical supervision.

Uses Of ONDERO MET 2.5/500MG TABLET

• For adults with Type 2 diabetes to help manage blood sugar.
• As replacement therapy for patients already stabilized on Linagliptin and Metformin taken separately

Benefits of ONDERO MET 2.5/500MG TABLET

Dual therapy for blood sugar management benefits

Ondero Met 2.5/500mg Tablet is typically indicated for adults who need additional support in managing their blood sugar levels, especially when a single medication like Metformin alone may not be sufficient.

This tablet combines two active agents:

• Linagliptin (2.5mg) – a DPP-4 inhibitor
• Metformin (500mg) – a biguanide

The dual mechanism of action provides several practical benefits:

• Works through complementary pathways to support post-meal and fasting blood sugar control
• Helps reduce glucose production by the liver while enhancing the body’s natural insulin response
• May provide a more consistent glucose profile across the day, especially in individuals with erratic glucose patterns

This dual therapy is often suggested when lifestyle measures and initial single-agent approaches do not provide sufficient glycemic control.

Real-world benefit of combination therapy in diabetes care

In everyday use, combination tablets like Ondero Met 2.5/500mg offer several practical advantages, especially for individuals following a structured health plan advised by a healthcare provider.

Based on its indication for adults with elevated blood sugar levels inadequately managed by diet, exercise, and Metformin alone, this product is often part of a step-up care strategy.

Real-world benefits include:

• Simplified medication routine: Combining two ingredients in one tablet may reduce pill burden and promote better adherence
• Convenient scheduling with meals: Designed to be taken with food, making it easy to integrate into morning or evening routines
• Supports long-term care goals: Aligns with clinical practices that recommend combination therapy for more consistent glucose outcomes

This approach helps bridge the gap between lifestyle measures and more intensive interventions.

Can Ondero Met support lifestyle changes?

Ondero Met 2.5/500mg Tablet can complement structured lifestyle adjustments such as improved meal planning, regular activity, and routine blood sugar monitoring—especially when advised by healthcare professionals.

While it is not a substitute for these changes, its indicated use for individuals needing enhanced blood sugar support makes it a valuable part of a broader wellness strategy.

How it supports lifestyle integration:

• Meal-aligned intake encourages routine and mindful eating habits
• Dual action formula works alongside lifestyle measures to support daily glucose goals
• One-tablet convenience fits well with simplified regimens and patient routines

How ONDERO MET 2.5/500MG TABLET Works

Understanding How Ondero Met Helps Manage Blood Sugar Levels in Type 2 Diabetes

It is typically considered in adults with Type 2 Diabetes Mellitus who require additional support in managing their blood sugar levels.

How It Works:

• Metformin (500 mg):
  Acts primarily on the liver to reduce excess glucose production. It also helps improve the body’s sensitivity to insulin, supporting better glucose use in the muscles.
• Linagliptin (2.5 mg):
  A DPP-4 inhibitor that increases levels of natural hormones called incretins. These hormones help the pancreas release insulin more effectively after meals and reduce sugar made by the liver, especially when blood glucose is high.

Dual Mechanism, Complementary Action:

Together, these two ingredients:

• Target both fasting and post-meal blood sugar levels
• Support more stable glucose levels throughout the day
• Allow for glucose control through different but complementary pathways

This combination approach supports improved glycemic outcomes, particularly in individuals whose blood sugar is not adequately controlled by Metformin alone.

How to use ONDERO MET 2.5/500MG TABLET

Dosage schedule for Ondero Met in Type 2 Diabetes

• Taken once or twice daily, depending on the doctor’s advice and individual glucose profile.
• The dosage is based on current blood sugar levels, previous medications, and response to ongoing therapy.
• May be prescribed as a replacement for those already stabilized on separate doses of Linagliptin and Metformin.
• Should be taken exactly as advised by the healthcare provider—do not self-adjust the dose or frequency.
• Regular monitoring of blood glucose is encouraged to assess effectiveness and adjust dosage if required.

Food and Timing Instructions for Ondero Met Tablet

• Ondero Met 2.5/500mg should be taken with meals—usually during or just after food.
• Taking it with food helps reduce the risk of gastrointestinal discomfort such as nausea or upset stomach.
• Do not crush or chew the tablet; swallow it whole with a glass of water.
• Maintain a consistent time each day for better blood sugar stability.
• Avoid skipping meals while on this medication, as it may increase the risk of low blood sugar if used with other agents.
• Hydration is important—drink enough water unless otherwise restricted by your healthcare provider.

Ondero Met 2.5/500mg Tablet: Usage and Safety Guidelines

• Not recommended for people with Type 1 Diabetes or a history of diabetic ketoacidosis.
• Patients with kidney or liver problems should consult their doctor before use—dose adjustment may be required.
• Avoid alcohol consumption, which may increase the risk of lactic acidosis (a rare but serious condition).
• Not suitable during pregnancy or breastfeeding, unless specifically advised by a healthcare provider.
• Common side effects may include nausea, bloating, or mild diarrhea, especially when starting treatment.
• Seek medical attention if experiencing signs of unusual tiredness, shortness of breath, or abdominal discomfort.

What if I forgot to take ONDERO MET 2.5/500MG TABLET

If you forget to take a dose of Ondero Met 2.5/500mg Tablet, take it as soon as you remember, preferably with food. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing routine. Do not take two doses at the same time or extra doses to make up for the missed one, as this may increase the risk of side effects such as low blood sugar. Setting daily reminders or using a pill organizer can help ensure consistent use. If you frequently miss doses, consult your healthcare provider for advice on managing your dosing schedule.

Overdose

Taking more than the prescribed dose of Ondero Met 2.5/500mg Tablet can lead to serious side effects. Overconsumption of Metformin may increase the risk of lactic acidosis, a rare but potentially serious condition marked by symptoms such as unusual tiredness, rapid breathing, muscle pain, stomach discomfort, or dizziness. Overdose of Linagliptin may cause symptoms like low blood sugar, especially when used with other glucose-lowering agents. In case of accidental or intentional overdosage, seek immediate medical attention or contact a nearby hospital. It is advisable to keep the tablet out of reach of children and never share your medicine with others.

Side Effects Of ONDERO MET 2.5/500MG TABLET

Like all medicines, ONDERO MET 2.5/500MG TABLET may cause certain side effects, although not everybody gets them.

The most common side effects of taking ONDERO MET 2.5/500MG TABLET are:

• Nausea and vomiting
• diarrhea, stomach pain
• changes in taste (metallic taste)
• increased lipase levels in blood
• Hypoglycemia

When to Seek Medical Attention?

• signs of severe decrease in blood sugar levels (such as increased sweating, feeling shaky, anxiety, blurred vision, tingling sensation in the lips, pale skin, mood changes or confusion)
• serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• severe skin rashes with redness and blistering of the skin
• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
• signs of liver damage (such as tiredness, loss of appetite, weight loss, with or without yellowing of the skin or whites of the eyes)

How To Manage Side Effects

Diarrhea

• Take the medicine with meals to lessen bowel disturbances.
• Drink plenty of fluids like water or electrolyte solutions to prevent dehydration.
• Avoid dairy, caffeine, or high-fiber foods until symptoms ease.
• If diarrhea lasts more than 2–3 days, consult your healthcare provider.

Nausea And Vomiting

• Take the tablet with meals to reduce stomach irritation.
• Eat smaller, more frequent meals instead of large ones.
• Avoid spicy, greasy, or heavy foods until nausea settles.
• Drink clear fluids like water or light soups to stay hydrated.
• Inform your doctor if nausea continues beyond a few days.

Stomach Pain

• Always take the medicine after food to reduce stomach discomfort.
• Avoid carbonated drinks, caffeine, and acidic foods temporarily.
• Use a heating pad or warm compress on the stomach to ease cramps.
• Do gentle activities like walking instead of lying down after meals.
• Persistent or sharp pain should be reported to your doctor.

Warning & Precautions

Pregnancy

Monitoring required

It is not known whether the use of ONDERO MET 2.5/500MG TABLET could affect the unborn baby. Animal studies on rats and rabbits have shown no evidence of teratogenicity (birth defects). However, at very high doses, there were some reports of maternal toxicity, delayed fetal development, and reduced offspring weight. Therefore, it should not be used during pregnancy unless recommended by your doctor.

Breastfeeding

Monitoring required

It is not known whether the use of ONDERO MET 2.5/500MG TABLET could pass through the breast milk. In lactating rats, the medicine was found in milk. Potential risks to the nursing infant are unknown. Therefore, it should be used in breastfeeding only if considered necessary by the physician.

Driving and Using Machines

Safe

ONDERO MET 2.5/500MG TABLET has no influence on your ability to drive or handle heavy tools or machines. However, do not drive or operate any machines if your ability is affected by ONDERO MET 2.5/500MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking ONDERO MET 2.5/500MG TABLET as it may increase the risk of unwanted side effects.

Kidney

Contraindicated

ONDERO MET 2.5/500MG TABLET is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

ONDERO MET 2.5/500MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gall stones. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take ONDERO MET 2.5/500MG TABLET if you are allergic to Metformin or Linagliptin or any other ingredients of this medicine.

Lungs

Contraindicated

ONDERO MET 2.5/500MG TABLET is not recommended for use in patients with severe infections of the lungs or respiratory tract. Therefore, consult your doctor before taking it.

Heart Disease

Contraindicated

ONDERO MET 2.5/500MG TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure, recent heart attack, arrythmia, prolonged QT interval). Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

ONDERO MET 2.5/500MG TABLET is not generally recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Use In Geriatrics

Monitoring required

ONDERO MET 2.5/500MG TABLET should be used with caution among the elderly patients (aged 65 years or above). Studies in aged animals show no age-specific adverse effects, but older subjects may have reduced renal or hepatic function that could influence drug metabolism. Regular monitoring of renal function, blood sugar levels, and signs of drug intolerance should be checked. Therefore, consult your doctor before taking it.

Other Warnings for ONDERO MET 2.5/500MG TABLET

Before taking ONDERO MET 2.5/500MG TABLET, inform your doctor if you:

• have type I diabetes mellitus (insulin-dependent diabetes)
• have a need for any surgery

Who should not take [GBNKEYWORD

ONDERO MET 2.5/500MG TABLET is not recommended for use if you:

• have severe, uncontrollable diabetes
• have diabetic coma
• have nausea, vomiting, diarrhea or rapid weight loss
• have lactic acidosis or ketoacidosis (buildup of lactic acid or ketones in the body)
• are dehydrated (due to drinking less fluid or had severe vomiting or diarrhea during the recent days)
• have any severe systemic infections
• have shock or problems in blood circulation

Safety Advice

Important Warnings to Know Before Taking Ondero Met 2.5/500mg Tablet

Before starting Ondero Met 2.5/500mg Tablet, it is essential to be aware of a few key precautions:

• Kidney Function: This tablet contains Metformin, which is cleared through the kidneys. Impaired kidney function may increase the risk of side effects. A renal function test is advised before starting and periodically during use.
• Liver Function: Liver-related issues may interfere with how the body processes this medicine.
• Lactic Acidosis Risk: A rare but serious condition called lactic acidosis has been associated with Metformin, particularly in individuals with kidney, liver, or heart conditions.
• Surgical or Radiological Procedures: Use of contrast dye or undergoing surgery may require temporary discontinuation of this tablet. Always inform your doctor beforehand.
• Alcohol Use: Frequent or heavy alcohol consumption can increase the risk of unwanted side effects, including lactic acid build-up.
• Other Medicines: Inform your doctor of all ongoing medications, including over-the-counter and herbal products, to avoid potential interactions.

Special Situations Where Ondero Met Should Be Used Carefully

Certain health conditions or life stages may require closer supervision or dose adjustments:

• Pregnancy and Breastfeeding: Use during pregnancy or while breastfeeding should be discussed with a healthcare professional. The safety of this combination in these conditions is not well established.
• Older Adults: Kidney function naturally declines with age. Older adults should have kidney function assessed regularly when using Metformin-containing medicines.
• Heart Conditions: If there is a history of heart failure or other cardiac concerns, caution is advised as certain complications may elevate risk.
• Acute Illness: Conditions like severe infection, dehydration, or reduced food intake may temporarily affect how the body handles blood sugar medications.
• Planned Surgeries: Temporary discontinuation may be required before and after certain medical or surgical procedures.

Monitoring and Lab Tests While Taking Ondero Met Tablet

Regular health monitoring helps ensure safe and effective use of Ondero Met 2.5/500mg Tablet. Key tests and follow-ups may include:

• Kidney Function Tests (eGFR, Creatinine): Essential before starting and periodically during treatment to ensure kidneys are clearing the medicine effectively.
• Liver Function Tests (LFTs): Helps track liver health, especially in long-term users.
• Blood Sugar Monitoring: Fasting and post-meal glucose levels may be checked routinely to guide ongoing therapy.
• HbA1c Test: Provides an average blood sugar level over the past 2–3 months; typically measured every 3–6 months.
• Vitamin B12 Levels: Long-term use of Metformin may affect absorption of vitamin B12. Periodic screening may be advised.
• Lactic Acid Levels (if needed): In specific cases where lactic acidosis is suspected, additional lab tests may be ordered.

Diet and Lifestyle Advice

While the tablet supports glucose control, maintaining a healthy lifestyle is equally important to enhance its benefits and support overall well-being.

Below are key dietary and lifestyle recommendations that can work alongside regular use of this medicine.

1. Meal Planning Tips

• Take the tablet with or just after meals to help reduce the risk of stomach discomfort.
• Focus on balanced meals that include whole grains, lean proteins, vegetables, and healthy fats.
• Avoid skipping meals or having long gaps between eating, as this may affect blood sugar balance.
• Limit salt intake to support cardiovascular health.
• Minimize consumption of sugary foods, sweetened beverages, and processed snacks.

2. Foods to Include

• Non-starchy vegetables like spinach, broccoli, and cauliflower
• Lean proteins such as eggs, fish, tofu, or skinless poultry
• Whole grains including brown rice, oats, and quinoa
• Legumes such as lentils, chickpeas, and beans
• Fruits in moderation, especially those with lower glycemic index like berries or apples
• Nuts and seeds in small quantities

3. Foods to Limit or Avoid

• Sugar-rich drinks such as packaged juices and sodas
• Fried, fatty, or processed foods
• Excess caffeine and alcohol
• High-sodium packaged or ready-to-eat meals

4. Physical Activity Suggestions

• Aim for at least 30 minutes of moderate activity most days of the week, such as walking or cycling.
• Include stretching or light exercises like yoga to improve flexibility and reduce stress.
• Stay active throughout the day and avoid sitting for long periods without movement.
• Choose activities that can be maintained consistently and safely.

5. Healthy Habits and Monitoring

• Take Ondero Met at the same time each day preferably with meals as directed by your doctor.
• Monitor blood sugar levels regularly, if recommended.
• Stay well-hydrated with water and non-sweetened beverages.
• Get enough rest each night—ideally 7 to 8 hours of sleep.
• Practice stress-reducing techniques such as deep breathing, quiet reading, or hobbies.

Benefits of Following a Healthy Lifestyle with Ondero Met

• Helps support more stable daily blood sugar levels
• May reduce the likelihood of digestive discomfort
• Encourages sustained energy and focus throughout the day
• Promotes long-term wellness when used consistently with healthy habits

Ondero Met vs single Metformin benefits

Drug - Drug interaction

Ondero Met 2.5/500mg Tablet which may interact with certain other medicines. Understanding possible drug interactions can help ensure safe use and avoid undesired effects. Below are common medications that may interact, along with general management guidance.  

1. Diuretics (e.g., Furosemide, Hydrochlorothiazide)

• Interaction: May reduce Metformin clearance, increasing the risk of lactic acidosis. Can also affect blood sugar levels.
• Management: Monitor kidney function and blood sugar more frequently. Dose adjustments may be necessary in long-term use.

2. Beta-Blockers (e.g., Atenolol, Metoprolol)

• Interaction: May mask symptoms of low blood sugar such as tremors and palpitations.
• Management: Educate patients to watch for other signs like hunger, sweating, or confusion. Regular monitoring is recommended.

3. Corticosteroids (e.g., Prednisolone, Dexamethasone)

• Interaction: May increase blood sugar levels and reduce the effectiveness of Linagliptin or Metformin.
• Management: Blood glucose levels should be monitored more closely, especially during long-term steroid use.

4. ACE Inhibitors (e.g., Enalapril, Ramipril)

• Interaction: May increase the glucose-lowering effect, leading to a higher risk of low blood sugar in some users.
• Management: Monitor blood sugar levels, especially during the initial phase of co-administration.

 5. Anticonvulsants (e.g., Phenytoin, Carbamazepine)

• Interaction: May affect blood glucose control by altering liver enzyme activity.
• Management: Regular glucose checks may be necessary; dose adjustments of Ondero Met may be considered in some cases.

6. Thyroid Medications (e.g., Levothyroxine)

• Interaction: May affect blood sugar control indirectly by altering metabolism.
• Management: Blood sugar levels should be assessed more frequently when initiating or adjusting thyroid therapy.

 7. Iodinated Contrast Media

• Interaction: May impair kidney function and increase the risk of Metformin-associated lactic acidosis.
• Management: Stop Metformin temporarily before and after contrast procedures; resume only after kidney function is confirmed to be normal.

Drug - Food interaction

How and when the medicine is taken-especially in relation to food-plays an important role in its effectiveness and safety. Certain food-related interactions can impact how the body responds to the medication.

Below are some important food and beverage interactions, along with general management tips:

1. Alcohol Consumption

• Interaction: Excessive alcohol can interfere with how the body processes lactic acid, especially when using Metformin. This raises the risk of a rare condition called lactic acidosis. Alcohol may also unpredictably affect blood sugar levels.
• Management Tip:
  ? Limit or avoid alcohol. If you consume alcohol occasionally, do so in moderation and never on an empty stomach.

2. High-Fat or Heavy Meals

• Interaction: Very high-fat meals may slow digestion and mildly delay the action of Metformin. In some individuals, fatty meals may also contribute to stomach discomfort when taken with the tablet.
• Management Tip:
  ? Choose light to moderate meals with a balance of carbohydrates, proteins, and healthy fats. Avoid oily or deep-fried foods at the time of taking the tablet.

3. Low-Carbohydrate Diets or Skipping Meals

• Interaction: Skipping meals or following a very low-carb diet can increase the risk of low blood sugar (hypoglycemia), especially when combined with other glucose-lowering agents.
• Management Tip:
  ? Maintain consistent meal timing. Avoid skipping meals when taking this medicine to support balanced blood glucose levels.

4. Caffeinated Beverages (Coffee, Energy Drinks)

• Interaction: While not a direct interaction, excessive caffeine may irritate the stomach and indirectly affect blood sugar in sensitive individuals.
• Management Tip:
  ? Limit caffeine to moderate levels (1–2 cups/day), especially around the time of medicine intake, if stomach upset occurs.

5. Fiber-Rich Foods (Whole Grains, Vegetables)

• Interaction: High-fiber meals may slow the absorption of carbohydrates, which can work synergistically with Metformin. However, extremely high fiber may mildly affect absorption of some drugs.
• Management Tip:
  ?A balanced fiber intake is generally beneficial. No need to avoid fiber unless advised otherwise by your healthcare provider.

Synopsis

More Information

Duration of Action: the medication provides extended blood sugar control for 12-24 hours, with Linagliptin contributing longer action, while Metformin works over a shorter but still effective duration.

Onset of Action: The onset of action for blood sugar reduction will typically be observed within 1 to 2 hours, with maximum effect occurring gradually over several hours to days.

FAQs About ONDERO MET 2.5/500MG TABLET

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.

2. Thomas Haak. Combination of Linagliptin and Metformin for the Treatment of Patients with Type 2 Diabetes. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. January 2015. [Accessed on 13th June 2025] 

3. Dragenopharm Apotheker Püschl GmbH. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 13th June 2025] 

4. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 13th June 2025] 

5. Central Drugs Standard Control Organization. Linagliptin 2.5mg/2.5mg/2.5mg + Metformin 500mg/850mg/1000mg Film coated Tablet. July 2013. [Accessed on 13th June 2025] 

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Vital Diabetes Care
• Comprehensive Diabetes Care
• Netmeds Diabetic Checkup
• Routine Diabetes Care
• Diabetes Care Package

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 14 Jun 2025 | 01:05 PM(IST)